Motif ID: TFAP4.p2

Z-value: 1.440


Transcription factors associated with TFAP4.p2:

Gene SymbolEntrez IDGene Name
TFAP4 7023 transcription factor AP-4 (activating enhancer binding protein 4)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TFAP4chr16_-_42626960.068.2e-01Click!


Activity profile for motif TFAP4.p2.

activity profile for motif TFAP4.p2


Sorted Z-values histogram for motif TFAP4.p2

Sorted Z-values for motif TFAP4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_43769065 3.184 NM_002840
NM_130440
PTPRF

protein tyrosine phosphatase, receptor type, F

chr1_+_67168470 2.785 NM_001077701
NM_001077704
MIER1

mesoderm induction early response 1 homolog (Xenopus laevis)

chr8_+_97575370 2.609 SDC2
syndecan 2
chr3_-_126088530 2.474 ITGB5
integrin, beta 5
chr1_-_94475504 2.346 ARHGAP29
Rho GTPase activating protein 29
chr8_+_97575244 2.341 SDC2
syndecan 2
chr3_-_87122936 2.297 NM_016206
VGLL3
vestigial like 3 (Drosophila)
chr1_-_56817568 2.279 PPAP2B
phosphatidic acid phosphatase type 2B
chr10_+_124211353 2.258 HTRA1
HtrA serine peptidase 1
chr10_+_124210980 2.247 NM_002775
HTRA1
HtrA serine peptidase 1
chr3_-_31997738 2.221 OSBPL10
oxysterol binding protein-like 10
chr10_-_126839056 2.144 NM_001329
CTBP2
C-terminal binding protein 2
chr1_-_56817717 2.120 PPAP2B
phosphatidic acid phosphatase type 2B
chr5_+_135392482 2.067 NM_000358
TGFBI
transforming growth factor, beta-induced, 68kDa
chr21_+_41461597 2.006 NM_012105
NM_138991
NM_138992
BACE2


beta-site APP-cleaving enzyme 2


chr16_+_69060325 1.915 FUK
fucokinase
chr17_-_74432671 1.888 TIMP2
TIMP metallopeptidase inhibitor 2
chr1_-_93919789 1.883 NM_003567
BCAR3
breast cancer anti-estrogen resistance 3
chr15_+_72006015 1.880 LOXL1
lysyl oxidase-like 1
chr3_-_187025501 1.873 NM_001007225
NM_006548
IGF2BP2

insulin-like growth factor 2 mRNA binding protein 2

chr2_-_158440587 1.790 NM_001111067
ACVR1
activin A receptor, type I
chr12_-_53099203 1.752 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr1_+_178390646 1.734 QSOX1
quiescin Q6 sulfhydryl oxidase 1
chr14_-_51605487 1.711 NID2
nidogen 2 (osteonidogen)
chr17_-_74432800 1.706 TIMP2
TIMP metallopeptidase inhibitor 2
chr12_-_53099277 1.660 NM_002205
ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr20_+_19818209 1.606 NM_018993
RIN2
Ras and Rab interactor 2
chr14_-_51605695 1.600 NM_007361
NID2
nidogen 2 (osteonidogen)
chr3_-_151171576 1.561 PFN2
profilin 2
chr14_-_51605461 1.558 NID2
nidogen 2 (osteonidogen)
chr1_+_178390660 1.554 QSOX1
quiescin Q6 sulfhydryl oxidase 1
chr12_-_53099269 1.515 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr16_+_55199978 1.487 NM_005953
MT2A
metallothionein 2A
chr1_+_178390654 1.471 QSOX1
quiescin Q6 sulfhydryl oxidase 1
chr3_-_31998241 1.450 NM_001174060
NM_017784
OSBPL10

oxysterol binding protein-like 10

chr2_-_161058550 1.449 NM_002897
NM_016836
RBMS1

RNA binding motif, single stranded interacting protein 1

chr8_+_98857190 1.399 LAPTM4B
lysosomal protein transmembrane 4 beta
chr2_-_161058120 1.387 RBMS1
RNA binding motif, single stranded interacting protein 1
chr12_+_13240987 1.377 EMP1
epithelial membrane protein 1
chr5_-_122400312 1.373 NM_000943
PPIC
peptidylprolyl isomerase C (cyclophilin C)
chr12_+_13240868 1.369 NM_001423
EMP1
epithelial membrane protein 1
chr1_+_181259317 1.346


chr8_-_13178399 1.335 DLC1
deleted in liver cancer 1
chr15_+_72005839 1.319 NM_005576
LOXL1
lysyl oxidase-like 1
chr15_+_72005875 1.316 LOXL1
lysyl oxidase-like 1
chr2_-_20075889 1.308 MATN3
matrilin 3
chr15_+_72005864 1.302 LOXL1
lysyl oxidase-like 1
chr8_+_97575071 1.301 SDC2
syndecan 2
chr7_+_17304707 1.295 NM_001621
AHR
aryl hydrocarbon receptor
chr9_+_123070191 1.282 NM_001127662
NM_001127663
NM_001127664
NM_001127665
NM_001127666
NM_001127667
NM_198252
GSN






gelsolin






chr16_-_4106022 1.269 ADCY9
adenylate cyclase 9
chr10_-_126839000 1.267 CTBP2
C-terminal binding protein 2
chr8_+_97575317 1.262 SDC2
syndecan 2
chr1_-_56817802 1.251 PPAP2B
phosphatidic acid phosphatase type 2B
chr9_+_123070276 1.251 GSN
gelsolin
chrX_+_54852217 1.244 NM_201222
MAGED2
melanoma antigen family D, 2
chr7_+_102340579 1.217 NM_001031692
NM_005824
LRRC17

leucine rich repeat containing 17

chr19_-_18912112 1.211 NM_001145722
NM_001145721
HOMER3

homer homolog 3 (Drosophila)

chr8_-_48813236 1.200 CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr13_+_113546912 1.199 GAS6
growth arrest-specific 6
chr9_-_128924706 1.197 ANGPTL2
angiopoietin-like 2
chr19_+_3045528 1.194 GNA11
guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
chr11_+_133444175 1.186 JAM3
junctional adhesion molecule 3
chr10_-_126839546 1.179 NM_001083914
CTBP2
C-terminal binding protein 2
chr3_-_126088819 1.171 NM_002213
ITGB5
integrin, beta 5
chrX_-_37964924 1.161 NM_001170750
NM_001170751
NM_001170752
NM_006307
SRPX



sushi-repeat containing protein, X-linked



chr8_+_97575196 1.157 SDC2
syndecan 2
chr3_-_187025438 1.150 IGF2BP2
insulin-like growth factor 2 mRNA binding protein 2
chr9_-_128924819 1.137 NM_012098
ANGPTL2
angiopoietin-like 2
chr16_-_4106186 1.134 NM_001116
ADCY9
adenylate cyclase 9
chr11_-_35503720 1.133 NM_001001991
NM_015430
PAMR1

peptidase domain containing associated with muscle regeneration 1

chr6_-_132314004 1.132 NM_001901
CTGF
connective tissue growth factor
chr1_+_181258952 1.123 NM_002293
LAMC1
laminin, gamma 1 (formerly LAMB2)
chr15_+_72005847 1.119 LOXL1
lysyl oxidase-like 1
chr13_+_113546897 1.101 GAS6
growth arrest-specific 6
chr15_-_68933481 1.099 NM_018357
NM_197958
LARP6

La ribonucleoprotein domain family, member 6

chr13_+_113546943 1.092 GAS6
growth arrest-specific 6
chr5_-_122400219 1.065 PPIC
peptidylprolyl isomerase C (cyclophilin C)
chr6_-_47385470 1.062 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr8_+_98856984 1.056 NM_018407
LAPTM4B
lysosomal protein transmembrane 4 beta
chr3_+_124268545 1.050 NM_006810
PDIA5
protein disulfide isomerase family A, member 5
chr5_+_52812165 1.041 FST
follistatin
chr13_+_113546841 1.040 NM_000820
GAS6
growth arrest-specific 6
chr21_+_41461924 1.039 BACE2
beta-site APP-cleaving enzyme 2
chr6_-_47385605 1.025 NM_014452
TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr15_-_88143721 1.017 ANPEP
alanyl (membrane) aminopeptidase
chr21_+_41461962 1.012 BACE2
beta-site APP-cleaving enzyme 2
chr3_-_150578207 1.011 NM_014220
TM4SF1
transmembrane 4 L six family member 1
chr11_+_133444029 1.008 NM_032801
JAM3
junctional adhesion molecule 3
chr4_+_169989680 1.006 NM_001166110
PALLD
palladin, cytoskeletal associated protein
chr5_-_136862786 0.997 NM_004598
SPOCK1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
chr16_-_63713382 0.992 NM_001797
CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr15_+_30721161 0.992 NM_001144757
NM_003020
SCG5

secretogranin V (7B2 protein)

chr6_-_47385313 0.989 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr5_-_39461054 0.980 NM_001343
DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr9_+_89530848 0.979 CTSL1
cathepsin L1
chr9_+_89530896 0.978 CTSL1
cathepsin L1
chr6_-_47385205 0.976 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr17_-_74433048 0.976 NM_003255
TIMP2
TIMP metallopeptidase inhibitor 2
chr20_+_3399615 0.974 NM_139321
NM_139322
ATRN

attractin

chr12_+_6179736 0.971 NM_001769
CD9
CD9 molecule
chr9_-_83493415 0.963 NM_005077
TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr5_+_52812236 0.961 NM_006350
NM_013409
FST

follistatin

chr9_-_73573121 0.958 NM_001135820
NM_013390
TMEM2

transmembrane protein 2

chr2_+_187162969 0.955 NM_001145000
NM_002210
ITGAV

integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)

chr8_-_145090892 0.953 NM_201381
PLEC
plectin
chr9_+_89530838 0.939 CTSL1
cathepsin L1
chr8_+_1759502 0.925 NM_014629
ARHGEF10
Rho guanine nucleotide exchange factor (GEF) 10
chr1_-_59022275 0.922 NM_002228
JUN
jun proto-oncogene
chr9_+_89530793 0.919 NM_001912
NM_145918
CTSL1

cathepsin L1

chr9_+_89530943 0.919 CTSL1
cathepsin L1
chr5_+_150807331 0.903 NM_078483
SLC36A1
solute carrier family 36 (proton/amino acid symporter), member 1
chr5_-_121440704 0.902 NM_001178102
LOX
lysyl oxidase
chr11_+_832821 0.902 NM_001025238
NM_001025239
NM_003271
NM_001025235
NM_001025236
TSPAN4




tetraspanin 4




chr17_-_60088773 0.900 NM_022739
SMURF2
SMAD specific E3 ubiquitin protein ligase 2
chr17_-_60088637 0.894 SMURF2
SMAD specific E3 ubiquitin protein ligase 2
chr1_-_120413798 0.886 NM_024408
NOTCH2
notch 2
chr19_+_3045266 0.881 NM_002067
GNA11
guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
chr14_+_20608179 0.877 NM_018071
ARHGEF40
Rho guanine nucleotide exchange factor (GEF) 40
chr11_+_101485946 0.874 NM_001130145
NM_001195044
NM_006106
YAP1


Yes-associated protein 1


chr13_-_44048391 0.847 TSC22D1
TSC22 domain family, member 1
chr13_-_109757442 0.837 NM_001845
COL4A1
collagen, type IV, alpha 1
chr20_+_48241334 0.830 CEBPB
CCAAT/enhancer binding protein (C/EBP), beta
chr7_+_129918408 0.828 NM_177525
MEST
mesoderm specific transcript homolog (mouse)
chr14_-_23734598 0.824 NM_001014842
NM_006405
TM9SF1

transmembrane 9 superfamily member 1

chr12_-_105057940 0.820 NM_014840
NUAK1
NUAK family, SNF1-like kinase, 1
chr1_-_94475840 0.819 NM_004815
ARHGAP29
Rho GTPase activating protein 29
chr10_-_3817205 0.816 KLF6
Kruppel-like factor 6
chr8_+_136538739 0.814 NM_006558
KHDRBS3
KH domain containing, RNA binding, signal transduction associated 3
chr3_-_124821868 0.803 MYLK
myosin light chain kinase
chr12_-_74710741 0.800 PHLDA1
pleckstrin homology-like domain, family A, member 1
chr21_+_36429079 0.795 NM_001236
CBR3
carbonyl reductase 3
chr17_-_60088459 0.786 SMURF2
SMAD specific E3 ubiquitin protein ligase 2
chr8_+_95801277 0.779 NM_181787
DPY19L4
dpy-19-like 4 (C. elegans)
chr1_-_223907283 0.776 NM_001008493
NM_018212
ENAH

enabled homolog (Drosophila)

chr1_-_120413542 0.773 NOTCH2
notch 2
chr4_-_15549047 0.772 NM_005130
FGFBP1
fibroblast growth factor binding protein 1
chr2_-_73193419 0.761 RAB11FIP5
RAB11 family interacting protein 5 (class I)
chr9_-_35679799 0.759 TPM2
tropomyosin 2 (beta)
chrX_-_51256166 0.755 NM_018159
NUDT11
nudix (nucleoside diphosphate linked moiety X)-type motif 11
chr6_-_134537699 0.753 NM_005627
SGK1
serum/glucocorticoid regulated kinase 1
chr1_-_58815415 0.736 TACSTD2
tumor-associated calcium signal transducer 2
chr17_+_77261447 0.732 HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr7_+_100037817 0.728 NM_002593
PCOLCE
procollagen C-endopeptidase enhancer
chrX_-_37916138 0.724 SRPX
sushi-repeat containing protein, X-linked
chr1_+_191044791 0.703 NM_002923
RGS2
regulator of G-protein signaling 2, 24kDa
chr21_-_27139143 0.702 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr20_-_14266200 0.701 NM_013281
NM_198391
FLRT3

fibronectin leucine rich transmembrane protein 3

chr7_-_124192265 0.699 GPR37
G protein-coupled receptor 37 (endothelin receptor type B-like)
chr6_-_134537637 0.695 SGK1
serum/glucocorticoid regulated kinase 1
chr21_-_27139563 0.694 NM_006988
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr11_+_57123927 0.694 SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr1_-_225572419 0.691 NM_003607
NM_014826
CDC42BPA

CDC42 binding protein kinase alpha (DMPK-like)

chr17_-_63965156 0.691 NM_017983
WIPI1
WD repeat domain, phosphoinositide interacting 1
chrX_-_128485062 0.690 SMARCA1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
chr11_-_8788765 0.688 NM_213618
ST5
suppression of tumorigenicity 5
chr1_+_167342493 0.680 NM_001677
ATP1B1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr8_+_97575052 0.679 NM_002998
SDC2
syndecan 2
chr1_-_22136263 0.678 NM_005529
HSPG2
heparan sulfate proteoglycan 2
chr19_-_48866111 0.678 NM_001005376
NM_001005377
NM_002659
PLAUR


plasminogen activator, urokinase receptor


chr1_+_24944346 0.677 NM_013943
CLIC4
chloride intracellular channel 4
chr2_-_220144427 0.676 OBSL1
obscurin-like 1
chr3_-_51971915 0.674 NM_033010
PCBP4
poly(rC) binding protein 4
chr5_-_73972055 0.673 ENC1
ectodermal-neural cortex 1 (with BTB-like domain)
chr10_-_125841840 0.673 NM_014863
NM_015892
CHST15

carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15

chr2_+_234286376 0.672 NM_019078
UGT1A5
UDP glucuronosyltransferase 1 family, polypeptide A5
chr13_-_44048601 0.672 NM_183422
TSC22D1
TSC22 domain family, member 1
chr12_+_79995927 0.670 NM_024560
ACSS3
acyl-CoA synthetase short-chain family member 3
chrX_-_106130098 0.670 NM_001085354
NM_024657
MORC4

MORC family CW-type zinc finger 4

chr3_-_147361912 0.668 NM_000935
NM_182943
PLOD2

procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2

chr2_-_47022406 0.665 NM_001171508
NM_001171511
MCFD2

multiple coagulation factor deficiency 2

chr17_+_77261440 0.664 HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr12_-_6535481 0.664 NM_001039670
NM_001193457
NM_080730
IFFO1


intermediate filament family orphan 1


chr1_+_154297588 0.662 NM_020387
RAB25
RAB25, member RAS oncogene family
chr5_-_72780107 0.655 NM_004472
FOXD1
forkhead box D1
chrX_-_128485121 0.651 SMARCA1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
chr3_-_135452253 0.649 NM_001005861
NM_002958
RYK

RYK receptor-like tyrosine kinase

chrX_-_128485134 0.639 NM_003069
NM_139035
SMARCA1

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1

chr9_-_35679902 0.634 NM_003289
NM_213674
TPM2

tropomyosin 2 (beta)

chr1_+_149779384 0.625 NM_001126337
NM_020127
TUFT1

tuftelin 1

chr11_-_310775 0.623 NM_021034
IFITM3
interferon induced transmembrane protein 3 (1-8U)
chr19_+_38376980 0.622 LRP3
low density lipoprotein receptor-related protein 3
chr12_-_12394402 0.621 NM_018050
MANSC1
MANSC domain containing 1
chr20_+_42593849 0.618 NM_007066
NM_181804
NM_181805
PKIG


protein kinase (cAMP-dependent, catalytic) inhibitor gamma


chr16_-_31013626 0.618 NM_024006
NM_206824
VKORC1

vitamin K epoxide reductase complex, subunit 1

chr4_+_166519392 0.612 NM_001873
CPE
carboxypeptidase E
chr12_-_54409107 0.607 NM_001040034
NM_001780
CD63

CD63 molecule

chr8_+_9450849 0.603 NM_003747
TNKS
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chr4_+_15313789 0.601 BST1
bone marrow stromal cell antigen 1
chr1_-_151804929 0.601 NM_005978
S100A2
S100 calcium binding protein A2
chr21_+_29374743 0.600 NM_020152
C21orf7
chromosome 21 open reading frame 7
chr16_-_31013550 0.600 VKORC1
vitamin K epoxide reductase complex, subunit 1
chr11_+_834062 0.600 NM_001025234
TSPAN4
tetraspanin 4
chr5_+_40715778 0.597 NM_000958
PTGER4
prostaglandin E receptor 4 (subtype EP4)
chrX_-_51256035 0.592 NUDT11
nudix (nucleoside diphosphate linked moiety X)-type motif 11
chr18_+_7557313 0.587 NM_001105244
NM_002845
PTPRM

protein tyrosine phosphatase, receptor type, M

chr5_+_109053034 0.586 NM_002372
MAN2A1
mannosidase, alpha, class 2A, member 1
chr16_+_15435825 0.585 NM_033201
C16orf45
chromosome 16 open reading frame 45
chr9_+_123070234 0.583 GSN
gelsolin
chr16_-_31013423 0.583



Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.14 1.77e-05 GO:0016020 membrane
1.17 8.36e-04 GO:0031224 intrinsic to membrane
1.14 1.33e-03 GO:0044425 membrane part
1.16 2.31e-03 GO:0016021 integral to membrane
1.28 3.93e-03 GO:0005576 extracellular region
1.28 1.11e-02 GO:0012505 endomembrane system
1.42 1.39e-02 GO:0031988 membrane-bounded vesicle
1.08 2.60e-02 GO:0005737 cytoplasm

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.19 9.90e-03 GO:0019838 growth factor binding