Motif ID: AIRE.p2

Z-value: 0.943


Transcription factors associated with AIRE.p2:

Gene SymbolEntrez IDGene Name
AIRE 326 autoimmune regulator

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
AIREchr21_+_445301480.194.9e-01Click!


Activity profile for motif AIRE.p2.

activity profile for motif AIRE.p2


Sorted Z-values histogram for motif AIRE.p2

Sorted Z-values for motif AIRE.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of AIRE.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr18_+_27425727 2.078 NM_000371
TTR
transthyretin
chr4_-_84254912 1.824 PLAC8
placenta-specific 8
chr19_-_44518516 1.619 NM_004877
GMFG
glia maturation factor, gamma
chr17_-_59437782 1.535 NM_000873
ICAM2
intercellular adhesion molecule 2
chr4_-_84254873 1.417 PLAC8
placenta-specific 8
chr4_+_69716298 1.307 NM_001075
NM_001144767
UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr4_-_84254932 1.306 NM_001130715
NM_016619
PLAC8

placenta-specific 8

chr5_+_75734759 1.293 NM_006633
IQGAP2
IQ motif containing GTPase activating protein 2
chr10_+_7785360 1.253 ITIH2
inter-alpha (globulin) inhibitor H2
chr16_+_10430225 1.174 NM_024997
ATF7IP2
activating transcription factor 7 interacting protein 2
chr10_+_7785331 1.125 ITIH2
inter-alpha (globulin) inhibitor H2
chr10_+_7785347 1.119 ITIH2
inter-alpha (globulin) inhibitor H2
chr7_-_149960612 1.050 NM_024711
GIMAP6
GTPase, IMAP family member 6
chr19_-_53450953 1.047 NM_001184902
NM_001184904
CARD8

caspase recruitment domain family, member 8

chr10_+_7785290 1.031 ITIH2
inter-alpha (globulin) inhibitor H2
chrX_-_2892288 0.971 NM_000047
ARSE
arylsulfatase E (chondrodysplasia punctata 1)
chr5_-_94442941 0.923 MCTP1
multiple C2 domains, transmembrane 1
chr5_-_149772563 0.921 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr15_-_43458247 0.918 NM_001482
GATM
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr16_+_80370400 0.878 PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr11_-_73371531 0.855 NM_003355
UCP2
uncoupling protein 2 (mitochondrial, proton carrier)
chr2_+_201689060 0.838 NM_001127184
NM_003879
CFLAR

CASP8 and FADD-like apoptosis regulator

chr19_-_53444733 0.837 NM_001184901
NM_001184903
NM_014959
CARD8


caspase recruitment domain family, member 8


chr10_-_101831579 0.822 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr17_+_38259620 0.819 AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr22_+_21340757 0.803


chr4_+_70180805 0.791 NM_053039
UGT2B28
UDP glucuronosyltransferase 2 family, polypeptide B28
chr17_+_38256710 0.754 NM_003734
AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr8_-_30704984 0.744 NM_000637
NM_001195102
NM_001195103
NM_001195104
GSR



glutathione reductase



chr9_+_116413443 0.703 NM_153045
C9orf91
chromosome 9 open reading frame 91
chr1_+_158975662 0.660 NM_021181
SLAMF7
SLAM family member 7
chr13_-_40454188 0.639 ELF1
E74-like factor 1 (ets domain transcription factor)
chr6_-_99957253 0.620 SFRS18
splicing factor, arginine/serine-rich 18
chr19_-_6542012 0.614 CD70
CD70 molecule
chr6_+_6533932 0.610 NM_004271
LY86
lymphocyte antigen 86
chr1_-_167947301 0.587 NM_000655
SELL
selectin L
chr2_+_65069081 0.582 NM_001193493
SLC1A4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr4_+_17187936 0.561 NM_015907
LAP3
leucine aminopeptidase 3
chr1_-_114855281 0.556 NM_015906
NM_033020
TRIM33

tripartite motif containing 33

chr19_+_50144267 0.555 APOC2
apolipoprotein C-II
chr17_-_31231421 0.554 NM_002985
CCL5
chemokine (C-C motif) ligand 5
chr19_+_18069596 0.539 NM_015016
MAST3
microtubule associated serine/threonine kinase 3
chr14_+_73105515 0.526 NM_006821
ACOT2
acyl-CoA thioesterase 2
chr5_-_94250357 0.520 MCTP1
multiple C2 domains, transmembrane 1
chr14_-_105796665 0.490 IGHV4-31
IGHV3-23
IGHA1
IGHG1
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy variable 3-23
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr1_+_28637247 0.490 NM_023923
PHACTR4
phosphatase and actin regulator 4
chr14_+_38804226 0.487 NM_203354
CTAGE5
CTAGE family, member 5
chr4_+_74493918 0.483 ALB
albumin
chr12_-_51887266 0.473 NM_000889
ITGB7
integrin, beta 7
chr1_-_9052207 0.472 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr1_+_157067729 0.446 NM_002432
MNDA
myeloid cell nuclear differentiation antigen
chr4_-_70115037 0.444 NM_001073
UGT2B11
UDP glucuronosyltransferase 2 family, polypeptide B11
chr2_-_170138558 0.433 NM_024622
FASTKD1
FAST kinase domains 1
chr13_-_98708549 0.420 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chr1_+_159451708 0.417 NM_004106
FCER1G
Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
chr16_-_28528780 0.406 NM_001055
NM_177529
SULT1A1

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

chr13_-_47885018 0.405 LPAR6
lysophosphatidic acid receptor 6
chr14_+_94148466 0.402 NM_001085
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr4_-_139382672 0.400 NM_014331
SLC7A11
solute carrier family 7, (cationic amino acid transporter, y+ system) member 11
chr12_+_49605010 0.395 METTL7A
methyltransferase like 7A
chr19_-_6621078 0.395 TNFSF14
tumor necrosis factor (ligand) superfamily, member 14
chr2_-_20390601 0.395 NM_015317
PUM2
pumilio homolog 2 (Drosophila)
chr13_-_47885248 0.389 LPAR6
lysophosphatidic acid receptor 6
chr3_-_184363157 0.384 NM_014398
LAMP3
lysosomal-associated membrane protein 3
chr6_-_32892705 0.382 NM_002120
HLA-DOB
major histocompatibility complex, class II, DO beta
chr10_+_7785235 0.381 NM_002216
ITIH2
inter-alpha (globulin) inhibitor H2
chr1_-_89437098 0.377 NM_052941
GBP4
guanylate binding protein 4
chr13_-_45640679 0.370 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr1_+_51855343 0.369 OSBPL9
oxysterol binding protein-like 9
chr21_-_42608774 0.368 NM_003226
TFF3
trefoil factor 3 (intestinal)
chr13_+_30207668 0.365 NM_001629
ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr1_+_159451685 0.361 FCER1G
Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
chr17_+_64922420 0.358 NM_002758
MAP2K6
mitogen-activated protein kinase kinase 6
chr4_+_74493218 0.350 ALB
albumin
chr18_-_46068689 0.349 NM_001101654
NM_014593
CXXC1

CXXC finger protein 1

chr4_-_103464491 0.349 NM_001135148
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr17_+_70092651 0.348 NM_152460
C17orf77
chromosome 17 open reading frame 77
chr4_+_69996780 0.347 NM_001074
UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr2_-_188021117 0.343 NM_005795
CALCRL
calcitonin receptor-like
chr2_+_113911737 0.342 NM_172003
CBWD2
CBWD1
COBW domain containing 2
COBW domain containing 1
chr9_+_79158164 0.341 VPS13A
vacuolar protein sorting 13 homolog A (S. cerevisiae)
chr17_+_72692889 0.341 NM_001144001
SEC14L1
SEC14-like 1 (S. cerevisiae)
chr13_+_49100435 0.340 NM_138450
ARL11
ADP-ribosylation factor-like 11
chr22_-_34886727 0.340 NM_145640
APOL3
apolipoprotein L, 3
chr22_+_34126294 0.340 MCM5
minichromosome maintenance complex component 5
chr16_+_20328355 0.335 NM_017888
ACSM5
acyl-CoA synthetase medium-chain family member 5
chr17_-_18207416 0.331 NM_004169
NM_148918
SHMT1

serine hydroxymethyltransferase 1 (soluble)

chr13_-_40454360 0.329 NM_001145353
ELF1
E74-like factor 1 (ets domain transcription factor)
chrX_-_131401319 0.326 NM_018388
NM_133486
MBNL3

muscleblind-like 3 (Drosophila)

chr6_+_43005214 0.322 CNPY3
canopy 3 homolog (zebrafish)
chr9_-_135923373 0.321 BRD3
bromodomain containing 3
chr4_+_74493266 0.320 ALB
albumin
chr10_+_135057597 0.314 NM_138384
MTG1
mitochondrial GTPase 1 homolog (S. cerevisiae)
chr10_+_97461525 0.312 NM_001098175
ENTPD1
ectonucleoside triphosphate diphosphohydrolase 1
chr11_+_73339011 0.311 NM_153614
DNAJB13
DnaJ (Hsp40) homolog, subfamily B, member 13
chr19_-_10474767 0.306 NM_203500
KEAP1
kelch-like ECH-associated protein 1
chr2_+_215885053 0.304 ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr8_-_6407882 0.299 NM_001118887
NM_001118888
NM_001147
ANGPT2


angiopoietin 2


chr17_-_18118441 0.295 TOP3A
topoisomerase (DNA) III alpha
chr2_+_68445821 0.295 NM_002664
PLEK
pleckstrin
chr6_-_133120587 0.295 NM_004665
VNN2
vanin 2
chr9_-_115877104 0.293 AMBP
alpha-1-microglobulin/bikunin precursor
chr6_-_31938572 0.293 NM_000434
NEU1
sialidase 1 (lysosomal sialidase)
chr15_+_64372876 0.291 NM_001143688
DIS3L
DIS3 mitotic control homolog (S. cerevisiae)-like
chr3_-_56810869 0.290 NM_019555
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr2_-_101134146 0.287 NM_001102426
TBC1D8
TBC1 domain family, member 8 (with GRAM domain)
chr4_+_53986759 0.280 FIP1L1
FIP1 like 1 (S. cerevisiae)
chr6_+_10629550 0.279 NM_145649
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr13_+_30207690 0.274 ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr12_+_8224056 0.273 FAM66C
family with sequence similarity 66, member C
chr19_-_55358091 0.271 NM_152358
IZUMO2
IZUMO family member 2
chr19_-_8548337 0.270 MYO1F
myosin IF
chr4_+_106851415 0.270 NM_001031720
GSTCD
glutathione S-transferase, C-terminal domain containing
chr1_+_938709 0.270 NM_005101
ISG15
ISG15 ubiquitin-like modifier
chr13_-_40491491 0.269 NM_172373
ELF1
E74-like factor 1 (ets domain transcription factor)
chr3_+_39399770 0.268 NM_017875
SLC25A38
solute carrier family 25, member 38
chr7_-_149960218 0.263 GIMAP6
GTPase, IMAP family member 6
chr1_-_9052253 0.262 NM_001135585
NM_003039
SLC2A5

solute carrier family 2 (facilitated glucose/fructose transporter), member 5

chr4_-_176970895 0.258 GPM6A
glycoprotein M6A
chr14_-_105796268 0.252 ZCWPW2
IGHV3-23
IGKV3-20
zinc finger, CW type with PWWP domain 2
immunoglobulin heavy variable 3-23
immunoglobulin kappa variable 3-20
chr1_+_239762179 0.250 NM_003679
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr2_+_215884923 0.250 NM_004044
ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr2_-_213723298 0.248 NM_016260
IKZF2
IKAROS family zinc finger 2 (Helios)
chr6_-_90119169 0.239 UBE2J1
ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast)
chr12_-_7979896 0.236 NM_006931
SLC2A3
solute carrier family 2 (facilitated glucose transporter), member 3
chr10_-_42183441 0.235 LOC283027
hypothetical protein LOC283027
chr17_-_64649608 0.234 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr12_+_21059896 0.230 NM_001009562
LST-3TM12
organic anion transporter LST-3b
chr13_-_40491405 0.229 ELF1
E74-like factor 1 (ets domain transcription factor)
chr20_+_35755865 0.229 CTNNBL1
catenin, beta like 1
chr2_+_215885063 0.225 ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr6_-_11490487 0.225 NM_001142393
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr15_-_74941339 0.224 NM_001145923
SCAPER
S-phase cyclin A-associated protein in the ER
chr19_-_44014228 0.222 NM_001398
ECH1
enoyl CoA hydratase 1, peroxisomal
chr6_+_43005126 0.220 CNPY3
canopy 3 homolog (zebrafish)
chr3_+_63859114 0.220 NM_001177387
ATXN7
ataxin 7
chr19_+_57564981 0.219 NM_001145434
ZNF880
zinc finger protein 880
chr11_+_43622348 0.218


chr1_-_7895873 0.216 UTS2
urotensin 2
chr6_-_90119329 0.213 NM_016021
UBE2J1
ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast)
chr19_-_13478037 0.212 NM_000068
NM_001127221
NM_001127222
NM_001174080
NM_023035
CACNA1A




calcium channel, voltage-dependent, P/Q type, alpha 1A subunit




chr14_-_105681377 0.212 IGHV4-31
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant gamma 1 (G1m marker)
chr12_+_49604782 0.211 NM_014033
METTL7A
methyltransferase like 7A
chrX_-_100193747 0.210 NM_001167970
NM_001167971
NM_001167972
NM_024917
TRMT2B



TRM2 tRNA methyltransferase 2 homolog B (S. cerevisiae)



chr19_-_6542136 0.210 NM_001252
CD70
CD70 molecule
chr19_-_10281220 0.209 NM_001103167
ZGLP1
zinc finger, GATA-like protein 1
chr8_+_38763878 0.209 NM_001122824
NM_006283
TACC1

transforming, acidic coiled-coil containing protein 1

chr4_+_39874921 0.208 NM_004310
RHOH
ras homolog gene family, member H
chr2_+_68445936 0.207 PLEK
pleckstrin
chr21_-_42689192 0.207 NM_024022
NM_032405
TMPRSS3

transmembrane protease, serine 3

chr4_+_170817787 0.207 CLCN3
chloride channel 3
chr19_+_39402167 0.204 LSM14A
LSM14A, SCD6 homolog A (S. cerevisiae)
chrM_+_4465 0.204


chrX_-_71709335 0.203 HDAC8
histone deacetylase 8
chr6_+_36318922 0.201 NM_173676
NM_001145716
PNPLA1

patatin-like phospholipase domain containing 1

chr3_+_9451506 0.201


chr10_-_99042348 0.200 ARHGAP19
Rho GTPase activating protein 19
chr9_-_85761353 0.200 C9orf64
chromosome 9 open reading frame 64
chr15_+_57696016 0.197 GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr11_-_73371452 0.195 UCP2
uncoupling protein 2 (mitochondrial, proton carrier)
chr8_+_38763911 0.195 TACC1
transforming, acidic coiled-coil containing protein 1
chr7_-_63660889 0.193 NM_001130022
NM_178558
ZNF680

zinc finger protein 680

chr20_+_35755857 0.192 CTNNBL1
catenin, beta like 1
chr4_-_186814852 0.188 SORBS2
sorbin and SH3 domain containing 2
chr6_+_26473376 0.187 NM_001197247
NM_001197249
NM_007047
NM_001197248
BTN3A2



butyrophilin, subfamily 3, member A2



chr12_+_99391870 0.184 NR1H4
nuclear receptor subfamily 1, group H, member 4
chr19_+_52504914 0.182 NM_001736
C5AR1
complement component 5a receptor 1
chr19_+_17499064 0.182 FAM129C
family with sequence similarity 129, member C
chr9_+_70840298 0.182 NM_000144
NM_001161706
NM_181425
FXN


frataxin


chr19_+_2818332 0.181 NM_024967
ZNF556
zinc finger protein 556
chr20_+_35755832 0.180 NM_030877
CTNNBL1
catenin, beta like 1
chr6_-_43129368 0.177 CUL7
cullin 7
chr3_-_106903734 0.177 CBLB
Cas-Br-M (murine) ecotropic retroviral transforming sequence b
chr14_-_94677807 0.176 NM_030621
DICER1
dicer 1, ribonuclease type III
chr4_-_123761615 0.174 NM_021803
IL21
interleukin 21
chr18_+_27925923 0.174 RNF138
ring finger protein 138
chr12_-_55405209 0.174 NM_001113201
NM_005594
NACA

nascent polypeptide-associated complex alpha subunit

chr15_-_63199228 0.173 PDCD7
programmed cell death 7
chr19_+_10223598 0.172 NM_015956
NM_146387
NM_146388
MRPL4


mitochondrial ribosomal protein L4


chrX_-_100193698 0.171 TRMT2B
TRM2 tRNA methyltransferase 2 homolog B (S. cerevisiae)
chr3_-_172227152 0.170 SLC2A2
solute carrier family 2 (facilitated glucose transporter), member 2
chr7_-_97439590 0.170


chr3_+_142175329 0.168 SLC25A36
solute carrier family 25, member 36
chr16_-_11588257 0.162 NM_001136472
NM_001136473
LITAF

lipopolysaccharide-induced TNF factor

chr2_-_20375497 0.160 PUM2
pumilio homolog 2 (Drosophila)
chr8_-_42742729 0.160 NM_004198
CHRNA6
cholinergic receptor, nicotinic, alpha 6
chr12_+_70119785 0.160 LGR5
leucine-rich repeat containing G protein-coupled receptor 5
chr7_+_94130752 0.159 PEG10
paternally expressed 10
chr8_+_144802972 0.158 NM_014789
ZNF623
zinc finger protein 623
chr11_+_65236261 0.156 KAT5
K(lysine) acetyltransferase 5
chr11_-_64335341 0.154 NM_130803
NM_130804
MEN1

multiple endocrine neoplasia I

chr22_+_34979062 0.154 NM_001136540
NM_001136541
NM_003661
NM_145343
APOL1



apolipoprotein L, 1



chr6_+_31698447 0.154


chr14_-_94855848 0.153 NM_024734
CLMN
calmin (calponin-like, transmembrane)
chr12_+_25096472 0.151 NM_006152
LRMP
lymphoid-restricted membrane protein
chr8_-_81155564 0.151 NM_001025252
TPD52
tumor protein D52
chr8_-_37847095 0.151 RAB11FIP1
RAB11 family interacting protein 1 (class I)
chr10_-_99042381 0.147 NM_032900
ARHGAP19-SLIT1
ARHGAP19
ARHGAP19-SLIT1 read-through transcript
Rho GTPase activating protein 19
chr11_+_5597749 0.147 NM_001003827
TRIM34
tripartite motif containing 34
chr5_-_96175560 0.147 NM_001198541
ERAP1
endoplasmic reticulum aminopeptidase 1

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.