Motif ID: HMX1.p2

Z-value: 1.142


Transcription factors associated with HMX1.p2:

Gene SymbolEntrez IDGene Name
HMX1 3166 H6 family homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot


Activity profile for motif HMX1.p2.

activity profile for motif HMX1.p2


Sorted Z-values histogram for motif HMX1.p2

Sorted Z-values for motif HMX1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HMX1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_+_48915127 2.551 NM_002668
PLP2
proteolipid protein 2 (colonic epithelium-enriched)
chr1_-_58815415 2.111 TACSTD2
tumor-associated calcium signal transducer 2
chr22_-_35970230 1.932 NM_002872
RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr14_-_104705753 1.879 JAG2
jagged 2
chr22_-_35970133 1.640 RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr19_+_43447078 1.558 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr19_+_43446937 1.407 NM_001166103
NM_021102
SPINT2

serine peptidase inhibitor, Kunitz type, 2

chr1_+_166461881 1.212 SFT2D2
SFT2 domain containing 2
chr5_-_81082699 1.176 NM_012446
SSBP2
single-stranded DNA binding protein 2
chr19_+_43447262 1.168 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr5_-_81082614 1.136 SSBP2
single-stranded DNA binding protein 2
chr1_+_166461872 1.134 NM_199344
SFT2D2
SFT2 domain containing 2
chrX_-_78509662 1.127 NM_001171581
NM_004867
ITM2A

integral membrane protein 2A

chr13_+_40929679 1.121 C13orf15
chromosome 13 open reading frame 15
chr13_+_40929690 1.113 C13orf15
chromosome 13 open reading frame 15
chr11_-_33847507 1.111 LMO2
LIM domain only 2 (rhombotin-like 1)
chr13_+_40929525 1.102 NM_014059
C13orf15
chromosome 13 open reading frame 15
chr11_-_33847834 1.098 LMO2
LIM domain only 2 (rhombotin-like 1)
chr17_-_59451662 1.069 NM_001099786
NM_001099787
NM_001099788
NM_001099789
ICAM2



intercellular adhesion molecule 2



chr3_-_112796855 1.038 NM_024508
ZBED2
zinc finger, BED-type containing 2
chr7_+_5609416 1.006 FSCN1
fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
chr6_-_42017337 0.944 NM_001136125
NM_001760
CCND3

cyclin D3

chr1_+_234372454 0.943 NM_003272
GPR137B
G protein-coupled receptor 137B
chrX_-_78509367 0.937 ITM2A
integral membrane protein 2A
chr5_-_41906459 0.895 NM_000436
OXCT1
3-oxoacid CoA transferase 1
chr14_-_104706159 0.873 NM_002226
NM_145159
JAG2

jagged 2

chrX_-_140099014 0.858 LDOC1
leucine zipper, down-regulated in cancer 1
chrX_-_140098941 0.844 LDOC1
leucine zipper, down-regulated in cancer 1
chrX_-_140098959 0.843 NM_012317
LDOC1
leucine zipper, down-regulated in cancer 1
chr17_-_7106987 0.833 NM_001185023
NM_001307
CLDN7

claudin 7

chr11_+_59279481 0.797 STX3
syntaxin 3
chr2_-_151854379 0.796 NMI
N-myc (and STAT) interactor
chr4_-_177950658 0.790 NM_005429
VEGFC
vascular endothelial growth factor C
chr8_+_31616809 0.758 NM_013962
NRG1
neuregulin 1
chr19_+_40299058 0.737 FXYD3
FXYD domain containing ion transport regulator 3
chr8_-_29263714 0.736 NM_001394
DUSP4
dual specificity phosphatase 4
chr8_+_95722448 0.733 ESRP1
epithelial splicing regulatory protein 1
chr11_-_19219000 0.717 NM_024680
E2F8
E2F transcription factor 8
chr7_+_133982070 0.700 NM_001724
NM_199186
BPGM

2,3-bisphosphoglycerate mutase

chr5_+_76150637 0.697 F2RL1
coagulation factor II (thrombin) receptor-like 1
chr6_+_7672009 0.693 NM_001718
BMP6
bone morphogenetic protein 6
chr11_+_59279377 0.661 STX3
syntaxin 3
chr11_-_33700831 0.649 NM_001127223
NM_001127225
NM_001127226
CD59


CD59 molecule, complement regulatory protein


chr11_+_66580861 0.647 NM_014578
RHOD
ras homolog gene family, member D
chr3_+_153469421 0.635 MBNL1
muscleblind-like (Drosophila)
chr22_-_16020076 0.626 CECR5
cat eye syndrome chromosome region, candidate 5
chr15_-_56093477 0.602 NM_170697
ALDH1A2
aldehyde dehydrogenase 1 family, member A2
chr9_+_115303527 0.597 NM_130795
RGS3
regulator of G-protein signaling 3
chr5_+_76150588 0.581 NM_005242
F2RL1
coagulation factor II (thrombin) receptor-like 1
chr1_+_12149637 0.580 NM_001066
TNFRSF1B
tumor necrosis factor receptor superfamily, member 1B
chr11_+_60886407 0.576 TMEM138
transmembrane protein 138
chr14_+_89491989 0.569 NM_001008744
NM_018319
TDP1

tyrosyl-DNA phosphodiesterase 1

chr5_-_37406955 0.567 NUP155
nucleoporin 155kDa
chr11_+_69602055 0.561 NM_018043
ANO1
anoctamin 1, calcium activated chloride channel
chr17_-_7106497 0.559 CLDN7
claudin 7
chr11_-_407324 0.555 NM_001135053
NM_021805
SIGIRR

single immunoglobulin and toll-interleukin 1 receptor (TIR) domain

chr4_-_90977149 0.553 NM_001146054
NM_007308
NM_000345
SNCA


synuclein, alpha (non A4 component of amyloid precursor)


chr14_+_89492013 0.547 TDP1
tyrosyl-DNA phosphodiesterase 1
chr17_-_3573822 0.547 ITGAE
integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
chr11_-_67032125 0.545 CDK2AP2
cyclin-dependent kinase 2 associated protein 2
chr11_+_19095215 0.545 NM_001001483
NM_019028
ZDHHC13

zinc finger, DHHC-type containing 13

chr17_+_77582774 0.543 NM_005052
RAC3
ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
chr1_+_153545162 0.533 NM_001135822
NM_002004
FDPS

farnesyl diphosphate synthase

chr18_-_490583 0.530 NM_130386
COLEC12
collectin sub-family member 12
chr1_-_205161821 0.520 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr18_-_20231709 0.520 OSBPL1A
oxysterol binding protein-like 1A
chr1_+_26479167 0.513 SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
chr18_-_20105814 0.511 OSBPL1A
oxysterol binding protein-like 1A
chr17_-_8092098 0.510 NM_025099
CTC1
CTS telomere maintenance complex component 1
chr1_+_154297588 0.510 NM_020387
RAB25
RAB25, member RAS oncogene family
chr5_-_41906257 0.509 OXCT1
3-oxoacid CoA transferase 1
chr1_+_153545301 0.508 NM_001135821
FDPS
farnesyl diphosphate synthase
chr1_+_153545351 0.507 FDPS
farnesyl diphosphate synthase
chr12_-_15005761 0.505 NM_001175
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr1_-_199742871 0.505 NM_001193570
NM_004078
CSRP1

cysteine and glycine-rich protein 1

chr1_-_199742841 0.503 CSRP1
cysteine and glycine-rich protein 1
chr17_-_3651236 0.502 NM_002208
ITGAE
integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
chr18_-_20105644 0.499 OSBPL1A
oxysterol binding protein-like 1A
chr18_-_20231783 0.498 NM_080597
OSBPL1A
oxysterol binding protein-like 1A
chr15_+_81567327 0.484 NM_001144903
NM_023003
TM6SF1

transmembrane 6 superfamily member 1

chr5_-_37406939 0.481 NM_153485
NUP155
nucleoporin 155kDa
chr3_-_18441763 0.471 NM_001195470
NM_002971
SATB1

SATB homeobox 1

chr9_-_129656581 0.471 ENG
endoglin
chr6_+_16346759 0.470 NM_006877
GMPR
guanosine monophosphate reductase
chr4_-_11039600 0.468 NM_005114
HS3ST1
heparan sulfate (glucosamine) 3-O-sulfotransferase 1
chr2_-_133144094 0.465 LYPD1
LY6/PLAUR domain containing 1
chr1_+_35020425 0.460 NM_001005752
GJB3
gap junction protein, beta 3, 31kDa
chr9_-_129656830 0.458 NM_000118
NM_001114753
ENG

endoglin

chr17_-_38385511 0.456 NM_025267
AARSD1
alanyl-tRNA synthetase domain containing 1
chr9_-_129656778 0.452 ENG
endoglin
chr12_+_4253143 0.450 NM_001759
CCND2
cyclin D2
chr1_+_221966849 0.450 CAPN2
calpain 2, (m/II) large subunit
chr17_-_31337798 0.449 NM_032962
NM_032963
CCL14

chemokine (C-C motif) ligand 14

chr17_-_8092078 0.447 CTC1
CTS telomere maintenance complex component 1
chr3_+_103029523 0.438 NM_001005474
NFKBIZ
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr1_+_166461865 0.433 SFT2D2
SFT2 domain containing 2
chr8_+_32525269 0.424 NM_001160002
NM_001160004
NM_001160005
NM_001160007
NM_001160008
NM_004495
NM_013956
NM_013957
NM_013958
NM_013960
NM_013964
NRG1










neuregulin 1










chr6_-_136913649 0.415 NM_001198616
NM_001198617
NM_003980
MAP7


microtubule-associated protein 7


chr2_+_203208064 0.413 NM_173511
FAM117B
family with sequence similarity 117, member B
chr17_+_71229191 0.409 ITGB4
integrin, beta 4
chr13_+_75021886 0.402 NM_006002
UCHL3
ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
chr1_-_28113817 0.397 NM_002946
RPA2
replication protein A2, 32kDa
chr4_-_647424 0.396


chr1_+_26479173 0.394 SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
chr4_+_86615275 0.387 NM_001025616
ARHGAP24
Rho GTPase activating protein 24
chr22_+_28032950 0.387 NM_006478
NM_152236
NM_152237
GAS2L1


growth arrest-specific 2 like 1


chr6_-_13594361 0.385 NM_033069
C6orf114
chromosome 6 open reading frame 114
chrX_+_37429927 0.384 NM_021083
XK
X-linked Kx blood group (McLeod syndrome)
chr7_+_44207131 0.383 YKT6
YKT6 v-SNARE homolog (S. cerevisiae)
chr1_-_207891264 0.382 NM_001017402
LAMB3
laminin, beta 3
chr4_-_84475328 0.377 NM_001166498
NM_006665
HPSE

heparanase

chr16_-_65751263 0.376 TRADD
TNFRSF1A-associated via death domain
chr1_+_26479208 0.370 SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
chr17_-_73694669 0.369 NM_003258
TK1
thymidine kinase 1, soluble
chr1_-_28113540 0.368 RPA2
replication protein A2, 32kDa
chr8_+_32623792 0.367 NM_013959
NRG1
neuregulin 1
chr19_-_54005916 0.363 NM_001164773
NM_001190
BCAT2

branched chain amino-acid transaminase 2, mitochondrial

chr17_+_37694007 0.361 STAT5A
signal transducer and activator of transcription 5A
chrX_+_109132994 0.360 NM_032227
TMEM164
transmembrane protein 164
chr17_+_5914364 0.360 NM_015253
WSCD1
WSC domain containing 1
chr9_-_129656413 0.358 ENG
endoglin
chrX_-_134013644 0.358 NM_001078172
NM_001134321
FAM127B

family with sequence similarity 127, member B

chr6_+_30402203 0.358


chr1_-_181871508 0.355 NM_005717
ARPC5
actin related protein 2/3 complex, subunit 5, 16kDa
chr8_-_126173186 0.348 KIAA0196
KIAA0196
chr7_+_44207080 0.346 YKT6
YKT6 v-SNARE homolog (S. cerevisiae)
chr9_-_125732005 0.345 NM_020946
NM_024820
DENND1A

DENN/MADD domain containing 1A

chr6_-_13594965 0.344 GFOD1
glucose-fructose oxidoreductase domain containing 1
chr16_-_65751305 0.342 NM_003789
TRADD
TNFRSF1A-associated via death domain
chr10_-_1092643 0.342 IDI1
isopentenyl-diphosphate delta isomerase 1
chr7_+_115637795 0.341 NM_015641
TES
testis derived transcript (3 LIM domains)
chr9_+_134843918 0.339 NM_001135031
NM_004188
GFI1B

growth factor independent 1B transcription repressor

chr6_+_76515690 0.338 MYO6
myosin VI
chr10_+_8137356 0.338 GATA3
GATA binding protein 3
chr1_-_181871490 0.337 ARPC5
actin related protein 2/3 complex, subunit 5, 16kDa
chr1_+_149521364 0.334 NM_020832
ZNF687
zinc finger protein 687
chr15_-_73818013 0.333


chr8_-_126173108 0.331 KIAA0196
KIAA0196
chr11_-_605649 0.330 NM_004031
IRF7
interferon regulatory factor 7
chr1_-_181871473 0.330 ARPC5
actin related protein 2/3 complex, subunit 5, 16kDa
chr1_-_109386112 0.329 NM_001142550
NM_001142551
NM_014969
WDR47


WD repeat domain 47


chr8_-_126173203 0.329 KIAA0196
KIAA0196
chr17_+_71229110 0.328 NM_000213
NM_001005731
ITGB4

integrin, beta 4

chr5_-_37406835 0.325 NUP155
nucleoporin 155kDa
chr13_+_57105859 0.325 PCDH17
protocadherin 17
chr1_-_181871447 0.324 ARPC5
actin related protein 2/3 complex, subunit 5, 16kDa
chr1_+_26478799 0.318 NM_031286
SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
chr8_-_126173189 0.317 KIAA0196
KIAA0196
chr8_+_102574012 0.315 GRHL2
grainyhead-like 2 (Drosophila)
chr1_-_181871462 0.314 ARPC5
actin related protein 2/3 complex, subunit 5, 16kDa
chr8_-_126173227 0.313 NM_014846
KIAA0196
KIAA0196
chr14_-_66948523 0.311 NM_016445
PLEK2
pleckstrin 2
chr12_+_4300607 0.309 NM_020375
C12orf5
chromosome 12 open reading frame 5
chr1_+_222611173 0.309 CNIH4
cornichon homolog 4 (Drosophila)
chr5_-_37406643 0.308 NM_004298
NUP155
nucleoporin 155kDa
chr12_+_32723539 0.307 DNM1L
dynamin 1-like
chr9_+_139202874 0.307 NM_003731
SSNA1
Sjogren syndrome nuclear autoantigen 1
chr16_+_43827 0.306 NM_024571
SNRNP25
small nuclear ribonucleoprotein 25kDa (U11/U12)
chr7_+_115926855 0.306 CAV2
caveolin 2
chr3_-_109423858 0.306 NM_018010
IFT57
intraflagellar transport 57 homolog (Chlamydomonas)
chr16_+_43892 0.305 SNRNP25
small nuclear ribonucleoprotein 25kDa (U11/U12)
chrX_-_100801472 0.304 NM_014782
NM_177949
ARMCX2

armadillo repeat containing, X-linked 2

chr1_+_222611213 0.303 NM_014184
CNIH4
cornichon homolog 4 (Drosophila)
chr3_+_20056527 0.302 NM_003884
KAT2B
K(lysine) acetyltransferase 2B
chr19_-_14177980 0.301 NM_001008701
NM_014921
LPHN1

latrophilin 1

chr16_+_11966464 0.300 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr12_+_51931636 0.299 NM_001170790
MFSD5
major facilitator superfamily domain containing 5
chr1_+_222611220 0.298 CNIH4
cornichon homolog 4 (Drosophila)
chr13_+_76464044 0.298 NM_006493
CLN5
ceroid-lipofuscinosis, neuronal 5
chr2_+_102345528 0.297 NM_003855
IL18R1
interleukin 18 receptor 1
chr3_+_11171213 0.297 NM_001098212
HRH1
histamine receptor H1
chr1_-_181871416 0.296 ARPC5
actin related protein 2/3 complex, subunit 5, 16kDa
chr12_-_48963505 0.294 NM_001113546
NM_016357
LIMA1

LIM domain and actin binding 1

chr11_+_125000245 0.293 NM_001114121
NM_001114122
CHEK1

CHK1 checkpoint homolog (S. pombe)

chr19_-_52045890 0.292 NM_004069
NM_021575
AP2S1

adaptor-related protein complex 2, sigma 1 subunit

chr20_+_43236953 0.290 NM_002638
PI3
peptidase inhibitor 3, skin-derived
chr7_+_50314801 0.289 NM_006060
IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr12_-_56447090 0.288 NM_000785
CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chr11_-_67032675 0.285 NM_005851
CDK2AP2
cyclin-dependent kinase 2 associated protein 2
chr7_+_12693435 0.284 NM_001195396
NM_005738
ARL4A

ADP-ribosylation factor-like 4A

chr22_-_37598176 0.284 NM_014292
CBX6
chromobox homolog 6
chr19_-_11352850 0.283 EPOR
erythropoietin receptor
chr16_+_43859 0.281 SNRNP25
small nuclear ribonucleoprotein 25kDa (U11/U12)
chr19_+_62443863 0.279 NM_001023563
NM_001145078
ZNF805

zinc finger protein 805

chr4_+_40953652 0.279 NM_004181
UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr22_-_37598115 0.276 CBX6
chromobox homolog 6
chr12_+_103374771 0.276 NM_001173982
NM_018413
CHST11

carbohydrate (chondroitin 4) sulfotransferase 11

chr3_-_191321601 0.274 NM_018192
LEPREL1
leprecan-like 1
chr11_-_63770716 0.273 PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr4_-_145281237 0.271 NM_002099
GYPA
glycophorin A (MNS blood group)
chr22_-_37598160 0.270 CBX6
chromobox homolog 6
chr1_+_153213771 0.269 CKS1B
CDC28 protein kinase regulatory subunit 1B
chr1_-_222584426 0.269 NM_002533
NM_206840
NVL

nuclear VCP-like

chr6_-_31658044 0.268 NM_002341
NM_009588
LTB

lymphotoxin beta (TNF superfamily, member 3)

chr4_+_75529716 0.267 NM_001657
AREG
amphiregulin
chr5_-_168660293 0.267 NM_003062
SLIT3
slit homolog 3 (Drosophila)
chr5_+_96024434 0.266 CAST
calpastatin
chr6_+_89912464 0.265 NM_001010853
PM20D2
peptidase M20 domain containing 2
chr15_-_66900266 0.265 ANP32A
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
chr7_-_37454933 0.265 NM_014800
ELMO1
engulfment and cell motility 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.37 9.91e-04 GO:0030154 cell differentiation
1.34 3.70e-03 GO:0048869 cellular developmental process
1.58 5.21e-03 GO:2000026 regulation of multicellular organismal development
1.65 1.25e-02 GO:0055086 nucleobase, nucleoside and nucleotide metabolic process
1.33 1.48e-02 GO:0048513 organ development
1.29 1.89e-02 GO:0048519 negative regulation of biological process
1.71 1.95e-02 GO:0051094 positive regulation of developmental process
1.21 2.25e-02 GO:0023052 signaling
1.30 2.32e-02 GO:0048523 negative regulation of cellular process
1.76 2.32e-02 GO:0006163 purine nucleotide metabolic process
1.71 2.70e-02 GO:0072521 purine-containing compound metabolic process
1.66 2.73e-02 GO:0006753 nucleoside phosphate metabolic process
1.66 2.73e-02 GO:0009117 nucleotide metabolic process
1.18 3.16e-02 GO:0032501 multicellular organismal process
1.25 3.74e-02 GO:0048518 positive regulation of biological process
1.47 4.53e-02 GO:0050793 regulation of developmental process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.24 1.80e-04 GO:0005886 plasma membrane
1.24 1.82e-04 GO:0071944 cell periphery

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.11 4.40e-02 GO:0005515 protein binding