Motif ID: RXRG_dimer.p3

Z-value: 1.073


Transcription factors associated with RXRG_dimer.p3:

Gene SymbolEntrez IDGene Name
NR1H2 7376 nuclear receptor subfamily 1, group H, member 2
PPARA 5465 peroxisome proliferator-activated receptor alpha
PPARG 5468 peroxisome proliferator-activated receptor gamma
RXRA 6256 retinoid X receptor, alpha
RXRB 6257 retinoid X receptor, beta
RXRG 6258 retinoid X receptor, gamma

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NR1H2chr19_+_55571493-0.665.0e-03Click!
RXRBchr6_-_332763470.514.6e-02Click!
RXRGchr1_-_163680941-0.439.5e-02Click!
PPARAchr22_+_44925354-0.391.4e-01Click!
PPARGchr3_+_12367993,
chr3_+_12304332
0.371.6e-01Click!
RXRAchr9_+_1363581450.312.4e-01Click!


Activity profile for motif RXRG_dimer.p3.

activity profile for motif RXRG_dimer.p3


Sorted Z-values histogram for motif RXRG_dimer.p3

Sorted Z-values for motif RXRG_dimer.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of RXRG_dimer.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_116213511 2.654 NM_000039
APOA1
apolipoprotein A-I
chr11_+_116205830 2.531 NM_000040
APOC3
apolipoprotein C-III
chr6_+_31731667 2.124 APOM
apolipoprotein M
chr6_+_31731647 2.049 NM_019101
APOM
apolipoprotein M
chr20_+_55569542 1.756 NM_002591
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr19_+_54708302 1.575 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr2_+_218992053 1.564 NM_007127
VIL1
villin 1
chr10_-_52315390 1.527 A1CF
APOBEC1 complementation factor
chr12_-_6535481 1.472 NM_001039670
NM_001193457
NM_080730
IFFO1


intermediate filament family orphan 1


chr19_+_54708312 1.471 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr2_+_108432097 1.407 GCC2
GRIP and coiled-coil domain containing 2
chr5_-_42847716 1.328 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr2_+_108432008 1.299 NM_181453
GCC2
GRIP and coiled-coil domain containing 2
chr10_-_52315436 1.259 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr10_+_102722275 1.165 NM_017893
SEMA4G
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr20_-_19981005 1.092 CRNKL1
crooked neck pre-mRNA splicing factor-like 1 (Drosophila)
chr2_+_177965617 1.087 NM_003659
AGPS
alkylglycerone phosphate synthase
chr2_+_177965734 1.057 AGPS
alkylglycerone phosphate synthase
chr5_+_92944680 1.042 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr6_+_144040751 0.988 NM_001100164
NM_001100165
PHACTR2

phosphatase and actin regulator 2

chr1_-_172153087 0.988 NM_000488
SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr13_+_99539269 0.909 NM_000282
NM_001127692
NM_001178004
PCCA


propionyl CoA carboxylase, alpha polypeptide


chr7_-_65084668 0.907 NM_000181
GUSB
glucuronidase, beta
chr16_+_4654710 0.863 MGRN1
mahogunin, ring finger 1
chr7_-_65084597 0.795 GUSB
glucuronidase, beta
chr1_+_144439069 0.791 NM_002614
PDZK1
PDZ domain containing 1
chr2_-_64099935 0.769 VPS54
vacuolar protein sorting 54 homolog (S. cerevisiae)
chr7_-_65084622 0.739 GUSB
glucuronidase, beta
chr6_+_30632641 0.736 PRR3
proline rich 3
chr16_-_86527608 0.724 NM_001739
CA5A
carbonic anhydrase VA, mitochondrial
chr2_+_138438277 0.713 NM_001024074
NM_001024075
NM_006895
HNMT


histamine N-methyltransferase


chr7_-_65084641 0.691 GUSB
glucuronidase, beta
chr7_-_72574474 0.690 BAZ1B
bromodomain adjacent to zinc finger domain, 1B
chr2_+_219354692 0.673 NM_000784
CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1
chr20_+_30409649 0.649 NM_001164603
NM_015338
ASXL1

additional sex combs like 1 (Drosophila)

chr4_+_140806536 0.607 MGST2
microsomal glutathione S-transferase 2
chr19_+_54708247 0.602 NM_004107
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr1_-_172153024 0.567 SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr7_-_74127572 0.566 WBSCR16
Williams-Beuren syndrome chromosome region 16
chrX_-_122694569 0.565 NM_001081550
THOC2
THO complex 2
chr2_-_27966715 0.550 NM_022128
RBKS
ribokinase
chr1_+_43628186 0.505 C1orf84
chromosome 1 open reading frame 84
chr19_+_54708389 0.473 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr20_+_37024383 0.452 NM_001190809
NM_021931
DHX35

DEAH (Asp-Glu-Ala-His) box polypeptide 35

chr20_-_36095236 0.449 NM_014657
TTI1
Tel2 interacting protein 1 homolog (S. pombe)
chr2_+_73294852 0.445 NM_006062
SMYD5
SMYD family member 5
chr17_-_33179118 0.421 NM_000458
NM_001165923
HNF1B

HNF1 homeobox B

chr2_-_206732348 0.415 NM_005006
NDUFS1
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
chr22_-_22389524 0.414 LOC91316
glucuronidase, beta/immunoglobulin lambda-like polypeptide 1 pseudogene
chr2_+_159021653 0.407 PKP4
plakophilin 4
chr22_+_40195058 0.402 NM_001098
ACO2
aconitase 2, mitochondrial
chr18_-_45594206 0.388 NM_006111
ACAA2
acetyl-CoA acyltransferase 2
chr3_+_151747204 0.386 NM_032025
EIF2A
eukaryotic translation initiation factor 2A, 65kDa
chr19_-_45888259 0.381 NM_004756
NUMBL
numb homolog (Drosophila)-like
chr1_-_32632601 0.377 NM_001143888
NM_001143889
NM_001143890
NM_018045
BSDC1



BSD domain containing 1



chr12_-_49708279 0.376 NM_001174125
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr7_-_74127508 0.371 WBSCR16
Williams-Beuren syndrome chromosome region 16
chr7_-_72574528 0.368 NM_032408
BAZ1B
bromodomain adjacent to zinc finger domain, 1B
chr3_-_52287297 0.367 WDR82
WD repeat domain 82
chr20_+_42593849 0.363 NM_007066
NM_181804
NM_181805
PKIG


protein kinase (cAMP-dependent, catalytic) inhibitor gamma


chr11_+_86426518 0.357 NM_001168724
NM_022918
TMEM135

transmembrane protein 135

chr18_-_45593852 0.356 ACAA2
acetyl-CoA acyltransferase 2
chrX_+_38305634 0.351 NM_004615
TSPAN7
tetraspanin 7
chrX_-_122694562 0.331 THOC2
THO complex 2
chr1_+_158579685 0.314 NM_015331
NCSTN
nicastrin
chr4_+_91035025 0.285 NM_007351
MMRN1
multimerin 1
chr1_-_158579653 0.279 COPA
coatomer protein complex, subunit alpha
chr1_-_43628035 0.278 MED8
mediator complex subunit 8
chr2_+_161725172 0.264 TANK
TRAF family member-associated NFKB activator
chr7_+_137411717 0.262 NM_001190906
NM_001190907
NM_005989
AKR1D1


aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)


chr11_+_117735502 0.249 NM_004788
UBE4A
ubiquitination factor E4A (UFD2 homolog, yeast)
chr7_-_74127622 0.246 NM_030798
WBSCR16
Williams-Beuren syndrome chromosome region 16
chr19_+_11407485 0.237 PRKCSH
protein kinase C substrate 80K-H
chr9_+_114182216 0.236 HSDL2
hydroxysteroid dehydrogenase like 2
chr14_-_94693418 0.232 NM_177438
DICER1
dicer 1, ribonuclease type III
chr2_+_86521781 0.230 NM_018433
KDM3A
lysine (K)-specific demethylase 3A
chr9_+_114182009 0.224 NM_001195822
NM_032303
HSDL2

hydroxysteroid dehydrogenase like 2

chr18_-_44731078 0.222 NM_001190821
NM_005904
SMAD7

SMAD family member 7

chr4_+_140806371 0.220 NM_002413
MGST2
microsomal glutathione S-transferase 2
chr7_+_120415958 0.204 NM_024913
C7orf58
chromosome 7 open reading frame 58
chr19_+_11407085 0.195 NM_001001329
NM_002743
PRKCSH

protein kinase C substrate 80K-H

chr4_-_4594591 0.192 STX18
syntaxin 18
chr2_-_198072805 0.190 HSPD1
heat shock 60kDa protein 1 (chaperonin)
chr2_-_198073242 0.190 NM_199440
HSPD1
heat shock 60kDa protein 1 (chaperonin)
chr22_+_23333610 0.189 NM_001032365
GGT1
gamma-glutamyltransferase 1
chr3_+_185538998 0.188 FAM131A
family with sequence similarity 131, member A
chr12_+_119900931 0.187 NM_000545
HNF1A
HNF1 homeobox A
chr2_+_108604111 0.186 NM_001193484
LIMS1
LIM and senescent cell antigen-like domains 1
chr11_+_117735558 0.184 UBE4A
ubiquitination factor E4A (UFD2 homolog, yeast)
chr11_+_117948301 0.179 NM_001142281
NM_001655
ARCN1

archain 1

chr2_+_201691664 0.177 CFLAR
CASP8 and FADD-like apoptosis regulator
chr17_+_1592879 0.175 NM_000934
NM_001165921
SERPINF2

serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2

chr2_-_198072767 0.171 HSPD1
heat shock 60kDa protein 1 (chaperonin)
chr20_-_34005619 0.170 SCAND1
SCAN domain containing 1
chr22_+_22445035 0.169 NM_005940
MMP11
matrix metallopeptidase 11 (stromelysin 3)
chr3_-_151746954 0.167 SERP1
stress-associated endoplasmic reticulum protein 1
chr3_-_49289285 0.166 NM_198562
C3orf62
chromosome 3 open reading frame 62
chr11_+_117948350 0.165 ARCN1
archain 1
chr1_+_78126787 0.162 NM_001172309
NM_144573
NEXN

nexilin (F actin binding protein)

chr1_-_79244948 0.157 NM_022159
ELTD1
EGF, latrophilin and seven transmembrane domain containing 1
chr17_+_7063970 0.153 ACADVL
acyl-CoA dehydrogenase, very long chain
chr9_+_91123204 0.148 NM_024077
SECISBP2
SECIS binding protein 2
chr1_+_36169260 0.144 NM_024852
NM_177422
EIF2C3

eukaryotic translation initiation factor 2C, 3

chr19_+_15024014 0.144 NM_012114
CASP14
caspase 14, apoptosis-related cysteine peptidase
chr12_-_49706190 0.142 NM_001174129
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr16_-_45565068 0.141 NM_005880
DNAJA2
DnaJ (Hsp40) homolog, subfamily A, member 2
chr18_-_50004458 0.137 MBD2
methyl-CpG binding domain protein 2
chr1_+_44870256 0.136 RNF220
ring finger protein 220
chrX_-_64171317 0.136 NM_001178032
ZC4H2
zinc finger, C4H2 domain containing
chr1_-_43628060 0.133 NM_052877
NM_201542
MED8

mediator complex subunit 8

chr12_-_49706364 0.130 NM_000617
NM_001174126
NM_001174127
NM_001174128
SLC11A2



solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2



chr2_-_198072868 0.128 NM_002156
HSPD1
heat shock 60kDa protein 1 (chaperonin)
chr2_+_201691513 0.127 NM_001127183
CFLAR
CASP8 and FADD-like apoptosis regulator
chr16_-_45564984 0.127 DNAJA2
DnaJ (Hsp40) homolog, subfamily A, member 2
chr11_+_116555048 0.124 NM_001040455
SIDT2
SID1 transmembrane family, member 2
chr12_+_105692466 0.121 NM_018157
RIC8B
resistance to inhibitors of cholinesterase 8 homolog B (C. elegans)
chr12_+_94776836 0.113 NM_003095
SNRPF
small nuclear ribonucleoprotein polypeptide F
chr16_-_30504309 0.110 NM_152458
ZNF785
zinc finger protein 785
chr22_-_30072329 0.109 PATZ1
POZ (BTB) and AT hook containing zinc finger 1
chr2_+_27967116 0.109 BRE
brain and reproductive organ-expressed (TNFRSF1A modulator)
chr12_+_119900677 0.106 HNF1A
HNF1 homeobox A
chr1_-_19450617 0.105 KIAA0090
KIAA0090
chr1_+_148603769 0.102 RPRD2
regulation of nuclear pre-mRNA domain containing 2
chr3_-_151746970 0.102 NM_014445
SERP1
stress-associated endoplasmic reticulum protein 1
chr2_+_27966985 0.101 NM_199193
NM_199194
NM_004899
NM_199191
NM_199192
BRE




brain and reproductive organ-expressed (TNFRSF1A modulator)




chr1_-_224441023 0.098 ACBD3
acyl-CoA binding domain containing 3
chr15_+_94674849 0.096 NM_021005
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr1_-_224441024 0.096 NM_022735
ACBD3
acyl-CoA binding domain containing 3
chr11_-_62170639 0.095 GANAB
glucosidase, alpha; neutral AB
chr2_+_206732859 0.093 EEF1B2
eukaryotic translation elongation factor 1 beta 2
chrX_-_1470862 0.092 NM_001636
SLC25A6
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
chrY_-_1470862 0.092 NM_001636
SLC25A6
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
chr20_+_43943254 0.092 NM_080603
ZSWIM1
zinc finger, SWIM-type containing 1
chr20_+_41621079 0.089 NM_170693
SGK2
serum/glucocorticoid regulated kinase 2
chr14_+_23937766 0.088 NM_025081
NYNRIN
NYN domain and retroviral integrase containing
chr2_+_198073257 0.088 HSPE1
heat shock 10kDa protein 1 (chaperonin 10)
chr22_+_45537181 0.088 NM_014346
TBC1D22A
TBC1 domain family, member 22A
chr20_-_54400628 0.088 NM_003600
NM_198433
NM_198434
NM_198435
NM_198436
NM_198437
AURKA





aurora kinase A





chrX_+_152423277 0.084 BGN
biglycan
chr20_-_34005799 0.084 NM_016558
NM_033630
SCAND1

SCAN domain containing 1

chr1_-_111771877 0.084 NM_002557
OVGP1
oviductal glycoprotein 1, 120kDa
chr16_+_30617962 0.084 NM_006662
SRCAP
Snf2-related CREBBP activator protein
chr2_+_27967159 0.081 BRE
brain and reproductive organ-expressed (TNFRSF1A modulator)
chr1_+_44870223 0.081 RNF220
ring finger protein 220
chr1_-_19450632 0.080 NM_015047
KIAA0090
KIAA0090
chr3_+_141136691 0.077 NM_022131
CLSTN2
calsyntenin 2
chr15_+_54998144 0.075 TCF12
transcription factor 12
chr12_-_52407470 0.072 NM_001143682
NM_020898
CALCOCO1

calcium binding and coiled-coil domain 1

chr2_+_206732562 0.071 NM_001037663
NM_001959
NM_021121
EEF1B2


eukaryotic translation elongation factor 1 beta 2


chr12_+_48003237 0.071 NM_001100620
NM_005480
TROAP

trophinin associated protein (tastin)

chr1_+_210525792 0.069 PPP2R5A
protein phosphatase 2, regulatory subunit B', alpha
chr6_-_30631912 0.069 GNL1
guanine nucleotide binding protein-like 1
chr15_+_54998115 0.069 NM_003205
NM_207036
NM_207037
NM_207038
TCF12



transcription factor 12



chr11_-_62170662 0.066 GANAB
glucosidase, alpha; neutral AB
chr4_-_4594648 0.063 NM_016930
STX18
syntaxin 18
chr10_+_75174125 0.063 NM_004922
NM_198597
SEC24C

SEC24 family, member C (S. cerevisiae)

chr1_+_210525885 0.063 PPP2R5A
protein phosphatase 2, regulatory subunit B', alpha
chr2_-_219742950 0.062 NM_001144889
NM_001144890
NM_144712
SLC23A3


solute carrier family 23 (nucleobase transporters), member 3


chr22_-_22389502 0.060 LOC91316
glucuronidase, beta/immunoglobulin lambda-like polypeptide 1 pseudogene
chr19_-_18196302 0.060 NM_001098819
PDE4C
phosphodiesterase 4C, cAMP-specific
chr19_+_11407447 0.059 PRKCSH
protein kinase C substrate 80K-H
chr20_+_54400979 0.057 NM_001324
CSTF1
cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
chr1_-_209915443 0.056 NM_002497
NEK2
NIMA (never in mitosis gene a)-related kinase 2
chr22_-_22389436 0.056


chr17_+_7063873 0.055 NM_000018
NM_001033859
ACADVL

acyl-CoA dehydrogenase, very long chain

chr9_+_139633272 0.054 EHMT1
euchromatic histone-lysine N-methyltransferase 1
chr10_+_75174151 0.054 SEC24C
SEC24 family, member C (S. cerevisiae)
chr5_-_32480486 0.049 ZFR
zinc finger RNA binding protein
chr19_-_48700824 0.048 NM_198850
PHLDB3
pleckstrin homology-like domain, family B, member 3
chr14_+_49157150 0.048 NM_002408
MGAT2
mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
chr10_+_120957084 0.047 NM_005308
GRK5
G protein-coupled receptor kinase 5
chr1_-_158579583 0.047


chr17_+_7474177 0.047 NM_001040
NM_001146279
NM_001146280
NM_001146281
SHBG



sex hormone-binding globulin



chr6_+_7052798 0.045 NM_001168344
RREB1
ras responsive element binding protein 1
chr19_-_40995564 0.045 PRODH2
proline dehydrogenase (oxidase) 2
chr2_+_27967102 0.044 BRE
brain and reproductive organ-expressed (TNFRSF1A modulator)
chr2_+_198073358 0.044 HSPE1
heat shock 10kDa protein 1 (chaperonin 10)
chr12_-_6949877 0.042 PHB2
prohibitin 2
chr10_-_79459296 0.041 NM_007055
POLR3A
polymerase (RNA) III (DNA directed) polypeptide A, 155kDa
chr2_+_74610333 0.040 HTRA2
HtrA serine peptidase 2
chr8_-_145521108 0.037 DGAT1
diacylglycerol O-acyltransferase 1
chr2_-_218843039 0.036 AAMP
angio-associated, migratory cell protein
chr2_-_74610481 0.035 NM_181575
AUP1
ancient ubiquitous protein 1
chr17_+_43328514 0.035 NM_003110
SP2
Sp2 transcription factor
chr12_+_67489063 0.029 MDM2
Mdm2 p53 binding protein homolog (mouse)
chr2_-_218843109 0.029 NM_001087
AAMP
angio-associated, migratory cell protein
chr9_+_88086932 0.028


chr2_+_74610395 0.027 HTRA2
HtrA serine peptidase 2
chr6_-_33389984 0.027 NM_003190
NM_172208
NM_172209
TAPBP


TAP binding protein (tapasin)


chr8_-_145521297 0.026 DGAT1
diacylglycerol O-acyltransferase 1
chr2_-_74610331 0.026 AUP1
ancient ubiquitous protein 1
chr2_+_198072965 0.026 NM_002157
HSPE1
heat shock 10kDa protein 1 (chaperonin 10)
chr10_-_119795663 0.025 NM_014904
RAB11FIP2
RAB11 family interacting protein 2 (class I)
chr4_+_156900053 0.025 GUCY1B3
guanylate cyclase 1, soluble, beta 3
chr17_+_55325224 0.025 NM_003161
RPS6KB1
ribosomal protein S6 kinase, 70kDa, polypeptide 1
chr9_-_115178161 0.025 NM_031219
HDHD3
haloacid dehalogenase-like hydrolase domain containing 3
chr1_-_201411533 0.023 NM_004997
MYBPH
myosin binding protein H
chr14_-_105245959 0.022 IGHA1
immunoglobulin heavy constant alpha 1
chr2_-_74610346 0.021 AUP1
ancient ubiquitous protein 1
chr15_-_81471373 0.021 NM_001160113
NM_001160114
NM_001160115
NM_001160116
NM_144597
C15orf40




chromosome 15 open reading frame 40





Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
28.15 7.30e-03 GO:0034377 plasma lipoprotein particle assembly
28.15 7.30e-03 GO:0065005 protein-lipid complex assembly
19.87 3.35e-02 GO:0043691 reverse cholesterol transport

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
31.66 1.48e-02 GO:0034366 spherical high-density lipoprotein particle

Nothing significant found in function category.