Motif ID: NFE2L1.p2

Z-value: 1.856


Transcription factors associated with NFE2L1.p2:

Gene SymbolEntrez IDGene Name
NFE2L1 4779 nuclear factor (erythroid-derived 2)-like 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NFE2L1chr17_+_434806740.391.3e-01Click!


Activity profile for motif NFE2L1.p2.

activity profile for motif NFE2L1.p2


Sorted Z-values histogram for motif NFE2L1.p2

Sorted Z-values for motif NFE2L1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFE2L1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_-_10495476 3.852 NM_001193278
NM_001193279
NM_001193280
NM_001193281
MID1



midline 1 (Opitz/BBB syndrome)



chr21_+_46370220 3.776 COL6A2
collagen, type VI, alpha 2
chr3_+_160473729 3.384 NM_001197107
NM_001197108
NM_014575
SCHIP1


schwannomin interacting protein 1


chr2_-_215967442 3.119 FN1
fibronectin 1
chr21_+_46369606 3.079 COL6A2
collagen, type VI, alpha 2
chr21_+_46369617 2.826 COL6A2
collagen, type VI, alpha 2
chr15_-_88150823 2.779 ANPEP
alanyl (membrane) aminopeptidase
chr1_-_68470585 2.752 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr12_+_13240868 2.694 NM_001423
EMP1
epithelial membrane protein 1
chr1_-_20682541 2.629


chr9_-_16717887 2.609 BNC2
basonuclin 2
chr12_+_13240987 2.579 EMP1
epithelial membrane protein 1
chr17_-_37034288 2.458 NM_000422
KRT17
keratin 17
chr3_-_45242072 2.427 TMEM158
transmembrane protein 158 (gene/pseudogene)
chr10_+_75343352 2.390 PLAU
plasminogen activator, urokinase
chr12_+_76749199 2.365 NM_014903
NAV3
neuron navigator 3
chr16_+_81218074 2.319 NM_001257
CDH13
cadherin 13, H-cadherin (heart)
chr21_-_26175068 2.290 APP
amyloid beta (A4) precursor protein
chr5_+_34720368 2.220 NM_001145521
NM_001145525
RAI14

retinoic acid induced 14

chr17_-_36996611 2.168 NM_000526
KRT14
keratin 14
chr15_-_88143721 1.989 ANPEP
alanyl (membrane) aminopeptidase
chr5_+_148186348 1.983 NM_000024
ADRB2
adrenergic, beta-2-, receptor, surface
chrX_-_10605726 1.978 NM_001098624
MID1
midline 1 (Opitz/BBB syndrome)
chr10_+_124211353 1.945 HTRA1
HtrA serine peptidase 1
chr13_+_113546841 1.905 NM_000820
GAS6
growth arrest-specific 6
chr1_-_58815415 1.824 TACSTD2
tumor-associated calcium signal transducer 2
chr5_+_35892747 1.794 NM_002185
IL7R
interleukin 7 receptor
chr7_-_27149750 1.763 NM_019102
HOXA5
homeobox A5
chr6_-_112682573 1.758 LAMA4
laminin, alpha 4
chr17_-_45619038 1.753 COL1A1
collagen, type I, alpha 1
chr3_+_158637273 1.739 NM_002852
PTX3
pentraxin 3, long
chr10_+_124210980 1.730 NM_002775
HTRA1
HtrA serine peptidase 1
chr10_-_92671005 1.722 NM_014391
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr13_+_113546943 1.711 GAS6
growth arrest-specific 6
chr9_-_14303899 1.698 NFIB
nuclear factor I/B
chr17_-_44037332 1.690 NM_018952
HOXB6
homeobox B6
chr3_-_129023850 1.633 NM_007283
MGLL
monoglyceride lipase
chr11_-_27700180 1.627 NM_170731
BDNF
brain-derived neurotrophic factor
chrX_+_99785818 1.576 NM_014467
SRPX2
sushi-repeat containing protein, X-linked 2
chrX_-_99778340 1.572 NM_003270
TSPAN6
tetraspanin 6
chr6_-_112682459 1.563 NM_001105206
NM_001105207
NM_001105208
NM_001105209
NM_002290
LAMA4




laminin, alpha 4




chr12_-_51173238 1.558 NM_005554
KRT6A
keratin 6A
chr1_-_59020875 1.552 JUN
jun proto-oncogene
chr4_-_177950658 1.547 NM_005429
VEGFC
vascular endothelial growth factor C
chrX_+_106956115 1.499 MID2
midline 2
chr2_-_105381855 1.475 NM_001039492
NM_001450
NM_201555
FHL2


four and a half LIM domains 2


chr9_+_96561750 1.463 NM_001193329
C9orf3
chromosome 9 open reading frame 3
chr9_-_14303509 1.443 NFIB
nuclear factor I/B
chr1_-_153209625 1.424 NM_001130040
NM_183001
SHC1

SHC (Src homology 2 domain containing) transforming protein 1

chr10_-_92670764 1.379 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chrX_+_99786044 1.365 SRPX2
sushi-repeat containing protein, X-linked 2
chr7_+_134114701 1.334 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chr4_-_40631397 1.331 APBB2
amyloid beta (A4) precursor protein-binding, family B, member 2
chr1_+_84382529 1.305 NM_182948
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr5_+_140848905 1.272 NM_018929
NM_032407
PCDHGC5

protocadherin gamma subfamily C, 5

chr1_-_95165037 1.267 CNN3
calponin 3, acidic
chr4_-_16509446 1.255 NM_001130834
NM_001290
LDB2

LIM domain binding 2

chr4_-_16509126 1.253 LDB2
LIM domain binding 2
chr8_-_23233426 1.246 LOXL2
lysyl oxidase-like 2
chr5_-_54317102 1.232 NM_001135604
NM_007036
ESM1

endothelial cell-specific molecule 1

chr18_+_54681657 1.230 ZNF532
zinc finger protein 532
chr7_+_134114957 1.225 CALD1
caldesmon 1
chr16_+_85101605 1.213 NM_001451
FOXF1
forkhead box F1
chr5_+_140871107 1.213


chr17_-_37828643 1.212 NM_012232
PTRF
polymerase I and transcript release factor
chr12_-_90100733 1.206 NM_001920
DCN
decorin
chr8_-_93099040 1.203 NM_175636
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr8_-_42184350 1.200 NM_000930
NM_033011
PLAT

plasminogen activator, tissue

chr4_-_16509354 1.195 LDB2
LIM domain binding 2
chr11_+_12652427 1.192 NM_021961
TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr8_-_42184194 1.186 PLAT
plasminogen activator, tissue
chr12_-_103846186 1.144 NM_032148
SLC41A2
solute carrier family 41, member 2
chr10_+_5556923 1.139 NM_005185
CALML3
calmodulin-like 3
chr2_+_36436873 1.135 NM_016441
CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr5_+_140790365 1.135 PCDHGA12
protocadherin gamma subfamily A, 12
chr19_+_51804260 1.124 CALM3
calmodulin 3 (phosphorylase kinase, delta)
chr8_-_102029997 1.120 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chrX_+_106955737 1.103 NM_012216
NM_052817
MID2

midline 2

chr1_-_95165089 1.098 NM_001839
CNN3
calponin 3, acidic
chr8_+_70541412 1.095 NM_001128204
NM_015170
SULF1

sulfatase 1

chr5_+_36644187 1.079 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr21_-_26269298 1.077 APP
amyloid beta (A4) precursor protein
chrX_-_10548458 1.069 NM_000381
NM_033289
MID1

midline 1 (Opitz/BBB syndrome)

chr6_-_169395847 1.066 THBS2
thrombospondin 2
chr13_+_109952014 1.055 COL4A2
collagen, type IV, alpha 2
chr8_-_145090892 1.048 NM_201381
PLEC
plectin
chr20_+_9406460 1.048 PLCB4
phospholipase C, beta 4
chr2_-_224974954 1.045 NM_001122779
NM_024785
FAM124B

family with sequence similarity 124B

chr14_-_74148422 1.038 NM_000428
LTBP2
latent transforming growth factor beta binding protein 2
chr5_+_140790310 1.022 NM_003735
NM_032094
PCDHGA12

protocadherin gamma subfamily A, 12

chr10_+_17311788 1.021 VIM
vimentin
chr5_-_39461054 1.016 NM_001343
DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr6_-_134537637 1.006 SGK1
serum/glucocorticoid regulated kinase 1
chr5_-_39460687 0.998 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr2_+_201182187 0.998 AOX1
aldehyde oxidase 1
chr5_-_175775966 0.985 CLTB
clathrin, light chain B
chr3_+_171619346 0.974 NM_005602
CLDN11
claudin 11
chrX_+_114734074 0.971 NM_001136025
NM_001172335
PLS3

plastin 3

chr6_-_169395972 0.969 NM_003247
THBS2
thrombospondin 2
chr4_+_169654742 0.968 NM_001166108
NM_016081
PALLD

palladin, cytoskeletal associated protein

chr6_-_134537699 0.962 NM_005627
SGK1
serum/glucocorticoid regulated kinase 1
chr22_+_36928011 0.958 MAFF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr1_+_114323552 0.956 NM_020190
OLFML3
olfactomedin-like 3
chr21_+_46370831 0.951 COL6A2
collagen, type VI, alpha 2
chr10_+_17311242 0.950 VIM
vimentin
chr22_+_36927884 0.950 NM_001161572
NM_001161574
NM_012323
MAFF


v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)


chr7_+_75769765 0.948 NM_001540
HSPB1
heat shock 27kDa protein 1
chr15_+_72006015 0.945 LOXL1
lysyl oxidase-like 1
chr21_+_46369911 0.943 COL6A2
collagen, type VI, alpha 2
chr17_-_15109315 0.943 NM_000304
PMP22
peripheral myelin protein 22
chr5_+_140733664 0.943 NM_018919
NM_032086
PCDHGA6

protocadherin gamma subfamily A, 6

chr6_-_46933901 0.941 GPR116
G protein-coupled receptor 116
chr12_+_52708460 0.934 NM_004503
HOXC6
homeobox C6
chr6_-_110607857 0.932 NM_001024934
NM_001024935
NM_001024936
NM_003931
WASF1



WAS protein family, member 1



chr7_+_129720209 0.930 NM_001163446
NM_016352
CPA4

carboxypeptidase A4

chr10_+_86121526 0.930 FAM190B
family with sequence similarity 190, member B
chr2_-_175578156 0.929 NM_001025201
NM_001822
CHN1

chimerin (chimaerin) 1

chr10_+_17311282 0.923 VIM
vimentin
chr10_+_17311347 0.923 VIM
vimentin
chr16_+_15503623 0.922 NM_001142469
C16orf45
chromosome 16 open reading frame 45
chr8_-_126173108 0.921 KIAA0196
KIAA0196
chrX_+_135079461 0.915 NM_001167819
FHL1
four and a half LIM domains 1
chr6_-_10527772 0.910 NM_001042425
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr5_+_71438796 0.908 NM_005909
MAP1B
microtubule-associated protein 1B
chr3_+_160269734 0.906 NM_001197113
NM_001197114
NM_001042705
NM_001042706
NM_001197100
IQCJ-SCHIP1

IQCJ


IQCJ-SCHIP1 readthrough

IQ motif containing J


chr5_+_102229425 0.905 NM_000919
NM_001177306
NM_138766
NM_138821
NM_138822
PAM




peptidylglycine alpha-amidating monooxygenase




chr10_+_17311283 0.904 VIM
vimentin
chr11_-_8788765 0.902 NM_213618
ST5
suppression of tumorigenicity 5
chr9_-_14076901 0.898 NFIB
nuclear factor I/B
chr17_-_77093603 0.898 ACTG1
actin, gamma 1
chr8_-_126173189 0.897 KIAA0196
KIAA0196
chr8_-_93144366 0.893 NM_004349
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr10_+_17311307 0.884 VIM
vimentin
chr15_+_61356801 0.882 NM_001145646
NM_031301
APH1B

anterior pharynx defective 1 homolog B (C. elegans)

chr13_-_37070862 0.880 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr2_+_189547377 0.869 COL3A1
collagen, type III, alpha 1
chr7_+_75769927 0.865 HSPB1
heat shock 27kDa protein 1
chr8_-_126173186 0.865 KIAA0196
KIAA0196
chr5_+_140709907 0.857 NM_018922
NM_032095
PCDHGB1

protocadherin gamma subfamily B, 1

chr9_-_14304036 0.857 NM_001190737
NM_005596
NFIB

nuclear factor I/B

chr21_-_35343456 0.853 NM_001754
RUNX1
runt-related transcription factor 1
chr6_+_7486836 0.850 DSP
desmoplakin
chr6_+_7486891 0.848 DSP
desmoplakin
chrX_-_48818585 0.847 NM_007213
PRAF2
PRA1 domain family, member 2
chr5_+_140790510 0.844 PCDHGA12
protocadherin gamma subfamily A, 12
chr15_+_72005847 0.838 LOXL1
lysyl oxidase-like 1
chrX_+_135106578 0.836 NM_001159701
NM_001159699
FHL1

four and a half LIM domains 1

chr8_+_94999167 0.836 NM_001161778
PDP1
pyruvate dehyrogenase phosphatase catalytic subunit 1
chr21_-_35343500 0.831 RUNX1
runt-related transcription factor 1
chr14_+_64077171 0.831 HSPA2
heat shock 70kDa protein 2
chr5_-_39460787 0.831 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr19_+_3045266 0.824 NM_002067
GNA11
guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
chr20_-_22978141 0.817 NM_000361
THBD
thrombomodulin
chr15_+_65205107 0.816 NM_001145102
SMAD3
SMAD family member 3
chr18_+_59705918 0.816 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr10_-_126839546 0.811 NM_001083914
CTBP2
C-terminal binding protein 2
chr3_-_150578207 0.808 NM_014220
TM4SF1
transmembrane 4 L six family member 1
chr7_-_41709191 0.806 NM_002192
INHBA
inhibin, beta A
chr1_-_153477511 0.803 GBA
glucosidase, beta, acid
chr15_+_72005839 0.802 NM_005576
LOXL1
lysyl oxidase-like 1
chrX_-_140098959 0.798 NM_012317
LDOC1
leucine zipper, down-regulated in cancer 1
chr8_-_126173227 0.795 NM_014846
KIAA0196
KIAA0196
chr2_+_189547358 0.794 COL3A1
collagen, type III, alpha 1
chr5_+_125786975 0.794 GRAMD3
GRAM domain containing 3
chr5_+_125786717 0.791 NM_001146320
NM_001146321
NM_023927
GRAMD3


GRAM domain containing 3


chr7_+_142790047 0.791 ZYX
zyxin
chr10_+_17311962 0.790 VIM
vimentin
chrX_-_34585287 0.789 NM_031442
TMEM47
transmembrane protein 47
chr2_+_189547323 0.788 NM_000090
COL3A1
collagen, type III, alpha 1
chr11_-_6600385 0.786 DCHS1
dachsous 1 (Drosophila)
chr1_-_58815753 0.784 NM_002353
TACSTD2
tumor-associated calcium signal transducer 2
chr12_+_7038240 0.781 NM_001734
NM_201442
C1S

complement component 1, s subcomponent

chrX_-_140098941 0.780 LDOC1
leucine zipper, down-regulated in cancer 1
chr15_+_72005875 0.778 LOXL1
lysyl oxidase-like 1
chr7_-_129379947 0.771 NM_003344
NM_182697
UBE2H

ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)

chr17_-_77093468 0.768 ACTG1
actin, gamma 1
chr1_+_51474558 0.768 RNF11
ring finger protein 11
chr5_+_102229612 0.767 PAM
peptidylglycine alpha-amidating monooxygenase
chr15_+_72005864 0.767 LOXL1
lysyl oxidase-like 1
chr12_+_51777715 0.765 IGFBP6
insulin-like growth factor binding protein 6
chr8_-_126173203 0.764 KIAA0196
KIAA0196
chr6_+_7486862 0.759 NM_001008844
NM_004415
DSP

desmoplakin

chr13_-_32658215 0.758 NM_178007
STARD13
StAR-related lipid transfer (START) domain containing 13
chr16_+_55156461 0.756 NM_032935
MT4
metallothionein 4
chr10_-_33663777 0.755 NM_001024628
NM_001024629
NM_003873
NRP1


neuropilin 1


chr10_+_128583984 0.752 NM_001380
DOCK1
dedicator of cytokinesis 1
chr12_+_51777684 0.752 NM_002178
IGFBP6
insulin-like growth factor binding protein 6
chr12_+_54838733 0.751 MYL6
myosin, light chain 6, alkali, smooth muscle and non-muscle
chr8_+_95722575 0.745 ESRP1
epithelial splicing regulatory protein 1
chr9_+_119506446 0.745 TLR4
toll-like receptor 4
chr18_+_45342398 0.743 NM_006033
LIPG
lipase, endothelial
chr22_+_36472262 0.742 TRIOBP
TRIO and F-actin binding protein
chr4_-_75183860 0.739 NM_002089
CXCL2
chemokine (C-X-C motif) ligand 2
chr3_-_124893875 0.738 MYLK
myosin light chain kinase
chr9_-_128910132 0.734 ANGPTL2
angiopoietin-like 2
chr12_-_105165805 0.727 NM_006825
CKAP4
cytoskeleton-associated protein 4
chr7_-_151142858 0.725 NM_001040633
PRKAG2
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chr17_-_44026321 0.724 HOXB5
homeobox B5
chr10_+_8136778 0.723 GATA3
GATA binding protein 3
chr11_+_35154775 0.719 CD44
CD44 molecule (Indian blood group)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.37 2.82e-08 GO:0007608 sensory perception of smell
1.45 1.64e-07 GO:0003008 system process
2.68 5.42e-06 GO:0007606 sensory perception of chemical stimulus
1.18 2.57e-05 GO:0032501 multicellular organismal process
1.40 2.87e-03 GO:0050877 neurological system process
2.11 4.71e-03 GO:0007156 homophilic cell adhesion
1.59 6.23e-03 GO:0007600 sensory perception
1.17 7.59e-03 GO:0023052 signaling
3.79 1.10e-02 GO:0071478 cellular response to radiation
1.18 1.20e-02 GO:0007165 signal transduction
1.54 1.28e-02 GO:0072358 cardiovascular system development
1.54 1.28e-02 GO:0072359 circulatory system development
1.12 1.55e-02 GO:0050896 response to stimulus
1.34 3.98e-02 GO:0007154 cell communication
1.45 4.06e-02 GO:0042060 wound healing

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.17 2.94e-10 GO:0016020 membrane
1.24 2.11e-08 GO:0071944 cell periphery
1.24 3.30e-08 GO:0005886 plasma membrane
1.16 3.49e-05 GO:0044425 membrane part
1.58 7.11e-05 GO:0030054 cell junction
1.45 3.59e-04 GO:0031410 cytoplasmic vesicle
1.43 8.26e-04 GO:0031982 vesicle
1.45 8.62e-04 GO:0016023 cytoplasmic membrane-bounded vesicle
1.44 1.13e-03 GO:0031988 membrane-bounded vesicle
1.15 3.84e-03 GO:0016021 integral to membrane
1.95 4.15e-03 GO:0005912 adherens junction
1.14 9.27e-03 GO:0031224 intrinsic to membrane
1.83 1.43e-02 GO:0070161 anchoring junction
1.61 1.56e-02 GO:0015629 actin cytoskeleton
1.21 1.66e-02 GO:0044459 plasma membrane part
1.26 3.11e-02 GO:0005856 cytoskeleton
2.07 3.13e-02 GO:0030017 sarcomere
1.94 3.98e-02 GO:0030016 myofibril

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.76 1.76e-08 GO:0004984 olfactory receptor activity