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Motif ID: NKX2-3_NKX2-5.p2

Z-value: 1.451

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr7_+_94135384	4.648		PEG10	paternally expressed 10
chr17_-_53849888	4.346		RNF43	ring finger protein 43
chr4_+_74493174	4.238		ALB	albumin
chr3_-_79899748	3.974	NM_002941	ROBO1	roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr17_-_61655915	3.714	NM_000042	APOH	apolipoprotein H (beta-2-glycoprotein I)
chrX_+_105823723	3.593	NM_024539	RNF128	ring finger protein 128
chr10_+_7785360	3.556		ITIH2	inter-alpha (globulin) inhibitor H2
chr10_+_7785347	3.526		ITIH2	inter-alpha (globulin) inhibitor H2
chr4_+_74493266	3.480		ALB	albumin
chr10_-_105835609	3.467	NM_000494	COL17A1	collagen, type XVII, alpha 1
chr10_+_7785290	3.328		ITIH2	inter-alpha (globulin) inhibitor H2
chr10_+_7785331	3.303		ITIH2	inter-alpha (globulin) inhibitor H2
chr12_-_51173238	3.272	NM_005554	KRT6A	keratin 6A
chr4_+_74493218	3.149		ALB	albumin
chrX_+_115481774	3.148	NM_007231	SLC6A14	solute carrier family 6 (amino acid transporter), member 14
chr3_-_152517204	3.031	NM_023915	GPR87	G protein-coupled receptor 87
chr4_+_74520796	3.029	NM_001134	AFP	alpha-fetoprotein
chr4_+_74493331	2.884		ALB	albumin
chr10_-_105835525	2.787		COL17A1	collagen, type XVII, alpha 1
chr4_+_74493301	2.703		ALB	albumin
chr12_-_51200347	2.646	NM_000424	KRT5	keratin 5
chr4_+_74499651	2.403		ALB	albumin
chr19_+_50100843	2.314	NM_000041	APOE	apolipoprotein E
chr12_-_28016182	2.274	NM_002820 NM_198965	PTHLH	parathyroid hormone-like hormone
chr17_-_36346240	2.263		KRT23	keratin 23 (histone deacetylase inducible)
chr12_-_6355165	2.213	NM_001038	SCNN1A	sodium channel, nonvoltage-gated 1 alpha
chr3_-_121884091	2.182	NM_000187	HGD	homogentisate 1,2-dioxygenase
chr4_+_140806536	2.151		MGST2	microsomal glutathione S-transferase 2
chr11_+_86710076	2.122		TMEM135	transmembrane protein 135
chr10_+_7785235	2.117	NM_002216	ITIH2	inter-alpha (globulin) inhibitor H2
chr12_-_9123126	2.100		A2M	alpha-2-macroglobulin
chr21_+_39117064	1.956		ETS2	v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
chr17_+_24394281	1.948		PIPOX	pipecolic acid oxidase
chr19_-_53081383	1.879	NM_003167	SULT2A1	sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr3_+_143824955	1.877	NM_002670	PLS1	plastin 1
chr11_+_101488380	1.865	NM_001195045	YAP1	Yes-associated protein 1
chrX_+_43400385	1.857		MAOA	monoamine oxidase A
chr1_-_180624380	1.831		GLUL	glutamate-ammonia ligase
chrX_-_131401319	1.800	NM_018388 NM_133486	MBNL3	muscleblind-like 3 (Drosophila)
chr8_+_104900591	1.791	NM_014677	RIMS2	regulating synaptic membrane exocytosis 2
chr2_+_101874809	1.746		MAP4K4	mitogen-activated protein kinase kinase kinase kinase 4
chr17_-_36347197	1.735	NM_015515	KRT23	keratin 23 (histone deacetylase inducible)
chr2_-_65447370	1.711	NM_001128210	SPRED2	sprouty-related, EVH1 domain containing 2
chr3_-_121883647	1.688		HGD	homogentisate 1,2-dioxygenase
chr10_+_101532544	1.665		ABCC2	ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr1_-_180622083	1.653		GLUL	glutamate-ammonia ligase
chr10_-_52315390	1.652		A1CF	APOBEC1 complementation factor
chr11_-_18214891	1.644	NM_006512	SAA4	serum amyloid A4, constitutive
chr3_-_150578103	1.643		TM4SF1	transmembrane 4 L six family member 1
chr6_+_155579788	1.635	NM_001010927	TIAM2	T-cell lymphoma invasion and metastasis 2
chr4_+_155703581	1.619	NM_001184741 NM_005141	FGB	fibrinogen beta chain
chr10_+_101532450	1.589	NM_000392	ABCC2	ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chrX_-_130251068	1.537	NM_001170961 NM_001170962 NM_001555 NM_205833	IGSF1	immunoglobulin superfamily, member 1
chr19_-_53081326	1.533		SULT2A1	sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr4_-_110942576	1.513		CFI	complement factor I
chr5_+_59819761	1.512		PART1	prostate androgen-regulated transcript 1 (non-protein coding)
chr2_+_211166323	1.478	NM_001122634	CPS1	carbamoyl-phosphate synthase 1, mitochondrial
chr6_-_47361921	1.469		TNFRSF21	tumor necrosis factor receptor superfamily, member 21
chr2_+_101874765	1.445		MAP4K4	mitogen-activated protein kinase kinase kinase kinase 4
chrX_+_43400475	1.438		MAOA	monoamine oxidase A
chr10_-_52315436	1.438	NM_001198818 NM_001198819 NM_001198820 NM_014576 NM_138932 NM_138933	A1CF	APOBEC1 complementation factor
chrX_-_100920493	1.425		GK	glycerol kinase
chr4_+_70180805	1.387	NM_053039	UGT2B28	UDP glucuronosyltransferase 2 family, polypeptide B28
chr4_+_69716298	1.384	NM_001075 NM_001144767	UGT2B10	UDP glucuronosyltransferase 2 family, polypeptide B10
chr12_-_6354650	1.349	NM_001159576	SCNN1A	sodium channel, nonvoltage-gated 1 alpha
chr14_-_64479198	1.343	NM_002083	GPX2	glutathione peroxidase 2 (gastrointestinal)
chr2_-_165133239	1.339		GRB14	growth factor receptor-bound protein 14
chr1_+_154297588	1.335	NM_020387	RAB25	RAB25, member RAS oncogene family
chr16_+_68238460	1.270		NFAT5	nuclear factor of activated T-cells 5, tonicity-responsive
chr20_+_30160952	1.236	NM_014742	TM9SF4	transmembrane 9 superfamily protein member 4
chr10_-_123346148	1.231	NM_001144915	FGFR2	fibroblast growth factor receptor 2
chr8_-_17624009	1.205	NM_001001931	MTUS1	microtubule associated tumor suppressor 1
chr11_+_43622348	1.200
chr6_+_31731647	1.147	NM_019101	APOM	apolipoprotein M
chr3_+_63859114	1.146	NM_001177387	ATXN7	ataxin 7
chr4_+_89115892	1.135		SPP1	secreted phosphoprotein 1
chr1_-_180624494	1.127		GLUL	glutamate-ammonia ligase
chr10_+_102113410	1.124
chr4_+_89115923	1.091		SPP1	secreted phosphoprotein 1
chr7_-_87180499	1.081	NM_000927	ABCB1	ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr12_-_23995220	1.066		SOX5	SRY (sex determining region Y)-box 5
chr6_+_31731667	1.059		APOM	apolipoprotein M
chr4_+_100714995	1.057		MTTP	microsomal triglyceride transfer protein
chr5_-_43326922	1.033		HMGCS1	3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
chr5_+_52812236	1.030	NM_006350 NM_013409	FST	follistatin
chr10_+_102722275	1.022	NM_017893	SEMA4G	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr10_+_5126589	1.019		AKR1C3	aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr22_-_43987010	1.011	NM_015264	KIAA0930	KIAA0930
chr11_-_128567302	0.999	NM_001142685	ARHGAP32	Rho GTPase activating protein 32
chr4_-_23500706	0.966	NM_013261	PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr15_+_56511466	0.959	NM_000236	LIPC	lipase, hepatic
chr13_-_47885248	0.956		LPAR6	lysophosphatidic acid receptor 6
chr12_+_49604782	0.932	NM_014033	METTL7A	methyltransferase like 7A
chr4_-_69852090	0.917	NM_024743	UGT2A3	UDP glucuronosyltransferase 2 family, polypeptide A3
chr14_+_38804226	0.917	NM_203354	CTAGE5	CTAGE family, member 5
chr6_+_136214495	0.914	NM_018945	PDE7B	phosphodiesterase 7B
chr4_-_110942783	0.902	NM_000204	CFI	complement factor I
chr10_-_5050191	0.885	NM_001354 NM_205845	AKR1C2	aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
chr10_-_118670968	0.884		KIAA1598	KIAA1598
chr3_-_150578023	0.879		TM4SF1	transmembrane 4 L six family member 1
chr2_+_225973845	0.875	NM_020864	KIAA1486	KIAA1486
chr6_-_136888771	0.870	NM_001198608 NM_001198609 NM_001198611	MAP7	microtubule-associated protein 7
chr7_+_115650240	0.868	NM_152829	TES	testis derived transcript (3 LIM domains)
chr1_+_165564904	0.864	NM_001198783	POU2F1	POU class 2 homeobox 1
chr8_-_110724594	0.863	NM_001099756	SYBU	syntabulin (syntaxin-interacting)
chr4_+_74497998	0.844		ALB	albumin
chr13_+_77007809	0.838	NM_001160706 NM_003843 NM_144777	SCEL	sciellin
chr17_-_71285992	0.831		H3F3B	H3 histone, family 3B (H3.3B)
chr12_-_49689295	0.809	NM_001174130	SLC11A2	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr14_-_20969706	0.808	NM_001170629	CHD8	chromodomain helicase DNA binding protein 8
chr1_+_151270301	0.784	NM_003125	SPRR1B	small proline-rich protein 1B
chr22_+_38903825	0.783	NM_001162501 NM_015088	TNRC6B	trinucleotide repeat containing 6B
chr17_+_54587882	0.764		PRR11	proline rich 11
chr12_+_48027307	0.755	NM_024902	DNAJC22	DnaJ (Hsp40) homolog, subfamily C, member 22
chr14_-_37134191	0.749	NM_004496	FOXA1	forkhead box A1
chr12_+_49605010	0.749		METTL7A	methyltransferase like 7A
chr8_-_17624304	0.737	NM_001166393	MTUS1	microtubule associated tumor suppressor 1
chr12_-_88270369	0.732		DUSP6	dual specificity phosphatase 6
chrX_+_68752635	0.726	NM_001005609 NM_001005610 NM_001005612 NM_001005613 NM_001399	EDA	ectodysplasin A
chr4_+_74498042	0.722		ALB	albumin
chr4_+_89115825	0.722	NM_000582 NM_001040058 NM_001040060	SPP1	secreted phosphoprotein 1
chr14_-_37133927	0.721		FOXA1	forkhead box A1
chr4_+_89115862	0.711		SPP1	secreted phosphoprotein 1
chr21_-_35343448	0.707		RUNX1	runt-related transcription factor 1
chr16_+_20682812	0.702	NM_005622 NM_202000	ACSM3	acyl-CoA synthetase medium-chain family member 3
chr15_+_92700167	0.702	NM_001159644	MCTP2	multiple C2 domains, transmembrane 2
chr2_-_160764819	0.682	NM_000888	ITGB6	integrin, beta 6
chr12_-_6354818	0.677		SCNN1A	sodium channel, nonvoltage-gated 1 alpha
chr21_-_35343456	0.675	NM_001754	RUNX1	runt-related transcription factor 1
chr12_-_51298599	0.669	NM_175068	KRT73	keratin 73
chr11_-_2108035	0.667		IGF2	insulin-like growth factor 2 (somatomedin A)
chr1_+_165565006	0.665		POU2F1	POU class 2 homeobox 1
chrX_-_110541029	0.657	NM_000555	DCX	doublecortin
chr12_-_121767272	0.648	NM_006018	GPR109B	G protein-coupled receptor 109B
chr16_+_70646008	0.644	NM_001126102 NM_005143	HP	haptoglobin
chr6_+_158653679	0.642	NM_001007466 NM_020245	TULP4	tubby like protein 4
chr6_-_32265489	0.642	NM_002586	PBX2	pre-B-cell leukemia homeobox 2
chr10_+_4995597	0.642		AKR1C1 AKR1C3	aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr21_-_35343500	0.624		RUNX1	runt-related transcription factor 1
chr12_-_31370351	0.624		FAM60A	family with sequence similarity 60, member A
chr12_+_40117751	0.616	NM_013377	PDZRN4	PDZ domain containing ring finger 4
chr19_-_47724365	0.613	NM_001024912 NM_001184813 NM_001184815 NM_001184816 NM_001712	CEACAM1	carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
chr2_+_234490781	0.602	NM_024080	TRPM8	transient receptor potential cation channel, subfamily M, member 8
chr20_+_30161173	0.591		TM9SF4	transmembrane 9 superfamily protein member 4
chr5_-_131907071	0.579	NM_000879	IL5	interleukin 5 (colony-stimulating factor, eosinophil)
chr12_-_23995109	0.578		SOX5	SRY (sex determining region Y)-box 5
chr1_+_50347188	0.578		ELAVL4	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr17_+_24394043	0.573	NM_016518	PIPOX	pipecolic acid oxidase
chr3_-_150578207	0.573	NM_014220	TM4SF1	transmembrane 4 L six family member 1
chr6_-_26038817	0.571	NM_005835	SLC17A2	solute carrier family 17 (sodium phosphate), member 2
chr9_-_103185621	0.569	NM_001127610	BAAT	bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chr2_+_37282516	0.556		LOC100505876	hypothetical LOC100505876
chr18_-_72857665	0.550		MBP	myelin basic protein
chr15_+_91244422	0.548	NM_001042572 NM_001271	CHD2	chromodomain helicase DNA binding protein 2
chr12_+_48443232	0.538		TMBIM6	transmembrane BAX inhibitor motif containing 6
chr4_+_3341521	0.533	NM_198227	RGS12	regulator of G-protein signaling 12
chr12_-_121753795	0.532	NM_177551	GPR109A	G protein-coupled receptor 109A
chr6_-_41823056	0.532	NM_001166424 NM_002630	PGC	progastricsin (pepsinogen C)
chr18_-_28247186	0.521
chr21_-_42219849	0.506	NM_199050	C2CD2	C2 calcium-dependent domain containing 2
chr7_+_129634935	0.496	NM_145268	C7orf45	chromosome 7 open reading frame 45
chr2_+_234266250	0.492	NM_001072	UGT1A6	UDP glucuronosyltransferase 1 family, polypeptide A6
chr1_+_15862887	0.489
chr15_-_68781662	0.487	NM_001008224	UACA	uveal autoantigen with coiled-coil domains and ankyrin repeats
chr3_-_52454082	0.486	NM_020163	SEMA3G	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
chr21_-_35343331	0.477		RUNX1	runt-related transcription factor 1
chr19_-_40996040	0.473	NM_021232	PRODH2	proline dehydrogenase (oxidase) 2
chr7_+_29486010	0.467	NM_001039936	CHN2	chimerin (chimaerin) 2
chr3_-_139960874	0.466	NM_006219	PIK3CB	phosphoinositide-3-kinase, catalytic, beta polypeptide
chr3_+_122769467	0.456	NM_001012659	ARGFX	arginine-fifty homeobox
chr7_+_18501876	0.454	NM_014707 NM_178423	HDAC9	histone deacetylase 9
chrX_-_15198093	0.447	NM_001031739 NM_001168530 NM_024087	ASB9	ankyrin repeat and SOCS box containing 9
chr11_+_57285809	0.442	NM_001085458 NM_001085459 NM_001085460 NM_001085461 NM_001085462 NM_001085463 NM_001085464 NM_001085465 NM_001085466 NM_001085467 NM_001085468 NM_001085469 NM_001331	CTNND1	catenin (cadherin-associated protein), delta 1
chr11_+_91724909	0.441	NM_001008781	FAT3	FAT tumor suppressor homolog 3 (Drosophila)
chr9_+_79158164	0.438		VPS13A	vacuolar protein sorting 13 homolog A (S. cerevisiae)
chr16_+_70654625	0.436	NM_020995	HPR	haptoglobin-related protein
chr11_+_34599227	0.436		EHF	ets homologous factor
chr3_-_11598829	0.434	NM_001128220	VGLL4	vestigial like 4 (Drosophila)
chr20_-_62052922	0.433	NM_001193379	UCKL1	uridine-cytidine kinase 1-like 1
chrX_+_123062143	0.430		STAG2	stromal antigen 2
chr7_+_18502342	0.422	NM_058176 NM_178425	HDAC9	histone deacetylase 9
chr1_-_108032645	0.421	NM_001079874	VAV3	vav 3 guanine nucleotide exchange factor
chr19_-_40995606	0.419		PRODH2	proline dehydrogenase (oxidase) 2
chr10_+_71833920	0.416		EIF4EBP2	eukaryotic translation initiation factor 4E binding protein 2
chr12_-_69837831	0.413		TSPAN8	tetraspanin 8
chr20_+_56919233	0.413		GNAS	GNAS complex locus
chr4_-_100359353	0.412	NM_000672 NM_001102470	ADH6	alcohol dehydrogenase 6 (class V)
chr5_-_1935764	0.410	NM_016358	IRX4	iroquois homeobox 4
chrX_+_28515479	0.407	NM_014271	IL1RAPL1	interleukin 1 receptor accessory protein-like 1
chr11_-_111539881	0.404	NM_001562	IL18	interleukin 18 (interferon-gamma-inducing factor)
chr1_+_86662356	0.404	NM_006536	CLCA2	chloride channel accessory 2
chr2_-_200033445	0.402		SATB2	SATB homeobox 2
chr1_-_93030538	0.398	NM_005665	EVI5	ecotropic viral integration site 5
chr14_+_38719462	0.393		PNN	pinin, desmosome associated protein
chr8_+_98856984	0.391	NM_018407	LAPTM4B	lysosomal protein transmembrane 4 beta
chr17_+_46176105	0.389		LUC7L3	LUC7-like 3 (S. cerevisiae)
chr20_-_33706532	0.389		RBM12	RNA binding motif protein 12
chr6_+_144654565	0.387	NM_007124	UTRN	utrophin
chr3_+_195336631	0.385		HES1	hairy and enhancer of split 1, (Drosophila)
chr16_-_68317855	0.382		NQO1	NAD(P)H dehydrogenase, quinone 1

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.30	4.79e-04	GO:0032501	multicellular organismal process
1.58	1.63e-02	GO:0003008	system process
1.30	3.34e-02	GO:0023052	signaling

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.36	3.61e-02	GO:0044459	plasma membrane part

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
9.43	3.99e-02	GO:0008527	taste receptor activity