Motif ID: GFI1.p2

Z-value: 1.746


Transcription factors associated with GFI1.p2:

Gene SymbolEntrez IDGene Name
GFI1 2672 growth factor independent 1 transcription repressor

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
GFI1chr1_-_92724181-0.639.2e-03Click!


Activity profile for motif GFI1.p2.

activity profile for motif GFI1.p2


Sorted Z-values histogram for motif GFI1.p2

Sorted Z-values for motif GFI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GFI1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_+_103251798 3.707 NM_001198953
NM_024071
ZFYVE21

zinc finger, FYVE domain containing 21

chr17_-_1566223 3.255 C17orf91
chromosome 17 open reading frame 91
chr12_-_28016182 2.780 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr12_-_21702046 2.435 NM_002300
LDHB
lactate dehydrogenase B
chr12_-_21702021 2.414 LDHB
lactate dehydrogenase B
chr12_-_21701985 2.403 NM_001174097
LDHB
lactate dehydrogenase B
chr12_-_21702000 2.393 LDHB
lactate dehydrogenase B
chr12_-_21702036 2.366 LDHB
lactate dehydrogenase B
chr10_+_17311242 2.182 VIM
vimentin
chr10_+_17311282 2.180 VIM
vimentin
chr10_+_17311283 2.125 VIM
vimentin
chr12_-_45759691 2.088 NM_001143668
NM_181847
AMIGO2

adhesion molecule with Ig-like domain 2

chr2_-_189752575 2.057 NM_000393
COL5A2
collagen, type V, alpha 2
chr9_+_74956494 2.006 NM_000700
ANXA1
annexin A1
chr8_-_102033409 1.984 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr9_+_74956601 1.964 ANXA1
annexin A1
chrX_-_13744933 1.944 GPM6B
glycoprotein M6B
chr11_+_13255836 1.873 NM_001030272
NM_001030273
NM_001178
ARNTL


aryl hydrocarbon receptor nuclear translocator-like


chr9_+_74956614 1.850 ANXA1
annexin A1
chr10_+_17310475 1.783 VIM
vimentin
chr11_+_13255913 1.776 ARNTL
aryl hydrocarbon receptor nuclear translocator-like
chr8_-_41286088 1.759 NM_003012
SFRP1
secreted frizzled-related protein 1
chr11_+_13255948 1.703 ARNTL
aryl hydrocarbon receptor nuclear translocator-like
chr11_+_13255925 1.696 ARNTL
aryl hydrocarbon receptor nuclear translocator-like
chr8_-_49996353 1.674 NM_003068
SNAI2
snail homolog 2 (Drosophila)
chr15_+_39032927 1.669 NM_001142776
NM_024111
CHAC1

ChaC, cation transport regulator homolog 1 (E. coli)

chr11_+_13255952 1.658 ARNTL
aryl hydrocarbon receptor nuclear translocator-like
chr4_+_47181987 1.643 NM_020453
ATP10D
ATPase, class V, type 10D
chr16_+_81218074 1.636 NM_001257
CDH13
cadherin 13, H-cadherin (heart)
chr5_-_127901633 1.618 NM_001999
FBN2
fibrillin 2
chr8_-_42184350 1.585 NM_000930
NM_033011
PLAT

plasminogen activator, tissue

chr1_-_151630168 1.560 NM_002964
S100A8
S100 calcium binding protein A8
chr8_-_98359248 1.550 TSPYL5
TSPY-like 5
chr3_+_161040343 1.545 NM_001197109
SCHIP1
schwannomin interacting protein 1
chr16_+_67236730 1.533 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr11_+_13255967 1.514 ARNTL
aryl hydrocarbon receptor nuclear translocator-like
chr11_+_13255905 1.508 ARNTL
aryl hydrocarbon receptor nuclear translocator-like
chr6_-_166960690 1.462 NM_021135
RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr3_+_50248639 1.444 GNAI2
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
chr12_+_77782719 1.412 SYT1
synaptotagmin I
chr3_+_50248579 1.404 GNAI2
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
chr3_+_50248649 1.399 NM_002070
GNAI2
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
chr1_-_205272619 1.391 NM_001083924
NM_023938
C1orf116

chromosome 1 open reading frame 116

chrX_+_103103848 1.388 NM_194324
TMSB15B
thymosin beta 15B
chr10_+_17312654 1.387 VIM
vimentin
chr15_-_81667773 1.387 HDGFRP3
hepatoma-derived growth factor, related protein 3
chr17_+_73694992 1.380 NM_001010982
NM_001145526
AFMID

arylformamidase

chr9_-_35062545 1.380 VCP
valosin containing protein
chr3_+_50248678 1.374 GNAI2
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
chr14_-_51605515 1.371 NID2
nidogen 2 (osteonidogen)
chr8_-_102033444 1.367 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr12_+_4300607 1.364 NM_020375
C12orf5
chromosome 12 open reading frame 5
chr8_-_98359347 1.363 NM_033512
TSPYL5
TSPY-like 5
chr16_+_67236699 1.363 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr1_-_68470585 1.343 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chrX_+_64804318 1.330 MSN
moesin
chr14_-_51605461 1.327 NID2
nidogen 2 (osteonidogen)
chr14_-_51605487 1.327 NID2
nidogen 2 (osteonidogen)
chr3_+_50248749 1.310 GNAI2
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
chr14_-_51605695 1.283 NM_007361
NID2
nidogen 2 (osteonidogen)
chr9_-_35062578 1.256 VCP
valosin containing protein
chr8_-_102033372 1.238 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr2_-_85969527 1.231 NM_003896
ST3GAL5
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
chr7_+_65307691 1.229 NM_003596
TPST1
tyrosylprotein sulfotransferase 1
chr3_+_50248652 1.228 GNAI2
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
chr18_+_19706979 1.223 NM_000227
NM_001127718
LAMA3

laminin, alpha 3

chr7_-_93357881 1.207 NM_006528
TFPI2
tissue factor pathway inhibitor 2
chr7_+_65307816 1.204 TPST1
tyrosylprotein sulfotransferase 1
chr9_+_78283076 1.193 NM_001097635
GCNT1
glucosaminyl (N-acetyl) transferase 1, core 2
chr9_+_33614214 1.185 ANXA2P2
annexin A2 pseudogene 2
chr3_+_48463184 1.178 NM_032166
NM_130384
TREX1
ATRIP

three prime repair exonuclease 1
ATR interacting protein

chr22_-_16020168 1.168 NM_033070
CECR5
cat eye syndrome chromosome region, candidate 5
chr9_-_35062596 1.159 VCP
valosin containing protein
chrX_+_119622012 1.140 MCTS1
malignant T cell amplified sequence 1
chr15_-_81667169 1.127 NM_016073
HDGFRP3
hepatoma-derived growth factor, related protein 3
chr9_-_35062643 1.122 NM_007126
VCP
valosin containing protein
chr2_-_179380301 1.121 NM_003319
NM_133378
NM_133379
NM_133432
NM_133437
TTN




titin




chr8_+_31616809 1.096 NM_013962
NRG1
neuregulin 1
chr9_+_36180885 1.089 CLTA
clathrin, light chain A
chrX_+_107221552 1.065 NM_052936
NM_178270
ATG4A

ATG4 autophagy related 4 homolog A (S. cerevisiae)

chr1_-_46370837 1.054 NM_003629
NM_001114172
PIK3R3

phosphoinositide-3-kinase, regulatory subunit 3 (gamma)

chr1_+_101474892 1.046 NM_001400
S1PR1
sphingosine-1-phosphate receptor 1
chr9_+_36180927 1.029 CLTA
clathrin, light chain A
chr1_-_93919789 1.026 NM_003567
BCAR3
breast cancer anti-estrogen resistance 3
chrX_+_119621933 1.026 MCTS1
malignant T cell amplified sequence 1
chr10_+_102782156 1.023 SFXN3
sideroflexin 3
chr8_+_42129620 1.021 NM_001134296
NM_006803
AP3M2

adaptor-related protein complex 3, mu 2 subunit

chr22_-_16020076 1.018 CECR5
cat eye syndrome chromosome region, candidate 5
chr22_-_16020153 1.017 CECR5
cat eye syndrome chromosome region, candidate 5
chr8_-_102033424 1.016 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr4_+_78297418 1.013 CCNG2
cyclin G2
chr3_-_69517913 1.011 FRMD4B
FERM domain containing 4B
chr1_+_179324458 1.004 IER5
immediate early response 5
chr4_+_78297356 0.997 NM_004354
CCNG2
cyclin G2
chr10_+_70745615 0.988 NM_033496
HK1
hexokinase 1
chr9_+_36180936 0.987 CLTA
clathrin, light chain A
chrX_+_102517909 0.965 NM_206915
NM_206917
NGFRAP1

nerve growth factor receptor (TNFRSF16) associated protein 1

chr16_+_31391998 0.958 NM_015927
TGFB1I1
transforming growth factor beta 1 induced transcript 1
chr11_-_58099884 0.954 NM_004811
LPXN
leupaxin
chr9_+_36180852 0.949 NM_001076677
NM_001184760
NM_001184761
NM_001184762
NM_001833
NM_007096
CLTA





clathrin, light chain A





chr18_+_27281729 0.942 NM_001944
DSG3
desmoglein 3
chr10_+_102782151 0.937 SFXN3
sideroflexin 3
chr12_+_77782648 0.936 SYT1
synaptotagmin I
chr22_+_17847413 0.932 NM_001178010
NM_001178011
NM_003504
CDC45


cell division cycle 45 homolog (S. cerevisiae)


chr8_-_25371858 0.926 NM_017634
KCTD9
potassium channel tetramerisation domain containing 9
chr1_+_149299307 0.922 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr20_-_31771550 0.915 NM_007238
NM_183397
PXMP4

peroxisomal membrane protein 4, 24kDa

chr9_-_98841186 0.906 NM_001333
CTSL2
cathepsin L2
chr17_-_3518628 0.900 TAX1BP3
Tax1 (human T-cell leukemia virus type I) binding protein 3
chr14_-_90596665 0.898 NM_004755
NM_182398
RPS6KA5

ribosomal protein S6 kinase, 90kDa, polypeptide 5

chr17_-_43977273 0.898 NM_002145
HOXB2
homeobox B2
chr9_+_36180956 0.896 CLTA
clathrin, light chain A
chr9_+_115367122 0.888 NM_134427
RGS3
regulator of G-protein signaling 3
chr17_-_7248137 0.886 NM_152766
C17orf61-PLSCR3
C17orf61
C17orf61-PLSCR3 read-through transcript
chromosome 17 open reading frame 61
chr8_-_102033423 0.886 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr12_+_77782579 0.868 NM_005639
SYT1
synaptotagmin I
chr12_+_52733927 0.866 NM_153633
HOXC4
HOXC6
homeobox C4
homeobox C6
chrX_+_102518064 0.860 NGFRAP1
nerve growth factor receptor (TNFRSF16) associated protein 1
chr14_-_54727958 0.860 NM_001146015
NM_014750
DLGAP5

discs, large (Drosophila) homolog-associated protein 5

chr8_-_42184194 0.858 PLAT
plasminogen activator, tissue
chr8_-_78074851 0.857 NM_000318
NM_001079867
PEX2

peroxisomal biogenesis factor 2

chr9_+_81376666 0.851 NM_007005
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr19_+_45976001 0.845 NM_016154
RAB4B-EGLN2
RAB4B
RAB4B-EGLN2 read-through transcript
RAB4B, member RAS oncogene family
chr18_+_45342398 0.845 NM_006033
LIPG
lipase, endothelial
chr15_-_81744469 0.838 NM_001717
BNC1
basonuclin 1
chr17_-_3518568 0.832 TAX1BP3
Tax1 (human T-cell leukemia virus type I) binding protein 3
chr1_-_165789640 0.829 NM_003851
CREG1
cellular repressor of E1A-stimulated genes 1
chr8_-_102033434 0.826 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr10_-_101680645 0.826 DNMBP
dynamin binding protein
chr14_-_103251497 0.821 NM_001100118
NM_001100119
NM_005432
XRCC3


X-ray repair complementing defective repair in Chinese hamster cells 3


chr11_-_122438016 0.819 NM_006597
NM_153201
HSPA8

heat shock 70kDa protein 8

chr7_+_98084531 0.811 NM_002523
NPTX2
neuronal pentraxin II
chr1_+_149299490 0.802 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr5_+_140871107 0.800


chr5_+_140709907 0.795 NM_018922
NM_032095
PCDHGB1

protocadherin gamma subfamily B, 1

chr1_-_95165089 0.788 NM_001839
CNN3
calponin 3, acidic
chr22_+_17847467 0.780 CDC45
cell division cycle 45 homolog (S. cerevisiae)
chr13_+_35904408 0.779 NM_001111045
NM_003914
CCNA1

cyclin A1

chr4_-_90978469 0.777 NM_001146055
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chrX_+_135058402 0.774 NM_001159700
FHL1
four and a half LIM domains 1
chr14_-_99911528 0.769 WARS
tryptophanyl-tRNA synthetase
chr1_+_179324260 0.768 NM_016545
IER5
immediate early response 5
chrX_-_101658297 0.766 NM_021992
TMSB15A
TMSB15B
thymosin beta 15a
thymosin beta 15B
chr1_-_95165037 0.750 CNN3
calponin 3, acidic
chr12_-_21545751 0.746 NM_002907
NM_032941
RECQL

RecQ protein-like (DNA helicase Q1-like)

chr5_+_140742585 0.746 NM_018920
NM_032087
PCDHGA7

protocadherin gamma subfamily A, 7

chr4_+_1273662 0.740 NM_001017405
NM_005882
MAEA

macrophage erythroblast attacher

chr12_+_52618815 0.740 NM_017410
HOXC13
homeobox C13
chr17_-_5263706 0.739 NM_002532
NUP88
nucleoporin 88kDa
chr9_+_136673464 0.733 NM_000093
COL5A1
collagen, type V, alpha 1
chr17_-_5330204 0.731 NM_016041
DERL2
Der1-like domain family, member 2
chr4_+_1273679 0.730 MAEA
macrophage erythroblast attacher
chr4_-_115120251 0.718 NM_024590
ARSJ
arylsulfatase family, member J
chr5_+_151131676 0.715 G3BP1
GTPase activating protein (SH3 domain) binding protein 1
chr9_-_23816062 0.695 NM_004432
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr9_+_36181015 0.694 CLTA
clathrin, light chain A
chr17_-_30783631 0.684 NM_018042
SLFN12
schlafen family member 12
chr1_-_109386112 0.684 NM_001142550
NM_001142551
NM_014969
WDR47


WD repeat domain 47


chr22_-_17891777 0.681 CLDN5
claudin 5
chr1_-_103346639 0.676 NM_001190709
NM_001854
NM_080629
NM_080630
COL11A1



collagen, type XI, alpha 1



chr14_-_22458220 0.673 NM_001077351
NM_001077352
NM_018107
RBM23


RNA binding motif protein 23


chr2_+_9264360 0.670 ASAP2
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
chr1_-_68735267 0.667 DEPDC1
DEP domain containing 1
chr12_-_21545473 0.667 RECQL
RecQ protein-like (DNA helicase Q1-like)
chr7_-_133794344 0.666 AKR1B1
aldo-keto reductase family 1, member B1 (aldose reductase)
chr8_-_102033510 0.664 NM_145690
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr11_-_4585947 0.663 NM_018073
TRIM68
tripartite motif containing 68
chr9_+_115246831 0.661 NM_144488
RGS3
regulator of G-protein signaling 3
chr3_-_168935287 0.654 NM_007217
NM_145860
NM_145859
PDCD10


programmed cell death 10


chr6_+_137185441 0.654 PEX7
peroxisomal biogenesis factor 7
chr5_+_140870881 0.653


chr8_+_102573837 0.651 NM_024915
GRHL2
grainyhead-like 2 (Drosophila)
chr14_-_99912340 0.650 WARS
tryptophanyl-tRNA synthetase
chr14_-_99912390 0.649 WARS
tryptophanyl-tRNA synthetase
chr3_-_100103142 0.647 NM_080927
DCBLD2
discoidin, CUB and LCCL domain containing 2
chr7_-_133794404 0.645 NM_001628
AKR1B1
aldo-keto reductase family 1, member B1 (aldose reductase)
chr11_-_67032125 0.641 CDK2AP2
cyclin-dependent kinase 2 associated protein 2
chr3_-_49736297 0.631 NM_013334
NM_021971
GMPPB

GDP-mannose pyrophosphorylase B

chr5_+_102229612 0.628 PAM
peptidylglycine alpha-amidating monooxygenase
chr14_-_99912429 0.624 NM_173701
NM_213645
WARS

tryptophanyl-tRNA synthetase

chr1_+_149299530 0.623 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr19_+_57385146 0.622 PPP2R1A
protein phosphatase 2, regulatory subunit A, alpha
chr5_+_66160359 0.622 NM_015183
MAST4
microtubule associated serine/threonine kinase family member 4
chr11_-_118799058 0.620 THY1
Thy-1 cell surface antigen
chr2_+_241023703 0.615 NM_002081
GPC1
glypican 1
chr3_+_173951163 0.614 ECT2
epithelial cell transforming sequence 2 oncogene
chr1_+_149299504 0.609 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr19_-_52045890 0.605 NM_004069
NM_021575
AP2S1

adaptor-related protein complex 2, sigma 1 subunit

chr8_+_102574012 0.604 GRHL2
grainyhead-like 2 (Drosophila)
chr14_-_22458199 0.604 RBM23
RNA binding motif protein 23
chr16_+_55836480 0.603 NM_012106
ARL2BP
ADP-ribosylation factor-like 2 binding protein
chr1_-_43605935 0.602 ELOVL1
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1
chr12_-_47869067 0.598 NM_006009
TUBA1A
tubulin, alpha 1a
chr17_-_5263594 0.598 NUP88
nucleoporin 88kDa
chr2_-_130603264 0.597 NM_001099771
POTEF
POTE ankyrin domain family, member F
chr11_-_118799452 0.592 NM_006288
THY1
Thy-1 cell surface antigen
chr1_+_46413335 0.590 NM_005727
TSPAN1
tetraspanin 1
chr2_-_130672481 0.582 NM_207312
TUBA3E
tubulin, alpha 3e
chr18_-_43711143 0.581 SMAD2
SMAD family member 2
chr5_+_151131655 0.580 NM_005754
NM_198395
G3BP1

GTPase activating protein (SH3 domain) binding protein 1


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.08 1.66e-03 GO:0009987 cellular process
1.45 1.10e-02 GO:0007049 cell cycle
1.98 2.27e-02 GO:0000075 cell cycle checkpoint

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.33 4.85e-05 GO:0005829 cytosol
1.54 5.37e-03 GO:0015630 microtubule cytoskeleton
1.33 1.01e-02 GO:0005856 cytoskeleton
1.14 2.97e-02 GO:0005634 nucleus

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.12 5.29e-03 GO:0005515 protein binding