Motif ID: NKX3-1.p2

Z-value: 1.965


Transcription factors associated with NKX3-1.p2:

Gene SymbolEntrez IDGene Name
NKX3-1 4824 NK3 homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX3-1chr8_-_235963460.332.1e-01Click!


Activity profile for motif NKX3-1.p2.

activity profile for motif NKX3-1.p2


Sorted Z-values histogram for motif NKX3-1.p2

Sorted Z-values for motif NKX3-1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX3-1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_-_61655915 11.575 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr4_+_74488947 10.135 ALB
albumin
chr7_+_45899080 9.448 IGFBP1
insulin-like growth factor binding protein 1
chr7_+_45899621 9.074


chr4_+_74520796 8.124 NM_001134
AFP
alpha-fetoprotein
chr4_+_89115825 7.797 NM_000582
NM_001040058
NM_001040060
SPP1


secreted phosphoprotein 1


chr4_+_89115923 7.763 SPP1
secreted phosphoprotein 1
chr4_+_89115892 7.744 SPP1
secreted phosphoprotein 1
chr4_+_89115862 7.730 SPP1
secreted phosphoprotein 1
chr4_+_74488835 6.583 NM_000477
ALB
albumin
chr20_+_30160952 5.814 NM_014742
TM9SF4
transmembrane 9 superfamily protein member 4
chr4_+_74498042 5.441 ALB
albumin
chrX_-_131401319 5.356 NM_018388
NM_133486
MBNL3

muscleblind-like 3 (Drosophila)

chr4_+_74493918 5.294 ALB
albumin
chr4_+_74497998 5.135 ALB
albumin
chr4_+_74491272 4.981 ALB
albumin
chr8_-_17787342 4.691 FGL1
fibrinogen-like 1
chr20_+_30161173 4.586 TM9SF4
transmembrane 9 superfamily protein member 4
chr4_+_74488910 4.336 ALB
albumin
chr17_-_53847937 4.326 RNF43
ring finger protein 43
chr7_+_94377145 3.431 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory (inhibitor) subunit 9A


chr14_+_94148466 3.105 NM_001085
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr6_+_32003180 3.003 NM_000063
NM_001145903
C2

complement component 2

chr12_-_101835510 2.992 NM_000277
PAH
phenylalanine hydroxylase
chr8_-_17797127 2.828 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chrX_+_105823723 2.749 NM_024539
RNF128
ring finger protein 128
chr10_-_69267774 2.567 NM_021800
NM_201262
DNAJC12

DnaJ (Hsp40) homolog, subfamily C, member 12

chr1_+_205329206 2.491 NM_000716
NM_001017364
NM_001017367
C4BPB


complement component 4 binding protein, beta


chr10_-_118670968 2.412 KIAA1598
KIAA1598
chr20_-_51633042 2.353 NM_006526
ZNF217
zinc finger protein 217
chrX_-_2892288 2.322 NM_000047
ARSE
arylsulfatase E (chondrodysplasia punctata 1)
chr16_+_80626331 2.269 NM_002153
HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chrX_+_107569671 2.245 NM_000495
NM_033380
COL4A5

collagen, type IV, alpha 5

chr5_+_156628929 2.214 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr3_-_184756101 2.182 NM_130446
KLHL6
kelch-like 6 (Drosophila)
chr5_-_98290117 2.149 NM_001270
CHD1
chromodomain helicase DNA binding protein 1
chr16_+_80626459 2.145 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr6_+_30238961 2.099 NM_033229
TRIM15
tripartite motif containing 15
chr15_+_57691382 2.061 GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr4_-_84254932 2.030 NM_001130715
NM_016619
PLAC8

placenta-specific 8

chr14_+_38804226 1.943 NM_203354
CTAGE5
CTAGE family, member 5
chr16_+_80626402 1.855 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr10_-_7722747 1.845 ITIH5
inter-alpha (globulin) inhibitor H5
chr2_-_188127294 1.766 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chrX_-_32340291 1.746 NM_004011
NM_004012
DMD

dystrophin

chr10_+_7785360 1.722 ITIH2
inter-alpha (globulin) inhibitor H2
chr16_+_80626456 1.663 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr6_+_32003380 1.659 C2
complement component 2
chr3_+_143858428 1.657 NM_001172312
PLS1
plastin 1
chr3_-_188946168 1.640 NM_001706
BCL6
B-cell CLL/lymphoma 6
chr6_+_64344307 1.615 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr15_-_58706934 1.601 NM_002943
NM_134260
RORA

RAR-related orphan receptor A

chr11_-_128399218 1.568 NM_014715
ARHGAP32
Rho GTPase activating protein 32
chr2_-_165259334 1.559 COBLL1
COBL-like 1
chr7_-_87180499 1.508 NM_000927
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr15_+_57691272 1.502 NM_004751
GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chrX_-_130251068 1.502 NM_001170961
NM_001170962
NM_001555
NM_205833
IGSF1



immunoglobulin superfamily, member 1



chr10_+_5478521 1.483 NM_005863
NET1
neuroepithelial cell transforming 1
chr10_+_7785290 1.472 ITIH2
inter-alpha (globulin) inhibitor H2
chr2_-_20375497 1.427 PUM2
pumilio homolog 2 (Drosophila)
chr6_-_76259976 1.420 NM_015687
FILIP1
filamin A interacting protein 1
chr10_+_7785235 1.394 NM_002216
ITIH2
inter-alpha (globulin) inhibitor H2
chr10_-_11614279 1.372 NM_001080491
USP6NL
USP6 N-terminal like
chr18_-_50776276 1.348 NM_001143829
CCDC68
coiled-coil domain containing 68
chr17_+_35097851 1.334 NM_001005862
ERBB2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
chr10_-_116434364 1.308 NM_001003407
NM_001003408
ABLIM1

actin binding LIM protein 1

chr10_+_7785331 1.303 ITIH2
inter-alpha (globulin) inhibitor H2
chr1_+_15862887 1.301


chr4_-_84254912 1.301 PLAC8
placenta-specific 8
chr6_-_79732391 1.269 PHIP
pleckstrin homology domain interacting protein
chr19_+_54707347 1.236 NM_001136019
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr4_-_186934059 1.223 NM_001145673
SORBS2
sorbin and SH3 domain containing 2
chr3_-_195553297 1.222 NM_001080513
CPN2
carboxypeptidase N, polypeptide 2
chr6_+_27885692 1.221 NM_003536
HIST1H3H
histone cluster 1, H3h
chr2_+_64534774 1.216 NM_014181
HSPC159
galectin-related protein
chr4_+_166519392 1.202 NM_001873
CPE
carboxypeptidase E
chrX_-_100920493 1.196 GK
glycerol kinase
chr4_-_84254873 1.193 PLAC8
placenta-specific 8
chr9_-_74757735 1.183 NM_000689
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr11_+_73036241 1.176 NM_001130034
NM_001130035
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr4_-_69852090 1.165 NM_024743
UGT2A3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr1_-_229627412 1.156 NM_022051
EGLN1
egl nine homolog 1 (C. elegans)
chr21_-_42659671 1.150 NM_003225
TFF1
trefoil factor 1
chr3_+_171183203 1.144 SEC62
SEC62 homolog (S. cerevisiae)
chr18_+_54039818 1.135 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr4_+_1872150 1.130 NM_133334
WHSC1
Wolf-Hirschhorn syndrome candidate 1
chr17_+_24394043 1.110 NM_016518
PIPOX
pipecolic acid oxidase
chr12_-_49689295 1.098 NM_001174130
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr1_+_165565006 1.088 POU2F1
POU class 2 homeobox 1
chr4_+_155703581 1.063 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr16_-_21221872 1.056 NM_001014444
NM_001888
CRYM

crystallin, mu

chr17_+_50697355 1.041 HLF
hepatic leukemia factor
chr4_-_10295412 1.025 NM_052964
CLNK
cytokine-dependent hematopoietic cell linker
chr3_-_198784590 1.019 NM_203315
BDH1
3-hydroxybutyrate dehydrogenase, type 1
chr3_-_121883647 1.013 HGD
homogentisate 1,2-dioxygenase
chr5_+_92944680 0.958 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr2_-_188127430 0.957 NM_001032281
NM_006287
TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

chr10_-_52315436 0.952 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chrX_-_131375217 0.936 NM_001170701
NM_001170702
NM_001170703
MBNL3


muscleblind-like 3 (Drosophila)


chr12_+_52132151 0.927 NM_001098620
NM_001128911
NM_001128912
NM_001128913
NM_001128914
NM_005016
NM_031989
PCBP2






poly(rC) binding protein 2






chr1_-_149681265 0.926 NM_207171
POGZ
pogo transposable element with ZNF domain
chr4_-_186969041 0.917 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chr6_+_144654565 0.899 NM_007124
UTRN
utrophin
chr4_-_110942783 0.896 NM_000204
CFI
complement factor I
chr9_+_79158164 0.869 VPS13A
vacuolar protein sorting 13 homolog A (S. cerevisiae)
chr13_-_74799898 0.862 TBC1D4
TBC1 domain family, member 4
chr3_-_12916547 0.859 IQSEC1
IQ motif and Sec7 domain 1
chr10_+_112334066 0.844 SMC3
structural maintenance of chromosomes 3
chr3_-_150569574 0.835 TM4SF1
transmembrane 4 L six family member 1
chr16_-_29797172 0.830 SEZ6L2
seizure related 6 homolog (mouse)-like 2
chr8_+_40130143 0.825 NM_020130
C8orf4
chromosome 8 open reading frame 4
chr10_+_102111361 0.823 SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr12_-_78608873 0.821 NM_002583
PAWR
PRKC, apoptosis, WT1, regulator
chr16_+_68156497 0.810 NM_001113178
NM_006599
NM_138713
NM_138714
NM_173214
NFAT5




nuclear factor of activated T-cells 5, tonicity-responsive




chr1_+_57093030 0.808 NM_000562
C8A
complement component 8, alpha polypeptide
chr2_+_211166323 0.796 NM_001122634
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr13_-_40604587 0.789 NM_152903
KBTBD6
kelch repeat and BTB (POZ) domain containing 6
chr6_+_126282078 0.778 NCOA7
nuclear receptor coactivator 7
chr6_+_26473376 0.771 NM_001197247
NM_001197249
NM_007047
NM_001197248
BTN3A2



butyrophilin, subfamily 3, member A2



chr10_-_52315390 0.770 A1CF
APOBEC1 complementation factor
chr11_+_86710076 0.765 TMEM135
transmembrane protein 135
chr11_+_89507465 0.731 NM_005467
NAALAD2
N-acetylated alpha-linked acidic dipeptidase 2
chrX_-_130250880 0.727 IGSF1
immunoglobulin superfamily, member 1
chr6_+_134800533 0.712 LOC154092
hypothetical LOC154092
chr15_-_54175954 0.708 RFX7
regulatory factor X, 7
chr6_-_33016561 0.698 NM_002118
HLA-DMB
major histocompatibility complex, class II, DM beta
chr17_-_39500512 0.697 NM_152344
LSM12
LSM12 homolog (S. cerevisiae)
chr4_+_71096830 0.693 NM_017855
ODAM
odontogenic, ameloblast asssociated
chr4_-_151990061 0.668 LRBA
LPS-responsive vesicle trafficking, beach and anchor containing
chr6_+_167445284 0.651 NM_004367
CCR6
chemokine (C-C motif) receptor 6
chr6_-_25982418 0.650 NM_001098486
NM_006632
SLC17A3

solute carrier family 17 (sodium phosphate), member 3

chr1_+_54132447 0.650 NM_000792
NM_001039715
NM_001039716
NM_213593
DIO1



deiodinase, iodothyronine, type I



chr10_-_99084417 0.648 NM_012083
FRAT2
frequently rearranged in advanced T-cell lymphomas 2
chr19_-_56549853 0.648 NM_001014763
ETFB
electron-transfer-flavoprotein, beta polypeptide
chrX_-_76824726 0.639 ATRX
alpha thalassemia/mental retardation syndrome X-linked
chr5_+_139869819 0.637


chr12_+_119617060 0.637


chr13_-_47885653 0.631 NM_001162498
LPAR6
lysophosphatidic acid receptor 6
chr17_+_46176105 0.625 LUC7L3
LUC7-like 3 (S. cerevisiae)
chr2_+_37282516 0.585 LOC100505876
hypothetical LOC100505876
chr10_-_116434102 0.581 ABLIM1
actin binding LIM protein 1
chrX_+_90977115 0.576 NM_001168360
NM_001168361
NM_001168362
NM_001168363
PCDH11X



protocadherin 11 X-linked



chr9_+_89302239 0.572 DAPK1
death-associated protein kinase 1
chr17_-_53849929 0.569 NM_017763
RNF43
ring finger protein 43
chr7_+_20653490 0.564 NM_001163942
NM_001163993
NM_178559
ABCB5


ATP-binding cassette, sub-family B (MDR/TAP), member 5


chr1_+_50348052 0.563 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr5_+_126887056 0.556 PRRC1
proline-rich coiled-coil 1
chr4_-_140280031 0.555 NM_201999
ELF2
E74-like factor 2 (ets domain transcription factor)
chr13_-_47885018 0.547 LPAR6
lysophosphatidic acid receptor 6
chr14_+_87541220 0.539 NM_003608
GPR65
G protein-coupled receptor 65
chr3_-_180452096 0.514 NM_014407
KCNMB3
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr20_+_29565922 0.514 HM13
histocompatibility (minor) 13
chr1_+_158975662 0.512 NM_021181
SLAMF7
SLAM family member 7
chr14_+_20222575 0.510 ANG
RNASE4
angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family, 4
chr4_-_153523113 0.505 NM_001013415
FBXW7
F-box and WD repeat domain containing 7
chr15_-_74963246 0.498 NM_020843
SCAPER
S-phase cyclin A-associated protein in the ER
chr16_+_82540172 0.496 NM_013370
NM_182980
OSGIN1

oxidative stress induced growth inhibitor 1

chrX_+_99726445 0.494 NM_022144
TNMD
tenomodulin
chrX_-_131451675 0.494 NM_001170704
MBNL3
muscleblind-like 3 (Drosophila)
chr9_+_89302574 0.493 NM_004938
DAPK1
death-associated protein kinase 1
chrX_-_135783496 0.492


chr4_-_17415918 0.488 DCAF16
DDB1 and CUL4 associated factor 16
chrX_+_107174855 0.486 NM_001170553
NM_182607
VSIG1

V-set and immunoglobulin domain containing 1

chrY_-_2715478 0.486 NM_003140
SRY
sex determining region Y
chr10_-_98021144 0.484 NM_001114094
NM_013314
BLNK

B-cell linker

chr20_+_29565898 0.484 NM_030789
NM_178580
NM_178581
NM_178582
HM13



histocompatibility (minor) 13



chrX_-_64671319 0.478 LAS1L
LAS1-like (S. cerevisiae)
chr16_-_70763524 0.477 NM_031293
PMFBP1
polyamine modulated factor 1 binding protein 1
chr3_-_139960874 0.465 NM_006219
PIK3CB
phosphoinositide-3-kinase, catalytic, beta polypeptide
chr12_+_40117751 0.458 NM_013377
PDZRN4
PDZ domain containing ring finger 4
chr6_+_10629550 0.457 NM_145649
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr6_+_163904564 0.457 QKI
quaking homolog, KH domain RNA binding (mouse)
chrX_-_64671362 0.456 NM_001170649
NM_001170650
NM_031206
LAS1L


LAS1-like (S. cerevisiae)


chr4_+_70180805 0.455 NM_053039
UGT2B28
UDP glucuronosyltransferase 2 family, polypeptide B28
chr2_+_73911477 0.449 STAMBP
STAM binding protein
chr2_+_17585462 0.446 VSNL1
visinin-like 1
chr8_-_13416554 0.446 NM_024767
NM_182643
DLC1

deleted in liver cancer 1

chr2_+_74913289 0.441 NM_000189
HK2
hexokinase 2
chr3_+_142175329 0.441 SLC25A36
solute carrier family 25, member 36
chr12_-_52281050 0.438 NM_001130059
ATF7
activating transcription factor 7
chr15_+_92700167 0.436 NM_001159644
MCTP2
multiple C2 domains, transmembrane 2
chr6_+_132000134 0.435 NM_005021
ENPP3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr12_-_23628774 0.434 NM_178010
SOX5
SRY (sex determining region Y)-box 5
chr16_-_66535457 0.433 NM_000229
LCAT
lecithin-cholesterol acyltransferase
chr18_+_3443771 0.431 NM_173211
TGIF1
TGFB-induced factor homeobox 1
chr14_+_22859236 0.430 NM_004643
PABPN1
poly(A) binding protein, nuclear 1
chr1_-_41399632 0.423 NM_001031694
SCMH1
sex comb on midleg homolog 1 (Drosophila)
chr1_+_149165438 0.423 NM_001145415
NM_012432
SETDB1

SET domain, bifurcated 1

chr4_-_70115037 0.421 NM_001073
UGT2B11
UDP glucuronosyltransferase 2 family, polypeptide B11
chr2_-_233349469 0.421 NM_001172416
NM_001172417
NM_002242
KCNJ13


potassium inwardly-rectifying channel, subfamily J, member 13


chr17_-_16038607 0.419 NM_001190438
NM_001190440
NCOR1

nuclear receptor corepressor 1

chr21_+_39117064 0.412 ETS2
v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
chr15_+_64372876 0.412 NM_001143688
DIS3L
DIS3 mitotic control homolog (S. cerevisiae)-like
chr18_+_31488530 0.408 NM_020474
GALNT1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)
chr2_+_120487076 0.406 NM_001184938
EPB41L5
erythrocyte membrane protein band 4.1 like 5
chrM_+_4770 0.406


chr17_+_41457394 0.404 MAPT
microtubule-associated protein tau
chr6_-_99957253 0.403 SFRS18
splicing factor, arginine/serine-rich 18
chr1_+_114295289 0.403 NM_198269
HIPK1
homeodomain interacting protein kinase 1
chr10_-_64698831 0.402 NM_004241
JMJD1C
jumonji domain containing 1C

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.