Motif ID: NFIX.p2

Z-value: 2.670


Transcription factors associated with NFIX.p2:

Gene SymbolEntrez IDGene Name
NFIX 4784 nuclear factor I/X (CCAAT-binding transcription factor)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NFIXchr19_+_129963680.702.4e-03Click!


Activity profile for motif NFIX.p2.

activity profile for motif NFIX.p2


Sorted Z-values histogram for motif NFIX.p2

Sorted Z-values for motif NFIX.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFIX.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_150233337 12.113 NM_002966
S100A10
S100 calcium binding protein A10
chr1_-_150232927 11.577 S100A10
S100 calcium binding protein A10
chr1_-_150232900 11.245 S100A10
S100 calcium binding protein A10
chr10_+_124210980 8.077 NM_002775
HTRA1
HtrA serine peptidase 1
chr10_+_88718167 6.493 NM_006829
C10orf116
chromosome 10 open reading frame 116
chr15_+_61123327 6.373 TPM1
tropomyosin 1 (alpha)
chr16_+_3010311 5.751 NM_016639
TNFRSF12A
tumor necrosis factor receptor superfamily, member 12A
chr10_+_17312654 5.407 VIM
vimentin
chr10_+_17311788 5.316 VIM
vimentin
chr7_-_80386602 5.308 NM_006379
SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr10_+_17311962 5.123 VIM
vimentin
chr4_-_99798563 5.026 NM_005723
TSPAN5
tetraspanin 5
chr7_+_65307816 4.989 TPST1
tyrosylprotein sulfotransferase 1
chr7_-_80386258 4.542 SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr8_-_41286088 4.384 NM_003012
SFRP1
secreted frizzled-related protein 1
chr7_+_65307691 4.270 NM_003596
TPST1
tyrosylprotein sulfotransferase 1
chr9_+_123070191 4.042 NM_001127662
NM_001127663
NM_001127664
NM_001127665
NM_001127666
NM_001127667
NM_198252
GSN






gelsolin






chr2_+_241023703 3.958 NM_002081
GPC1
glypican 1
chr9_+_123070276 3.935 GSN
gelsolin
chr10_+_102782151 3.893 SFXN3
sideroflexin 3
chr9_+_123070234 3.795 GSN
gelsolin
chr10_+_124211353 3.683 HTRA1
HtrA serine peptidase 1
chr11_-_11986704 3.575 NM_001018057
DKK3
dickkopf homolog 3 (Xenopus laevis)
chr10_-_91001496 3.504 LIPA
lipase A, lysosomal acid, cholesterol esterase
chr21_-_27139563 3.477 NM_006988
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr9_+_114953048 3.330 NM_001860
SLC31A2
solute carrier family 31 (copper transporters), member 2
chr10_-_91001566 3.183 NM_000235
NM_001127605
LIPA

lipase A, lysosomal acid, cholesterol esterase

chr10_-_91001531 3.182 LIPA
lipase A, lysosomal acid, cholesterol esterase
chr1_+_43769065 3.181 NM_002840
NM_130440
PTPRF

protein tyrosine phosphatase, receptor type, F

chr10_-_91001542 3.073 LIPA
lipase A, lysosomal acid, cholesterol esterase
chr12_+_26239535 3.070 NM_001135823
SSPN
sarcospan (Kras oncogene-associated gene)
chr1_+_63832067 3.003 NM_001172819
PGM1
phosphoglucomutase 1
chr5_+_34692239 2.962 RAI14
retinoic acid induced 14
chrX_-_101658297 2.931 NM_021992
TMSB15A
TMSB15B
thymosin beta 15a
thymosin beta 15B
chr17_-_74432800 2.790 TIMP2
TIMP metallopeptidase inhibitor 2
chr13_-_76358433 2.718 NM_138444
KCTD12
potassium channel tetramerisation domain containing 12
chr3_+_156280129 2.715 NM_000902
MME
membrane metallo-endopeptidase
chr12_+_6179736 2.683 NM_001769
CD9
CD9 molecule
chr4_-_143987053 2.674 NM_001101669
NM_003866
INPP4B

inositol polyphosphate-4-phosphatase, type II, 105kDa

chr5_+_34692352 2.666 NM_001145520
RAI14
retinoic acid induced 14
chr5_+_34692124 2.564 NM_001145522
NM_015577
RAI14

retinoic acid induced 14

chr9_+_132309914 2.557 NM_000050
NM_054012
ASS1

argininosuccinate synthase 1

chr6_+_86216020 2.546 NM_002526
NT5E
5'-nucleotidase, ecto (CD73)
chr1_+_20788027 2.510 NM_001785
CDA
cytidine deaminase
chr12_+_26239755 2.444 NM_005086
SSPN
sarcospan (Kras oncogene-associated gene)
chr16_+_55261226 2.372 NM_005951
MT1H
metallothionein 1H
chr21_-_27139143 2.343 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr9_+_111582317 2.284 NM_053016
NM_007203
NM_147150
PALM2
PALM2-AKAP2

paralemmin 2
PALM2-AKAP2 readthrough

chr11_-_61491684 2.228 NM_002032
FTH1
ferritin, heavy polypeptide 1
chr9_+_111850698 2.213 NM_001004065
NM_001198656
AKAP2

A kinase (PRKA) anchor protein 2

chr6_+_30959839 2.206 NM_001954
DDR1
discoidin domain receptor tyrosine kinase 1
chr1_-_151866593 2.200 NM_001024211
S100A13
S100 calcium binding protein A13
chr12_+_74160779 2.197 NM_006851
GLIPR1
GLI pathogenesis-related 1
chr1_-_205272619 2.195 NM_001083924
NM_023938
C1orf116

chromosome 1 open reading frame 116

chr5_-_156935317 2.153 NM_033274
ADAM19
ADAM metallopeptidase domain 19
chr10_+_89409332 2.114 NM_001015880
NM_004670
PAPSS2

3'-phosphoadenosine 5'-phosphosulfate synthase 2

chr9_+_115382760 2.105 NM_021106
RGS3
regulator of G-protein signaling 3
chr11_-_46678691 2.045 NM_004308
ARHGAP1
Rho GTPase activating protein 1
chr5_+_150380325 2.041 GPX3
glutathione peroxidase 3 (plasma)
chr9_-_73573121 1.974 NM_001135820
NM_013390
TMEM2

transmembrane protein 2

chr11_-_11987115 1.973 DKK3
dickkopf homolog 3 (Xenopus laevis)
chr8_-_119192985 1.965 NM_000127
EXT1
exostosin 1
chr3_+_139550368 1.951 MRAS
muscle RAS oncogene homolog
chr6_+_86216457 1.943 NT5E
5'-nucleotidase, ecto (CD73)
chr1_-_68470585 1.928 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr5_+_150380270 1.904 GPX3
glutathione peroxidase 3 (plasma)
chr4_+_146622154 1.887 NM_005900
SMAD1
SMAD family member 1
chr5_+_150380173 1.886 NM_002084
GPX3
glutathione peroxidase 3 (plasma)
chr2_-_105381855 1.871 NM_001039492
NM_001450
NM_201555
FHL2


four and a half LIM domains 2


chr4_+_75699652 1.844 NM_001657
AREG
amphiregulin
chrX_-_68301974 1.820 NM_001032396
NM_022368
NM_145119
PJA1


praja ring finger 1


chr15_+_65145248 1.815 NM_005902
SMAD3
SMAD family member 3
chr1_-_94779727 1.813 NM_001178096
NM_001993
F3

coagulation factor III (thromboplastin, tissue factor)

chr6_-_150285838 1.806 NM_001001788
RAET1G
retinoic acid early transcript 1G
chr22_+_37193961 1.782 NM_006855
NM_016657
KDELR3

KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3

chr5_+_34720368 1.774 NM_001145521
NM_001145525
RAI14

retinoic acid induced 14

chr9_+_114953087 1.771 SLC31A2
solute carrier family 31 (copper transporters), member 2
chr2_+_37425240 1.730 NM_012413
QPCT
glutaminyl-peptide cyclotransferase
chr8_-_11762918 1.670 CTSB
cathepsin B
chr8_-_11763004 1.670 CTSB
cathepsin B
chr12_+_54611212 1.667 NM_001345
DGKA
diacylglycerol kinase, alpha 80kDa
chr12_+_54612055 1.659 NM_201444
NM_201445
NM_201554
DGKA


diacylglycerol kinase, alpha 80kDa


chr9_-_112840801 1.646 LPAR1
lysophosphatidic acid receptor 1
chr20_+_17498507 1.621 NM_001011546
NM_006870
DSTN

destrin (actin depolymerizing factor)

chr4_+_158216631 1.616 NM_000824
NM_001166061
NM_001166060
GLRB


glycine receptor, beta


chr15_+_65145215 1.613 SMAD3
SMAD family member 3
chr11_-_11987198 1.613 NM_015881
DKK3
dickkopf homolog 3 (Xenopus laevis)
chr9_+_115382990 1.607 RGS3
regulator of G-protein signaling 3
chr14_-_23734598 1.594 NM_001014842
NM_006405
TM9SF1

transmembrane 9 superfamily member 1

chr8_-_11763023 1.580 CTSB
cathepsin B
chr13_+_47705308 1.573 ITM2B
integral membrane protein 2B
chr17_+_35097851 1.548 NM_001005862
ERBB2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
chr19_-_63758115 1.496 CHMP2A
chromatin modifying protein 2A
chr1_-_151855413 1.495 NM_020672
S100A14
S100 calcium binding protein A14
chrX_+_154264931 1.486 NM_001007523
NM_001007524
NM_012151
F8A2
F8A3
F8A1
coagulation factor VIII-associated (intronic transcript) 2
coagulation factor VIII-associated (intronic transcript) 3
coagulation factor VIII-associated (intronic transcript) 1
chr11_-_46678715 1.475 ARHGAP1
Rho GTPase activating protein 1
chr10_-_725522 1.455 NM_014974
DIP2C
DIP2 disco-interacting protein 2 homolog C (Drosophila)
chr19_-_63758165 1.452 NM_198426
CHMP2A
chromatin modifying protein 2A
chr11_-_46678736 1.447 ARHGAP1
Rho GTPase activating protein 1
chr19_-_63758184 1.435 CHMP2A
chromatin modifying protein 2A
chr17_-_74433048 1.420 NM_003255
TIMP2
TIMP metallopeptidase inhibitor 2
chr3_-_50371934 1.412 NM_007024
TMEM115
transmembrane protein 115
chrX_-_151749915 1.405 NM_004344
CETN2
centrin, EF-hand protein, 2
chr4_+_148621518 1.396 NM_001166055
NM_001957
EDNRA

endothelin receptor type A

chr3_-_50371896 1.383 TMEM115
transmembrane protein 115
chr19_-_63758270 1.379 CHMP2A
chromatin modifying protein 2A
chr9_+_123123364 1.367 GSN
gelsolin
chr19_-_50619015 1.363 NM_001166049
NM_001983
ERCC1

excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)

chr19_-_50618659 1.358 NM_202001
ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr3_-_50371960 1.355 TMEM115
transmembrane protein 115
chr9_+_132310068 1.340 ASS1
argininosuccinate synthase 1
chr9_-_129656830 1.334 NM_000118
NM_001114753
ENG

endoglin

chr14_-_23734433 1.328 TM9SF1
transmembrane 9 superfamily member 1
chr19_-_50618599 1.317 ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr9_-_129656581 1.317 ENG
endoglin
chr4_-_111777584 1.315 PITX2
paired-like homeodomain 2
chr15_-_75150177 1.312 TSPAN3
tetraspanin 3
chr14_-_23734446 1.310 TM9SF1
transmembrane 9 superfamily member 1
chr19_-_63758289 1.296 NM_014453
CHMP2A
chromatin modifying protein 2A
chr19_-_50618921 1.294 ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr9_-_32516164 1.285 NM_014314
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr18_-_20231783 1.266 NM_080597
OSBPL1A
oxysterol binding protein-like 1A
chr19_-_50618982 1.263 ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr21_-_43671355 1.254 NM_173354
SIK1
salt-inducible kinase 1
chr9_+_35595339 1.246 TESK1
testis-specific kinase 1
chr17_-_43470134 1.243 NM_016429
COPZ2
coatomer protein complex, subunit zeta 2
chr3_+_132228383 1.237 NM_001146003
NM_024800
NM_145910
NEK11


NIMA (never in mitosis gene a)- related kinase 11


chr5_+_141468568 1.224 NDFIP1
Nedd4 family interacting protein 1
chr4_-_111777651 1.216 PITX2
paired-like homeodomain 2
chr1_+_208569262 1.215 NM_001170580
HHAT
hedgehog acyltransferase
chr3_+_156280604 1.213 NM_007288
MME
membrane metallo-endopeptidase
chr3_+_191714533 1.211 NM_001167928
NM_001167929
NM_001167930
NM_001167931
NM_002182
NM_134470
IL1RAP





interleukin 1 receptor accessory protein





chr15_-_68971665 1.203 NM_020147
THAP10
THAP domain containing 10
chr5_+_141468498 1.196 NM_030571
NDFIP1
Nedd4 family interacting protein 1
chr11_-_61491472 1.177 FTH1
ferritin, heavy polypeptide 1
chr1_-_151866367 1.173 NM_001024212
S100A13
S100 calcium binding protein A13
chr1_+_226394605 1.171 GUK1
guanylate kinase 1
chr9_+_35595275 1.150 NM_006285
TESK1
testis-specific kinase 1
chr9_-_129656778 1.150 ENG
endoglin
chr1_-_109386112 1.145 NM_001142550
NM_001142551
NM_014969
WDR47


WD repeat domain 47


chr1_+_77105709 1.144 ST6GALNAC5
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
chr1_+_226394626 1.142 GUK1
guanylate kinase 1
chr4_+_6627801 1.138 NM_015274
MAN2B2
mannosidase, alpha, class 2B, member 2
chr9_-_100057809 1.124 NM_018421
TBC1D2
TBC1 domain family, member 2
chr3_-_49916304 1.118 NM_002447
MST1R
macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
chr1_+_77105746 1.116 NM_030965
ST6GALNAC5
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
chr1_-_6243621 1.115 NM_207370
GPR153
G protein-coupled receptor 153
chr8_-_11763037 1.112 NM_001908
NM_147780
NM_147781
NM_147782
NM_147783
CTSB




cathepsin B




chr1_+_226394638 1.103 GUK1
guanylate kinase 1
chr19_+_52908412 1.091 NM_014601
EHD2
EH-domain containing 2
chr9_-_129656413 1.088 ENG
endoglin
chr5_-_122400219 1.080 PPIC
peptidylprolyl isomerase C (cyclophilin C)
chr14_+_58174489 1.075 NM_001079520
NM_016651
DACT1

dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)

chr4_+_148621567 1.073 EDNRA
endothelin receptor type A
chr15_-_58477407 1.070 NM_001002857
NM_001002858
NM_001136015
NM_004039
ANXA2



annexin A2



chr1_+_226394545 1.057 NM_000858
NM_001159390
GUK1

guanylate kinase 1

chr4_+_38545741 1.055 NM_138389
FAM114A1
family with sequence similarity 114, member A1
chr5_+_141468569 1.053 NDFIP1
Nedd4 family interacting protein 1
chr19_+_52973653 1.049 NM_003009
SEPW1
selenoprotein W, 1
chr15_+_65217412 1.034 NM_001145103
SMAD3
SMAD family member 3
chrX_+_118254233 1.033 NM_006667
PGRMC1
progesterone receptor membrane component 1
chr5_+_96024434 1.025 CAST
calpastatin
chr17_-_78249750 1.024 NM_006822
RAB40B
RAB40B, member RAS oncogene family
chr5_+_140777454 1.013 NM_018927
NM_032101
PCDHGB7

protocadherin gamma subfamily B, 7

chr11_+_93501791 1.002 PANX1
pannexin 1
chr20_+_42777419 1.001 WISP2
WNT1 inducible signaling pathway protein 2
chr1_+_226394589 0.994 GUK1
guanylate kinase 1
chr6_-_139737477 0.991 NM_006079
CITED2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
chr9_+_129951552 0.990 NM_005564
LCN2
lipocalin 2
chr1_-_94475504 0.970 ARHGAP29
Rho GTPase activating protein 29
chr9_-_100057313 0.968 TBC1D2
TBC1 domain family, member 2
chr4_+_15313789 0.963 BST1
bone marrow stromal cell antigen 1
chr4_+_6627816 0.946 MAN2B2
mannosidase, alpha, class 2B, member 2
chr11_+_93501708 0.945 NM_015368
PANX1
pannexin 1
chr5_+_15553288 0.927 NM_012304
FBXL7
F-box and leucine-rich repeat protein 7
chr3_+_139550134 0.926 NM_001085049
MRAS
muscle RAS oncogene homolog
chr17_+_19221606 0.923 NM_139032
NM_139033
MAPK7

mitogen-activated protein kinase 7

chr15_-_56829069 0.920 ADAM10
ADAM metallopeptidase domain 10
chr8_+_22493928 0.919 NM_176871
NM_198042
PDLIM2

PDZ and LIM domain 2 (mystique)

chr19_-_50618471 0.914 ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr17_-_53335748 0.908 NM_017949
CUEDC1
CUE domain containing 1
chr6_-_139737432 0.905 CITED2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
chr8_-_54918325 0.903 ATP6V1H
ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
chr18_+_12298189 0.901 TUBB6
tubulin, beta 6
chr16_+_65765256 0.898 NM_003946
NM_001185057
NOL3

nucleolar protein 3 (apoptosis repressor with CARD domain)

chr12_-_100979923 0.889 NM_016053
CCDC53
coiled-coil domain containing 53
chr14_+_89934358 0.882 NM_001166106
CALM1
calmodulin 1 (phosphorylase kinase, delta)
chr8_-_11763031 0.879 CTSB
cathepsin B
chr2_-_55131096 0.874 RTN4
reticulon 4
chr8_+_1759502 0.874 NM_014629
ARHGEF10
Rho guanine nucleotide exchange factor (GEF) 10
chr19_-_4351357 0.873 SH3GL1
SH3-domain GRB2-like 1
chr10_+_17311282 0.869 VIM
vimentin
chr8_+_79740813 0.868 NM_016010
FAM164A
family with sequence similarity 164, member A
chr21_-_42247007 0.866 NM_015500
C2CD2
C2 calcium-dependent domain containing 2
chr19_+_54722686 0.866 NM_020650
RCN3
reticulocalbin 3, EF-hand calcium binding domain
chr1_+_201862552 0.859 ATP2B4
ATPase, Ca++ transporting, plasma membrane 4
chr1_+_208568811 0.845 NM_001170587
NM_001170588
NM_018194
HHAT


hedgehog acyltransferase


chr8_-_54918369 0.837 ATP6V1H
ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
chr11_-_61491643 0.833 FTH1
CPSF7
ferritin, heavy polypeptide 1
cleavage and polyadenylation specific factor 7, 59kDa
chr14_-_74148422 0.831 NM_000428
LTBP2
latent transforming growth factor beta binding protein 2

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.18 1.62e-06 GO:0005737 cytoplasm
1.25 1.68e-06 GO:0044444 cytoplasmic part
1.21 2.29e-05 GO:0016020 membrane
1.84 8.53e-04 GO:0044431 Golgi apparatus part
1.89 2.85e-03 GO:0000139 Golgi membrane
1.62 1.12e-02 GO:0031410 cytoplasmic vesicle
1.60 1.20e-02 GO:0031982 vesicle
1.54 1.25e-02 GO:0005794 Golgi apparatus
1.40 2.37e-02 GO:0012505 endomembrane system
1.60 3.02e-02 GO:0016023 cytoplasmic membrane-bounded vesicle
1.33 3.18e-02 GO:0031090 organelle membrane
1.59 3.28e-02 GO:0031988 membrane-bounded vesicle
1.93 4.12e-02 GO:0005773 vacuole

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.76 1.46e-02 GO:0008092 cytoskeletal protein binding