Motif ID: FOXD3.p2

Z-value: 1.631


Transcription factors associated with FOXD3.p2:

Gene SymbolEntrez IDGene Name
FOXD3 27022 forkhead box D3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOXD3chr1_+_635613170.292.8e-01Click!


Activity profile for motif FOXD3.p2.

activity profile for motif FOXD3.p2


Sorted Z-values histogram for motif FOXD3.p2

Sorted Z-values for motif FOXD3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXD3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_+_67235651 4.858 NM_001793
CDH3
cadherin 3, type 1, P-cadherin (placental)
chr18_+_27281729 3.715 NM_001944
DSG3
desmoglein 3
chr8_+_54926920 3.417 NM_170587
RGS20
regulator of G-protein signaling 20
chr20_+_19818209 2.722 NM_018993
RIN2
Ras and Rab interactor 2
chr4_+_89519004 2.592 HERC6
hect domain and RLD 6
chr1_+_181421796 2.354 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr3_-_191321367 2.336 LEPREL1
leprecan-like 1
chr4_+_89518898 2.252 NM_001165136
NM_017912
HERC6

hect domain and RLD 6

chr10_+_47875229 1.992 NM_001040084
NM_001098845
ANXA8L2
ANXA8
ANXA8L1
annexin A8-like 2
annexin A8
annexin A8-like 1
chr10_+_47216925 1.979 NM_001630
ANXA8L2
ANXA8
annexin A8-like 2
annexin A8
chr10_-_46593923 1.947 NM_001040084
NM_001098845
ANXA8L2
LOC653110
ANXA8
ANXA8L1
annexin A8-like 2
hypothetical LOC653110
annexin A8
annexin A8-like 1
chr3_-_191321601 1.943 NM_018192
LEPREL1
leprecan-like 1
chr7_-_87687276 1.941 SRI
sorcin
chr14_-_60818263 1.922 NM_001017970
TMEM30B
transmembrane protein 30B
chr19_-_4289750 1.784 NM_001013841
NM_017720
STAP2

signal transducing adaptor family member 2

chr4_-_153523113 1.751 NM_001013415
FBXW7
F-box and WD repeat domain containing 7
chr20_+_19863716 1.746 RIN2
Ras and Rab interactor 2
chr3_+_123526700 1.741 NM_005213
CSTA
cystatin A (stefin A)
chr1_+_218768170 1.737 NM_018650
MARK1
MAP/microtubule affinity-regulating kinase 1
chr18_-_46068689 1.735 NM_001101654
NM_014593
CXXC1

CXXC finger protein 1

chr22_+_43527101 1.734 NM_001017526
NM_001198726
NM_181335
ARHGAP8


Rho GTPase activating protein 8


chr4_-_90978469 1.731 NM_001146055
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr21_+_38550739 1.688 NM_170736
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr3_+_195336625 1.673 NM_005524
HES1
hairy and enhancer of split 1, (Drosophila)
chr12_+_27066749 1.604 NM_004264
MED21
mediator complex subunit 21
chr18_+_59405513 1.602 NM_012397
SERPINB13
serpin peptidase inhibitor, clade B (ovalbumin), member 13
chr20_-_14266200 1.557 NM_013281
NM_198391
FLRT3

fibronectin leucine rich transmembrane protein 3

chr12_-_28016182 1.549 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr12_+_27066768 1.532 MED21
mediator complex subunit 21
chr5_+_96237923 1.498 ERAP2
endoplasmic reticulum aminopeptidase 2
chr17_+_7883076 1.481 NM_001039130
NM_001039131
NM_001141
ALOX15B


arachidonate 15-lipoxygenase, type B


chr18_+_59571256 1.460 NM_001040147
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr9_-_99974994 1.456 NM_003389
CORO2A
coronin, actin binding protein, 2A
chr18_+_59705918 1.402 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr8_-_81155564 1.396 NM_001025252
TPD52
tumor protein D52
chr1_-_168310232 1.333 NM_014970
KIFAP3
kinesin-associated protein 3
chr2_-_85490997 1.325 NM_001747
CAPG
capping protein (actin filament), gelsolin-like
chr22_+_21384862 1.325 IGLV3-21
IGLJ3
IGLC1
immunoglobulin lambda variable 3-21
immunoglobulin lambda joining 3
immunoglobulin lambda constant 1 (Mcg marker)
chr6_+_121798443 1.310 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr3_-_15357878 1.285 NM_001018009
SH3BP5
SH3-domain binding protein 5 (BTK-associated)
chr19_-_4782711 1.268 NM_182919
TICAM1
toll-like receptor adaptor molecule 1
chr12_+_51628921 1.233 NM_199187
NM_000224
KRT18

keratin 18

chr7_-_87687302 1.197 NM_003130
SRI
sorcin
chr12_+_46799279 1.196 NM_000289
PFKM
phosphofructokinase, muscle
chr3_+_195336631 1.184 HES1
hairy and enhancer of split 1, (Drosophila)
chr17_-_26665213 1.172 EVI2B
ecotropic viral integration site 2B
chr6_+_150304813 1.167 NM_025217
ULBP2
UL16 binding protein 2
chr9_+_74956601 1.167 ANXA1
annexin A1
chr9_+_74956494 1.165 NM_000700
ANXA1
annexin A1
chr4_-_103485600 1.153 NM_001135146
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr12_+_32723539 1.146 DNM1L
dynamin 1-like
chr1_-_159275334 1.141 TSTD1
thiosulfate sulfurtransferase (rhodanese)-like domain containing 1
chr1_+_13784553 1.139 NM_001006624
NM_001006625
PDPN

podoplanin

chr2_-_218739891 1.131 NM_000634
CXCR1
chemokine (C-X-C motif) receptor 1
chr2_-_160765008 1.131 ITGB6
integrin, beta 6
chr6_+_83129641 1.117 NM_006670
TPBG
trophoblast glycoprotein
chr6_-_159160386 1.108 EZR
ezrin
chr15_-_61461127 1.106 NM_001218
NM_206925
CA12

carbonic anhydrase XII

chr1_-_42738535 1.101 TMSB4XP1
thymosin beta 4, X-linked pseudogene 1
chr15_-_61460967 1.095 CA12
carbonic anhydrase XII
chr6_-_159160387 1.095 EZR
ezrin
chr9_+_74956614 1.094 ANXA1
annexin A1
chr17_-_26665220 1.093 NM_006495
EVI2B
ecotropic viral integration site 2B
chr19_-_11550765 1.091 NM_001111035
NM_001111036
ACP5

acid phosphatase 5, tartrate resistant

chr17_-_26665144 1.073 EVI2B
ecotropic viral integration site 2B
chr12_+_32723476 1.067 DNM1L
dynamin 1-like
chr19_+_12995782 1.064 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr17_-_46296376 1.061 NM_005749
TOB1
transducer of ERBB2, 1
chr10_-_126839000 1.030 CTBP2
C-terminal binding protein 2
chr4_-_103464491 1.006 NM_001135148
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr5_+_140227951 1.001 NM_018902
NM_031861
PCDHA11

protocadherin alpha 11

chr3_-_127810087 0.999 NM_001039783
TXNRD3IT1
thioredoxin reductase 3 intronic transcript 1
chr18_-_59480082 0.997 NM_006919
SERPINB3
SERPINB4
serpin peptidase inhibitor, clade B (ovalbumin), member 3
serpin peptidase inhibitor, clade B (ovalbumin), member 4
chr6_-_159160355 0.986 EZR
ezrin
chr2_-_215605054 0.977 NM_015657
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12
chr16_+_80370400 0.976 PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr12_+_53178834 0.976 NM_001184976
NCKAP1L
NCK-associated protein 1-like
chr14_+_31868229 0.971 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6
chr3_+_143858428 0.946 NM_001172312
PLS1
plastin 1
chr11_+_67107852 0.945 GSTP1
glutathione S-transferase pi 1
chr3_-_112796855 0.930 NM_024508
ZBED2
zinc finger, BED-type containing 2
chr8_+_66744659 0.928 NM_001145838
MTFR1
mitochondrial fission regulator 1
chr6_-_159160421 0.914 NM_001111077
EZR
ezrin
chr10_+_124135574 0.907 NM_001195608
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr6_+_7486862 0.904 NM_001008844
NM_004415
DSP

desmoplakin

chr7_+_26298136 0.899 SNX10
sorting nexin 10
chr12_+_32723395 0.896 NM_005690
NM_012062
NM_012063
DNM1L


dynamin 1-like


chr2_-_170138558 0.895 NM_024622
FASTKD1
FAST kinase domains 1
chr15_-_70288071 0.895 PKM2
pyruvate kinase, muscle
chr1_+_239762179 0.887 NM_003679
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr17_-_26665194 0.884 EVI2B
ecotropic viral integration site 2B
chr6_+_7486836 0.883 DSP
desmoplakin
chr12_-_15005761 0.880 NM_001175
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr6_+_7486891 0.877 DSP
desmoplakin
chr1_-_159275357 0.846 NM_001113205
NM_001113206
NM_001113207
TSTD1


F11R
thiosulfate sulfurtransferase (rhodanese)-like domain containing 1


F11 receptor
chr11_-_107969554 0.837 NM_015065
EXPH5
exophilin 5
chr13_-_40491491 0.837 NM_172373
ELF1
E74-like factor 1 (ets domain transcription factor)
chr12_-_44919818 0.834 SLC38A1
solute carrier family 38, member 1
chr3_+_190990142 0.833 NM_001114980
NM_001114981
NM_001114982
TP63


tumor protein p63


chr7_-_16471817 0.831 NM_015464
SOSTDC1
sclerostin domain containing 1
chr19_+_45973139 0.824 NM_006533
MIA
melanoma inhibitory activity
chr6_-_136889302 0.822 MAP7
microtubule-associated protein 7
chr1_+_13782838 0.801 NM_006474
NM_198389
PDPN

podoplanin

chr14_+_66901237 0.796 EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr3_+_137224266 0.789 NM_181897
PPP2R3A
protein phosphatase 2, regulatory subunit B'', alpha
chr8_-_110724594 0.779 NM_001099756
SYBU
syntabulin (syntaxin-interacting)
chrX_+_123062143 0.768 STAG2
stromal antigen 2
chr19_+_3087026 0.760 NM_002068
GNA15
guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
chr14_-_98807574 0.754 NM_022898
NM_138576
BCL11B

B-cell CLL/lymphoma 11B (zinc finger protein)

chr4_+_146250978 0.753 ABCE1
ATP-binding cassette, sub-family E (OABP), member 1
chr1_+_34993234 0.751 NM_005268
GJB5
gap junction protein, beta 5, 31.1kDa
chr16_+_67328693 0.748 NM_004360
CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr19_-_14853166 0.740 NM_030901
OR7A17
olfactory receptor, family 7, subfamily A, member 17
chr4_-_123596921 0.735 NM_000586
IL2
interleukin 2
chr21_+_38550533 0.735 NM_002243
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr18_+_59593591 0.734 NM_003784
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr8_-_110726921 0.733 NM_001099751
NM_001099752
SYBU

syntabulin (syntaxin-interacting)

chr12_-_44877769 0.729 SLC38A1
solute carrier family 38, member 1
chr19_+_11061037 0.726 NM_000527
NM_001195798
NM_001195799
NM_001195800
NM_001195802
NM_001195803
LDLR





low density lipoprotein receptor





chr15_+_92642433 0.721 NM_001159643
NM_018349
MCTP2

multiple C2 domains, transmembrane 2

chr15_-_53349775 0.719 NM_183234
NM_004580
RAB27A

RAB27A, member RAS oncogene family

chr3_+_123256902 0.712 NM_175862
CD86
CD86 molecule
chr19_-_48977247 0.709 NM_002250
KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr9_-_109291866 0.701 NM_004235
KLF4
Kruppel-like factor 4 (gut)
chr5_+_159546951 0.701 NM_001130958
FABP6
fatty acid binding protein 6, ileal
chr1_+_74473672 0.690 NM_015978
TNNI3K
TNNI3 interacting kinase
chr10_-_98021144 0.686 NM_001114094
NM_013314
BLNK

B-cell linker

chr11_+_67107641 0.685 NM_000852
GSTP1
glutathione S-transferase pi 1
chr4_+_3285671 0.680 NM_002926
NM_198229
RGS12

regulator of G-protein signaling 12

chr1_+_86662356 0.666 NM_006536
CLCA2
chloride channel accessory 2
chr13_-_98708549 0.661 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chr19_-_14646626 0.646 NM_032571
EMR3
egf-like module containing, mucin-like, hormone receptor-like 3
chr9_+_78305368 0.643 NM_001097636
GCNT1
glucosaminyl (N-acetyl) transferase 1, core 2
chr21_-_42219849 0.638 NM_199050
C2CD2
C2 calcium-dependent domain containing 2
chr1_-_151630168 0.638 NM_002964
S100A8
S100 calcium binding protein A8
chr3_-_191322919 0.635 NM_001134418
LEPREL1
leprecan-like 1
chr8_+_133060353 0.635 EFR3A
EFR3 homolog A (S. cerevisiae)
chr3_-_198784590 0.627 NM_203315
BDH1
3-hydroxybutyrate dehydrogenase, type 1
chr12_+_52696908 0.626 NM_014620
NM_153693
HOXC4
HOXC6
homeobox C4
homeobox C6
chr13_-_98757634 0.626 NM_004951
GPR183
G protein-coupled receptor 183
chr11_-_87710549 0.617 CTSC
cathepsin C
chr18_-_59462469 0.617 NM_002974
SERPINB4
serpin peptidase inhibitor, clade B (ovalbumin), member 4
chr11_-_87710488 0.616 CTSC
cathepsin C
chr18_-_3864252 0.610 DLGAP1
discs, large (Drosophila) homolog-associated protein 1
chr2_-_72228427 0.610 NM_019885
CYP26B1
cytochrome P450, family 26, subfamily B, polypeptide 1
chr9_-_14076901 0.609 NFIB
nuclear factor I/B
chr4_+_75449720 0.603 NM_001432
EREG
epiregulin
chr11_+_125678856 0.600 NM_014026
DCPS
decapping enzyme, scavenger
chr5_+_140790141 0.595 PCDHGA12
protocadherin gamma subfamily A, 12
chr5_+_173405298 0.592 NM_015980
HMP19
HMP19 protein
chr5_+_161427225 0.592 NM_000816
NM_198903
NM_198904
GABRG2


gamma-aminobutyric acid (GABA) A receptor, gamma 2


chr16_+_67328715 0.592 CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chrX_-_114158388 0.592 NM_000640
IL13RA2
interleukin 13 receptor, alpha 2
chr15_-_53350383 0.591 NM_183236
RAB27A
RAB27A, member RAS oncogene family
chr1_-_151352587 0.590 NM_001014450
SPRR2A
SPRR2F
small proline-rich protein 2A
small proline-rich protein 2F
chr1_+_15637521 0.583 NM_007272
CTRC
chymotrypsin C (caldecrin)
chr6_+_26609427 0.582 NM_001732
BTN1A1
butyrophilin, subfamily 1, member A1
chr1_-_158948176 0.578 NM_001778
CD48
CD48 molecule
chr1_-_149245503 0.577 NM_001163259
NM_001163260
NM_001040217
FAM63A


family with sequence similarity 63, member A


chr3_+_62280435 0.577 NM_020685
C3orf14
chromosome 3 open reading frame 14
chr21_+_39117064 0.576 ETS2
v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
chr13_-_40491405 0.575 ELF1
E74-like factor 1 (ets domain transcription factor)
chr1_-_150564302 0.575 NM_002016
FLG
filaggrin
chr1_-_114231519 0.571 BCL2L15
BCL2-like 15
chr6_-_38778807 0.570 GLO1
glyoxalase I
chr1_+_150753601 0.566 NM_019060
CRCT1
cysteine-rich C-terminal 1
chr15_+_92700167 0.566 NM_001159644
MCTP2
multiple C2 domains, transmembrane 2
chr3_-_171070314 0.565 NM_024727
LRRC31
leucine rich repeat containing 31
chr2_-_121759237 0.556 NM_014553
TFCP2L1
transcription factor CP2-like 1
chr9_+_101717278 0.555 STX17
syntaxin 17
chr9_-_109291575 0.553 KLF4
Kruppel-like factor 4 (gut)
chr22_-_41366550 0.552 NM_001165877
ATP5L2
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G2
chr8_+_104900591 0.551 NM_014677
RIMS2
regulating synaptic membrane exocytosis 2
chr15_-_64436045 0.551 NM_017858
TIPIN
TIMELESS interacting protein
chr19_+_977271 0.537 NM_004368
NM_201277
CNN2

calponin 2

chrM_-_8294 0.533 FTH1
ferritin, heavy polypeptide 1
chr6_-_32892705 0.533 NM_002120
HLA-DOB
major histocompatibility complex, class II, DO beta
chr12_+_55201854 0.526 NM_002898
RBMS2
RNA binding motif, single stranded interacting protein 2
chr1_-_195818927 0.525 DENND1B
DENN/MADD domain containing 1B
chr6_-_123999640 0.524 NM_006073
TRDN
triadin
chr12_+_13240987 0.522 EMP1
epithelial membrane protein 1
chr2_-_160764819 0.516 NM_000888
ITGB6
integrin, beta 6
chr3_+_190831909 0.511 NM_001114978
NM_001114979
NM_003722
TP63


tumor protein p63


chr12_-_10042956 0.509 NM_001099431
NM_016509
CLEC1B

C-type lectin domain family 1, member B

chr2_+_47449951 0.507 EPCAM
epithelial cell adhesion molecule
chr18_+_27152049 0.503 NM_001942
DSG1
desmoglein 1
chr15_+_56217686 0.502 NM_020980
AQP9
aquaporin 9
chr11_-_17147863 0.498 NM_002645
PIK3C2A
phosphoinositide-3-kinase, class 2, alpha polypeptide
chr21_+_36364168 0.496 CBR1
carbonyl reductase 1
chr21_+_36364091 0.491 NM_001757
CBR1
carbonyl reductase 1
chr18_-_26935883 0.489 NM_004949
NM_024422
DSC2

desmocollin 2

chr21_+_41719847 0.486 NM_002462
NM_001178046
MX1

myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)

chrX_+_100241453 0.486 NM_006733
CENPI
centromere protein I
chr16_+_29734990 0.482 NM_024516
C16orf53
chromosome 16 open reading frame 53
chr13_-_36577800 0.480 NM_145203
CSNK1A1L
casein kinase 1, alpha 1-like
chr2_+_165858586 0.479 NM_021007
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr12_+_12935222 0.477 NM_003979
GPRC5A
G protein-coupled receptor, family C, group 5, member A
chr1_-_27353987 0.476 NM_003047
SLC9A1
solute carrier family 9 (sodium/hydrogen exchanger), member 1
chr6_+_30402203 0.473


chr2_-_215711313 0.473 NM_173076
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.45 1.09e-05 GO:0007156 homophilic cell adhesion
1.31 2.43e-02 GO:0002376 immune system process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.18 5.31e-04 GO:0071944 cell periphery
1.18 6.58e-04 GO:0005886 plasma membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.53 2.35e-04 GO:0005509 calcium ion binding
3.07 1.59e-03 GO:0003823 antigen binding