Motif ID: MYBL2.p2

Z-value: 1.049


Transcription factors associated with MYBL2.p2:

Gene SymbolEntrez IDGene Name
MYBL2 4605 v-myb myeloblastosis viral oncogene homolog (avian)-like 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
MYBL2chr20_+_41729161-0.204.6e-01Click!


Activity profile for motif MYBL2.p2.

activity profile for motif MYBL2.p2


Sorted Z-values histogram for motif MYBL2.p2

Sorted Z-values for motif MYBL2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MYBL2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_+_158637273 5.383 NM_002852
PTX3
pentraxin 3, long
chr10_+_17310263 3.169 NM_003380
VIM
vimentin
chr10_+_17310475 2.634 VIM
vimentin
chr3_-_124821868 2.314 MYLK
myosin light chain kinase
chr17_-_45617899 2.312 COL1A1
collagen, type I, alpha 1
chr12_+_76749199 2.302 NM_014903
NAV3
neuron navigator 3
chr2_-_189752575 2.177 NM_000393
COL5A2
collagen, type V, alpha 2
chr5_-_39460787 2.105 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr5_-_39460687 1.949 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr2_+_170074457 1.897 NM_006063
KBTBD10
kelch repeat and BTB (POZ) domain containing 10
chr5_-_39461054 1.767 NM_001343
DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr1_-_191422346 1.616 NM_003783
B3GALT2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr17_-_45619038 1.555 COL1A1
collagen, type I, alpha 1
chr2_+_151922350 1.379 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr3_-_124822113 1.347 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr15_+_41597097 1.319 NM_002373
MAP1A
microtubule-associated protein 1A
chr1_-_103269356 1.305 COL11A1
collagen, type XI, alpha 1
chrX_+_135106578 1.299 NM_001159701
NM_001159699
FHL1

four and a half LIM domains 1

chr21_+_29439768 1.249 C21orf7
chromosome 21 open reading frame 7
chr9_+_78246401 1.219 NM_001097634
GCNT1
glucosaminyl (N-acetyl) transferase 1, core 2
chr1_+_173111306 1.173 NM_001035230
RABGAP1L
RAB GTPase activating protein 1-like
chr11_-_111287657 1.137 NM_001885
CRYAB
crystallin, alpha B
chr3_+_35696119 1.084 NM_001025068
NM_001025069
ARPP21

cAMP-regulated phosphoprotein, 21kDa

chr3_-_115960807 1.068 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr20_+_9236446 1.064 NM_000933
PLCB4
phospholipase C, beta 4
chr1_+_84402962 1.051 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr3_-_15814678 1.048 NM_001195098
ANKRD28
ankyrin repeat domain 28
chr7_+_93388951 0.999 NM_004126
GNG11
guanine nucleotide binding protein (G protein), gamma 11
chr17_+_7753428 0.952 CHD3
chromodomain helicase DNA binding protein 3
chr10_-_121286034 0.950 NM_002925
RGS10
regulator of G-protein signaling 10
chr9_+_115396020 0.918 NM_144489
RGS3
regulator of G-protein signaling 3
chr13_+_100902942 0.916 NM_004791
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr8_-_122722674 0.896 NM_005328
HAS2
hyaluronan synthase 2
chr11_-_35503720 0.885 NM_001001991
NM_015430
PAMR1

peptidase domain containing associated with muscle regeneration 1

chr16_+_11966464 0.879 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr5_+_155686750 0.872 SGCD
sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
chr12_+_20854904 0.845 NM_019844
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr2_-_152299229 0.835 NM_001164507
NM_001164508
NM_004543
NEB


nebulin


chr5_-_94442941 0.833 MCTP1
multiple C2 domains, transmembrane 1
chr10_-_69762654 0.772 NM_001033083
NM_022129
PBLD

phenazine biosynthesis-like protein domain containing

chr10_-_98021144 0.734 NM_001114094
NM_013314
BLNK

B-cell linker

chr9_-_14076901 0.714 NFIB
nuclear factor I/B
chr5_-_94443300 0.679 NM_001002796
MCTP1
multiple C2 domains, transmembrane 1
chr8_-_95343696 0.669 GEM
GTP binding protein overexpressed in skeletal muscle
chr9_-_94338072 0.669 NM_001197295
NM_001197296
NM_001393
ECM2


extracellular matrix protein 2, female organ and adipocyte specific


chr3_-_49372584 0.648 RHOA
ras homolog gene family, member A
chr10_-_95231933 0.639 NM_013451
NM_133337
MYOF

myoferlin

chr21_+_36429079 0.633 NM_001236
CBR3
carbonyl reductase 3
chr1_-_9052207 0.632 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chrX_+_149364377 0.627 NM_001177466
NM_005491
MAMLD1

mastermind-like domain containing 1

chr15_-_91078307 0.626 FAM174B
family with sequence similarity 174, member B
chr4_+_120276386 0.625 NM_016599
MYOZ2
myozenin 2
chrX_+_12795111 0.600 NM_016562
TLR7
toll-like receptor 7
chr14_-_106270497 0.584 IGHG3
immunoglobulin heavy constant gamma 3 (G3m marker)
chr3_+_142525744 0.569 NM_001080412
ZBTB38
zinc finger and BTB domain containing 38
chr14_-_22358752 0.560 NM_001126106
SLC7A7
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
chr11_+_124048949 0.552 NM_017425
SPA17
sperm autoantigenic protein 17
chr5_+_155686333 0.552 NM_000337
NM_001128209
NM_172244
SGCD


sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)


chr9_-_14388981 0.550 NM_001190738
NFIB
nuclear factor I/B
chr7_+_80105858 0.545 CD36
CD36 molecule (thrombospondin receptor)
chr1_+_143807748 0.543 NM_004892
SEC22B
SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
chr1_-_149047329 0.538 NM_000396
CTSK
cathepsin K
chr6_-_112186977 0.537 NM_153048
FYN
FYN oncogene related to SRC, FGR, YES
chrX_+_80343958 0.530 NM_003022
SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr7_-_81237162 0.523 NM_000601
NM_001010931
NM_001010932
NM_001010933
NM_001010934
HGF




hepatocyte growth factor (hepapoietin A; scatter factor)




chr20_-_52120710 0.522 NM_003657
BCAS1
breast carcinoma amplified sequence 1
chr1_-_9052253 0.509 NM_001135585
NM_003039
SLC2A5

solute carrier family 2 (facilitated glucose/fructose transporter), member 5

chr8_-_95343716 0.509 NM_005261
NM_181702
GEM

GTP binding protein overexpressed in skeletal muscle

chr6_-_24985432 0.505 NM_015864
FAM65B
family with sequence similarity 65, member B
chr5_+_43645018 0.492 NNT
nicotinamide nucleotide transhydrogenase
chr1_-_101132993 0.487 NM_001033025
NM_001439
EXTL2

exostoses (multiple)-like 2

chr2_+_230989150 0.487 SP100
SP100 nuclear antigen
chrX_-_10548458 0.478 NM_000381
NM_033289
MID1

midline 1 (Opitz/BBB syndrome)

chr1_-_116112921 0.478 NM_001232
CASQ2
calsequestrin 2 (cardiac muscle)
chr20_+_19863716 0.471 RIN2
Ras and Rab interactor 2
chr3_+_137167153 0.465 NM_001190447
NM_002718
PPP2R3A

protein phosphatase 2, regulatory subunit B'', alpha

chr6_+_151602787 0.465 NM_005100
AKAP12
A kinase (PRKA) anchor protein 12
chr12_-_48902692 0.463 NM_001113547
LIMA1
LIM domain and actin binding 1
chr19_+_53520632 0.460 EMP3
epithelial membrane protein 3
chr4_+_148621567 0.442 EDNRA
endothelin receptor type A
chr19_+_53520439 0.439 NM_001425
EMP3
epithelial membrane protein 3
chr3_-_129023850 0.435 NM_007283
MGLL
monoglyceride lipase
chr17_-_15495534 0.421 TRIM16
tripartite motif containing 16
chr14_+_66901237 0.420 EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr15_+_65205107 0.418 NM_001145102
SMAD3
SMAD family member 3
chr2_+_127130209 0.417 GYPC
glycophorin C (Gerbich blood group)
chr1_+_216585298 0.415 NM_001135599
NM_003238
TGFB2

transforming growth factor, beta 2

chr2_-_224175386 0.403 NM_003469
SCG2
secretogranin II
chr3_+_151803755 0.402 NM_016275
SELT
selenoprotein T
chr1_-_195302973 0.402 NM_001994
F13B
coagulation factor XIII, B polypeptide
chr22_+_36401558 0.401 NM_002305
LGALS1
lectin, galactoside-binding, soluble, 1
chr17_+_39990124 0.392 NM_001466
FZD2
frizzled homolog 2 (Drosophila)
chr1_+_146843980 0.389 NM_001102663
NBPF15
NBPF8
NBPF16
neuroblastoma breakpoint family, member 15
neuroblastoma breakpoint family, member 8
neuroblastoma breakpoint family, member 16
chr7_+_80105907 0.384 CD36
CD36 molecule (thrombospondin receptor)
chr17_-_55958274 0.380 NM_006380
APPBP2
amyloid beta precursor protein (cytoplasmic tail) binding protein 2
chr2_+_230989114 0.378 NM_001080391
NM_003113
SP100

SP100 nuclear antigen

chrX_-_21686079 0.378 NM_014332
SMPX
small muscle protein, X-linked
chr14_+_58174489 0.378 NM_001079520
NM_016651
DACT1

dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)

chr12_-_74765004 0.375 NM_004537
NM_139207
NAP1L1

nucleosome assembly protein 1-like 1

chr2_+_230989177 0.373 SP100
SP100 nuclear antigen
chr1_-_110735158 0.372 NM_004696
SLC16A4
solute carrier family 16, member 4 (monocarboxylic acid transporter 5)
chr4_+_148621518 0.372 NM_001166055
NM_001957
EDNRA

endothelin receptor type A

chr1_-_42738535 0.370 TMSB4XP1
thymosin beta 4, X-linked pseudogene 1
chr3_-_27473248 0.369 NM_003615
SLC4A7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
chr1_-_115102106 0.366 CSDE1
cold shock domain containing E1, RNA-binding
chrX_-_33139349 0.362 NM_004006
DMD
dystrophin
chr11_+_130745580 0.359 NM_001048209
NTM
neurotrimin
chr12_-_74764677 0.356 NAP1L1
nucleosome assembly protein 1-like 1
chr1_+_161305019 0.356 NM_001102445
RGS4
regulator of G-protein signaling 4
chr20_-_52120421 0.355 BCAS1
breast carcinoma amplified sequence 1
chr1_+_154120170 0.354 SYT11
synaptotagmin XI
chr3_+_33293915 0.353 NM_012157
NM_001171713
FBXL2

F-box and leucine-rich repeat protein 2

chr1_-_116112853 0.351 CASQ2
calsequestrin 2 (cardiac muscle)
chr10_-_90740935 0.351 NM_001141945
ACTA2
actin, alpha 2, smooth muscle, aorta
chr5_-_143530408 0.349 NM_001024947
NM_030799
YIPF5

Yip1 domain family, member 5

chr1_-_115102084 0.347 CSDE1
cold shock domain containing E1, RNA-binding
chr17_-_31441390 0.347 NM_002983
CCL3
chemokine (C-C motif) ligand 3
chr3_+_70068440 0.344 NM_000248
NM_001184968
NM_198158
NM_198178
MITF



microphthalmia-associated transcription factor



chr12_+_55201854 0.343 NM_002898
RBMS2
RNA binding motif, single stranded interacting protein 2
chr1_-_9052170 0.340 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr15_-_23201740 0.339 NM_130838
UBE3A
ubiquitin protein ligase E3A
chr2_+_33555182 0.333 RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr2_-_224175293 0.332 SCG2
secretogranin II
chr1_-_115102124 0.331 CSDE1
cold shock domain containing E1, RNA-binding
chr11_-_104332631 0.329 NM_033306
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr1_-_115102109 0.324 CSDE1
cold shock domain containing E1, RNA-binding
chr12_+_14429499 0.322 ATF7IP
activating transcription factor 7 interacting protein
chr12_-_16649211 0.321 LMO3
LIM domain only 3 (rhombotin-like 2)
chr12_+_52708460 0.321 NM_004503
HOXC6
homeobox C6
chr15_+_47502666 0.320 NM_002009
FGF7
fibroblast growth factor 7
chr3_+_16949585 0.319 NM_015184
PLCL2
phospholipase C-like 2
chr10_-_92670764 0.317 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr14_-_88086559 0.315 PTPN21
protein tyrosine phosphatase, non-receptor type 21
chr11_-_27698800 0.311 NM_001143805
NM_001143806
NM_170732
BDNF


brain-derived neurotrophic factor


chr4_-_71751070 0.310 IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr1_+_143326315 0.309 NM_001037675
NBPF10
NBPF9
NBPF8
neuroblastoma breakpoint family, member 10
neuroblastoma breakpoint family, member 9
neuroblastoma breakpoint family, member 8
chr13_+_30207668 0.308 NM_001629
ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr1_+_35623688 0.300 ZMYM4
zinc finger, MYM-type 4
chr12_-_15005761 0.300 NM_001175
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr2_-_224175339 0.300 SCG2
secretogranin II
chr10_-_28611020 0.297 NM_173496
MPP7
membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
chr2_-_210876560 0.292 NM_079422
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr5_-_88155360 0.291 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr1_-_116112684 0.290 CASQ2
calsequestrin 2 (cardiac muscle)
chr13_+_75232797 0.290 NM_015842
LMO7
LIM domain 7
chr2_+_127130148 0.286 NM_002101
NM_016815
GYPC

glycophorin C (Gerbich blood group)

chr1_-_115102138 0.282 NM_001007553
NM_007158
NM_001130523
CSDE1


cold shock domain containing E1, RNA-binding


chr1_-_143786993 0.272 NM_022359
PDE4DIP
phosphodiesterase 4D interacting protein
chr12_-_55791443 0.266 NM_001178078
NM_001178080
NM_001178081
NM_003153
STAT6



signal transducer and activator of transcription 6, interleukin-4 induced



chrX_-_114158388 0.265 NM_000640
IL13RA2
interleukin 13 receptor, alpha 2
chr7_+_28418668 0.265 NM_182898
CREB5
cAMP responsive element binding protein 5
chr10_-_92671005 0.263 NM_014391
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr12_-_9804682 0.260 NM_001781
CD69
CD69 molecule
chr11_+_128068982 0.259 NM_002017
FLI1
Friend leukemia virus integration 1
chr3_-_116272911 0.258 NM_001164343
ZBTB20
zinc finger and BTB domain containing 20
chr13_+_30207690 0.257 ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr4_+_148621694 0.255 EDNRA
endothelin receptor type A
chr7_+_119700924 0.255 NM_012281
KCND2
potassium voltage-gated channel, Shal-related subfamily, member 2
chr2_+_33592445 0.254 NM_015376
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr1_+_100957883 0.253 NM_001078
NM_080682
VCAM1

vascular cell adhesion molecule 1

chr3_+_123256902 0.252 NM_175862
CD86
CD86 molecule
chr4_+_114190233 0.251 NM_001148
NM_020977
ANK2

ankyrin 2, neuronal

chr4_-_120768563 0.251 NM_033437
PDE5A
phosphodiesterase 5A, cGMP-specific
chr22_+_42726423 0.251 NM_001003828
PARVB
parvin, beta
chr1_-_153209625 0.248 NM_001130040
NM_183001
SHC1

SHC (Src homology 2 domain containing) transforming protein 1

chr14_+_70209807 0.246 TTC9
tetratricopeptide repeat domain 9
chr1_-_56750235 0.244 PPAP2B
phosphatidic acid phosphatase type 2B
chr22_-_37598115 0.241 CBX6
chromobox homolog 6
chr13_-_36577800 0.239 NM_145203
CSNK1A1L
casein kinase 1, alpha 1-like
chr1_+_242283129 0.235 NM_006352
ZNF238
zinc finger protein 238
chr21_-_29179482 0.233 NM_013240
NM_182749
N6AMT1

N-6 adenine-specific DNA methyltransferase 1 (putative)

chr4_+_78172966 0.232 SEPT11
septin 11
chr3_-_56673113 0.224 NM_015224
C3orf63
chromosome 3 open reading frame 63
chr18_+_19286784 0.224 NM_003831
RIOK3
RIO kinase 3 (yeast)
chr6_-_56220274 0.223 NM_030820
COL21A1
collagen, type XXI, alpha 1
chr14_-_74669864 0.221 TMED10
transmembrane emp24-like trafficking protein 10 (yeast)
chr15_-_75135496 0.220 TSPAN3
tetraspanin 3
chr22_-_37598176 0.220 NM_014292
CBX6
chromobox homolog 6
chr22_-_37598160 0.218 CBX6
chromobox homolog 6
chr3_-_127810087 0.218 NM_001039783
TXNRD3IT1
thioredoxin reductase 3 intronic transcript 1
chr5_-_156935317 0.215 NM_033274
ADAM19
ADAM metallopeptidase domain 19
chr6_+_110119190 0.215 FIG4
FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae)
chr12_+_49922592 0.214 DAZAP2
DAZ associated protein 2
chr9_-_16717887 0.214 BNC2
basonuclin 2
chr5_+_140730014 0.213 NM_018924
NM_032097
PCDHGB3

protocadherin gamma subfamily B, 3

chr1_-_201586872 0.211


chr17_-_43390108 0.210 NM_024320
PRR15L
proline rich 15-like
chrM_-_855 0.209


chrX_+_100220491 0.208 NM_021637
TMEM35
transmembrane protein 35
chr1_-_115071195 0.205 CSDE1
cold shock domain containing E1, RNA-binding
chr6_-_117853710 0.205 NM_002944
ROS1
c-ros oncogene 1 , receptor tyrosine kinase
chr12_-_55791388 0.205 STAT6
signal transducer and activator of transcription 6, interleukin-4 induced
chr19_-_44518516 0.204 NM_004877
GMFG
glia maturation factor, gamma
chr6_-_152681171 0.204 NM_015293
SYNE1
spectrin repeat containing, nuclear envelope 1
chr5_+_32824701 0.203 NM_024563
NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr8_+_107807415 0.201 NM_001198534
NM_001198535
OXR1

oxidation resistance 1

chr12_+_54400417 0.200 NM_002905
RDH5
retinol dehydrogenase 5 (11-cis/9-cis)
chr19_+_46201665 0.196 CYP2B6
cytochrome P450, family 2, subfamily B, polypeptide 6
chr21_-_26345294 0.194


chr8_+_22493928 0.189 NM_176871
NM_198042
PDLIM2

PDZ and LIM domain 2 (mystique)


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.56 1.25e-03 GO:0006936 muscle contraction
3.27 4.96e-03 GO:0003012 muscle system process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
4.20 1.26e-04 GO:0043292 contractile fiber
4.34 1.71e-04 GO:0044449 contractile fiber part
4.22 2.57e-04 GO:0030016 myofibril
4.15 3.22e-03 GO:0030017 sarcomere
1.49 4.54e-02 GO:0005576 extracellular region
1.30 4.94e-02 GO:0071944 cell periphery

Nothing significant found in function category.