Motif ID: TBX4,5.p2

Z-value: 1.862


Transcription factors associated with TBX4,5.p2:

Gene SymbolEntrez IDGene Name
TBX4 9496 T-box 4
TBX5 6910 T-box 5

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TBX5chr12_-_1133305740.204.7e-01Click!
TBX4chr17_+_56888588-0.097.5e-01Click!


Activity profile for motif TBX4,5.p2.

activity profile for motif TBX4,5.p2


Sorted Z-values histogram for motif TBX4,5.p2

Sorted Z-values for motif TBX4,5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TBX4,5.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_2108035 6.545 IGF2
insulin-like growth factor 2 (somatomedin A)
chr17_+_4621924 4.564 NM_003963
TM4SF5
transmembrane 4 L six family member 5
chr17_-_6958282 4.189 NM_080914
ASGR2
asialoglycoprotein receptor 2
chr14_+_94148466 3.806 NM_001085
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr3_+_187813553 3.487 AHSG
alpha-2-HS-glycoprotein
chr12_+_7039453 2.880


chr6_+_132170888 2.677 ENPP1
ectonucleotide pyrophosphatase/phosphodiesterase 1
chr10_+_114125003 2.648 NM_203380
ACSL5
acyl-CoA synthetase long-chain family member 5
chr14_-_53491019 2.578 NM_130851
BMP4
bone morphogenetic protein 4
chr6_+_31731647 2.571 NM_019101
APOM
apolipoprotein M
chr3_+_187813538 2.503 NM_001622
AHSG
alpha-2-HS-glycoprotein
chr1_-_171441234 2.319 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr9_-_115877104 2.278 AMBP
alpha-1-microglobulin/bikunin precursor
chr1_-_85703198 2.267 DDAH1
dimethylarginine dimethylaminohydrolase 1
chr1_-_95165089 2.246 NM_001839
CNN3
calponin 3, acidic
chr3_+_187813405 2.238 AHSG
alpha-2-HS-glycoprotein
chr22_+_36531059 2.149 NM_005318
H1F0
H1 histone family, member 0
chr11_-_2116048 2.071 IGF2
insulin-like growth factor 2 (somatomedin A)
chr1_-_159459814 2.037 APOA2
apolipoprotein A-II
chr9_-_122877231 2.021 C5
complement component 5
chrX_+_46825179 1.973 RGN
regucalcin (senescence marker protein-30)
chr7_+_94123556 1.870 NM_001040152
NM_001184961
NM_001184962
NM_015068
PEG10



paternally expressed 10



chr3_+_134947788 1.865 TF
transferrin
chr8_+_26569709 1.858 DPYSL2
dihydropyrimidinase-like 2
chr3_-_49701085 1.839 NM_020998
MST1
macrophage stimulating 1 (hepatocyte growth factor-like)
chrY_+_13525412 1.834 NM_001122665
DDX3Y
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chr6_+_31731667 1.831 APOM
apolipoprotein M
chr6_-_11340887 1.824 NM_006403
NM_182966
NEDD9

neural precursor cell expressed, developmentally down-regulated 9

chr16_+_3055640 1.793 IL32
interleukin 32
chr6_+_32057779 1.738 NM_007293
NM_001002029
C4A
C4B
complement component 4A (Rodgers blood group)
complement component 4B (Chido blood group)
chr16_+_3055639 1.738 NM_001012634
IL32
interleukin 32
chr11_+_61204392 1.725 NM_006133
DAGLA
diacylglycerol lipase, alpha
chrY_+_13526092 1.707 NM_004660
DDX3Y
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chr6_+_26476384 1.700 NM_001197246
BTN3A2
butyrophilin, subfamily 3, member A2
chr7_+_94123612 1.674 NM_001172437
NM_001172438
PEG10

paternally expressed 10

chr12_-_26877189 1.660 NM_002223
ITPR2
inositol 1,4,5-triphosphate receptor, type 2
chr7_+_94123672 1.653 PEG10
paternally expressed 10
chr16_+_3055313 1.636 NM_001012631
NM_001012633
NM_001012718
NM_004221
IL32



interleukin 32



chr6_+_132170847 1.632 NM_006208
ENPP1
ectonucleotide pyrophosphatase/phosphodiesterase 1
chr6_+_32090516 1.619 NM_007293
NM_001002029
C4A
C4B
complement component 4A (Rodgers blood group)
complement component 4B (Chido blood group)
chr7_-_111633620 1.561 NM_014705
DOCK4
dedicator of cytokinesis 4
chr15_-_88143721 1.533 ANPEP
alanyl (membrane) aminopeptidase
chr11_-_114880275 1.506 NM_001098517
NM_014333
CADM1

cell adhesion molecule 1

chr3_+_134947894 1.501 TF
transferrin
chrX_+_114701432 1.501 NM_005032
PLS3
plastin 3
chrX_-_130251068 1.495 NM_001170961
NM_001170962
NM_001555
NM_205833
IGSF1



immunoglobulin superfamily, member 1



chr2_-_168812132 1.492 NM_013233
STK39
serine threonine kinase 39
chr7_-_94123362 1.485 SGCE
sarcoglycan, epsilon
chr16_+_3055642 1.483 NM_001012632
NM_001012636
IL32

interleukin 32

chrX_-_130250880 1.444 IGSF1
immunoglobulin superfamily, member 1
chr3_-_151171576 1.438 PFN2
profilin 2
chr11_+_73036241 1.427 NM_001130034
NM_001130035
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr7_-_94123413 1.427 NM_001099400
NM_001099401
NM_003919
SGCE


sarcoglycan, epsilon


chr2_-_188127294 1.425 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr7_-_94123308 1.414 SGCE
sarcoglycan, epsilon
chr2_+_218992053 1.412 NM_007127
VIL1
villin 1
chr11_-_63138416 1.362 PLA2G16
phospholipase A2, group XVI
chrY_+_13526169 1.360 DDX3Y
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chr20_+_8060762 1.320 NM_015192
NM_182734
PLCB1

phospholipase C, beta 1 (phosphoinositide-specific)

chr11_-_74914066 1.317 NM_030792
GDPD5
glycerophosphodiester phosphodiesterase domain containing 5
chr22_+_34107051 1.279 NM_002133
HMOX1
heme oxygenase (decycling) 1
chr11_-_2127368 1.269 NM_001007139
IGF2
insulin-like growth factor 2 (somatomedin A)
chr2_+_176761552 1.266 NM_024501
HOXD1
homeobox D1
chr12_-_116021473 1.254 NM_001168325
NM_017899
TESC

tescalcin

chr4_-_186970366 1.239 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr10_+_31648103 1.238 NM_001174093
NM_001174095
NM_001174096
NM_030751
ZEB1



zinc finger E-box binding homeobox 1



chr1_-_172153087 1.230 NM_000488
SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr11_-_63138061 1.221 PLA2G16
phospholipase A2, group XVI
chr16_+_3055602 1.209 NM_001012635
IL32
interleukin 32
chr10_-_101831579 1.199 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr16_+_80626456 1.193 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr3_-_151171190 1.192 NM_002628
NM_053024
PFN2

profilin 2

chr3_-_121883647 1.184 HGD
homogentisate 1,2-dioxygenase
chr6_+_28200365 1.184 NM_025231
ZSCAN16
zinc finger and SCAN domain containing 16
chr16_+_80626331 1.178 NM_002153
HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr17_+_77529070 1.172 ASPSCR1
alveolar soft part sarcoma chromosome region, candidate 1
chr17_-_44794325 1.167 NM_001145365
NM_014897
ZNF652

zinc finger protein 652

chr21_+_37367432 1.167 NM_001001894
TTC3
tetratricopeptide repeat domain 3
chr2_+_69822754 1.161 ANXA4
annexin A4
chr8_+_56177567 1.138 NM_052898
XKR4
XK, Kell blood group complex subunit-related family, member 4
chr2_+_71149193 1.124 NAGK
N-acetylglucosamine kinase
chr6_-_11340869 1.121 NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr2_+_30223253 1.119 NM_001127399
NM_001127400
NM_001127401
NM_016061
YPEL5



yippee-like 5 (Drosophila)



chr7_-_103417198 1.119 NM_005045
NM_173054
RELN

reelin

chr20_+_34143983 1.114 EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr9_-_131845277 1.107 NM_015033
FNBP1
formin binding protein 1
chr10_+_114125955 1.092 ACSL5
acyl-CoA synthetase long-chain family member 5
chr2_+_69822609 1.085 NM_001153
ANXA4
annexin A4
chr2_+_65070030 1.078 SLC1A4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr3_+_134947573 1.078 NM_001063
TF
transferrin
chrY_+_2769596 1.072 NM_001008
RPS4Y1
ribosomal protein S4, Y-linked 1
chr20_-_22513050 1.053 NM_021784
FOXA2
forkhead box A2
chr10_+_124758391 1.045 NM_001609
ACADSB
acyl-CoA dehydrogenase, short/branched chain
chr16_+_80626459 1.042 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr9_-_131845077 1.038 FNBP1
formin binding protein 1
chr22_+_36927884 1.034 NM_001161572
NM_001161574
NM_012323
MAFF


v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)


chr10_-_93382735 1.024 PPP1R3C
protein phosphatase 1, regulatory (inhibitor) subunit 3C
chr5_-_42847716 1.024 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr17_-_50854054 1.014 NM_012329
MMD
monocyte to macrophage differentiation-associated
chr4_-_155731288 1.011 NM_000508
NM_021871
FGA

fibrinogen alpha chain

chr2_+_30223372 1.009 YPEL5
yippee-like 5 (Drosophila)
chr2_+_30223304 1.008 YPEL5
yippee-like 5 (Drosophila)
chr10_-_95350949 1.002 NM_006744
RBP4
retinol binding protein 4, plasma
chr17_-_37221976 0.995 NM_006455
LEPREL4
leprecan-like 4
chr2_+_62786290 0.995 NM_001142616
NM_015252
EHBP1

EH domain binding protein 1

chr10_+_114125927 0.989 NM_016234
ACSL5
acyl-CoA synthetase long-chain family member 5
chrX_+_70359780 0.988 NM_000166
GJB1
gap junction protein, beta 1, 32kDa
chr1_-_20860524 0.981 DDOST
dolichyl-diphosphooligosaccharide--protein glycosyltransferase
chrX_+_95826507 0.981 DIAPH2
diaphanous homolog 2 (Drosophila)
chr10_-_93382837 0.967 NM_005398
PPP1R3C
protein phosphatase 1, regulatory (inhibitor) subunit 3C
chr13_+_34414390 0.946 NM_015678
NBEA
neurobeachin
chr1_+_149851138 0.942 NM_030918
SNX27
sorting nexin family member 27
chr11_-_685010 0.939 DEAF1
deformed epidermal autoregulatory factor 1 (Drosophila)
chr2_-_216654708 0.934 NM_018441
PECR
peroxisomal trans-2-enoyl-CoA reductase
chr1_-_27113018 0.930 NM_021969
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr5_-_172688024 0.929 STC2
stanniocalcin 2
chr22_+_36928011 0.921 MAFF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr7_-_22363036 0.921 NM_012294
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr1_-_172153024 0.920 SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr1_-_23758503 0.918 ID3
inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
chr13_+_112808102 0.916 NM_000131
NM_019616
F7

coagulation factor VII (serum prothrombin conversion accelerator)

chr20_-_4752067 0.904 NM_014737
RASSF2
Ras association (RalGDS/AF-6) domain family member 2
chr12_+_68028397 0.902 NM_000239
LYZ
lysozyme
chr19_-_6643953 0.900 C3
complement component 3
chr10_-_125843092 0.895 CHST15
carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
chr5_+_71438796 0.890 NM_005909
MAP1B
microtubule-associated protein 1B
chr12_+_70120028 0.887 NM_003667
LGR5
leucine-rich repeat containing G protein-coupled receptor 5
chr5_-_78318112 0.885 NM_000046
ARSB
arylsulfatase B
chr2_-_188127430 0.879 NM_001032281
NM_006287
TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

chr7_+_29200636 0.871 NM_004067
CHN2
chimerin (chimaerin) 2
chr6_-_31728121 0.871 NM_001098534
BAG6
BCL2-associated athanogene 6
chr11_-_684842 0.864 DEAF1
deformed epidermal autoregulatory factor 1 (Drosophila)
chrX_+_152562013 0.853 DUSP9
dual specificity phosphatase 9
chr11_-_685069 0.850 DEAF1
deformed epidermal autoregulatory factor 1 (Drosophila)
chr2_+_127892489 0.837 PROC
protein C (inactivator of coagulation factors Va and VIIIa)
chr7_-_133794344 0.817 AKR1B1
aldo-keto reductase family 1, member B1 (aldose reductase)
chr2_-_175578156 0.817 NM_001025201
NM_001822
CHN1

chimerin (chimaerin) 1

chr17_+_77783432 0.816 NM_001042423
SLC16A3
solute carrier family 16, member 3 (monocarboxylic acid transporter 4)
chr12_+_68028407 0.811 LYZ
lysozyme
chr4_-_141568210 0.808 NM_001130675
NM_004362
CLGN

calmegin

chr17_+_45979518 0.789 NM_022827
SPATA20
spermatogenesis associated 20
chr1_+_149221122 0.786 NM_003568
ANXA9
annexin A9
chr13_+_112789669 0.780 MCF2L
MCF.2 cell line derived transforming sequence-like
chr6_-_47362102 0.780 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr9_+_123088690 0.779 GSN
gelsolin
chr18_-_45593852 0.777 ACAA2
acetyl-CoA acyltransferase 2
chr6_-_31727460 0.776


chr16_+_55963899 0.774 NM_002996
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr17_-_36346240 0.773 KRT23
keratin 23 (histone deacetylase inducible)
chr15_+_86983038 0.764 NM_002201
ISG20
interferon stimulated exonuclease gene 20kDa
chrX_-_2428963 0.760 NM_145177
NM_001171136
NM_004729
DHRSX
ZBED1

dehydrogenase/reductase (SDR family) X-linked
zinc finger, BED-type containing 1

chrY_-_2428963 0.760 NM_145177
NM_001171136
NM_004729
DHRSX
ZBED1

dehydrogenase/reductase (SDR family) X-linked
zinc finger, BED-type containing 1

chr17_+_16225130 0.759


chr1_+_17719405 0.750 ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr20_-_22512893 0.747 FOXA2
forkhead box A2
chr10_+_124758488 0.743 ACADSB
acyl-CoA dehydrogenase, short/branched chain
chr22_-_27405708 0.741 NM_001145418
TTC28
tetratricopeptide repeat domain 28
chr13_-_33148899 0.737 STARD13
StAR-related lipid transfer (START) domain containing 13
chr5_+_150380173 0.735 NM_002084
GPX3
glutathione peroxidase 3 (plasma)
chr6_-_47361921 0.733 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr9_-_74757735 0.729 NM_000689
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr16_+_8622974 0.724 NM_024109
METTL22
methyltransferase like 22
chr3_+_50279993 0.723 NM_001005914
NM_004636
SEMA3B

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B

chr11_+_61279436 0.716 NM_013279
C11orf9
chromosome 11 open reading frame 9
chr4_+_140594410 0.709 NM_031296
RAB33B
RAB33B, member RAS oncogene family
chr10_+_31647425 0.703 ZEB1
zinc finger E-box binding homeobox 1
chr19_-_56561444 0.703 NM_001985
ETFB
electron-transfer-flavoprotein, beta polypeptide
chr13_+_26029879 0.697 WASF3
WAS protein family, member 3
chr9_-_129782624 0.695 NM_001035254
FAM102A
family with sequence similarity 102, member A
chr8_+_22492586 0.695 PDLIM2
PDZ and LIM domain 2 (mystique)
chr1_-_85816520 0.694 NM_001134445
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr17_-_39936271 0.692 GPATCH8
G patch domain containing 8
chr3_-_51971915 0.690 NM_033010
PCBP4
poly(rC) binding protein 4
chr6_+_32021742 0.685 CFB
complement factor B
chr22_-_49240594 0.685 SBF1
SET binding factor 1
chr17_-_39936453 0.683 NM_001002909
GPATCH8
G patch domain containing 8
chr16_-_51139214 0.678 NM_001146188
TOX3
TOX high mobility group box family member 3
chr13_+_26029799 0.675 NM_006646
WASF3
WAS protein family, member 3
chr2_+_65069986 0.662 NM_003038
SLC1A4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr8_+_21968273 0.659 NM_001114136
NM_001114139
EPB49

erythrocyte membrane protein band 4.9 (dematin)

chr14_-_87806913 0.658 NM_138318
KCNK10
potassium channel, subfamily K, member 10
chr9_+_123083540 0.657 GSN
gelsolin
chr16_+_2527990 0.652 PDPK1
3-phosphoinositide dependent protein kinase-1
chr17_-_5345167 0.645 LOC728392
hypothetical protein LOC728392
chr4_+_91035025 0.637 NM_007351
MMRN1
multimerin 1
chr20_-_3097070 0.636 NM_014731
ProSAPiP1
ProSAPiP1 protein
chr16_-_54424517 0.635 NM_001025194
NM_001025195
NM_001266
CES1


carboxylesterase 1


chr11_+_22652894 0.635 NM_005256
GAS2
growth arrest-specific 2
chr4_-_44423275 0.634 NM_138335
GNPDA2
glucosamine-6-phosphate deaminase 2
chr16_+_2528001 0.633 PDPK1
3-phosphoinositide dependent protein kinase-1
chr2_+_108432008 0.624 NM_181453
GCC2
GRIP and coiled-coil domain containing 2
chr12_-_116112495 0.621 NM_015002
NM_033624
FBXO21

F-box protein 21

chr14_-_106084519 0.621 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr16_+_64958025 0.619 NM_001795
CDH5
cadherin 5, type 2 (vascular endothelium)
chr19_-_43800374 0.617 NM_001042600
NM_007181
MAP4K1

mitogen-activated protein kinase kinase kinase kinase 1

chr7_+_100557098 0.617 NM_000602
NM_001165413
SERPINE1

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

chr3_+_168936125 0.611 NM_001122752
NM_005025
SERPINI1

serpin peptidase inhibitor, clade I (neuroserpin), member 1

chr3_-_50335113 0.607 NM_003773
NM_033158
HYAL2

hyaluronoglucosaminidase 2

chr2_-_152663454 0.605 NM_001005746
CACNB4
calcium channel, voltage-dependent, beta 4 subunit
chr2_-_152663748 0.604 NM_000726
NM_001145798
CACNB4

calcium channel, voltage-dependent, beta 4 subunit


Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.68 2.99e-03 GO:0030695 GTPase regulator activity
1.66 4.39e-03 GO:0060589 nucleoside-triphosphatase regulator activity