Motif ID: HNF1A.p2

Z-value: 4.504


Transcription factors associated with HNF1A.p2:

Gene SymbolEntrez IDGene Name
HNF1A 6927 HNF1 homeobox A

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HNF1Achr12_+_1199009310.977.9e-10Click!


Activity profile for motif HNF1A.p2.

activity profile for motif HNF1A.p2


Sorted Z-values histogram for motif HNF1A.p2

Sorted Z-values for motif HNF1A.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HNF1A.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_-_105169370 37.330 NM_000354
 SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr17_-_61655915 32.187 NM_000042
 APOH
apolipoprotein H (beta-2-glycoprotein I)
chr4_+_74520796 30.525 NM_001134
 AFP
alpha-fetoprotein
chr4_+_74488910 28.807 ALB
albumin
chr4_+_74488947 28.438 ALB
albumin
chr14_-_93924663 27.328 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr14_-_93924873 26.299 NM_000295
 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr4_+_74488835 25.762 NM_000477
 ALB
albumin
chr4_+_74497998 24.922 ALB
albumin
chr7_+_45894480 23.515 NM_000596
 IGFBP1
insulin-like growth factor binding protein 1
chr4_+_74498042 20.974 ALB
albumin
chr11_+_46697345 20.348 F2
coagulation factor II (thrombin)
chr4_-_155731288 20.277 NM_000508
NM_021871
 FGA

fibrinogen alpha chain

chr4_-_110942576 19.547 CFI
complement factor I
chr8_-_17797127 18.899 NM_147203
NM_201553
NM_004467
NM_201552
 FGL1



fibrinogen-like 1



chr14_-_93859394 18.702 NM_001756
 SERPINA6
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
chr19_-_40995606 18.665 PRODH2
proline dehydrogenase (oxidase) 2
chr9_-_122852356 17.859 NM_001735
 C5
complement component 5
chr11_+_46697312 17.830 NM_000506
 F2
coagulation factor II (thrombin)
chr6_+_31731667 17.308 APOM
apolipoprotein M

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 26 entries
enrichment   p-value GO term description
51.68 1.22e-02 GO:0015712 hexose phosphate transport
51.68 1.22e-02 GO:0015760 glucose-6-phosphate transport
34.46 2.94e-03 GO:0051918 negative regulation of fibrinolysis
31.32 2.68e-04 GO:0051917 regulation of fibrinolysis
22.97 1.99e-02 GO:0030194 positive regulation of blood coagulation
19.69 3.93e-02 GO:0050820 positive regulation of coagulation
18.14 6.13e-03 GO:0034381 plasma lipoprotein particle clearance
14.77 2.53e-03 GO:0030195 negative regulation of blood coagulation
14.26 3.15e-03 GO:0050819 negative regulation of coagulation
12.70 1.06e-03 GO:0030301 cholesterol transport
12.37 1.27e-03 GO:0015918 sterol transport
12.16 8.41e-03 GO:0097006 regulation of plasma lipoprotein particle levels
10.88 1.64e-02 GO:0030193 regulation of blood coagulation
10.09 2.58e-02 GO:0050818 regulation of coagulation
10.03 1.16e-03 GO:0033500 carbohydrate homeostasis
10.03 1.16e-03 GO:0042593 glucose homeostasis
9.85 1.34e-03 GO:0010951 negative regulation of endopeptidase activity
8.32 1.98e-02 GO:0055088 lipid homeostasis
8.04 2.48e-02 GO:0072376 protein activation cascade
6.49 3.18e-02 GO:0010466 negative regulation of peptidase activity

Gene overrepresentation in compartment category:

Showing 1 to 12 of 12 entries
enrichment   p-value GO term description
29.54 1.73e-02 GO:0005577 fibrinogen complex
12.53 4.38e-02 GO:0034364 high-density lipoprotein particle
9.28 1.58e-03 GO:0031983 vesicle lumen
8.80 9.59e-03 GO:0031093 platelet alpha granule lumen
8.62 1.08e-02 GO:0034774 secretory granule lumen
8.47 2.94e-03 GO:0031091 platelet alpha granule
8.27 1.37e-02 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
5.59 2.67e-04 GO:0016324 apical plasma membrane
5.16 9.31e-05 GO:0045177 apical part of cell
3.07 3.39e-02 GO:0044463 cell projection part
2.57 2.17e-03 GO:0005615 extracellular space
2.21 1.39e-02 GO:0044421 extracellular region part

Gene overrepresentation in function category:

Showing 1 to 8 of 8 entries
enrichment   p-value GO term description
25.06 3.13e-03 GO:0034185 apolipoprotein binding
10.14 2.87e-02 GO:0005504 fatty acid binding
9.62 7.99e-03 GO:0043498 cell surface binding
8.75 7.83e-04 GO:0004867 serine-type endopeptidase inhibitor activity
5.45 9.70e-03 GO:0004866 endopeptidase inhibitor activity
5.35 1.11e-02 GO:0030414 peptidase inhibitor activity
5.22 1.36e-02 GO:0061135 endopeptidase regulator activity
4.00 5.43e-03 GO:0004857 enzyme inhibitor activity