Motif ID: SRF.p3

Z-value: 3.811


Transcription factors associated with SRF.p3:

Gene SymbolEntrez IDGene Name
SRF 6722 serum response factor (c-fos serum response element-binding transcription factor)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SRFchr6_+_43247168-0.273.1e-01Click!


Activity profile for motif SRF.p3.

activity profile for motif SRF.p3


Sorted Z-values histogram for motif SRF.p3

Sorted Z-values for motif SRF.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of SRF.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_+_34603290 30.789 NM_006097
NM_181526
MYL9

myosin, light chain 9, regulatory

chr20_+_34603311 30.426 MYL9
myosin, light chain 9, regulatory
chr2_+_73973640 18.480 ACTG2
actin, gamma 2, smooth muscle, enteric
chr2_+_73973600 18.044 NM_001615
ACTG2
actin, gamma 2, smooth muscle, enteric
chr15_-_32875040 17.149 NM_005159
ACTC1
actin, alpha, cardiac muscle 1
chr11_+_116575249 13.608 NM_001001522
NM_003186
TAGLN

transgelin

chr12_+_74160779 12.865 NM_006851
GLIPR1
GLI pathogenesis-related 1
chr10_-_90702490 11.502 NM_001613
ACTA2
actin, alpha 2, smooth muscle, aorta
chr3_-_124822113 10.688 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr6_+_151602787 9.954 NM_005100
AKAP12
A kinase (PRKA) anchor protein 12
chr14_-_52487558 9.803 NM_001134999
NM_001135000
NM_006832
FERMT2


fermitin family member 2


chr3_-_124821868 9.003 MYLK
myosin light chain kinase
chr1_-_89303478 8.606 NM_002053
GBP1
guanylate binding protein 1, interferon-inducible, 67kDa
chr3_-_101077605 7.439 NM_014890
FILIP1L
filamin A interacting protein 1-like
chr6_+_151603201 7.173 AKAP12
A kinase (PRKA) anchor protein 12
chr9_-_78710698 6.885 NM_015225
PRUNE2
prune homolog 2 (Drosophila)
chr7_-_94123308 6.420 SGCE
sarcoglycan, epsilon
chr19_+_16039170 6.315 NM_001145160
TPM4
tropomyosin 4
chr1_-_227636462 6.153 NM_001100
ACTA1
actin, alpha 1, skeletal muscle
chr7_-_94123413 5.911 NM_001099400
NM_001099401
NM_003919
SGCE


sarcoglycan, epsilon


chr7_-_107430566 5.830 NM_002291
LAMB1
laminin, beta 1
chr1_+_221955876 5.713 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chr7_-_94123362 5.397 SGCE
sarcoglycan, epsilon
chr12_-_48902692 4.911 NM_001113547
LIMA1
LIM domain and actin binding 1
chr12_-_90029672 4.729 NM_002345
LUM
lumican
chr19_-_40939756 4.604 NM_144617
HSPB6
heat shock protein, alpha-crystallin-related, B6
chr2_-_105381855 4.578 NM_001039492
NM_001450
NM_201555
FHL2


four and a half LIM domains 2


chr17_-_44026042 4.491 NM_002147
HOXB5
homeobox B5
chr16_+_55523526 4.451 HERPUD1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr15_+_72006015 4.381 LOXL1
lysyl oxidase-like 1
chr2_-_151052391 4.346 NM_005168
RND3
Rho family GTPase 3
chr11_-_118799058 4.142 THY1
Thy-1 cell surface antigen
chr5_+_137829077 4.035 NM_001964
EGR1
early growth response 1
chr3_+_189413414 3.748 NM_005578
LPP
LIM domain containing preferred translocation partner in lipoma
chr17_+_39990124 3.694 NM_001466
FZD2
frizzled homolog 2 (Drosophila)
chr17_-_44026321 3.644 HOXB5
homeobox B5
chr2_-_160972606 3.597 RBMS1
RNA binding motif, single stranded interacting protein 1
chr19_-_50517971 3.512 CKM
creatine kinase, muscle
chr19_-_50518072 3.474 NM_001824
CKM
creatine kinase, muscle
chr10_+_31650069 3.421 NM_001128128
NM_001174094
ZEB1

zinc finger E-box binding homeobox 1

chrX_-_10761729 3.359 NM_033290
MID1
midline 1 (Opitz/BBB syndrome)
chr7_+_142788480 3.337 NM_001010972
NM_003461
ZYX

zyxin

chr22_-_35114001 3.241 NM_002473
MYH9
myosin, heavy chain 9, non-muscle
chr7_+_94123612 3.220 NM_001172437
NM_001172438
PEG10

paternally expressed 10

chrX_-_37591760 3.185 NM_006520
DYNLT3
dynein, light chain, Tctex-type 3
chr7_-_27149750 3.065 NM_019102
HOXA5
homeobox A5
chr7_+_142788521 2.920 ZYX
zyxin
chr7_+_142788517 2.858 ZYX
zyxin
chr10_-_16899395 2.849 RSU1
Ras suppressor protein 1
chr7_+_142788566 2.821 ZYX
zyxin
chr2_-_231697999 2.789 NM_000867
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B
chr7_+_142788569 2.764 ZYX
zyxin
chrX_-_37591703 2.759 DYNLT3
dynein, light chain, Tctex-type 3
chr10_-_16899414 2.754 NM_012425
NM_152724
RSU1

Ras suppressor protein 1

chr6_-_109882116 2.753 MICAL1
microtubule associated monoxygenase, calponin and LIM domain containing 1
chr10_-_16899342 2.742 RSU1
Ras suppressor protein 1
chr19_+_2427122 2.724 NM_015675
GADD45B
growth arrest and DNA-damage-inducible, beta
chr7_+_134114701 2.707 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chr1_-_31618405 2.528 NM_004102
FABP3
fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
chr10_+_75427853 2.428 NM_003373
NM_014000
VCL

vinculin

chr4_-_158111995 2.367 NM_016205
PDGFC
platelet derived growth factor C
chr7_+_94123672 2.311 PEG10
paternally expressed 10
chr16_+_31390567 2.256 NM_001042454
NM_001164719
TGFB1I1

transforming growth factor beta 1 induced transcript 1

chr11_-_65424434 2.189 FOSL1
FOS-like antigen 1
chr7_+_142788579 2.186 ZYX
zyxin
chr7_-_526005 2.176 NM_002607
NM_033023
PDGFA

platelet-derived growth factor alpha polypeptide

chr10_+_88418147 2.163 NM_001171610
LDB3
LIM domain binding 3
chr5_+_140730014 2.142 NM_018924
NM_032097
PCDHGB3

protocadherin gamma subfamily B, 3

chr5_+_92944680 2.098 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr5_-_141981083 2.090 NM_001144892
FGF1
fibroblast growth factor 1 (acidic)
chr6_-_16869579 2.043 NM_000332
NM_001128164
ATXN1

ataxin 1

chr19_+_977608 2.036 CNN2
calponin 2
chr7_-_80386602 1.899 NM_006379
SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr22_+_29810981 1.869 SMTN
smoothelin
chr14_+_74815233 1.862 NM_005252
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr11_+_74950893 1.856 SERPINH1
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
chr15_-_63147350 1.849 NM_016563
RASL12
RAS-like, family 12
chr19_+_12996368 1.836 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr5_-_39461054 1.801 NM_001343
DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr10_-_29963906 1.737 NM_021738
SVIL
supervillin
chr7_-_5536783 1.727 ACTB
actin, beta
chr3_+_189354167 1.699 NM_001167672
LPP
LIM domain containing preferred translocation partner in lipoma
chr11_-_65424436 1.677 NM_005438
FOSL1
FOS-like antigen 1
chr7_+_142788730 1.630 ZYX
zyxin
chr11_-_65424385 1.585 FOSL1
FOS-like antigen 1
chr10_+_123912930 1.557 TACC2
transforming, acidic coiled-coil containing protein 2
chr1_+_27972269 1.538 NM_177424
STX12
syntaxin 12
chr19_+_977582 1.493 CNN2
calponin 2
chr2_-_128149112 1.484 NM_001136037
NM_001161403
LIMS2

LIM and senescent cell antigen-like domains 2

chr9_+_91409746 1.460 NM_006705
GADD45G
growth arrest and DNA-damage-inducible, gamma
chr5_-_111120929 1.450 NM_001142482
NM_001142481
C5orf13

chromosome 5 open reading frame 13

chr10_+_112247614 1.410 NM_004419
DUSP5
dual specificity phosphatase 5
chr4_+_24406182 1.380 NM_003102
SOD3
superoxide dismutase 3, extracellular
chr17_-_77094375 1.371 NM_001614
ACTG1
actin, gamma 1
chr19_+_977601 1.358 CNN2
calponin 2
chr7_-_80386258 1.358 SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr1_+_11917330 1.327 NM_000302
PLOD1
procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1
chr15_-_57452361 1.317 NM_004998
MYO1E
myosin IE
chr6_-_132314004 1.285 NM_001901
CTGF
connective tissue growth factor
chr17_+_3326045 1.237 NM_000049
ASPA
aspartoacylase
chr4_+_156899575 1.222 NM_000857
GUCY1B3
guanylate cyclase 1, soluble, beta 3
chr7_-_5536704 1.214 NM_001101
ACTB
actin, beta
chr19_+_977627 1.211 CNN2
calponin 2
chr12_-_6642513 1.185 NM_001127582
NM_001127583
NM_001127584
NM_001127585
NM_001127586
NM_016162
ING4





inhibitor of growth family, member 4





chr17_-_77094426 1.173 ACTG1
actin, gamma 1
chr3_+_62279707 1.168 C3orf14
chromosome 3 open reading frame 14
chr15_+_94674849 1.068 NM_021005
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr1_-_89364273 1.057 NM_004120
GBP2
guanylate binding protein 2, interferon-inducible
chr10_+_88418243 1.041 NM_001080116
NM_001080114
NM_001080115
NM_001171611
NM_007078
LDB3




LIM domain binding 3




chr2_-_105421661 1.028 NM_201557
FHL2
four and a half LIM domains 2
chr15_-_63147228 1.017 RASL12
RAS-like, family 12
chr21_-_27139143 1.004 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr9_+_115396020 0.991 NM_144489
RGS3
regulator of G-protein signaling 3
chr1_+_149779384 0.971 NM_001126337
NM_020127
TUFT1

tuftelin 1

chr5_-_111121150 0.935 NM_001142479
NM_001142480
NM_001142478
C5orf13


chromosome 5 open reading frame 13


chr7_+_94123556 0.908 NM_001040152
NM_001184961
NM_001184962
NM_015068
PEG10



paternally expressed 10



chr15_-_57452345 0.907 MYO1E
myosin IE
chr12_+_26239755 0.889 NM_005086
SSPN
sarcospan (Kras oncogene-associated gene)
chr6_-_76022565 0.879 TMEM30A
transmembrane protein 30A
chr1_-_166373434 0.866 GPR161
G protein-coupled receptor 161
chr7_-_5535726 0.846 ACTB
actin, beta
chr4_-_9727542 0.831 WDR1
WD repeat domain 1
chr3_+_54131731 0.826 NM_018398
CACNA2D3
calcium channel, voltage-dependent, alpha 2/delta subunit 3
chr10_+_123744131 0.823 TACC2
transforming, acidic coiled-coil containing protein 2
chr17_-_71611450 0.818 NM_001013839
NM_001145297
NM_001145298
NM_001145299
NM_015219
EXOC7




exocyst complex component 7




chr9_+_96561750 0.815 NM_001193329
C9orf3
chromosome 9 open reading frame 3
chr1_-_240228987 0.786 NM_001004343
MAP1LC3C
microtubule-associated protein 1 light chain 3 gamma
chr1_-_166373159 0.776 GPR161
G protein-coupled receptor 161
chrX_-_68301974 0.775 NM_001032396
NM_022368
NM_145119
PJA1


praja ring finger 1


chr1_+_11917365 0.768 PLOD1
procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1
chr2_+_84986273 0.750 NM_021103
TMSB10
thymosin beta 10
chr17_-_1335763 0.740 NM_001080950
MYO1C
myosin IC
chr15_+_94670160 0.732 NM_001145155
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr8_-_48813236 0.726 CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr11_-_8982107 0.653 NM_020645
NRIP3
nuclear receptor interacting protein 3
chr4_-_9727598 0.622 NM_005112
NM_017491
WDR1

WD repeat domain 1

chrX_+_153318662 0.615 GDI1
GDP dissociation inhibitor 1
chr1_-_152431175 0.608 NM_152263
TPM3
tropomyosin 3
chr10_+_6226884 0.600 PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr8_+_24827173 0.599 NM_005382
NEFM
neurofilament, medium polypeptide
chr4_-_9727558 0.597 WDR1
WD repeat domain 1
chrX_-_153256192 0.572 NM_001110556
NM_001456
LOC100131857
FLNA

hypothetical protein LOC100131857
filamin A, alpha

chr10_+_6226909 0.566 PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr3_-_9809357 0.543 NM_006354
NM_133480
TADA3

transcriptional adaptor 3

chr11_-_2118743 0.523 IGF2
insulin-like growth factor 2 (somatomedin A)
chr18_+_52469559 0.522 NM_015285
NM_052834
WDR7

WD repeat domain 7

chr12_-_11439752 0.511 NM_006248
PRB1
PRB2
proline-rich protein BstNI subfamily 1
proline-rich protein BstNI subfamily 2
chr19_+_62566690 0.511 NM_173631
TRAPPC2P1
ZNF547
trafficking protein particle complex 2 pseudogene 1
zinc finger protein 547
chr4_-_9727476 0.494 WDR1
WD repeat domain 1
chr4_-_9727384 0.483


chr19_-_50975603 0.482 NM_001081563
DMPK
dystrophia myotonica-protein kinase
chr3_+_9809776 0.481 NM_001198780
ARPC4
actin related protein 2/3 complex, subunit 4, 20kDa
chr1_-_166373351 0.475 GPR161
G protein-coupled receptor 161
chr12_+_51931636 0.473 NM_001170790
MFSD5
major facilitator superfamily domain containing 5
chr1_+_179324458 0.470 IER5
immediate early response 5
chr3_-_9809065 0.459 TADA3
transcriptional adaptor 3
chr1_+_19843261 0.422 NM_005380
NBL1
neuroblastoma, suppression of tumorigenicity 1
chr5_-_178983281 0.403 NM_005520
HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr2_-_241903657 0.401 HDLBP
high density lipoprotein binding protein
chr21_+_34112456 0.379 ITSN1
intersectin 1 (SH3 domain protein)
chr10_+_6226764 0.375 NM_001145443
PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr8_-_102034272 0.368 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr8_+_24827181 0.346 NEFM
neurofilament, medium polypeptide
chr5_-_58331515 0.334 NM_001197223
PDE4D
phosphodiesterase 4D, cAMP-specific
chr17_+_30938433 0.310 AP2B1
adaptor-related protein complex 2, beta 1 subunit
chr13_+_26723689 0.308 NM_000982
RPL21
ribosomal protein L21
chrX_+_70438352 0.299 NM_012278
ITGB1BP2
integrin beta 1 binding protein (melusin) 2
chr4_+_120276386 0.294 NM_016599
MYOZ2
myozenin 2
chr4_-_88669267 0.287 SPARCL1
SPARC-like 1 (hevin)
chr11_-_64402629 0.287 NM_006795
EHD1
EH-domain containing 1
chr6_-_73991895 0.269 NM_001126063
KHDC1L
KH homology domain containing 1-like
chr22_-_36998615 0.268 NM_001195071
TMEM184B
transmembrane protein 184B
chr5_-_178983241 0.251 HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chrX_+_150635162 0.250 NM_033085
FATE1
fetal and adult testis expressed 1
chr2_+_161701711 0.235 NM_004180
NM_133484
TANK

TRAF family member-associated NFKB activator

chr7_-_5535432 0.221 ACTB
actin, beta
chr20_-_61728774 0.214 NM_012384
GMEB2
glucocorticoid modulatory element binding protein 2
chr19_+_62593000 0.212 NM_001172773
NM_152909
ZNF548

zinc finger protein 548

chr17_-_4831388 0.211 NM_001171167
NM_001171168
CAMTA2

calmodulin binding transcription activator 2

chr22_+_36412277 0.207 NM_024313
NOL12
nucleolar protein 12
chr18_+_3237527 0.197 NM_006471
MYL12A
myosin, light chain 12A, regulatory, non-sarcomeric
chr3_-_12680329 0.196 RAF1
v-raf-1 murine leukemia viral oncogene homolog 1
chr17_-_71611198 0.195 EXOC7
exocyst complex component 7
chr15_+_75010997 0.185 NM_002902
RCN2
reticulocalbin 2, EF-hand calcium binding domain
chr19_+_60845229 0.183 NM_016202
NM_001163423
ZNF580

zinc finger protein 580

chr10_-_44794146 0.174 NM_007021
C10orf10
chromosome 10 open reading frame 10
chr12_-_123965099 0.146 UBC
ubiquitin C
chr2_+_28469172 0.141 FOSL2
FOS-like antigen 2
chr3_+_9809201 0.140 NM_001198793
NM_005718
ARPC4-TTLL3
ARPC4
ARPC4-TTLL3 readthrough
actin related protein 2/3 complex, subunit 4, 20kDa
chr22_+_36334400 0.140 NM_001001560
NM_001001561
NM_001172687
NM_013365
GGA1



golgi-associated, gamma adaptin ear containing, ARF binding protein 1



chr5_+_176955595 0.138


chr19_+_9222605 0.131 NM_001079935
OR7E24
olfactory receptor, family 7, subfamily E, member 24
chr13_-_77447664 0.128 NM_000115
EDNRB
endothelin receptor type B
chr12_-_78853365 0.118 NM_001143885
PPP1R12A
protein phosphatase 1, regulatory (inhibitor) subunit 12A
chr1_+_242883057 0.113 PPPDE1
PPPDE peptidase domain containing 1
chr19_+_40541327 0.111 NM_005304
FFAR3
free fatty acid receptor 3
chr19_+_54068373 0.108 PPP1R15A
protein phosphatase 1, regulatory (inhibitor) subunit 15A
chr4_+_166350620 0.101 NM_001161521
NM_001161522
KLHL2

kelch-like 2, Mayven (Drosophila)

chr3_-_158361175 0.099 NM_020307
CCNL1
cyclin L1
chr19_+_54068300 0.098 PPP1R15A
protein phosphatase 1, regulatory (inhibitor) subunit 15A

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
6.86 4.18e-06 GO:0003012 muscle system process
6.99 1.10e-05 GO:0006936 muscle contraction
4.39 3.32e-03 GO:0030029 actin filament-based process
2.19 2.27e-02 GO:0003008 system process
1.49 3.82e-02 GO:0032501 multicellular organismal process
9.04 4.27e-02 GO:0030048 actin filament-based movement
3.98 4.45e-02 GO:0061061 muscle structure development
4.69 4.86e-02 GO:0007517 muscle organ development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
7.12 5.34e-12 GO:0015629 actin cytoskeleton
24.00 8.09e-10 GO:0042641 actomyosin
25.60 4.98e-09 GO:0001725 stress fiber
23.84 1.04e-08 GO:0032432 actin filament bundle
2.74 2.41e-07 GO:0005856 cytoskeleton
8.31 3.11e-06 GO:0043292 contractile fiber
8.37 1.14e-05 GO:0044449 contractile fiber part
8.13 1.54e-05 GO:0030016 myofibril
7.68 3.72e-04 GO:0005925 focal adhesion
7.36 5.36e-04 GO:0005924 cell-substrate adherens junction
7.06 7.59e-04 GO:0030055 cell-substrate junction
5.82 1.28e-03 GO:0005912 adherens junction
7.15 2.34e-03 GO:0030017 sarcomere
5.23 3.29e-03 GO:0070161 anchoring junction
2.48 3.54e-03 GO:0044430 cytoskeletal part
8.54 1.02e-02 GO:0016459 myosin complex
1.69 2.61e-02 GO:0043228 non-membrane-bounded organelle
1.69 2.61e-02 GO:0043232 intracellular non-membrane-bounded organelle

Gene overrepresentation in function category:

enrichment   p-value GO term description
4.81 1.55e-05 GO:0003779 actin binding
3.46 2.19e-04 GO:0008092 cytoskeletal protein binding
4.92 3.77e-02 GO:0005516 calmodulin binding