Motif ID: SPIB.p2

Z-value: 2.123


Transcription factors associated with SPIB.p2:

Gene SymbolEntrez IDGene Name
SPIB 6689 Spi-B transcription factor (Spi-1/PU.1 related)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SPIBchr19_+_556140060.783.5e-04Click!


Activity profile for motif SPIB.p2.

activity profile for motif SPIB.p2


Sorted Z-values histogram for motif SPIB.p2

Sorted Z-values for motif SPIB.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SPIB.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_15005761 8.931 NM_001175
 ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chrX_+_48427103 4.987 NM_000377
 WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr18_-_51219880 4.463 TCF4
transcription factor 4
chr16_+_30102426 3.259 CORO1A
coronin, actin binding protein, 1A
chr2_-_175207521 3.249 NM_003387
 WIPF1
WAS/WASL interacting protein family, member 1
chr6_-_32742265 3.113 NM_002123
 HLA-DQB1
major histocompatibility complex, class II, DQ beta 1
chr10_-_64246129 3.112 NM_000399
NM_001136177
NM_001136179
 EGR2


early growth response 2


chr17_+_31455332 2.897 NM_002984
 CCL4
chemokine (C-C motif) ligand 4
chr12_+_25096755 2.856 LRMP
lymphoid-restricted membrane protein
chr2_-_96174865 2.693 NM_004418
 DUSP2
dual specificity phosphatase 2
chr17_+_31664143 2.613 NM_207007
NM_001001435
 CCL4L2
CCL4L1
chemokine (C-C motif) ligand 4-like 2
chemokine (C-C motif) ligand 4-like 1
chr3_-_122862447 2.577 NM_005335
 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr22_+_21552897 2.473 LOC100290481
immunoglobulin lambda light chain-like
chr19_+_54530497 2.446 CD37
CD37 molecule
chr10_+_70517863 2.440 SRGN
serglycin
chr19_+_54530485 2.434 NM_001040031
NM_001774
 CD37

CD37 molecule

chr1_-_181826086 2.431 NCF2
neutrophil cytosolic factor 2
chr6_-_32268267 2.420 GPSM3
G-protein signaling modulator 3
chr12_+_25096472 2.416 NM_006152
 LRMP
lymphoid-restricted membrane protein
chr1_-_181826633 2.415 NM_001127651
 NCF2
neutrophil cytosolic factor 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 43 entries
enrichment   p-value GO term description
2.36 4.99e-02 GO:0006413 translational initiation
2.14 1.45e-02 GO:0031294 lymphocyte costimulation
2.14 1.45e-02 GO:0031295 T cell costimulation
1.99 2.04e-03 GO:0050851 antigen receptor-mediated signaling pathway
1.97 1.58e-05 GO:0050870 positive regulation of T cell activation
1.91 6.48e-06 GO:0051251 positive regulation of lymphocyte activation
1.84 1.47e-05 GO:0050867 positive regulation of cell activation
1.83 3.73e-05 GO:0002696 positive regulation of leukocyte activation
1.83 3.57e-02 GO:0002429 immune response-activating cell surface receptor signaling pathway
1.82 1.25e-04 GO:0050863 regulation of T cell activation
1.82 3.63e-02 GO:0002768 immune response-regulating cell surface receptor signaling pathway
1.78 3.71e-02 GO:0042110 T cell activation
1.73 8.03e-03 GO:0050900 leukocyte migration
1.71 2.89e-04 GO:0051249 regulation of lymphocyte activation
1.69 5.40e-03 GO:0002757 immune response-activating signal transduction
1.68 5.27e-03 GO:0002764 immune response-regulating signaling pathway
1.66 3.01e-04 GO:0050865 regulation of cell activation
1.66 8.79e-03 GO:0046649 lymphocyte activation
1.63 1.54e-03 GO:0002694 regulation of leukocyte activation
1.62 2.56e-03 GO:0045321 leukocyte activation

Gene overrepresentation in compartment category:

Showing 1 to 13 of 13 entries
enrichment   p-value GO term description
3.45 5.76e-03 GO:0005852 eukaryotic translation initiation factor 3 complex
1.49 1.23e-05 GO:0030529 ribonucleoprotein complex
1.23 5.73e-06 GO:0005829 cytosol
1.17 9.66e-06 GO:0032991 macromolecular complex
1.17 1.05e-02 GO:0044428 nuclear part
1.17 4.69e-02 GO:0031981 nuclear lumen
1.14 7.62e-03 GO:0043234 protein complex
1.09 9.58e-03 GO:0044446 intracellular organelle part
1.09 1.17e-02 GO:0044422 organelle part
1.06 2.45e-02 GO:0005737 cytoplasm
1.04 4.46e-02 GO:0044424 intracellular part
1.02 3.52e-02 GO:0005623 cell
1.02 4.33e-02 GO:0044464 cell part

Gene overrepresentation in function category:

Showing 1 to 4 of 4 entries
enrichment   p-value GO term description
1.39 1.26e-05 GO:0003723 RNA binding
1.14 1.22e-02 GO:0003676 nucleic acid binding
1.11 1.08e-07 GO:0005515 protein binding
1.04 3.33e-03 GO:0005488 binding