Motif ID: NKX3-2.p2

Z-value: 1.681


Transcription factors associated with NKX3-2.p2:

Gene SymbolEntrez IDGene Name
NKX3-2 579 NK3 homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX3-2chr4_-_131551350.165.5e-01Click!


Activity profile for motif NKX3-2.p2.

activity profile for motif NKX3-2.p2


Sorted Z-values histogram for motif NKX3-2.p2

Sorted Z-values for motif NKX3-2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX3-2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_32605898 2.353 NM_002125
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr5_-_149772563 2.331 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr10_-_90702490 2.131 NM_001613
ACTA2
actin, alpha 2, smooth muscle, aorta
chr11_-_110755112 2.061 POU2AF1
POU class 2 associating factor 1
chr6_-_41823056 2.047 NM_001166424
NM_002630
PGC

progastricsin (pepsinogen C)

chr17_-_35975227 1.975 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chr2_+_17585462 1.972 VSNL1
visinin-like 1
chr10_-_98021144 1.675 NM_001114094
NM_013314
BLNK

B-cell linker

chr2_+_228386800 1.663 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr14_+_105024576 1.637 CRIP1
cysteine-rich protein 1 (intestinal)
chr6_-_31432954 1.409 NM_005514
HLA-B
major histocompatibility complex, class I, B
chr4_+_74497998 1.401 ALB
albumin
chr6_-_32665409 1.340 NM_002124
HLA-DRB1
HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1
major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr3_+_180853473 1.291 NM_003940
USP13
ubiquitin specific peptidase 13 (isopeptidase T-3)
chr5_+_118632403 1.281 TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr6_+_32515596 1.265 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr9_+_2612052 1.244 VLDLR
very low density lipoprotein receptor
chr8_+_123863169 1.231 ZHX2
zinc fingers and homeoboxes 2
chr5_+_118632316 1.230 NM_001077654
TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr4_+_74498042 1.229 ALB
albumin
chr3_-_55490401 1.220 WNT5A
wingless-type MMTV integration site family, member 5A
chr5_-_149772469 1.200 NM_001025159
NM_004355
NM_001025158
CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chr8_+_123863075 1.187 NM_014943
ZHX2
zinc fingers and homeoboxes 2
chr2_+_17585287 1.182 NM_003385
VSNL1
visinin-like 1
chr11_-_110755366 1.123 NM_006235
POU2AF1
POU class 2 associating factor 1
chr14_-_106249999 1.117 IGHA1
immunoglobulin heavy constant alpha 1
chr10_+_7785347 1.108 ITIH2
inter-alpha (globulin) inhibitor H2
chr10_+_7785331 1.108 ITIH2
inter-alpha (globulin) inhibitor H2
chr2_-_220144427 1.101 OBSL1
obscurin-like 1
chr14_-_88953059 1.089 NM_005197
FOXN3
forkhead box N3
chr3_+_134978615 1.068 TF
transferrin
chr10_+_7785360 1.057 ITIH2
inter-alpha (globulin) inhibitor H2
chr10_+_7785290 1.021 ITIH2
inter-alpha (globulin) inhibitor H2
chr6_-_31432877 1.005 HLA-B
major histocompatibility complex, class I, B
chr3_+_187813405 0.997 AHSG
alpha-2-HS-glycoprotein
chr10_+_7785235 0.994 NM_002216
ITIH2
inter-alpha (globulin) inhibitor H2
chr5_-_42847716 0.990 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr1_-_111544820 0.968 DENND2D
DENN/MADD domain containing 2D
chr3_+_187813538 0.967 NM_001622
AHSG
alpha-2-HS-glycoprotein
chr3_+_187813553 0.950 AHSG
alpha-2-HS-glycoprotein
chr3_+_123256902 0.945 NM_175862
CD86
CD86 molecule
chr16_-_87244896 0.938 NM_000101
CYBA
cytochrome b-245, alpha polypeptide
chr17_-_6958282 0.930 NM_080914
ASGR2
asialoglycoprotein receptor 2
chr7_+_94130752 0.925 PEG10
paternally expressed 10
chr1_-_25129354 0.925 NM_004350
RUNX3
runt-related transcription factor 3
chr12_+_7039453 0.919


chr6_-_31432934 0.905 HLA-B
major histocompatibility complex, class I, B
chr12_-_101835026 0.902 PAH
phenylalanine hydroxylase
chr6_+_29963485 0.900


chr4_-_110942576 0.898 CFI
complement factor I
chr10_-_95350949 0.894 NM_006744
RBP4
retinol binding protein 4, plasma
chr2_-_237987509 0.883 COL6A3
collagen, type VI, alpha 3
chr16_+_55963899 0.883 NM_002996
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr14_-_105804211 0.877 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr4_+_74493218 0.869 ALB
albumin
chr3_-_79899748 0.869 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr9_+_116125123 0.869 NM_000607
ORM1
orosomucoid 1
chr8_-_122722674 0.867 NM_005328
HAS2
hyaluronan synthase 2
chr1_+_63861474 0.859 NM_001172818
PGM1
phosphoglucomutase 1
chr14_-_105476678 0.844 IGHM
immunoglobulin heavy constant mu
chr7_+_26298018 0.829 NM_013322
SNX10
sorting nexin 10
chr7_+_26298136 0.826 SNX10
sorting nexin 10
chr12_+_79995927 0.823 NM_024560
ACSS3
acyl-CoA synthetase short-chain family member 3
chr19_-_6671585 0.819 NM_000064
C3
complement component 3
chr5_+_52812236 0.806 NM_006350
NM_013409
FST

follistatin

chr2_-_237987579 0.804 NM_004369
NM_057164
NM_057165
NM_057166
NM_057167
COL6A3




collagen, type VI, alpha 3




chr2_+_231437905 0.801 ITM2C
integral membrane protein 2C
chr2_-_238861830 0.791 NM_022817
PER2
period homolog 2 (Drosophila)
chr6_+_29963328 0.788 HLA-H
major histocompatibility complex, class I, H (pseudogene)
chrX_-_32083506 0.783 NM_004013
NM_004020
NM_004021
NM_004022
NM_004023
DMD




dystrophin




chr7_-_86686754 0.780 NM_024315
C7orf23
chromosome 7 open reading frame 23
chr6_-_31432543 0.778 HLA-B
major histocompatibility complex, class I, B
chr2_+_231437882 0.775 ITM2C
integral membrane protein 2C
chr2_-_109728958 0.774 NM_144710
NM_178584
SEPT10

septin 10

chr1_-_219982081 0.773 NM_007207
NM_144729
DUSP10

dual specificity phosphatase 10

chr17_-_26672757 0.770 NM_001003927
NM_014210
EVI2A

ecotropic viral integration site 2A

chr7_+_94130673 0.761 PEG10
paternally expressed 10
chr19_+_44590345 0.760 ZFP36
zinc finger protein 36, C3H type, homolog (mouse)
chr2_+_86521999 0.756 NM_001146688
KDM3A
lysine (K)-specific demethylase 3A
chr1_-_111544784 0.756 NM_024901
DENND2D
DENN/MADD domain containing 2D
chr3_-_115826481 0.754 NM_001164346
ZBTB20
zinc finger and BTB domain containing 20
chr5_-_1547872 0.753 LPCAT1
lysophosphatidylcholine acyltransferase 1
chr6_+_32713160 0.751 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr4_-_110942783 0.749 NM_000204
CFI
complement factor I
chr14_-_106184988 0.735 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr1_-_219982016 0.728 DUSP10
dual specificity phosphatase 10
chr9_+_2611740 0.720 NM_001018056
NM_003383
VLDLR

very low density lipoprotein receptor

chr9_+_2612099 0.718 VLDLR
very low density lipoprotein receptor
chr2_+_231437867 0.710 ITM2C
integral membrane protein 2C
chr6_+_30018287 0.706 NM_002116
HLA-A
major histocompatibility complex, class I, A
chr12_-_101835183 0.704 PAH
phenylalanine hydroxylase
chr6_-_16869579 0.704 NM_000332
NM_001128164
ATXN1

ataxin 1

chr1_-_25128951 0.704 RUNX3
runt-related transcription factor 3
chr9_+_116131889 0.701 NM_000608
ORM2
orosomucoid 2
chr3_+_106568334 0.698 NM_001627
ALCAM
activated leukocyte cell adhesion molecule
chr9_+_2612134 0.696 VLDLR
very low density lipoprotein receptor
chrX_+_128741562 0.684 NM_018990
SASH3
SAM and SH3 domain containing 3
chr1_-_56817823 0.684 NM_003713
PPAP2B
phosphatidic acid phosphatase type 2B
chr11_-_70185559 0.680 NM_133266
SHANK2
SH3 and multiple ankyrin repeat domains 2
chr3_+_123036719 0.679 NM_018456
EAF2
ELL associated factor 2
chr2_+_86521939 0.679 KDM3A
lysine (K)-specific demethylase 3A
chrX_+_128741578 0.675 SASH3
SAM and SH3 domain containing 3
chr1_+_210805319 0.671 NM_001030287
ATF3
activating transcription factor 3
chr4_+_74520796 0.666 NM_001134
AFP
alpha-fetoprotein
chr20_-_51633042 0.662 NM_006526
ZNF217
zinc finger protein 217
chr19_+_44591589 0.662


chr11_+_1846478 0.661 NM_001013253
LSP1
lymphocyte-specific protein 1
chr2_+_109729176 0.660 NM_023016
ANKRD57
ankyrin repeat domain 57
chr6_+_32003180 0.657 NM_000063
NM_001145903
C2

complement component 2

chr2_+_68445936 0.652 PLEK
pleckstrin
chr20_+_45564063 0.651 NCOA3
nuclear receptor coactivator 3
chr5_+_135392482 0.649 NM_000358
TGFBI
transforming growth factor, beta-induced, 68kDa
chr17_-_26665213 0.648 EVI2B
ecotropic viral integration site 2B
chr3_+_101694244 0.643 TMEM45A
transmembrane protein 45A
chr5_+_52812165 0.640 FST
follistatin
chr1_-_25164061 0.639 NM_001031680
RUNX3
runt-related transcription factor 3
chr2_-_220144511 0.639 NM_001173408
NM_001173431
NM_015311
OBSL1


obscurin-like 1


chr17_-_26665220 0.636 NM_006495
EVI2B
ecotropic viral integration site 2B
chr9_+_111582317 0.636 NM_053016
NM_007203
NM_147150
PALM2
PALM2-AKAP2

paralemmin 2
PALM2-AKAP2 readthrough

chr16_-_11588525 0.635 LITAF
lipopolysaccharide-induced TNF factor
chr19_+_55614006 0.633 NM_003121
SPIB
Spi-B transcription factor (Spi-1/PU.1 related)
chr19_-_7672978 0.631 NM_002002
FCER2
Fc fragment of IgE, low affinity II, receptor for (CD23)
chr22_+_35586950 0.630 NM_000631
NM_013416
NCF4

neutrophil cytosolic factor 4, 40kDa

chr3_+_106568430 0.630 ALCAM
activated leukocyte cell adhesion molecule
chr20_-_61028263 0.616 DIDO1
death inducer-obliterator 1
chr6_+_30018265 0.615 HLA-A
major histocompatibility complex, class I, A
chr20_+_45564007 0.610 NM_001174087
NM_001174088
NM_006534
NM_181659
NCOA3



nuclear receptor coactivator 3



chr14_-_105542441 0.610 IGLJ3
IGHA1
IGHG1
IGHM
immunoglobulin lambda joining 3
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr3_-_81893604 0.606 NM_000158
GBE1
glucan (1,4-alpha-), branching enzyme 1
chr22_-_35875890 0.603 NM_000878
IL2RB
interleukin 2 receptor, beta
chr3_-_188936941 0.602 NM_001130845
BCL6
B-cell CLL/lymphoma 6
chr5_+_133479196 0.594 NM_001134851
NM_201632
NM_201634
NM_213648
TCF7



transcription factor 7 (T-cell specific, HMG-box)



chr8_+_123863224 0.591 ZHX2
zinc fingers and homeoboxes 2
chr9_-_110736377 0.590 NM_003640
IKBKAP
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
chr6_+_29799182 0.588 HLA-F
major histocompatibility complex, class I, F
chr10_-_74526596 0.588 P4HA1
prolyl 4-hydroxylase, alpha polypeptide I
chr6_-_32742265 0.587 NM_002123
HLA-DQB1
major histocompatibility complex, class II, DQ beta 1
chr21_-_45165249 0.587 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr5_-_150517499 0.586 ANXA6
annexin A6
chr7_+_94135384 0.583 PEG10
paternally expressed 10
chr22_+_20899155 0.583


chr3_-_81893506 0.582 GBE1
glucan (1,4-alpha-), branching enzyme 1
chr13_+_75232797 0.577 NM_015842
LMO7
LIM domain 7
chr2_-_37727472 0.577 CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr19_+_62394645 0.573 NM_003417
ZNF264
zinc finger protein 264
chr2_-_21079145 0.572 APOB
apolipoprotein B (including Ag(x) antigen)
chrM_+_13453 0.567


chr13_+_112825113 0.567 NM_000504
F10
coagulation factor X
chr17_-_26665194 0.566 EVI2B
ecotropic viral integration site 2B
chr4_+_100714995 0.565 MTTP
microsomal triglyceride transfer protein
chr10_-_74526662 0.565 NM_000917
NM_001017962
NM_001142595
NM_001142596
P4HA1



prolyl 4-hydroxylase, alpha polypeptide I



chr9_+_132310068 0.564 ASS1
argininosuccinate synthase 1
chr14_+_23633101 0.562 NM_001018073
NM_004563
PCK2

phosphoenolpyruvate carboxykinase 2 (mitochondrial)

chr21_-_45165204 0.562 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr14_+_94148466 0.559 NM_001085
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr16_+_30293598 0.558 NM_013292
MYLPF
myosin light chain, phosphorylatable, fast skeletal muscle
chr11_+_116575249 0.557 NM_001001522
NM_003186
TAGLN

transgelin

chr12_+_99391870 0.556 NR1H4
nuclear receptor subfamily 1, group H, member 4
chr2_-_220144254 0.556 OBSL1
obscurin-like 1
chr11_-_2113297 0.555 IGF2
insulin-like growth factor 2 (somatomedin A)
chr3_-_180272291 0.553 NM_022470
NM_152240
ZMAT3

zinc finger, matrin-type 3

chr2_+_102345528 0.552 NM_003855
IL18R1
interleukin 18 receptor 1
chr5_+_53787187 0.545 NM_006308
HSPB3
heat shock 27kDa protein 3
chr2_+_85665041 0.544 NM_006634
VAMP5
vesicle-associated membrane protein 5 (myobrevin)
chr16_-_21197138 0.538 CRYM
crystallin, mu
chr3_-_81893308 0.538 GBE1
glucan (1,4-alpha-), branching enzyme 1
chr19_+_47073029 0.537 NM_001783
NM_021601
CD79A

CD79a molecule, immunoglobulin-associated alpha

chr5_-_150517528 0.536 NM_001155
ANXA6
annexin A6
chr12_+_51979721 0.535 NM_021640
C12orf10
chromosome 12 open reading frame 10
chr2_-_37752731 0.530 NM_006449
CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr8_-_17986690 0.530 NM_001127505
NM_004315
ASAH1

N-acylsphingosine amidohydrolase (acid ceramidase) 1

chr12_-_91063441 0.529 NM_001731
BTG1
B-cell translocation gene 1, anti-proliferative
chr1_-_145163779 0.528 NM_001144829
NM_001144830
NM_001461
FMO5


flavin containing monooxygenase 5


chr1_-_172153087 0.525 NM_000488
SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr10_+_76256305 0.525 NM_012330
MYST4
MYST histone acetyltransferase (monocytic leukemia) 4
chr5_+_156628929 0.524 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr7_-_99411573 0.524 NM_001185
AZGP1
alpha-2-glycoprotein 1, zinc-binding
chr9_+_89302239 0.523 DAPK1
death-associated protein kinase 1
chr6_-_41811916 0.521 NM_001167827
TFEB
transcription factor EB
chr6_+_32003380 0.515 C2
complement component 2
chr3_-_184363157 0.515 NM_014398
LAMP3
lysosomal-associated membrane protein 3
chr1_-_154665807 0.513 NM_006365
C1orf61
chromosome 1 open reading frame 61
chrX_+_105823723 0.512 NM_024539
RNF128
ring finger protein 128
chrX_+_38305634 0.511 NM_004615
TSPAN7
tetraspanin 7
chr2_+_95055155 0.510 NM_002371
NM_022438
NM_022439
NM_022440
MAL



mal, T-cell differentiation protein



chr4_+_78297356 0.504 NM_004354
CCNG2
cyclin G2
chr12_+_99391681 0.502 NM_005123
NR1H4
nuclear receptor subfamily 1, group H, member 4
chr6_-_31658044 0.501 NM_002341
NM_009588
LTB

lymphotoxin beta (TNF superfamily, member 3)

chr5_-_111120929 0.500 NM_001142482
NM_001142481
C5orf13

chromosome 5 open reading frame 13

chr14_+_64948332 0.499 FUT8
fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
chr4_+_74491272 0.497 ALB
albumin
chr1_-_172153024 0.495 SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr11_+_73037382 0.492 NM_001130036
PLEKHB1
pleckstrin homology domain containing, family B (evectins) member 1
chr6_-_32929721 0.487 NM_000593
TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr3_-_180272229 0.487 ZMAT3
zinc finger, matrin-type 3
chr1_-_56817802 0.483 PPAP2B
phosphatidic acid phosphatase type 2B
chr3_-_121884091 0.483 NM_000187
HGD
homogentisate 1,2-dioxygenase
chr16_+_80370426 0.483 NM_002661
PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr4_+_3737872 0.481 ADRA2C
adrenergic, alpha-2C-, receptor
chr1_+_154386358 0.475 NM_001193301
SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.62 1.01e-02 GO:0015629 actin cytoskeleton

Nothing significant found in function category.