Motif ID: FOXL1.p2

Z-value: 1.431


Transcription factors associated with FOXL1.p2:

Gene SymbolEntrez IDGene Name
FOXL1 2300 forkhead box L1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOXL1chr16_+_85169615-0.332.1e-01Click!


Activity profile for motif FOXL1.p2.

activity profile for motif FOXL1.p2


Sorted Z-values histogram for motif FOXL1.p2

Sorted Z-values for motif FOXL1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXL1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_74488947 8.985 ALB
albumin
chr4_+_74488835 8.722 NM_000477
ALB
albumin
chr7_+_45899080 8.672 IGFBP1
insulin-like growth factor binding protein 1
chr4_+_74488910 8.313 ALB
albumin
chr7_+_45899621 7.188


chr4_+_74498042 6.715 ALB
albumin
chr10_+_63331018 5.834 NM_032199
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr4_-_84254912 5.572 PLAC8
placenta-specific 8
chr4_-_84254932 4.410 NM_001130715
NM_016619
PLAC8

placenta-specific 8

chr4_-_84254873 4.362 PLAC8
placenta-specific 8
chr4_+_74493174 4.236 ALB
albumin
chr3_-_150422474 3.771 NM_000096
CP
ceruloplasmin (ferroxidase)
chr4_-_110942576 3.668 CFI
complement factor I
chr1_-_159459999 3.558 NM_001643
APOA2
apolipoprotein A-II
chr1_+_181380837 3.529 LAMC1
laminin, gamma 1 (formerly LAMB2)
chr3_-_78749633 3.337 ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr5_-_111119846 3.128 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr4_+_74493331 2.961 ALB
albumin
chr1_-_159459814 2.759 APOA2
apolipoprotein A-II
chr4_+_74493918 2.756 ALB
albumin
chr4_+_74497998 2.692 ALB
albumin
chr12_-_9123126 2.534 A2M
alpha-2-macroglobulin
chr14_+_20226762 2.447 NM_001097577
NM_194431
ANG
RNASE4
angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family, 4
chr4_+_74493266 2.392 ALB
albumin
chr4_+_155703581 2.313 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr17_-_26665213 2.289 EVI2B
ecotropic viral integration site 2B
chr13_+_75232797 2.241 NM_015842
LMO7
LIM domain 7
chr13_-_47885248 2.142 LPAR6
lysophosphatidic acid receptor 6
chr4_-_155753207 2.122 FGG
fibrinogen gamma chain
chr4_-_155753332 2.084 NM_000509
NM_021870
FGG

fibrinogen gamma chain

chr4_-_155753249 2.061 FGG
fibrinogen gamma chain
chr17_-_53847937 2.048 RNF43
ring finger protein 43
chr4_-_71751070 2.029 IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr4_-_155753287 1.986 FGG
fibrinogen gamma chain
chrM_+_12283 1.981


chr4_-_155753272 1.951 FGG
fibrinogen gamma chain
chr11_+_7574992 1.914 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr13_-_47885018 1.906 LPAR6
lysophosphatidic acid receptor 6
chr19_+_44591589 1.847


chr1_-_228916486 1.789 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr4_-_71751205 1.786 NM_144646
IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr4_-_110942783 1.774 NM_000204
CFI
complement factor I
chr2_-_98646367 1.770 NM_001160154
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr17_-_26665220 1.724 NM_006495
EVI2B
ecotropic viral integration site 2B
chr10_-_98021144 1.654 NM_001114094
NM_013314
BLNK

B-cell linker

chr14_-_94669547 1.648 NM_001195573
DICER1
dicer 1, ribonuclease type III
chr17_-_26665194 1.633 EVI2B
ecotropic viral integration site 2B
chr1_-_167822334 1.594 NM_000130
F5
coagulation factor V (proaccelerin, labile factor)
chr13_-_45577144 1.560 NM_001872
NM_016413
CPB2

carboxypeptidase B2 (plasma)

chr3_-_116272911 1.551 NM_001164343
ZBTB20
zinc finger and BTB domain containing 20
chr19_-_62028185 1.545 NM_001146186
PEG3
paternally expressed 3
chr13_-_47885653 1.528 NM_001162498
LPAR6
lysophosphatidic acid receptor 6
chr10_-_116434364 1.516 NM_001003407
NM_001003408
ABLIM1

actin binding LIM protein 1

chr10_-_52315436 1.456 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr17_-_26665144 1.453 EVI2B
ecotropic viral integration site 2B
chr3_-_188946168 1.450 NM_001706
BCL6
B-cell CLL/lymphoma 6
chr10_-_116434102 1.393 ABLIM1
actin binding LIM protein 1
chr1_-_27113018 1.383 NM_021969
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr4_+_74499651 1.315 ALB
albumin
chr12_-_9159780 1.305 A2M
alpha-2-macroglobulin
chr15_+_22772545 1.299 SNRPN
small nuclear ribonucleoprotein polypeptide N
chr1_-_85816520 1.297 NM_001134445
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr16_+_70646008 1.281 NM_001126102
NM_005143
HP

haptoglobin

chr1_-_167822248 1.275 F5
coagulation factor V (proaccelerin, labile factor)
chr3_+_134976965 1.236 TF
transferrin
chr2_-_88208650 1.235 NM_001443
FABP1
fatty acid binding protein 1, liver
chr12_-_9159789 1.159 NM_000014
A2M
alpha-2-macroglobulin
chr4_+_74491272 1.150 ALB
albumin
chr5_+_92944680 1.149 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr5_+_156628929 1.126 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr5_-_42847716 1.124 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr11_-_114593838 1.111 CADM1
cell adhesion molecule 1
chr9_-_122852356 1.067 NM_001735
C5
complement component 5
chr6_-_152542293 1.034 NM_133650
SYNE1
spectrin repeat containing, nuclear envelope 1
chr3_-_124821868 1.028 MYLK
myosin light chain kinase
chr17_-_23721468 1.026 VTN
vitronectin
chr15_-_74963246 1.025 NM_020843
SCAPER
S-phase cyclin A-associated protein in the ER
chr3_-_150578207 1.024 NM_014220
TM4SF1
transmembrane 4 L six family member 1
chr2_+_33514896 1.017 NM_170672
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr20_+_30160952 1.013 NM_014742
TM9SF4
transmembrane 9 superfamily protein member 4
chr10_+_101532450 1.011 NM_000392
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr2_+_189547323 1.010 NM_000090
COL3A1
collagen, type III, alpha 1
chr1_-_228916470 0.991 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr1_+_190811479 0.989 NM_002922
RGS1
regulator of G-protein signaling 1
chr1_-_20682541 0.970


chr12_-_9159707 0.968 A2M
alpha-2-macroglobulin
chr3_-_12916547 0.964 IQSEC1
IQ motif and Sec7 domain 1
chr4_+_155707089 0.963 FGB
fibrinogen beta chain
chr4_+_71096830 0.962 NM_017855
ODAM
odontogenic, ameloblast asssociated
chr9_-_36365965 0.959 RNF38
ring finger protein 38
chr10_-_116408046 0.949 NM_002313
ABLIM1
actin binding LIM protein 1
chr9_+_79158164 0.941 VPS13A
vacuolar protein sorting 13 homolog A (S. cerevisiae)
chr12_-_9159742 0.940 A2M
alpha-2-macroglobulin
chr15_-_78050515 0.935 NM_001114735
NM_004049
BCL2A1

BCL2-related protein A1

chr14_+_20319049 0.924 NM_005615
RNASE6
ribonuclease, RNase A family, k6
chr8_+_40130143 0.905 NM_020130
C8orf4
chromosome 8 open reading frame 4
chr12_+_58369392 0.898 NM_004731
SLC16A7
solute carrier family 16, member 7 (monocarboxylic acid transporter 2)
chr20_+_11846536 0.889 NM_014962
BTBD3
BTB (POZ) domain containing 3
chr2_-_88946767 0.873


chr16_+_68156497 0.867 NM_001113178
NM_006599
NM_138713
NM_138714
NM_173214
NFAT5




nuclear factor of activated T-cells 5, tonicity-responsive




chr3_-_49435114 0.867 NM_000481
NM_001164710
NM_001164711
NM_001164712
AMT



aminomethyltransferase



chr3_+_134978615 0.853 TF
transferrin
chr3_-_150578023 0.852 TM4SF1
transmembrane 4 L six family member 1
chr4_-_23500706 0.824 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr16_-_66535457 0.823 NM_000229
LCAT
lecithin-cholesterol acyltransferase
chr2_+_227900471 0.815 NM_020194
MFF
mitochondrial fission factor
chr15_-_58706934 0.812 NM_002943
NM_134260
RORA

RAR-related orphan receptor A

chr6_+_36752244 0.811 NM_078467
CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr2_+_33592445 0.809 NM_015376
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr14_-_105681377 0.808 IGHV4-31
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant gamma 1 (G1m marker)
chr3_-_49434874 0.808 AMT
aminomethyltransferase
chr7_+_94130752 0.797 PEG10
paternally expressed 10
chr9_+_102987137 0.796 NM_017753
LPPR1
lipid phosphate phosphatase-related protein type 1
chr6_-_32665409 0.796 NM_002124
HLA-DRB1
HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1
major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr2_-_165133239 0.789 GRB14
growth factor receptor-bound protein 14
chr7_+_134114701 0.783 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chr4_+_37569093 0.783 NM_015173
TBC1D1
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
chr21_-_26175068 0.776 APP
amyloid beta (A4) precursor protein
chr7_+_94377145 0.773 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory (inhibitor) subunit 9A


chr1_+_15862887 0.771


chr16_+_80626456 0.769 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr8_+_75066117 0.751 NM_001195797
NM_015364
LY96

lymphocyte antigen 96

chr16_+_80626459 0.740 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr2_+_20510312 0.739 NM_004040
RHOB
ras homolog gene family, member B
chr7_+_134114957 0.732 CALD1
caldesmon 1
chrM_+_13453 0.722


chr9_-_74757735 0.722 NM_000689
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr17_-_61655915 0.705 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr12_-_101835510 0.698 NM_000277
PAH
phenylalanine hydroxylase
chr13_-_74799898 0.691 TBC1D4
TBC1 domain family, member 4
chr16_+_70654625 0.683 NM_020995
HPR
haptoglobin-related protein
chr3_+_12367993 0.677 NM_015869
PPARG
peroxisome proliferator-activated receptor gamma
chr13_-_47899043 0.672 NM_001162497
LPAR6
lysophosphatidic acid receptor 6
chr10_-_44794146 0.667 NM_007021
C10orf10
chromosome 10 open reading frame 10
chrX_-_131375217 0.655 NM_001170701
NM_001170702
NM_001170703
MBNL3


muscleblind-like 3 (Drosophila)


chr1_-_145163520 0.655 FMO5
flavin containing monooxygenase 5
chr7_+_94130673 0.654 PEG10
paternally expressed 10
chr3_-_150578148 0.648 TM4SF1
transmembrane 4 L six family member 1
chrX_-_128485134 0.645 NM_003069
NM_139035
SMARCA1

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1

chr14_+_87541220 0.638 NM_003608
GPR65
G protein-coupled receptor 65
chr9_+_71009746 0.638 NM_001170415
NM_001170416
TJP2

tight junction protein 2 (zona occludens 2)

chr16_-_29817841 0.632 NM_001114099
NM_001114100
NM_012410
NM_201575
SEZ6L2



seizure related 6 homolog (mouse)-like 2



chr6_+_131508153 0.626 NM_016377
AKAP7
A kinase (PRKA) anchor protein 7
chr19_+_55614006 0.607 NM_003121
SPIB
Spi-B transcription factor (Spi-1/PU.1 related)
chr3_-_198784590 0.601 NM_203315
BDH1
3-hydroxybutyrate dehydrogenase, type 1
chr4_+_68107039 0.596 NM_012108
STAP1
signal transducing adaptor family member 1
chr1_+_81544432 0.592 LPHN2
latrophilin 2
chr14_-_64479198 0.591 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr15_-_88150823 0.590 ANPEP
alanyl (membrane) aminopeptidase
chr17_-_31353196 0.580 NM_032965
CCL15
chemokine (C-C motif) ligand 15
chr14_-_106270497 0.579 IGHG3
immunoglobulin heavy constant gamma 3 (G3m marker)
chr6_-_32920689 0.568 NM_004159
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr5_-_150501393 0.564 NM_001193544
ANXA6
annexin A6
chr4_+_113958652 0.563 NM_001127493
ANK2
ankyrin 2, neuronal
chr13_-_98757634 0.560 NM_004951
GPR183
G protein-coupled receptor 183
chr4_-_88531353 0.557 NM_016245
HSD17B11
hydroxysteroid (17-beta) dehydrogenase 11
chr8_-_28403652 0.552 NM_172366
FBXO16
ZNF395
F-box protein 16
zinc finger protein 395
chr14_+_63750611 0.549 NM_182913
SYNE2
spectrin repeat containing, nuclear envelope 2
chr12_+_25096472 0.549 NM_006152
LRMP
lymphoid-restricted membrane protein
chr4_+_100714995 0.543 MTTP
microsomal triglyceride transfer protein
chr4_-_88531245 0.538 HSD17B11
hydroxysteroid (17-beta) dehydrogenase 11
chr3_-_150578103 0.538 TM4SF1
transmembrane 4 L six family member 1
chr20_-_33705244 0.535 NM_003915
CPNE1
copine I
chr19_+_40322231 0.530 NM_005031
FXYD1
FXYD domain containing ion transport regulator 1
chrX_-_100920493 0.528 GK
glycerol kinase
chr14_+_38805251 0.525 NM_203356
CTAGE5
CTAGE family, member 5
chr6_-_152681171 0.525 NM_015293
SYNE1
spectrin repeat containing, nuclear envelope 1
chr17_-_9870292 0.523 NM_001130831
GAS7
growth arrest-specific 7
chr2_+_211129567 0.523 NM_001875
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr12_-_90100679 0.511 DCN
decorin
chr12_-_90097384 0.504 NM_133503
DCN
decorin
chr5_+_67622242 0.502 NM_181504
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr17_-_31352643 0.501 CCL14-CCL15
CCL15
CCL14-CCL15 read-through transcript
chemokine (C-C motif) ligand 15
chr3_-_115825742 0.501 NM_001164347
ZBTB20
zinc finger and BTB domain containing 20
chr5_-_94250357 0.500 MCTP1
multiple C2 domains, transmembrane 1
chr14_+_99633570 0.493 EVL
Enah/Vasp-like
chr15_+_97990705 0.491 NM_001130928
MEF2A
myocyte enhancer factor 2A
chr6_+_28200365 0.489 NM_025231
ZSCAN16
zinc finger and SCAN domain containing 16
chr16_+_68238460 0.476 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr1_-_148155986 0.474 NM_014849
SV2A
synaptic vesicle glycoprotein 2A
chr14_-_93924873 0.465 NM_000295
SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr12_+_68028407 0.461 LYZ
lysozyme
chr7_-_87180499 0.459 NM_000927
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr3_-_58175437 0.457 NM_004944
DNASE1L3
deoxyribonuclease I-like 3
chr7_+_80145461 0.457 CD36
CD36 molecule (thrombospondin receptor)
chr11_-_128399218 0.456 NM_014715
ARHGAP32
Rho GTPase activating protein 32
chr14_-_22354851 0.455 NM_001126105
NM_003982
SLC7A7

solute carrier family 7 (cationic amino acid transporter, y+ system), member 7

chr5_+_126887056 0.454 PRRC1
proline-rich coiled-coil 1
chr12_+_9713472 0.451 NM_001197318
NM_013269
NM_001004419
NM_001197317
NM_001197319
CLEC2D




C-type lectin domain family 2, member D




chr5_-_94442941 0.435 MCTP1
multiple C2 domains, transmembrane 1
chr2_-_215949566 0.432 FN1
fibronectin 1
chr16_+_11966464 0.422 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chrX_-_31436335 0.418 NM_004014
DMD
dystrophin
chr3_-_124822113 0.415 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr6_-_133120587 0.413 NM_004665
VNN2
vanin 2
chr14_-_106184988 0.405 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr14_+_71065794 0.401 NM_015556
SIPA1L1
signal-induced proliferation-associated 1 like 1
chr6_-_26038817 0.399 NM_005835
SLC17A2
solute carrier family 17 (sodium phosphate), member 2
chr14_-_94677807 0.393 NM_030621
DICER1
dicer 1, ribonuclease type III
chr15_-_68781662 0.393 NM_001008224
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.06 9.82e-05 GO:0006955 immune response
1.67 5.56e-03 GO:0002376 immune system process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.89 2.52e-10 GO:0005576 extracellular region
2.10 3.04e-08 GO:0044421 extracellular region part
2.08 4.32e-06 GO:0005615 extracellular space
1.38 8.69e-05 GO:0071944 cell periphery
1.37 2.01e-04 GO:0005886 plasma membrane
3.34 1.00e-02 GO:0044420 extracellular matrix part
1.41 1.77e-02 GO:0044459 plasma membrane part
3.15 2.04e-02 GO:0030016 myofibril
4.20 2.84e-02 GO:0031983 vesicle lumen
12.47 3.70e-02 GO:0005579 membrane attack complex
2.95 4.32e-02 GO:0043292 contractile fiber

Gene overrepresentation in function category:

enrichment   p-value GO term description
4.91 2.57e-02 GO:0003823 antigen binding