Motif ID: GATA6.p2

Z-value: 1.560


Transcription factors associated with GATA6.p2:

Gene SymbolEntrez IDGene Name
GATA6 2627 GATA binding protein 6

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
GATA6chr18_+_18003401-0.048.8e-01Click!


Activity profile for motif GATA6.p2.

activity profile for motif GATA6.p2


Sorted Z-values histogram for motif GATA6.p2

Sorted Z-values for motif GATA6.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GATA6.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_+_142853 6.592 NM_005332
HBZ
hemoglobin, zeta
chr12_-_52975823 5.714 NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr12_-_52975777 5.697 NM_006163
NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr6_-_49712483 4.037 NM_000324
RHAG
Rh-associated glycoprotein
chr7_-_100077072 3.624 NM_003227
TFR2
transferrin receptor 2
chr17_-_59437782 2.887 NM_000873
ICAM2
intercellular adhesion molecule 2
chr8_-_38127489 2.883 NM_000349
STAR
steroidogenic acute regulatory protein
chr16_-_87570716 2.358 NM_005187
CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr9_-_74757735 2.268 NM_000689
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr11_-_116213511 2.075 NM_000039
APOA1
apolipoprotein A-I
chr7_-_142369519 2.071 KEL
Kell blood group, metallo-endopeptidase
chr1_-_156923111 2.069 NM_003126
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr19_+_10258642 2.062 NM_001039132
NM_001544
NM_022377
ICAM4


intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)


chr7_-_142369534 2.045 NM_000420
KEL
Kell blood group, metallo-endopeptidase
chrX_+_15435351 2.039 NM_001721
BMX
BMX non-receptor tyrosine kinase
chrX_-_55074125 1.948 NM_000032
NM_001037967
NM_001037968
ALAS2


aminolevulinate, delta-, synthase 2


chr19_-_12858956 1.943 NM_006563
KLF1
Kruppel-like factor 1 (erythroid)
chr19_-_60360768 1.916 NM_000363
TNNI3
troponin I type 3 (cardiac)
chr19_-_13074513 1.824 LYL1
lymphoblastic leukemia derived sequence 1
chr7_+_150321771 1.809 NM_001160109
NM_001160110
NM_001160111
NOS3


nitric oxide synthase 3 (endothelial cell)


chr11_+_118463906 1.787 NM_001024382
HMBS
hydroxymethylbilane synthase
chr19_-_13074669 1.669 LYL1
lymphoblastic leukemia derived sequence 1
chr8_-_86477585 1.650 NM_001128829
NM_001128830
NM_001128831
NM_001738
CA1



carbonic anhydrase I



chr11_-_56914668 1.595 NM_002728
PRG2
proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
chrX_+_65299157 1.529 NM_138737
HEPH
hephaestin
chr1_+_181028016 1.469 NM_030769
NPL
N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
chr17_-_45196465 1.445 FAM117A
family with sequence similarity 117, member A
chr17_-_45196516 1.442 NM_030802
FAM117A
family with sequence similarity 117, member A
chrX_+_65299352 1.430 HEPH
hephaestin
chr17_-_61655915 1.407 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr1_-_27113018 1.253 NM_021969
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr16_+_31446703 1.233 NM_016633
AHSP
alpha hemoglobin stabilizing protein
chr4_-_186934059 1.224 NM_001145673
SORBS2
sorbin and SH3 domain containing 2
chr4_+_100714995 1.209 MTTP
microsomal triglyceride transfer protein
chr1_-_153537810 1.113 NM_000298
PKLR
pyruvate kinase, liver and RBC
chr16_-_45339605 1.085 NM_182493
MYLK3
myosin light chain kinase 3
chr2_+_138438277 1.080 NM_001024074
NM_001024075
NM_006895
HNMT


histamine N-methyltransferase


chr3_+_69895651 1.058 NM_006722
MITF
microphthalmia-associated transcription factor
chr11_-_2108035 1.008 IGF2
insulin-like growth factor 2 (somatomedin A)
chr1_-_25619863 1.008 NM_020485
NM_138616
NM_138617
NM_138618
RHCE



RHD
Rh blood group, CcEe antigens



Rh blood group, D antigen
chr2_-_188127294 0.997 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr2_-_43919392 0.992 NM_022436
ABCG5
ATP-binding cassette, sub-family G (WHITE), member 5
chr2_-_88208650 0.944 NM_001443
FABP1
fatty acid binding protein 1, liver
chr11_-_5247948 0.925 NM_005330
HBE1
hemoglobin, epsilon 1
chr17_+_4621924 0.908 NM_003963
TM4SF5
transmembrane 4 L six family member 5
chr1_+_25471470 0.905 NM_001127691
NM_016124
RHD

Rh blood group, D antigen

chr20_-_45410033 0.905 ZMYND8
zinc finger, MYND-type containing 8
chr16_+_20682812 0.881 NM_005622
NM_202000
ACSM3

acyl-CoA synthetase medium-chain family member 3

chr6_-_32251654 0.867 AGPAT1
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
chr18_+_27425727 0.859 NM_000371
TTR
transthyretin
chr1_+_43063817 0.852 NM_018538
ERMAP
erythroblast membrane-associated protein (Scianna blood group)
chr10_-_21226536 0.841 NM_006393
NEBL
nebulette
chr3_+_69895310 0.826 NM_001184967
MITF
microphthalmia-associated transcription factor
chr1_-_148124738 0.815 NM_003528
HIST2H2BE
histone cluster 2, H2be
chr2_-_21079145 0.793 APOB
apolipoprotein B (including Ag(x) antigen)
chr4_+_74493918 0.792 ALB
albumin
chr2_+_169465995 0.761 NM_001081686
NM_021176
G6PC2

glucose-6-phosphatase, catalytic, 2

chr4_+_155703581 0.759 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr20_+_42463387 0.756 HNF4A
hepatocyte nuclear factor 4, alpha
chr10_-_7722747 0.740 ITIH5
inter-alpha (globulin) inhibitor H5
chr11_-_65962836 0.732 NM_016050
NM_170738
NM_170739
MRPL11


mitochondrial ribosomal protein L11


chr1_-_153537362 0.713 NM_181871
PKLR
pyruvate kinase, liver and RBC
chr17_-_36346240 0.689 KRT23
keratin 23 (histone deacetylase inducible)
chr19_-_53081383 0.686 NM_003167
SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr14_+_101346032 0.685 PPP2R5C
protein phosphatase 2, regulatory subunit B', gamma
chr10_+_7785235 0.675 NM_002216
ITIH2
inter-alpha (globulin) inhibitor H2
chr12_-_69434330 0.674 PTPRR
protein tyrosine phosphatase, receptor type, R
chr10_+_70517863 0.662 SRGN
serglycin
chr5_-_59819642 0.657 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr1_-_180622083 0.657 GLUL
glutamate-ammonia ligase
chr12_-_6103945 0.656 NM_000552
VWF
von Willebrand factor
chr10_-_52315436 0.644 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr19_-_53081326 0.634 SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr12_-_14887648 0.633 NM_021071
ART4
ADP-ribosyltransferase 4 (Dombrock blood group)
chr4_+_74498042 0.623 ALB
albumin
chr13_-_45654296 0.623 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr7_+_111850367 0.615 NM_001007245
NM_001197080
IFRD1

interferon-related developmental regulator 1

chr21_-_14840506 0.613 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr10_+_7785360 0.606 ITIH2
inter-alpha (globulin) inhibitor H2
chr13_-_45654327 0.599 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr2_-_188127430 0.596 NM_001032281
NM_006287
TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

chr2_+_27573206 0.589 NM_001486
GCKR
glucokinase (hexokinase 4) regulator
chr4_+_69996780 0.586 NM_001074
UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr10_-_52315390 0.582 A1CF
APOBEC1 complementation factor
chr12_+_7039453 0.580


chrX_+_115481774 0.580 NM_007231
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr1_-_24342158 0.579 NM_021258
IL22RA1
interleukin 22 receptor, alpha 1
chr10_+_7785290 0.574 ITIH2
inter-alpha (globulin) inhibitor H2
chr20_-_54400628 0.567 NM_003600
NM_198433
NM_198434
NM_198435
NM_198436
NM_198437
AURKA





aurora kinase A





chrX_-_78509662 0.565 NM_001171581
NM_004867
ITM2A

integral membrane protein 2A

chr4_-_186970366 0.562 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr12_-_122272346 0.561 NM_022782
MPHOSPH9
M-phase phosphoprotein 9
chr4_+_74488910 0.557 ALB
albumin
chr2_-_98646367 0.551 NM_001160154
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr17_-_8364942 0.549 MYH10
myosin, heavy chain 10, non-muscle
chr14_+_101345878 0.549 NM_002719
NM_178586
NM_178587
PPP2R5C


protein phosphatase 2, regulatory subunit B', gamma


chr6_-_31954795 0.540 NM_001178044
NM_025257
SLC44A4

solute carrier family 44, member 4

chr10_+_70517823 0.536 NM_002727
SRGN
serglycin
chr10_+_70745615 0.535 NM_033496
HK1
hexokinase 1
chr10_-_99521701 0.528 NM_003015
SFRP5
secreted frizzled-related protein 5
chr7_+_20621769 0.519 NM_001163941
ABCB5
ATP-binding cassette, sub-family B (MDR/TAP), member 5
chr3_-_185912240 0.518 NM_022149
MAGEF1
melanoma antigen family F, 1
chr19_-_11355882 0.517 NM_000121
EPOR
erythropoietin receptor
chr2_+_108571209 0.514 LIMS1
LIM and senescent cell antigen-like domains 1
chr12_+_52105131 0.507 AMHR2
anti-Mullerian hormone receptor, type II
chr2_+_108571336 0.503 NM_001193488
LIMS1
LIM and senescent cell antigen-like domains 1
chr6_-_31954730 0.499 SLC44A4
solute carrier family 44, member 4
chr3_+_150065732 0.490 NM_001870
CPA3
carboxypeptidase A3 (mast cell)
chr8_-_41774296 0.472 NM_000037
NM_020475
NM_020476
NM_020477
ANK1



ankyrin 1, erythrocytic



chrX_-_78509367 0.471 ITM2A
integral membrane protein 2A
chr21_-_38792173 0.468 NM_001136155
NM_182918
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr2_+_220145197 0.451 NM_002191
INHA
inhibin, alpha
chr3_-_50624114 0.438 NM_013324
NM_145071
CISH

cytokine inducible SH2-containing protein

chr21_+_37714470 0.435 NM_130438
NM_001396
DYRK1A

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A

chrX_+_48640718 0.432 NM_001167992
PQBP1
polyglutamine binding protein 1
chr2_+_241456834 0.431 NM_000030
AGXT
alanine-glyoxylate aminotransferase
chr13_+_110165329 0.430 NM_005537
ING1
inhibitor of growth family, member 1
chr15_-_61913186 0.430 NM_003922
HERC1
hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1
chr1_+_26517032 0.429 CD52
CD52 molecule
chr10_-_11614279 0.425 NM_001080491
USP6NL
USP6 N-terminal like
chr1_+_196874867 0.424 PTPRC
protein tyrosine phosphatase, receptor type, C
chr10_+_118340460 0.415 NM_006229
PNLIPRP1
pancreatic lipase-related protein 1
chr14_-_22947320 0.411 NM_002471
MYH6
myosin, heavy chain 6, cardiac muscle, alpha
chr1_+_196874839 0.404 PTPRC
protein tyrosine phosphatase, receptor type, C
chr9_+_132579088 0.403 NM_007313
ABL1
c-abl oncogene 1, non-receptor tyrosine kinase
chr11_+_73034870 0.402 NM_001130033
NM_021200
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr14_-_93919305 0.400 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr6_-_31954745 0.396 SLC44A4
solute carrier family 44, member 4
chr11_-_64267037 0.395 RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr10_-_92670764 0.390 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr9_+_138677197 0.389 NM_201446
NM_016215
EGFL7

EGF-like-domain, multiple 7

chr17_-_17421050 0.387 PEMT
phosphatidylethanolamine N-methyltransferase
chr7_+_128166688 0.385 CALU
calumenin
chr6_+_167624792 0.385 NM_001143947
NM_018974
UNC93A

unc-93 homolog A (C. elegans)

chr20_+_42463279 0.384 NM_000457
NM_178849
NM_178850
HNF4A


hepatocyte nuclear factor 4, alpha


chr2_+_108604111 0.384 NM_001193484
LIMS1
LIM and senescent cell antigen-like domains 1
chr19_-_13074973 0.380 NM_005583
LYL1
lymphoblastic leukemia derived sequence 1
chr8_+_12847521 0.378 NM_020844
KIAA1456
KIAA1456
chr10_+_7785331 0.377 ITIH2
inter-alpha (globulin) inhibitor H2
chr1_+_15145001 0.373 NM_001017999
KAZN
kazrin, periplakin interacting protein
chr3_-_180467483 0.372 NM_001163677
NM_171828
KCNMB3

potassium large conductance calcium-activated channel, subfamily M beta member 3

chr6_-_33276426 0.371 RXRB
retinoid X receptor, beta
chr4_-_100359353 0.369 NM_000672
NM_001102470
ADH6

alcohol dehydrogenase 6 (class V)

chr4_-_74307637 0.366 ANKRD17
ankyrin repeat domain 17
chr14_-_20340377 0.366 NM_198232
RNASE1
ribonuclease, RNase A family, 1 (pancreatic)
chr2_-_130646415 0.366 SMPD4
sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)
chr16_-_2254318 0.363 RNPS1
RNA binding protein S1, serine-rich domain
chr19_-_60241424 0.360 NM_001083899
NM_016363
GP6

glycoprotein VI (platelet)

chr1_+_50347176 0.358 NM_001144774
NM_021952
ELAVL4

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)

chr21_-_34820916 0.357 NM_203418
RCAN1
regulator of calcineurin 1
chr4_+_74488835 0.356 NM_000477
ALB
albumin
chr10_-_92671005 0.354 NM_014391
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr12_-_110410730 0.354 ATXN2
ataxin 2
chr3_-_184756101 0.353 NM_130446
KLHL6
kelch-like 6 (Drosophila)
chr4_-_159313613 0.348 NM_001031700
NM_001128424
FAM198B

family with sequence similarity 198, member B

chr15_-_40537002 0.346 NM_022473
ZFP106
zinc finger protein 106 homolog (mouse)
chrX_-_74292800 0.346 NM_004299
ABCB7
ATP-binding cassette, sub-family B (MDR/TAP), member 7
chr7_+_128166636 0.344 CALU
calumenin
chr1_-_167822334 0.343 NM_000130
F5
coagulation factor V (proaccelerin, labile factor)
chr10_+_7785347 0.342 ITIH2
inter-alpha (globulin) inhibitor H2
chr11_-_47330797 0.342 NM_000256
MYBPC3
myosin binding protein C, cardiac
chr12_-_23628774 0.337 NM_178010
SOX5
SRY (sex determining region Y)-box 5
chr17_+_71892781 0.335 NM_001142602
SPHK1
sphingosine kinase 1
chr12_-_69434598 0.331 NM_130846
PTPRR
protein tyrosine phosphatase, receptor type, R
chr1_-_188713324 0.330 NM_199051
FAM5C
family with sequence similarity 5, member C
chr21_-_46529663 0.328 NM_003906
MCM3AP
minichromosome maintenance complex component 3 associated protein
chr1_-_171442937 0.324 NM_003326
TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr15_-_41300316 0.321 EPB42
erythrocyte membrane protein band 4.2
chr1_+_50347188 0.315 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr3_-_170347019 0.310 NM_001105078
MECOM
MDS1 and EVI1 complex locus
chr19_-_59383944 0.309 MBOAT7
membrane bound O-acyltransferase domain containing 7
chr20_+_55569542 0.308 NM_002591
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr8_-_6407882 0.304 NM_001118887
NM_001118888
NM_001147
ANGPT2


angiopoietin 2


chr1_+_196874759 0.304 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr11_-_129268113 0.303 NM_006165
NFRKB
nuclear factor related to kappaB binding protein
chr1_+_26516967 0.303 NM_001803
CD52
CD52 molecule
chr11_+_60858611 0.300 DAK
dihydroxyacetone kinase 2 homolog (S. cerevisiae)
chr7_+_128166664 0.298 CALU
calumenin
chrX_+_49480643 0.298 NM_007003
PAGE4
P antigen family, member 4 (prostate associated)
chr1_+_35623688 0.297 ZMYM4
zinc finger, MYM-type 4
chr1_-_150092702 0.296 NM_182578
THEM5
thioesterase superfamily member 5
chr4_+_120276386 0.295 NM_016599
MYOZ2
myozenin 2
chr6_+_12398514 0.295 NM_001168319
NM_001955
EDN1

endothelin 1

chr19_+_10642648 0.292 ILF3
interleukin enhancer binding factor 3, 90kDa
chr9_+_35663852 0.292 NM_001216
CA9
carbonic anhydrase IX
chr10_-_94247450 0.291 NM_001165946
IDE
insulin-degrading enzyme
chr1_-_26266571 0.290 NM_032588
TRIM63
tripartite motif containing 63
chr6_-_123999640 0.288 NM_006073
TRDN
triadin
chr19_-_56549853 0.284 NM_001014763
ETFB
electron-transfer-flavoprotein, beta polypeptide
chr2_+_220087135 0.281 NM_018674
NM_182847
ACCN4

amiloride-sensitive cation channel 4, pituitary

chr1_+_15128882 0.281 NM_001018001
KAZN
kazrin, periplakin interacting protein
chr17_+_71893014 0.280 SPHK1
sphingosine kinase 1
chr8_-_72431274 0.279 NM_172058
NM_172059
NM_172060
EYA1


eyes absent homolog 1 (Drosophila)


chr19_+_54068300 0.279 PPP1R15A
protein phosphatase 1, regulatory (inhibitor) subunit 15A
chr17_-_3766708 0.276 NM_002558
P2RX1
purinergic receptor P2X, ligand-gated ion channel, 1
chr5_+_159781454 0.273 PTTG1
pituitary tumor-transforming 1
chr12_-_61615124 0.272 PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr16_-_66535457 0.270 NM_000229
LCAT
lecithin-cholesterol acyltransferase
chr12_-_69434650 0.269 PTPRR
protein tyrosine phosphatase, receptor type, R
chrX_-_76824726 0.266 ATRX
alpha thalassemia/mental retardation syndrome X-linked

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.41 9.38e-07 GO:0032501 multicellular organismal process
1.67 2.86e-06 GO:0065008 regulation of biological quality
1.27 2.00e-03 GO:0050896 response to stimulus
2.24 2.04e-03 GO:0007599 hemostasis
3.04 3.46e-03 GO:0003013 circulatory system process
3.04 3.46e-03 GO:0008015 blood circulation
1.69 3.70e-03 GO:0003008 system process
2.11 4.01e-03 GO:0050878 regulation of body fluid levels
2.20 4.30e-03 GO:0007596 blood coagulation
2.20 4.30e-03 GO:0050817 coagulation
2.25 1.97e-02 GO:0071702 organic substance transport
1.99 2.22e-02 GO:0042060 wound healing
3.76 3.13e-02 GO:0007586 digestion

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.81 7.78e-08 GO:0005576 extracellular region
1.86 1.75e-04 GO:0044421 extracellular region part
1.88 1.58e-03 GO:0005615 extracellular space

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.70 1.10e-02 GO:0005102 receptor binding
4.08 2.71e-02 GO:0004867 serine-type endopeptidase inhibitor activity