Motif ID: SP1.p2

Z-value: 0.995


Transcription factors associated with SP1.p2:

Gene SymbolEntrez IDGene Name
SP1 6667 Sp1 transcription factor

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SP1chr12_+_52060689-0.421.0e-01Click!


Activity profile for motif SP1.p2.

activity profile for motif SP1.p2


Sorted Z-values histogram for motif SP1.p2

Sorted Z-values for motif SP1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SP1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_13035102 2.259 NM_006094
 DLC1
deleted in liver cancer 1
chr3_-_187025501 1.734 NM_001007225
NM_006548
 IGF2BP2

insulin-like growth factor 2 mRNA binding protein 2

chr11_+_46359878 1.601 NM_001012333
 MDK
midkine (neurite growth-promoting factor 2)
chr17_-_74432800 1.457 TIMP2
TIMP metallopeptidase inhibitor 2
chr12_-_13044467 1.431 NM_015987
 HEBP1
heme binding protein 1
chr11_+_46359855 1.380 MDK
midkine (neurite growth-promoting factor 2)
chr11_+_46359781 1.367 NM_002391
 MDK
midkine (neurite growth-promoting factor 2)
chr11_-_2907169 1.362 NM_003311
 PHLDA2
pleckstrin homology-like domain, family A, member 2
chr17_-_74432671 1.313 TIMP2
TIMP metallopeptidase inhibitor 2
chr6_-_2916980 1.297 SERPINB6
serpin peptidase inhibitor, clade B (ovalbumin), member 6
chr17_-_72218661 1.283 MXRA7
matrix-remodelling associated 7
chr12_-_13044314 1.229 HEBP1
heme binding protein 1
chr6_-_31805547 1.221 DDAH2
dimethylarginine dimethylaminohydrolase 2
chr19_+_50041400 1.203 PVRL2
poliovirus receptor-related 2 (herpesvirus entry mediator B)
chr1_-_20685314 1.182 NM_018584
 CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr1_-_223907283 1.178 NM_001008493
NM_018212
 ENAH

enabled homolog (Drosophila)

chr12_-_105056577 1.172 NUAK1
NUAK family, SNF1-like kinase, 1
chr11_+_46359821 1.171 MDK
midkine (neurite growth-promoting factor 2)
chr17_-_74433048 1.160 NM_003255
 TIMP2
TIMP metallopeptidase inhibitor 2
chr11_+_46359836 1.151 MDK
midkine (neurite growth-promoting factor 2)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 13 of 13 entries
enrichment   p-value GO term description
1.20 1.47e-03 GO:0048468 cell development
1.19 1.40e-02 GO:0048699 generation of neurons
1.18 1.45e-02 GO:0022008 neurogenesis
1.13 4.54e-02 GO:0009653 anatomical structure morphogenesis
1.11 4.05e-03 GO:0071842 cellular component organization at cellular level
1.11 4.19e-03 GO:0071841 cellular component organization or biogenesis at cellular level
1.11 1.80e-02 GO:0044267 cellular protein metabolic process
1.11 2.26e-02 GO:0048523 negative regulation of cellular process
1.10 9.71e-06 GO:0044260 cellular macromolecule metabolic process
1.10 3.19e-03 GO:0016043 cellular component organization
1.10 4.75e-02 GO:0048519 negative regulation of biological process
1.09 4.20e-03 GO:0071840 cellular component organization or biogenesis
1.06 5.75e-03 GO:0044237 cellular metabolic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 26 entries
enrichment   p-value GO term description
1.24 3.64e-03 GO:0005730 nucleolus
1.21 3.94e-03 GO:0015630 microtubule cytoskeleton
1.16 1.59e-02 GO:0044430 cytoskeletal part
1.15 2.17e-07 GO:0044428 nuclear part
1.15 1.29e-05 GO:0031981 nuclear lumen
1.14 3.43e-06 GO:0005829 cytosol
1.14 5.36e-03 GO:0005856 cytoskeleton
1.13 3.57e-06 GO:0043228 non-membrane-bounded organelle
1.13 3.57e-06 GO:0043232 intracellular non-membrane-bounded organelle
1.13 1.44e-05 GO:0070013 intracellular organelle lumen
1.13 4.97e-05 GO:0043233 organelle lumen
1.12 5.71e-05 GO:0031974 membrane-enclosed lumen
1.10 3.34e-09 GO:0044446 intracellular organelle part
1.10 2.36e-03 GO:0043234 protein complex
1.09 3.44e-09 GO:0044444 cytoplasmic part
1.09 6.14e-09 GO:0044422 organelle part
1.09 6.27e-08 GO:0005634 nucleus
1.08 2.40e-17 GO:0043229 intracellular organelle
1.08 2.64e-17 GO:0043226 organelle
1.08 1.52e-14 GO:0043227 membrane-bounded organelle

Gene overrepresentation in function category:

Showing 1 to 3 of 3 entries
enrichment   p-value GO term description
1.24 1.72e-02 GO:0019904 protein domain specific binding
1.10 3.68e-02 GO:0000166 nucleotide binding
1.06 3.46e-04 GO:0005515 protein binding