Motif ID: HIC1.p2

Z-value: 3.945


Transcription factors associated with HIC1.p2:

Gene SymbolEntrez IDGene Name
HIC1 3090 hypermethylated in cancer 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HIC1chr17_+_1905104,
chr17_+_1906262
0.146.1e-01Click!


Activity profile for motif HIC1.p2.

activity profile for motif HIC1.p2


Sorted Z-values histogram for motif HIC1.p2

Sorted Z-values for motif HIC1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HIC1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_224612177 10.688 NM_001136528
NM_006216
SERPINE2

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2

chr11_+_101485946 9.527 NM_001130145
NM_001195044
NM_006106
YAP1


Yes-associated protein 1


chr2_-_160972606 9.217 RBMS1
RNA binding motif, single stranded interacting protein 1
chr2_-_224611568 8.984 NM_001136530
SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr13_-_109757442 8.960 NM_001845
COL4A1
collagen, type IV, alpha 1
chr1_-_85703198 7.927 DDAH1
dimethylarginine dimethylaminohydrolase 1
chr13_+_109757593 7.246 NM_001846
COL4A2
collagen, type IV, alpha 2
chr1_-_20685314 7.213 NM_018584
CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr11_-_11987458 7.014 NM_013253
DKK3
dickkopf homolog 3 (Xenopus laevis)
chr11_-_11987414 6.961 DKK3
dickkopf homolog 3 (Xenopus laevis)
chr13_+_97593711 6.722 FARP1
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
chr2_+_235525355 6.417 NM_014521
SH3BP4
SH3-domain binding protein 4
chr8_+_26491317 6.336 NM_001386
DPYSL2
dihydropyrimidinase-like 2
chr10_+_124124196 6.270 PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr10_+_124211353 6.165 HTRA1
HtrA serine peptidase 1
chr11_-_11987198 5.920 NM_015881
DKK3
dickkopf homolog 3 (Xenopus laevis)
chr11_-_11987115 5.757 DKK3
dickkopf homolog 3 (Xenopus laevis)
chr4_-_177950658 5.678 NM_005429
VEGFC
vascular endothelial growth factor C
chr2_+_9264327 5.670 NM_001135191
NM_003887
ASAP2

ArfGAP with SH3 domain, ankyrin repeat and PH domain 2

chr13_-_39075304 5.644 LHFP
lipoma HMGIC fusion partner
chr1_-_223907283 5.614 NM_001008493
NM_018212
ENAH

enabled homolog (Drosophila)

chr2_+_9264360 5.604 ASAP2
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
chr10_+_124210980 5.591 NM_002775
HTRA1
HtrA serine peptidase 1
chr13_+_97593469 5.430 FARP1
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
chr15_+_99237527 5.272 NM_000693
ALDH1A3
aldehyde dehydrogenase 1 family, member A3
chr3_-_187025501 5.267 NM_001007225
NM_006548
IGF2BP2

insulin-like growth factor 2 mRNA binding protein 2

chr1_-_95165037 5.213 CNN3
calponin 3, acidic
chr12_-_123023052 5.183 NM_025140
CCDC92
coiled-coil domain containing 92
chr16_-_4106186 5.167 NM_001116
ADCY9
adenylate cyclase 9
chrX_+_9943793 5.098 NM_015691
WWC3
WWC family member 3
chr14_+_105012106 5.089 NM_001312
CRIP2
cysteine-rich protein 2
chr7_+_129919157 4.992 NM_002402
MEST
mesoderm specific transcript homolog (mouse)
chr1_-_95165089 4.846 NM_001839
CNN3
calponin 3, acidic
chr17_-_74433048 4.816 NM_003255
TIMP2
TIMP metallopeptidase inhibitor 2
chr13_+_26029879 4.807 WASF3
WAS protein family, member 3
chr16_-_4106022 4.766 ADCY9
adenylate cyclase 9
chr2_-_235070431 4.730 NM_005737
ARL4C
ADP-ribosylation factor-like 4C
chr2_-_1727247 4.711 PXDN
peroxidasin homolog (Drosophila)
chr14_+_104402626 4.641 NM_001112726
NM_015005
KIAA0284

KIAA0284

chr11_+_86189138 4.637 NM_007173
PRSS23
protease, serine, 23
chr8_-_41286088 4.586 NM_003012
SFRP1
secreted frizzled-related protein 1
chr2_-_1727292 4.535 NM_012293
PXDN
peroxidasin homolog (Drosophila)
chr1_-_94475504 4.535 ARHGAP29
Rho GTPase activating protein 29
chr3_-_151171190 4.489 NM_002628
NM_053024
PFN2

profilin 2

chr13_+_113546943 4.460 GAS6
growth arrest-specific 6
chrX_+_135057202 4.458 NM_001159702
NM_001159703
NM_001449
FHL1


four and a half LIM domains 1


chr2_+_101680594 4.434 NM_004834
NM_145686
NM_145687
MAP4K4


mitogen-activated protein kinase kinase kinase kinase 4


chr17_-_74432800 4.413 TIMP2
TIMP metallopeptidase inhibitor 2
chr12_-_105165805 4.352 NM_006825
CKAP4
cytoskeleton-associated protein 4
chr1_+_19843261 4.320 NM_005380
NBL1
neuroblastoma, suppression of tumorigenicity 1
chr1_-_94475840 4.307 NM_004815
ARHGAP29
Rho GTPase activating protein 29
chr8_+_22492586 4.274 PDLIM2
PDZ and LIM domain 2 (mystique)
chr18_+_7557313 4.273 NM_001105244
NM_002845
PTPRM

protein tyrosine phosphatase, receptor type, M

chr9_-_13269562 4.271 MPDZ
multiple PDZ domain protein
chr9_-_87904306 4.237 NM_016548
GOLM1
golgi membrane protein 1
chr17_-_74432671 4.232 TIMP2
TIMP metallopeptidase inhibitor 2
chr2_+_46377952 4.197 NM_001430
EPAS1
endothelial PAS domain protein 1
chr8_-_48813236 4.185 CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr2_-_161058120 4.162 RBMS1
RNA binding motif, single stranded interacting protein 1
chr1_+_181258952 4.132 NM_002293
LAMC1
laminin, gamma 1 (formerly LAMB2)
chr13_+_113546841 4.088 NM_000820
GAS6
growth arrest-specific 6
chr2_-_175578156 4.069 NM_001025201
NM_001822
CHN1

chimerin (chimaerin) 1

chr13_+_113546912 4.024 GAS6
growth arrest-specific 6
chrX_-_152804731 4.021 L1CAM
L1 cell adhesion molecule
chr21_+_41461962 4.013 BACE2
beta-site APP-cleaving enzyme 2
chr10_-_13381751 3.993 NM_001037537
PHYH
phytanoyl-CoA 2-hydroxylase
chr1_-_56817717 3.988 PPAP2B
phosphatidic acid phosphatase type 2B
chr20_+_4614796 3.984 NM_000311
NM_001080121
NM_001080122
NM_183079
NM_001080123
PRNP




prion protein




chr8_-_119192985 3.950 NM_000127
EXT1
exostosin 1
chr1_-_56817823 3.948 NM_003713
PPAP2B
phosphatidic acid phosphatase type 2B
chr13_-_39075355 3.930 NM_005780
LHFP
lipoma HMGIC fusion partner
chr10_-_17699371 3.929 NM_014241
PTPLA
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
chr9_-_139060285 3.927 NPDC1
neural proliferation, differentiation and control, 1
chr10_-_17699309 3.884 PTPLA
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
chr9_-_139060377 3.853 NPDC1
neural proliferation, differentiation and control, 1
chr1_-_56817568 3.847 PPAP2B
phosphatidic acid phosphatase type 2B
chr13_-_39075200 3.840 LHFP
lipoma HMGIC fusion partner
chr7_-_24763556 3.812 DFNA5
deafness, autosomal dominant 5
chr13_+_113546897 3.794 GAS6
growth arrest-specific 6
chr13_+_26029799 3.789 NM_006646
WASF3
WAS protein family, member 3
chr1_-_85703321 3.757 NM_012137
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr6_+_72055235 3.738 OGFRL1
opioid growth factor receptor-like 1
chr10_+_124124083 3.718 NM_001001974
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr7_-_29995809 3.702 NM_001145515
NM_014766
NM_001145513
SCRN1


secernin 1


chr4_-_52599181 3.684 NM_000232
SGCB
sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
chr3_-_126088819 3.663 NM_002213
ITGB5
integrin, beta 5
chr7_-_24763577 3.631 NM_001127453
DFNA5
deafness, autosomal dominant 5
chr22_+_31527678 3.588 TIMP3
TIMP metallopeptidase inhibitor 3
chr5_+_92946348 3.575 NR2F1
nuclear receptor subfamily 2, group F, member 1
chr5_-_16989371 3.565 NM_012334
MYO10
myosin X
chr11_+_19691397 3.490 NM_145117
NM_182964
NAV2

neuron navigator 2

chr21_+_45649719 3.416


chr13_+_47705493 3.394 ITM2B
integral membrane protein 2B
chr6_+_72055197 3.393 NM_024576
OGFRL1
opioid growth factor receptor-like 1
chr1_+_221966835 3.376 CAPN2
calpain 2, (m/II) large subunit
chr15_-_20637731 3.373 NM_144599
NIPA1
non imprinted in Prader-Willi/Angelman syndrome 1
chr7_+_129918408 3.327 NM_177525
MEST
mesoderm specific transcript homolog (mouse)
chr3_-_147361465 3.318 PLOD2
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
chr15_+_99237555 3.310 ALDH1A3
aldehyde dehydrogenase 1 family, member A3
chr9_+_132309914 3.288 NM_000050
NM_054012
ASS1

argininosuccinate synthase 1

chr6_+_72055229 3.279 OGFRL1
opioid growth factor receptor-like 1
chr5_-_122400312 3.263 NM_000943
PPIC
peptidylprolyl isomerase C (cyclophilin C)
chr10_-_15453060 3.260 NM_001010924
FAM171A1
family with sequence similarity 171, member A1
chr5_+_76150588 3.241 NM_005242
F2RL1
coagulation factor II (thrombin) receptor-like 1
chr17_-_72218661 3.239 MXRA7
matrix-remodelling associated 7
chr21_-_26465005 3.231 NM_000484
NM_001136129
NM_001136130
NM_201413
NM_201414
APP




amyloid beta (A4) precursor protein




chr16_-_62573 3.210 NM_022450
RHBDF1
rhomboid 5 homolog 1 (Drosophila)
chr9_-_139060416 3.182 NM_015392
NPDC1
neural proliferation, differentiation and control, 1
chr4_-_57671112 3.177 IGFBP7
insulin-like growth factor binding protein 7
chr3_+_61522219 3.159 NM_002841
PTPRG
protein tyrosine phosphatase, receptor type, G
chr1_+_98899734 3.137 NM_015976
NM_152238
SNX7

sorting nexin 7

chr18_-_20231709 3.077 OSBPL1A
oxysterol binding protein-like 1A
chr9_-_87904215 3.077 GOLM1
golgi membrane protein 1
chr9_-_87904280 3.069 GOLM1
golgi membrane protein 1
chr22_+_31527744 3.054 TIMP3
TIMP metallopeptidase inhibitor 3
chr17_-_72218535 3.051 NM_001008528
NM_001008529
NM_198530
MXRA7


matrix-remodelling associated 7


chr7_-_24763841 3.038 DFNA5
deafness, autosomal dominant 5
chr14_+_54104383 3.028 NM_001161576
NM_015589
SAMD4A

sterile alpha motif domain containing 4A

chr18_+_19523526 3.023 NM_001127717
NM_198129
LAMA3

laminin, alpha 3

chr21_+_41461924 3.022 BACE2
beta-site APP-cleaving enzyme 2
chr18_-_24011349 3.012 NM_001792
CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr2_-_1727324 2.994 PXDN
peroxidasin homolog (Drosophila)
chr12_+_3056781 2.975 NM_001168320
NM_006675
TSPAN9

tetraspanin 9

chr2_-_56004366 2.962 NM_001039348
NM_001039349
EFEMP1

EGF containing fibulin-like extracellular matrix protein 1

chr2_+_36436873 2.946 NM_016441
CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr20_+_11819364 2.896 NM_181443
BTBD3
BTB (POZ) domain containing 3
chr14_-_104515738 2.886 NM_138420
AHNAK2
AHNAK nucleoprotein 2
chr8_-_48813256 2.873 NM_005195
CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr10_+_120853548 2.863 FAM45A
family with sequence similarity 45, member A
chr8_+_26491383 2.863 DPYSL2
dihydropyrimidinase-like 2
chr20_-_55718351 2.842 NM_020182
PMEPA1
prostate transmembrane protein, androgen induced 1
chr12_-_123023312 2.830 CCDC92
coiled-coil domain containing 92
chr21_+_45649429 2.828 NM_130445
COL18A1
collagen, type XVIII, alpha 1
chr2_-_112907577 2.791 NM_001164463
RGPD8
RGPD5
RANBP2-like and GRIP domain containing 8
RANBP2-like and GRIP domain containing 5
chr3_-_187025438 2.782 IGF2BP2
insulin-like growth factor 2 mRNA binding protein 2
chr7_+_79602023 2.754 NM_002069
GNAI1
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
chr8_-_27528105 2.739 CLU
clusterin
chr21_+_41461597 2.725 NM_012105
NM_138991
NM_138992
BACE2


beta-site APP-cleaving enzyme 2


chr15_+_94674849 2.716 NM_021005
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr18_-_20105814 2.700 OSBPL1A
oxysterol binding protein-like 1A
chr3_-_126257425 2.672 NM_020733
HEG1
HEG homolog 1 (zebrafish)
chr10_+_120853600 2.669 NM_207009
FAM45A
family with sequence similarity 45, member A
chr1_+_85819004 2.661 NM_001554
CYR61
cysteine-rich, angiogenic inducer, 61
chr1_-_56817802 2.639 PPAP2B
phosphatidic acid phosphatase type 2B
chr3_+_50167424 2.636 SEMA3F
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr15_-_20929658 2.634 HERC2P2
hect domain and RLD 2 pseudogene 2
chr9_+_123003549 2.628 GSN
gelsolin
chr2_+_173000552 2.626 NM_000210
NM_001079818
ITGA6

integrin, alpha 6

chr3_-_147451509 2.625 PLSCR4
phospholipid scramblase 4
chr5_-_122400219 2.617 PPIC
peptidylprolyl isomerase C (cyclophilin C)
chr12_+_6179736 2.605 NM_001769
CD9
CD9 molecule
chr8_-_17702665 2.599 NM_001001924
NM_001001925
MTUS1

microtubule associated tumor suppressor 1

chr19_+_16048266 2.597 TPM4
tropomyosin 4
chr1_+_167342149 2.587 ATP1B1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr3_-_147361912 2.566 NM_000935
NM_182943
PLOD2

procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2

chr12_-_108802561 2.540 NM_016433
GLTP
glycolipid transfer protein
chr11_+_129445017 2.538 APLP2
amyloid beta (A4) precursor-like protein 2
chr4_-_22126437 2.532 NM_145290
GPR125
G protein-coupled receptor 125
chr11_+_129445057 2.497 APLP2
amyloid beta (A4) precursor-like protein 2
chr3_-_151171576 2.496 PFN2
profilin 2
chr13_+_97593411 2.487 NM_001001715
NM_005766
FARP1

FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)

chr3_-_147361626 2.471 PLOD2
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
chr5_+_76047536 2.467 NM_001992
F2R
coagulation factor II (thrombin) receptor
chr3_+_57969127 2.450 NM_001164317
NM_001164318
NM_001164319
NM_001457
FLNB



filamin B, beta



chr3_-_147451648 2.449 NM_001128306
NM_001177304
NM_020353
PLSCR4


phospholipid scramblase 4


chr5_-_57791544 2.449 NM_006622
PLK2
polo-like kinase 2
chr1_+_221966849 2.418 CAPN2
calpain 2, (m/II) large subunit
chr2_-_165406173 2.416 NM_014900
COBLL1
COBL-like 1
chr17_+_75689985 2.392 GAA
glucosidase, alpha; acid
chr15_-_81744469 2.389 NM_001717
BNC1
basonuclin 1
chr17_-_60088773 2.384 NM_022739
SMURF2
SMAD specific E3 ubiquitin protein ligase 2
chr17_-_60088459 2.376 SMURF2
SMAD specific E3 ubiquitin protein ligase 2
chr8_-_27528215 2.371 NM_001831
CLU
clusterin
chr18_-_20231783 2.363 NM_080597
OSBPL1A
oxysterol binding protein-like 1A
chr21_+_17807167 2.361 NM_001338
CXADR
coxsackie virus and adenovirus receptor
chr2_+_200879737 2.357 SPATS2L
spermatogenesis associated, serine-rich 2-like
chr19_-_4351470 2.348 NM_003025
SH3GL1
SH3-domain GRB2-like 1
chr7_-_150960086 2.344 NM_024429
PRKAG2
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chr5_+_52812165 2.343 FST
follistatin
chr19_+_16048306 2.342 TPM4
tropomyosin 4
chr9_+_123070276 2.321 GSN
gelsolin
chr9_+_123070191 2.319 NM_001127662
NM_001127663
NM_001127664
NM_001127665
NM_001127666
NM_001127667
NM_198252
GSN






gelsolin






chr11_+_13255913 2.314 ARNTL
aryl hydrocarbon receptor nuclear translocator-like
chr3_-_49370755 2.312 NM_000581
NM_201397
GPX1

glutathione peroxidase 1

chr16_-_10581944 2.298 NM_001424
EMP2
epithelial membrane protein 2
chr14_-_51605461 2.290 NID2
nidogen 2 (osteonidogen)
chr17_-_829655 2.288 NM_022463
NXN
nucleoredoxin
chr5_-_146869811 2.274 NM_001197294
DPYSL3
dihydropyrimidinase-like 3
chr11_+_13255836 2.267 NM_001030272
NM_001030273
NM_001178
ARNTL


aryl hydrocarbon receptor nuclear translocator-like


chr4_+_184257337 2.266 NM_024949
WWC2
WW and C2 domain containing 2
chr12_-_107775462 2.263 NM_001161330
NM_018984
SSH1

slingshot homolog 1 (Drosophila)

chr5_+_76150637 2.262 F2RL1
coagulation factor II (thrombin) receptor-like 1
chr1_-_43691932 2.260 HYI
hydroxypyruvate isomerase (putative)
chr6_-_52549774 2.256 NM_012288
TRAM2
translocation associated membrane protein 2
chr14_+_85069217 2.247


chr18_-_490583 2.246 NM_130386
COLEC12
collectin sub-family member 12
chr11_-_2907169 2.239 NM_003311
PHLDA2
pleckstrin homology-like domain, family A, member 2
chr12_-_15833617 2.233 NM_004447
EPS8
epidermal growth factor receptor pathway substrate 8
chr22_+_36928011 2.230 MAFF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr3_-_121652183 2.226 NM_007085
FSTL1
follistatin-like 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.37 1.26e-15 GO:0048869 cellular developmental process
1.37 1.23e-14 GO:0030154 cell differentiation
1.71 1.77e-14 GO:0000902 cell morphogenesis
1.77 2.15e-14 GO:0032990 cell part morphogenesis
1.58 2.25e-14 GO:0048699 generation of neurons
1.76 3.79e-14 GO:0048858 cell projection morphogenesis
1.67 5.52e-14 GO:0030030 cell projection organization
1.56 6.18e-14 GO:0022008 neurogenesis
1.66 2.13e-13 GO:0032989 cellular component morphogenesis
1.41 4.13e-13 GO:0009653 anatomical structure morphogenesis
1.74 5.45e-13 GO:0000904 cell morphogenesis involved in differentiation
1.76 1.76e-12 GO:0048812 neuron projection morphogenesis
1.53 2.22e-12 GO:0048468 cell development
1.61 2.33e-12 GO:0030182 neuron differentiation
1.71 7.00e-12 GO:0031175 neuron projection development
1.76 8.98e-12 GO:0007409 axonogenesis
1.65 1.24e-11 GO:0048666 neuron development
1.74 1.35e-11 GO:0048667 cell morphogenesis involved in neuron differentiation
1.22 2.94e-11 GO:0032502 developmental process
1.82 8.47e-11 GO:0007411 axon guidance
1.23 9.04e-11 GO:0007275 multicellular organismal development
1.38 1.44e-10 GO:0007399 nervous system development
1.22 9.68e-09 GO:0048856 anatomical structure development
1.35 3.50e-08 GO:0009966 regulation of signal transduction
1.31 1.27e-07 GO:0023051 regulation of signaling
1.22 2.12e-07 GO:0048731 system development
1.41 8.13e-07 GO:0040011 locomotion
1.47 1.08e-06 GO:0007167 enzyme linked receptor protein signaling pathway
2.14 1.21e-06 GO:0010769 regulation of cell morphogenesis involved in differentiation
2.12 1.97e-06 GO:0022604 regulation of cell morphogenesis
1.14 1.83e-05 GO:0032501 multicellular organismal process
1.49 3.76e-05 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.50 4.73e-05 GO:0072358 cardiovascular system development
1.50 4.73e-05 GO:0072359 circulatory system development
1.48 5.69e-05 GO:0006935 chemotaxis
1.48 5.69e-05 GO:0042330 taxis
1.63 1.13e-04 GO:0001944 vasculature development
1.62 1.42e-04 GO:0060284 regulation of cell development
1.19 2.10e-04 GO:0071842 cellular component organization at cellular level
1.58 2.54e-04 GO:0051056 regulation of small GTPase mediated signal transduction
1.93 4.75e-04 GO:0010975 regulation of neuron projection development
1.27 4.76e-04 GO:0035556 intracellular signal transduction
1.59 4.83e-04 GO:0051270 regulation of cellular component movement
2.26 5.28e-04 GO:0050770 regulation of axonogenesis
1.68 7.50e-04 GO:0046578 regulation of Ras protein signal transduction
1.40 1.08e-03 GO:0042060 wound healing
1.82 1.13e-03 GO:0031344 regulation of cell projection organization
1.22 1.17e-03 GO:0048583 regulation of response to stimulus
1.59 1.42e-03 GO:0001568 blood vessel development
1.57 1.61e-03 GO:0040012 regulation of locomotion
1.56 2.44e-03 GO:0022603 regulation of anatomical structure morphogenesis
1.45 3.17e-03 GO:0048646 anatomical structure formation involved in morphogenesis
1.50 4.30e-03 GO:0007264 small GTPase mediated signal transduction
1.32 4.68e-03 GO:0009888 tissue development
1.56 5.93e-03 GO:0030334 regulation of cell migration
1.14 6.45e-03 GO:0016043 cellular component organization
1.84 6.97e-03 GO:0030111 regulation of Wnt receptor signaling pathway
1.55 9.18e-03 GO:2000145 regulation of cell motility
1.33 1.05e-02 GO:2000026 regulation of multicellular organismal development
1.59 1.19e-02 GO:0048011 nerve growth factor receptor signaling pathway
1.90 1.24e-02 GO:0035023 regulation of Rho protein signal transduction
1.65 1.37e-02 GO:0045664 regulation of neuron differentiation
1.27 1.55e-02 GO:0010646 regulation of cell communication
1.43 1.69e-02 GO:0016477 cell migration
1.27 1.73e-02 GO:0008104 protein localization
1.34 1.79e-02 GO:0045595 regulation of cell differentiation
1.57 1.88e-02 GO:0050767 regulation of neurogenesis
1.54 1.89e-02 GO:0051960 regulation of nervous system development
1.08 1.90e-02 GO:0050794 regulation of cellular process
1.27 2.13e-02 GO:0032879 regulation of localization
1.16 2.28e-02 GO:0071841 cellular component organization or biogenesis at cellular level
1.28 3.40e-02 GO:0050793 regulation of developmental process
1.84 3.63e-02 GO:0010720 positive regulation of cell development
1.17 3.70e-02 GO:0048523 negative regulation of cellular process
1.29 4.01e-02 GO:0051128 regulation of cellular component organization
1.57 4.04e-02 GO:0048514 blood vessel morphogenesis
1.43 4.07e-02 GO:0090066 regulation of anatomical structure size

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.14 3.82e-11 GO:0070161 anchoring junction
2.15 5.91e-10 GO:0005912 adherens junction
1.96 2.62e-08 GO:0031252 cell leading edge
1.09 4.00e-07 GO:0005737 cytoplasm
1.51 4.25e-07 GO:0030054 cell junction
1.30 1.31e-06 GO:0005856 cytoskeleton
1.11 1.57e-06 GO:0016020 membrane
1.36 1.70e-06 GO:0005794 Golgi apparatus
2.10 9.48e-06 GO:0005925 focal adhesion
2.05 1.79e-05 GO:0005924 cell-substrate adherens junction
2.01 3.22e-05 GO:0030055 cell-substrate junction
1.60 4.14e-05 GO:0015629 actin cytoskeleton
2.30 4.31e-05 GO:0031256 leading edge membrane
1.43 5.44e-05 GO:0044431 Golgi apparatus part
1.34 1.48e-04 GO:0042995 cell projection
1.46 2.00e-04 GO:0000139 Golgi membrane
1.66 1.99e-03 GO:0005911 cell-cell junction
1.09 2.39e-03 GO:0044444 cytoplasmic part
1.94 6.31e-03 GO:0030027 lamellipodium
1.82 9.80e-03 GO:0019898 extrinsic to membrane
1.28 1.25e-02 GO:0031982 vesicle
1.72 1.61e-02 GO:0031253 cell projection membrane
1.28 1.89e-02 GO:0031410 cytoplasmic vesicle
1.12 2.25e-02 GO:0071944 cell periphery
1.04 4.97e-02 GO:0005622 intracellular

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.54 9.85e-08 GO:0008092 cytoskeletal protein binding
1.52 2.39e-05 GO:0030695 GTPase regulator activity
1.59 4.28e-05 GO:0003779 actin binding
1.50 4.92e-05 GO:0060589 nucleoside-triphosphatase regulator activity
1.57 7.39e-04 GO:0005083 small GTPase regulator activity
1.08 3.55e-03 GO:0005515 protein binding
1.91 1.68e-02 GO:0005088 Ras guanyl-nucleotide exchange factor activity
2.00 2.89e-02 GO:0005089 Rho guanyl-nucleotide exchange factor activity
1.64 3.88e-02 GO:0005085 guanyl-nucleotide exchange factor activity