Motif ID: NKX2-1,4.p2

Z-value: 0.727


Transcription factors associated with NKX2-1,4.p2:

Gene SymbolEntrez IDGene Name
NKX2-1 7080 NK2 homeobox 1
NKX2-4 644524 NK2 homeobox 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX2-1chr14_-_360586480.361.7e-01Click!


Activity profile for motif NKX2-1,4.p2.

activity profile for motif NKX2-1,4.p2


Sorted Z-values histogram for motif NKX2-1,4.p2

Sorted Z-values for motif NKX2-1,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-1,4.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_11966464 3.080 NM_001192
 TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr21_-_14840506 2.546 NM_022136
 SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chrX_+_78087484 2.221 NM_014499
NM_198333
 P2RY10

purinergic receptor P2Y, G-protein coupled, 10

chr17_-_26665213 1.737 EVI2B
ecotropic viral integration site 2B
chrX_-_154216929 1.684 NM_001289
 CLIC2
chloride intracellular channel 2
chr17_-_26665220 1.561 NM_006495
 EVI2B
ecotropic viral integration site 2B
chr17_-_26665144 1.351 EVI2B
ecotropic viral integration site 2B
chrX_+_48427103 1.256 NM_000377
 WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr11_+_59979857 1.246 NM_021950
NM_152866
 MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr1_+_32489426 0.982 NM_005356
 LCK
lymphocyte-specific protein tyrosine kinase
chr5_-_88155360 0.876 NM_001193348
NM_001193349
 MEF2C

myocyte enhancer factor 2C

chr12_-_51887266 0.795 NM_000889
 ITGB7
integrin, beta 7
chr19_-_6621598 0.762 NM_003807
NM_172014
 TNFSF14

tumor necrosis factor (ligand) superfamily, member 14

chr17_-_26665194 0.755 EVI2B
ecotropic viral integration site 2B
chr19_-_6621078 0.753 TNFSF14
tumor necrosis factor (ligand) superfamily, member 14
chr2_-_88946767 0.743


chr7_-_7724762 0.690 NM_002947
 RPA3
replication protein A3, 14kDa
chr3_-_143230124 0.686 NM_001178141
NM_001178142
NM_006286
 TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr11_+_22646229 0.684 NM_177553
 GAS2
growth arrest-specific 2
chr1_-_158948176 0.642 NM_001778
 CD48
CD48 molecule

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 11 of 11 entries
enrichment   p-value GO term description
10.33 5.22e-03 GO:0046651 lymphocyte proliferation
9.69 8.30e-03 GO:0032943 mononuclear cell proliferation
9.39 1.03e-02 GO:0070661 leukocyte proliferation
6.81 2.57e-03 GO:0042113 B cell activation
5.24 2.08e-06 GO:0046649 lymphocyte activation
4.41 1.87e-05 GO:0045321 leukocyte activation
2.84 1.66e-03 GO:0001775 cell activation
1.78 8.60e-03 GO:0048513 organ development
1.66 2.54e-02 GO:0065008 regulation of biological quality
1.42 7.23e-03 GO:0032501 multicellular organismal process
1.35 1.47e-02 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

Showing 1 to 4 of 4 entries
enrichment   p-value GO term description
4.34 2.11e-02 GO:0031968 organelle outer membrane
4.18 2.92e-02 GO:0019867 outer membrane
1.42 2.77e-02 GO:0005886 plasma membrane
1.40 4.85e-02 GO:0071944 cell periphery

Gene overrepresentation in function category:

Showing 1 to 3 of 3 entries
enrichment   p-value GO term description
1.81 3.45e-02 GO:0004872 receptor activity
1.70 3.15e-02 GO:0004871 signal transducer activity
1.70 3.15e-02 GO:0060089 molecular transducer activity