Motif ID: HIC1.p2

Z-value: 3.945


Transcription factors associated with HIC1.p2:

Gene SymbolEntrez IDGene Name
HIC1 3090 hypermethylated in cancer 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HIC1chr17_+_1905104,
chr17_+_1906262		0.146.1e-01Click!


Activity profile for motif HIC1.p2.

activity profile for motif HIC1.p2


Sorted Z-values histogram for motif HIC1.p2

Sorted Z-values for motif HIC1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HIC1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_224612177 10.688 NM_001136528
NM_006216
 SERPINE2

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2

chr11_+_101485946 9.527 NM_001130145
NM_001195044
NM_006106
 YAP1


Yes-associated protein 1


chr2_-_160972606 9.217 RBMS1
RNA binding motif, single stranded interacting protein 1
chr2_-_224611568 8.984 NM_001136530
 SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr13_-_109757442 8.960 NM_001845
 COL4A1
collagen, type IV, alpha 1
chr1_-_85703198 7.927 DDAH1
dimethylarginine dimethylaminohydrolase 1
chr13_+_109757593 7.246 NM_001846
 COL4A2
collagen, type IV, alpha 2
chr1_-_20685314 7.213 NM_018584
 CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr11_-_11987458 7.014 NM_013253
 DKK3
dickkopf homolog 3 (Xenopus laevis)
chr11_-_11987414 6.961 DKK3
dickkopf homolog 3 (Xenopus laevis)
chr13_+_97593711 6.722 FARP1
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
chr2_+_235525355 6.417 NM_014521
 SH3BP4
SH3-domain binding protein 4
chr8_+_26491317 6.336 NM_001386
 DPYSL2
dihydropyrimidinase-like 2
chr10_+_124124196 6.270 PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr10_+_124211353 6.165 HTRA1
HtrA serine peptidase 1
chr11_-_11987198 5.920 NM_015881
 DKK3
dickkopf homolog 3 (Xenopus laevis)
chr11_-_11987115 5.757 DKK3
dickkopf homolog 3 (Xenopus laevis)
chr4_-_177950658 5.678 NM_005429
 VEGFC
vascular endothelial growth factor C
chr2_+_9264327 5.670 NM_001135191
NM_003887
 ASAP2

ArfGAP with SH3 domain, ankyrin repeat and PH domain 2

chr13_-_39075304 5.644 LHFP
lipoma HMGIC fusion partner

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 77 entries
enrichment   p-value GO term description
2.26 5.28e-04 GO:0050770 regulation of axonogenesis
2.14 1.21e-06 GO:0010769 regulation of cell morphogenesis involved in differentiation
2.12 1.97e-06 GO:0022604 regulation of cell morphogenesis
1.93 4.75e-04 GO:0010975 regulation of neuron projection development
1.90 1.24e-02 GO:0035023 regulation of Rho protein signal transduction
1.84 6.97e-03 GO:0030111 regulation of Wnt receptor signaling pathway
1.84 3.63e-02 GO:0010720 positive regulation of cell development
1.82 8.47e-11 GO:0007411 axon guidance
1.82 1.13e-03 GO:0031344 regulation of cell projection organization
1.77 2.15e-14 GO:0032990 cell part morphogenesis
1.76 3.79e-14 GO:0048858 cell projection morphogenesis
1.76 1.76e-12 GO:0048812 neuron projection morphogenesis
1.76 8.98e-12 GO:0007409 axonogenesis
1.74 5.45e-13 GO:0000904 cell morphogenesis involved in differentiation
1.74 1.35e-11 GO:0048667 cell morphogenesis involved in neuron differentiation
1.71 1.77e-14 GO:0000902 cell morphogenesis
1.71 7.00e-12 GO:0031175 neuron projection development
1.68 7.50e-04 GO:0046578 regulation of Ras protein signal transduction
1.67 5.52e-14 GO:0030030 cell projection organization
1.66 2.13e-13 GO:0032989 cellular component morphogenesis

Gene overrepresentation in compartment category:

Showing 1 to 20 of 25 entries
enrichment   p-value GO term description
2.30 4.31e-05 GO:0031256 leading edge membrane
2.15 5.91e-10 GO:0005912 adherens junction
2.14 3.82e-11 GO:0070161 anchoring junction
2.10 9.48e-06 GO:0005925 focal adhesion
2.05 1.79e-05 GO:0005924 cell-substrate adherens junction
2.01 3.22e-05 GO:0030055 cell-substrate junction
1.96 2.62e-08 GO:0031252 cell leading edge
1.94 6.31e-03 GO:0030027 lamellipodium
1.82 9.80e-03 GO:0019898 extrinsic to membrane
1.72 1.61e-02 GO:0031253 cell projection membrane
1.66 1.99e-03 GO:0005911 cell-cell junction
1.60 4.14e-05 GO:0015629 actin cytoskeleton
1.51 4.25e-07 GO:0030054 cell junction
1.46 2.00e-04 GO:0000139 Golgi membrane
1.43 5.44e-05 GO:0044431 Golgi apparatus part
1.36 1.70e-06 GO:0005794 Golgi apparatus
1.34 1.48e-04 GO:0042995 cell projection
1.30 1.31e-06 GO:0005856 cytoskeleton
1.28 1.25e-02 GO:0031982 vesicle
1.28 1.89e-02 GO:0031410 cytoplasmic vesicle

Gene overrepresentation in function category:

Showing 1 to 9 of 9 entries
enrichment   p-value GO term description
2.00 2.89e-02 GO:0005089 Rho guanyl-nucleotide exchange factor activity
1.91 1.68e-02 GO:0005088 Ras guanyl-nucleotide exchange factor activity
1.64 3.88e-02 GO:0005085 guanyl-nucleotide exchange factor activity
1.59 4.28e-05 GO:0003779 actin binding
1.57 7.39e-04 GO:0005083 small GTPase regulator activity
1.54 9.85e-08 GO:0008092 cytoskeletal protein binding
1.52 2.39e-05 GO:0030695 GTPase regulator activity
1.50 4.92e-05 GO:0060589 nucleoside-triphosphatase regulator activity
1.08 3.55e-03 GO:0005515 protein binding