Motif ID: SP1.p2

Z-value: 0.995


Transcription factors associated with SP1.p2:

Gene SymbolEntrez IDGene Name
SP1 6667 Sp1 transcription factor

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SP1chr12_+_52060689-0.421.0e-01Click!


Activity profile for motif SP1.p2.

activity profile for motif SP1.p2


Sorted Z-values histogram for motif SP1.p2

Sorted Z-values for motif SP1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SP1.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_-_13035102 2.259 NM_006094
DLC1
deleted in liver cancer 1
chr3_-_187025501 1.734 NM_001007225
NM_006548
IGF2BP2

insulin-like growth factor 2 mRNA binding protein 2

chr11_+_46359878 1.601 NM_001012333
MDK
midkine (neurite growth-promoting factor 2)
chr17_-_74432800 1.457 TIMP2
TIMP metallopeptidase inhibitor 2
chr12_-_13044467 1.431 NM_015987
HEBP1
heme binding protein 1
chr11_+_46359855 1.380 MDK
midkine (neurite growth-promoting factor 2)
chr11_+_46359781 1.367 NM_002391
MDK
midkine (neurite growth-promoting factor 2)
chr11_-_2907169 1.362 NM_003311
PHLDA2
pleckstrin homology-like domain, family A, member 2
chr17_-_74432671 1.313 TIMP2
TIMP metallopeptidase inhibitor 2
chr6_-_2916980 1.297 SERPINB6
serpin peptidase inhibitor, clade B (ovalbumin), member 6
chr17_-_72218661 1.283 MXRA7
matrix-remodelling associated 7
chr12_-_13044314 1.229 HEBP1
heme binding protein 1
chr6_-_31805547 1.221 DDAH2
dimethylarginine dimethylaminohydrolase 2
chr19_+_50041400 1.203 PVRL2
poliovirus receptor-related 2 (herpesvirus entry mediator B)
chr1_-_20685314 1.182 NM_018584
CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr1_-_223907283 1.178 NM_001008493
NM_018212
ENAH

enabled homolog (Drosophila)

chr12_-_105056577 1.172 NUAK1
NUAK family, SNF1-like kinase, 1
chr11_+_46359821 1.171 MDK
midkine (neurite growth-promoting factor 2)
chr17_-_74433048 1.160 NM_003255
TIMP2
TIMP metallopeptidase inhibitor 2
chr11_+_46359836 1.151 MDK
midkine (neurite growth-promoting factor 2)
chr11_-_86343859 1.136 NM_012193
FZD4
frizzled homolog 4 (Drosophila)
chr2_+_10101081 1.126 NM_003597
NM_001177716
KLF11

Kruppel-like factor 11

chr12_-_123023052 1.110 NM_025140
CCDC92
coiled-coil domain containing 92
chr2_+_235525355 1.095 NM_014521
SH3BP4
SH3-domain binding protein 4
chr10_+_134201262 1.087 NM_005539
INPP5A
inositol polyphosphate-5-phosphatase, 40kDa
chr19_+_50041232 1.080 NM_001042724
NM_002856
PVRL2

poliovirus receptor-related 2 (herpesvirus entry mediator B)

chr10_-_15250616 1.076 NM_004808
NMT2
N-myristoyltransferase 2
chr10_-_80875097 1.063 NM_153367
ZCCHC24
zinc finger, CCHC domain containing 24
chr3_-_187025438 1.053 IGF2BP2
insulin-like growth factor 2 mRNA binding protein 2
chr19_+_50041424 1.024 PVRL2
poliovirus receptor-related 2 (herpesvirus entry mediator B)
chr14_-_52487558 1.024 NM_001134999
NM_001135000
NM_006832
FERMT2


fermitin family member 2


chr19_-_11169184 1.020 NM_001136191
KANK2
KN motif and ankyrin repeat domains 2
chr19_+_50041387 1.015 PVRL2
poliovirus receptor-related 2 (herpesvirus entry mediator B)
chr11_+_822965 0.986 CD151
CD151 molecule (Raph blood group)
chr6_+_2945025 0.984 NM_000904
NQO2
NAD(P)H dehydrogenase, quinone 2
chr11_+_823007 0.948 CD151
CD151 molecule (Raph blood group)
chr11_-_11987198 0.944 NM_015881
DKK3
dickkopf homolog 3 (Xenopus laevis)
chr21_+_45649429 0.942 NM_130445
COL18A1
collagen, type XVIII, alpha 1
chr5_+_71438796 0.927 NM_005909
MAP1B
microtubule-associated protein 1B
chr11_-_11987115 0.911 DKK3
dickkopf homolog 3 (Xenopus laevis)
chr3_-_43638471 0.906 NM_018075
ANO10
anoctamin 10
chr22_-_34754343 0.903 NM_001082578
NM_001082579
RBFOX2

RNA binding protein, fox-1 homolog (C. elegans) 2

chr3_-_43638425 0.902 ANO10
anoctamin 10
chr7_+_73506333 0.900 NM_005685
GTF2IRD1
GTF2I repeat domain containing 1
chr7_+_73506172 0.896 GTF2IRD1
GTF2I repeat domain containing 1
chr20_-_23566325 0.896 NM_000099
CST3
cystatin C
chr5_-_176832476 0.887 NM_080881
DBN1
drebrin 1
chr5_-_176833259 0.878 NM_004395
DBN1
drebrin 1
chr11_+_129445057 0.848 APLP2
amyloid beta (A4) precursor-like protein 2
chr11_-_11987414 0.848 DKK3
dickkopf homolog 3 (Xenopus laevis)
chr1_+_178390646 0.842 QSOX1
quiescin Q6 sulfhydryl oxidase 1
chr8_-_11762918 0.835 CTSB
cathepsin B
chr6_+_17501589 0.831 NM_006366
CAP2
CAP, adenylate cyclase-associated protein, 2 (yeast)
chr17_-_72218535 0.827 NM_001008528
NM_001008529
NM_198530
MXRA7


matrix-remodelling associated 7


chr22_+_21559959 0.815 NM_001178126
IGLL5
IGLC1
immunoglobulin lambda-like polypeptide 5
immunoglobulin lambda constant 1 (Mcg marker)
chr8_-_11763023 0.803 CTSB
cathepsin B
chr6_-_31805932 0.803 DDAH2
dimethylarginine dimethylaminohydrolase 2
chr3_-_125085834 0.802 NM_053025
NM_053026
NM_053027
NM_053028
MYLK



myosin light chain kinase



chr12_-_123023312 0.800 CCDC92
coiled-coil domain containing 92
chr3_-_130807865 0.795 NM_015103
PLXND1
plexin D1
chr21_+_45649719 0.787


chr5_-_176833197 0.780 DBN1
drebrin 1
chr6_-_31806012 0.780 NM_013974
DDAH2
dimethylarginine dimethylaminohydrolase 2
chr14_-_52487386 0.769 FERMT2
fermitin family member 2
chr14_-_106249999 0.764 IGHA1
immunoglobulin heavy constant alpha 1
chr11_+_46358909 0.764 NM_001012334
MDK
midkine (neurite growth-promoting factor 2)
chr17_-_78199384 0.752 NM_019613
WDR45L
WDR45-like
chr1_+_178390636 0.738 QSOX1
quiescin Q6 sulfhydryl oxidase 1
chr11_+_12652427 0.736 NM_021961
TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr2_-_36678657 0.731 NM_001042548
NM_005102
FEZ2

fasciculation and elongation protein zeta 2 (zygin II)

chr11_+_822909 0.729 NM_001039490
NM_004357
NM_139029
NM_139030
CD151



CD151 molecule (Raph blood group)



chr22_+_21340757 0.726


chr9_-_130912728 0.719 NM_000755
CRAT
carnitine O-acetyltransferase
chr1_+_178390529 0.714 NM_001004128
NM_002826
QSOX1

quiescin Q6 sulfhydryl oxidase 1

chr21_-_43368963 0.714 NM_000071
CBS
cystathionine-beta-synthase
chr11_-_61415429 0.709 NM_021727
FADS3
fatty acid desaturase 3
chr17_-_829655 0.706 NM_022463
NXN
nucleoredoxin
chr1_-_151873191 0.704 NM_001024210
S100A13
S100 calcium binding protein A13
chr1_+_178390654 0.698 QSOX1
quiescin Q6 sulfhydryl oxidase 1
chr19_+_54708247 0.697 NM_004107
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr6_-_32665409 0.697 NM_002124
HLA-DRB1
HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1
major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr8_-_11763004 0.692 CTSB
cathepsin B
chr1_+_178390660 0.687 QSOX1
quiescin Q6 sulfhydryl oxidase 1
chr7_+_73506047 0.687 NM_016328
GTF2IRD1
GTF2I repeat domain containing 1
chr11_+_129444877 0.685 NM_001142276
NM_001142277
NM_001142278
NM_001642
APLP2



amyloid beta (A4) precursor-like protein 2



chr19_+_54708312 0.683 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr21_+_46226072 0.683 NM_001848
COL6A1
collagen, type VI, alpha 1
chr2_-_183610992 0.678 NCKAP1
NCK-associated protein 1
chr2_-_158440587 0.675 NM_001111067
ACVR1
activin A receptor, type I
chr6_-_52549673 0.671 TRAM2
translocation associated membrane protein 2
chr10_-_126839000 0.666 CTBP2
C-terminal binding protein 2
chr15_-_27901828 0.666 NM_003257
NM_175610
TJP1

tight junction protein 1 (zona occludens 1)

chr22_+_21116283 0.665


chr19_+_59385930 0.664 NM_024075
TSEN34
tRNA splicing endonuclease 34 homolog (S. cerevisiae)
chr1_+_93686154 0.662 NM_001024948
NM_001164473
NM_017737
FNBP1L


formin binding protein 1-like


chr7_-_130891861 0.658 NM_001018111
NM_005397
PODXL

podocalyxin-like

chr6_+_33151703 0.653 NM_002121
HLA-DPB1
major histocompatibility complex, class II, DP beta 1
chr3_-_45242808 0.653 NM_015444
TMEM158
transmembrane protein 158 (gene/pseudogene)
chr11_-_110755112 0.653 POU2AF1
POU class 2 associating factor 1
chr9_-_130912603 0.652 CRAT
carnitine O-acetyltransferase
chr6_-_2916786 0.652 SERPINB6
serpin peptidase inhibitor, clade B (ovalbumin), member 6
chr19_-_18409788 0.651 NM_001170939
ISYNA1
inositol-3-phosphate synthase 1
chr8_-_11763031 0.650 CTSB
cathepsin B
chr10_-_126839056 0.646 NM_001329
CTBP2
C-terminal binding protein 2
chr19_+_3045528 0.636 GNA11
guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
chr3_-_45242624 0.635 TMEM158
transmembrane protein 158 (gene/pseudogene)
chr11_+_129444997 0.634 APLP2
amyloid beta (A4) precursor-like protein 2
chr1_-_22136263 0.629 NM_005529
HSPG2
heparan sulfate proteoglycan 2
chr5_+_141468498 0.627 NM_030571
NDFIP1
Nedd4 family interacting protein 1
chr4_-_158111995 0.627 NM_016205
PDGFC
platelet derived growth factor C
chr2_-_218551786 0.624 TNS1
tensin 1
chrX_-_101658297 0.621 NM_021992
TMSB15A
TMSB15B
thymosin beta 15a
thymosin beta 15B
chr11_-_2863536 0.620 NM_000076
NM_001122630
NM_001122631
CDKN1C


cyclin-dependent kinase inhibitor 1C (p57, Kip2)


chr15_-_20637731 0.618 NM_144599
NIPA1
non imprinted in Prader-Willi/Angelman syndrome 1
chr1_-_225572419 0.618 NM_003607
NM_014826
CDC42BPA

CDC42 binding protein kinase alpha (DMPK-like)

chr14_-_105163301 0.616 IGHG4
immunoglobulin heavy constant gamma 4 (G4m marker)
chr1_+_178390598 0.615 QSOX1
quiescin Q6 sulfhydryl oxidase 1
chr7_-_143230096 0.615 NM_014719
FAM115A
family with sequence similarity 115, member A
chr22_+_21370394 0.611 IGL@
immunoglobulin lambda locus
chr6_-_33149244 0.611 NM_033554
HLA-DPA1
major histocompatibility complex, class II, DP alpha 1
chr1_-_52228880 0.609 NM_002867
RAB3B
RAB3B, member RAS oncogene family
chr3_+_156280338 0.605 NM_007287
MME
membrane metallo-endopeptidase
chr4_-_177950658 0.603 NM_005429
VEGFC
vascular endothelial growth factor C
chr11_+_129445017 0.599 APLP2
amyloid beta (A4) precursor-like protein 2
chrX_-_34585287 0.597 NM_031442
TMEM47
transmembrane protein 47
chr3_+_123526700 0.596 NM_005213
CSTA
cystatin A (stefin A)
chr14_-_105182025 0.587


chr12_+_6424293 0.586 NM_001242
CD27
CD27 molecule
chr19_-_54835162 0.585 NM_006270
RRAS
related RAS viral (r-ras) oncogene homolog
chr10_+_94439658 0.585 NM_002729
HHEX
hematopoietically expressed homeobox
chr16_-_63713485 0.582 CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr10_-_725522 0.582 NM_014974
DIP2C
DIP2 disco-interacting protein 2 homolog C (Drosophila)
chr2_+_24126140 0.579 FKBP1B
FK506 binding protein 1B, 12.6 kDa
chr1_+_181259317 0.579


chr18_+_3439972 0.577 NM_173209
NM_173208
NM_003244
TGIF1


TGFB-induced factor homeobox 1


chr14_-_105181939 0.575 IGHG2
immunoglobulin heavy constant gamma 2 (G2m marker)
chr14_-_68515791 0.570 NM_001102
NM_001130004
NM_001130005
ACTN1


actinin, alpha 1


chr5_-_179166378 0.570 NM_014275
MGAT4B
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
chr17_-_1566223 0.570 C17orf91
chromosome 17 open reading frame 91
chr1_+_243200275 0.569 EFCAB2
EF-hand calcium binding domain 2
chr9_-_73573121 0.569 NM_001135820
NM_013390
TMEM2

transmembrane protein 2

chr14_-_105308639 0.567


chr11_-_11987458 0.566 NM_013253
DKK3
dickkopf homolog 3 (Xenopus laevis)
chr7_+_93861808 0.565 NM_000089
COL1A2
collagen, type I, alpha 2
chr2_+_24126087 0.563 NM_004116
NM_054033
FKBP1B

FK506 binding protein 1B, 12.6 kDa

chr1_+_181258952 0.561 NM_002293
LAMC1
laminin, gamma 1 (formerly LAMB2)
chr18_-_24010944 0.561 CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr1_-_95165037 0.555 CNN3
calponin 3, acidic
chr19_+_3045266 0.555 NM_002067
GNA11
guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
chr16_-_87450734 0.553 GALNS
galactosamine (N-acetyl)-6-sulfate sulfatase
chr14_-_105308720 0.553 IGHM
immunoglobulin heavy constant mu
chr7_-_1465487 0.548 MICALL2
MICAL-like 2
chr2_+_20510312 0.547 NM_004040
RHOB
ras homolog gene family, member B
chr17_-_60088637 0.544 SMURF2
SMAD specific E3 ubiquitin protein ligase 2
chr21_-_43369492 0.543 NM_001178008
NM_001178009
CBS

cystathionine-beta-synthase

chr14_-_105280425 0.540 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr3_-_15875932 0.534 NM_015199
ANKRD28
ankyrin repeat domain 28
chr7_-_50828608 0.533 NM_001001555
GRB10
growth factor receptor-bound protein 10
chr14_-_68515525 0.532 ACTN1
actinin, alpha 1
chr3_+_12813170 0.532 NM_001162499
NM_012298
CAND2

cullin-associated and neddylation-dissociated 2 (putative)

chr4_-_1156533 0.532 NM_012445
SPON2
spondin 2, extracellular matrix protein
chr20_+_30813851 0.530 NM_006892
NM_175848
NM_175849
DNMT3B


DNA (cytosine-5-)-methyltransferase 3 beta


chr17_-_1335763 0.529 NM_001080950
MYO1C
myosin IC
chr10_-_62373828 0.529 NM_014836
RHOBTB1
Rho-related BTB domain containing 1
chr14_+_95575319 0.523 C14orf132
chromosome 14 open reading frame 132
chr6_-_52549774 0.522 NM_012288
TRAM2
translocation associated membrane protein 2
chr6_+_37245860 0.521 NM_002648
PIM1
pim-1 oncogene
chr19_-_60350122 0.521 TNNT1
troponin T type 1 (skeletal, slow)
chr11_+_129445002 0.520 APLP2
amyloid beta (A4) precursor-like protein 2
chr19_+_54708302 0.519 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr14_+_105012106 0.518 NM_001312
CRIP2
cysteine-rich protein 2
chr10_+_121400741 0.515 NM_004281
BAG3
BCL2-associated athanogene 3
chr14_-_105182159 0.513 IGHG2
immunoglobulin heavy constant gamma 2 (G2m marker)
chr20_+_11819364 0.512 NM_181443
BTBD3
BTB (POZ) domain containing 3
chr11_-_65396775 0.511 NM_016938
EFEMP2
EGF containing fibulin-like extracellular matrix protein 2
chrX_+_54852217 0.511 NM_201222
MAGED2
melanoma antigen family D, 2
chr22_-_35875890 0.509 NM_000878
IL2RB
interleukin 2 receptor, beta
chr8_-_11763037 0.507 NM_001908
NM_147780
NM_147781
NM_147782
NM_147783
CTSB




cathepsin B




chr12_-_51132129 0.507 NM_005555
KRT6B
keratin 6B
chr17_+_77528699 0.506 NM_024083
ASPSCR1
alveolar soft part sarcoma chromosome region, candidate 1
chr5_-_179431204 0.505 RNF130
ring finger protein 130
chr9_+_102275455 0.505 TMEFF1
transmembrane protein with EGF-like and two follistatin-like domains 1
chrX_-_153428621 0.502 G6PD
glucose-6-phosphate dehydrogenase
chr5_-_16989371 0.499 NM_012334
MYO10
myosin X
chrX_-_17789276 0.497 NM_001172732
NM_001172739
NM_001172743
NM_021785
RAI2



retinoic acid induced 2



chr14_-_64508547 0.497 NM_198686
RAB15
RAB15, member RAS onocogene family
chr5_+_141468569 0.495 NDFIP1
Nedd4 family interacting protein 1
chr16_-_63713382 0.494 NM_001797
CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chrX_+_9392980 0.493 NM_005647
TBL1X
transducin (beta)-like 1X-linked
chr22_+_21495273 0.493


chr7_-_150847529 0.493 RHEB
Ras homolog enriched in brain
chr17_-_38427853 0.493 VAT1
vesicle amine transport protein 1 homolog (T. californica)
chr8_-_25371858 0.492 NM_017634
KCTD9
potassium channel tetramerisation domain containing 9
chr19_-_60350118 0.491 TNNT1
troponin T type 1 (skeletal, slow)
chr1_-_84928473 0.488 NM_001166295
NM_001166417
NM_001166293
NM_001166294
NM_014021
SSX2IP




synovial sarcoma, X breakpoint 2 interacting protein




chr14_-_29466562 0.487 NM_002742
PRKD1
protein kinase D1
chr19_-_59385265 0.487 MBOAT7
membrane bound O-acyltransferase domain containing 7
chr16_-_63713466 0.486 CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr2_+_46779553 0.486 NM_014011
SOCS5
suppressor of cytokine signaling 5
chr17_-_38427928 0.485 VAT1
vesicle amine transport protein 1 homolog (T. californica)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.10 9.71e-06 GO:0044260 cellular macromolecule metabolic process
1.20 1.47e-03 GO:0048468 cell development
1.10 3.19e-03 GO:0016043 cellular component organization
1.11 4.05e-03 GO:0071842 cellular component organization at cellular level
1.11 4.19e-03 GO:0071841 cellular component organization or biogenesis at cellular level
1.09 4.20e-03 GO:0071840 cellular component organization or biogenesis
1.06 5.75e-03 GO:0044237 cellular metabolic process
1.19 1.40e-02 GO:0048699 generation of neurons
1.18 1.45e-02 GO:0022008 neurogenesis
1.11 1.80e-02 GO:0044267 cellular protein metabolic process
1.11 2.26e-02 GO:0048523 negative regulation of cellular process
1.13 4.54e-02 GO:0009653 anatomical structure morphogenesis
1.10 4.75e-02 GO:0048519 negative regulation of biological process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.06 9.40e-21 GO:0005622 intracellular
1.07 6.99e-20 GO:0044424 intracellular part
1.08 2.40e-17 GO:0043229 intracellular organelle
1.08 2.64e-17 GO:0043226 organelle
1.08 1.52e-14 GO:0043227 membrane-bounded organelle
1.08 1.98e-14 GO:0043231 intracellular membrane-bounded organelle
1.08 1.96e-13 GO:0005737 cytoplasm
1.10 3.34e-09 GO:0044446 intracellular organelle part
1.09 3.44e-09 GO:0044444 cytoplasmic part
1.09 6.14e-09 GO:0044422 organelle part
1.03 3.15e-08 GO:0044464 cell part
1.03 3.70e-08 GO:0005623 cell
1.09 6.27e-08 GO:0005634 nucleus
1.15 2.17e-07 GO:0044428 nuclear part
1.14 3.43e-06 GO:0005829 cytosol
1.13 3.57e-06 GO:0043228 non-membrane-bounded organelle
1.13 3.57e-06 GO:0043232 intracellular non-membrane-bounded organelle
1.15 1.29e-05 GO:0031981 nuclear lumen
1.13 1.44e-05 GO:0070013 intracellular organelle lumen
1.13 4.97e-05 GO:0043233 organelle lumen
1.12 5.71e-05 GO:0031974 membrane-enclosed lumen
1.10 2.36e-03 GO:0043234 protein complex
1.24 3.64e-03 GO:0005730 nucleolus
1.21 3.94e-03 GO:0015630 microtubule cytoskeleton
1.14 5.36e-03 GO:0005856 cytoskeleton
1.16 1.59e-02 GO:0044430 cytoskeletal part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.06 3.46e-04 GO:0005515 protein binding
1.24 1.72e-02 GO:0019904 protein domain specific binding
1.10 3.68e-02 GO:0000166 nucleotide binding