Motif ID: TLX2.p2

Z-value: 0.949


Transcription factors associated with TLX2.p2:

Gene SymbolEntrez IDGene Name
TLX2 3196 T-cell leukemia homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TLX2chr2_+_745950730.292.8e-01Click!


Activity profile for motif TLX2.p2.

activity profile for motif TLX2.p2


Sorted Z-values histogram for motif TLX2.p2

Sorted Z-values for motif TLX2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TLX2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_-_46593923 1.578 NM_001040084
NM_001098845
ANXA8L2
LOC653110
ANXA8
ANXA8L1
annexin A8-like 2
hypothetical LOC653110
annexin A8
annexin A8-like 1
chr10_+_47875229 1.508 NM_001040084
NM_001098845
ANXA8L2
ANXA8
ANXA8L1
annexin A8-like 2
annexin A8
annexin A8-like 1
chr10_+_47216925 1.452 NM_001630
ANXA8L2
ANXA8
annexin A8-like 2
annexin A8
chr4_+_169789327 1.321 NM_001166109
PALLD
palladin, cytoskeletal associated protein
chr11_+_35117391 1.309 CD44
CD44 molecule (Indian blood group)
chr20_-_14266200 1.288 NM_013281
NM_198391
FLRT3

fibronectin leucine rich transmembrane protein 3

chr6_+_116798791 1.234 NM_013352
DSE
dermatan sulfate epimerase
chr11_+_35117408 1.214 CD44
CD44 molecule (Indian blood group)
chr1_-_151630168 1.127 NM_002964
S100A8
S100 calcium binding protein A8
chr8_+_26491317 1.063 NM_001386
DPYSL2
dihydropyrimidinase-like 2
chr6_-_31432954 1.044 NM_005514
HLA-B
major histocompatibility complex, class I, B
chr1_-_68470585 0.940 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr1_+_86662356 0.888 NM_006536
CLCA2
chloride channel accessory 2
chr19_-_50601406 0.867 NM_001142502
PPP1R13L
protein phosphatase 1, regulatory (inhibitor) subunit 13 like
chr11_+_86189138 0.861 NM_007173
PRSS23
protease, serine, 23
chr6_-_31432934 0.836 HLA-B
major histocompatibility complex, class I, B
chr1_+_151147646 0.796 NM_005547
IVL
involucrin
chr5_+_125786975 0.796 GRAMD3
GRAM domain containing 3
chr4_+_78297356 0.793 NM_004354
CCNG2
cyclin G2
chr3_-_78749633 0.792 ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr22_+_36472262 0.781 TRIOBP
TRIO and F-actin binding protein
chr7_+_48095464 0.760 UPP1
uridine phosphorylase 1
chr1_-_94779727 0.740 NM_001178096
NM_001993
F3

coagulation factor III (thromboplastin, tissue factor)

chr3_-_184363157 0.725 NM_014398
LAMP3
lysosomal-associated membrane protein 3
chr20_-_43316597 0.724 NM_003064
SLPI
secretory leukocyte peptidase inhibitor
chr4_+_78297418 0.718 CCNG2
cyclin G2
chr12_-_8706533 0.693 MFAP5
microfibrillar associated protein 5
chr12_-_51253875 0.693 NM_175053
KRT74
keratin 74
chr16_+_54070302 0.689 NM_004530
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr3_-_150578023 0.663 TM4SF1
transmembrane 4 L six family member 1
chr16_+_55199978 0.661 NM_005953
MT2A
metallothionein 2A
chr1_+_151596953 0.657 NM_002965
S100A9
S100 calcium binding protein A9
chr10_-_90702490 0.645 NM_001613
ACTA2
actin, alpha 2, smooth muscle, aorta
chr22_-_44015424 0.643 KIAA0930
KIAA0930
chr20_+_43875078 0.640 NM_181801
UBE2C
ubiquitin-conjugating enzyme E2C
chr3_+_69216747 0.638 NM_006407
ARL6IP5
ADP-ribosylation-like factor 6 interacting protein 5
chr22_+_36472176 0.620 NM_007032
NM_138632
TRIOBP

TRIO and F-actin binding protein

chr12_+_12935759 0.618 GPRC5A
G protein-coupled receptor, family C, group 5, member A
chr7_-_80386258 0.614 SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr22_+_41877470 0.614 NM_000714
NM_007311
TSPO

translocator protein (18kDa)

chr13_-_105985313 0.612 NM_004093
EFNB2
ephrin-B2
chr10_+_75343352 0.611 PLAU
plasminogen activator, urokinase
chr1_-_94475840 0.610 NM_004815
ARHGAP29
Rho GTPase activating protein 29
chr12_+_12935619 0.610 GPRC5A
G protein-coupled receptor, family C, group 5, member A
chr22_+_41877502 0.609 TSPO
translocator protein (18kDa)
chr5_-_156935317 0.605 NM_033274
ADAM19
ADAM metallopeptidase domain 19
chr14_+_54104383 0.604 NM_001161576
NM_015589
SAMD4A

sterile alpha motif domain containing 4A

chr1_-_94475504 0.597 ARHGAP29
Rho GTPase activating protein 29
chr4_-_99798563 0.591 NM_005723
TSPAN5
tetraspanin 5
chr7_+_48095263 0.580 NM_003364
UPP1
uridine phosphorylase 1
chr6_-_138470160 0.573 NM_022121
PERP
PERP, TP53 apoptosis effector
chr18_+_27281729 0.573 NM_001944
DSG3
desmoglein 3
chr2_-_189752575 0.565 NM_000393
COL5A2
collagen, type V, alpha 2
chr8_+_86563382 0.564 NM_000067
CA2
carbonic anhydrase II
chr3_+_101694244 0.555 TMEM45A
transmembrane protein 45A
chr1_-_31942206 0.554 NM_001856
COL16A1
collagen, type XVI, alpha 1
chr15_+_43714500 0.540 NM_021199
SQRDL
sulfide quinone reductase-like (yeast)
chr6_-_32665409 0.532 NM_002124
HLA-DRB1
HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1
major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr12_+_15955549 0.529 DERA
deoxyribose-phosphate aldolase (putative)
chr13_+_109936080 0.519 COL4A2
collagen, type IV, alpha 2
chr6_-_31432877 0.517 HLA-B
major histocompatibility complex, class I, B
chrX_+_48253007 0.517 NM_203474
NM_203475
PORCN

porcupine homolog (Drosophila)

chr1_+_150753601 0.516 NM_019060
CRCT1
cysteine-rich C-terminal 1
chr11_+_59979857 0.515 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr21_-_26175068 0.512 APP
amyloid beta (A4) precursor protein
chr4_-_35922288 0.511 NM_015230
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr4_+_166468266 0.508 NM_001017369
NM_006745
SC4MOL

sterol-C4-methyl oxidase-like

chr9_+_123123364 0.508 GSN
gelsolin
chr10_-_103805858 0.502 NM_024541
C10orf76
chromosome 10 open reading frame 76
chr10_+_75340867 0.502 NM_001145031
NM_002658
PLAU

plasminogen activator, urokinase

chr1_-_31942142 0.494 COL16A1
collagen, type XVI, alpha 1
chr19_+_16296632 0.492 NM_016270
KLF2
Kruppel-like factor 2 (lung)
chr12_+_46785922 0.491 NM_001166686
PFKM
phosphofructokinase, muscle
chr5_-_150517499 0.484 ANXA6
annexin A6
chr10_+_3141596 0.483 PFKP
phosphofructokinase, platelet
chr7_-_120285364 0.476 NM_012338
TSPAN12
tetraspanin 12
chr18_-_59185330 0.471 NM_002035
KDSR
3-ketodihydrosphingosine reductase
chr20_+_56318415 0.463 RAB22A
RAB22A, member RAS oncogene family
chr2_-_20288108 0.461 NM_002997
SDC1
syndecan 1
chr4_+_38545741 0.455 NM_138389
FAM114A1
family with sequence similarity 114, member A1
chr12_+_15955372 0.454 NM_015954
DERA
deoxyribose-phosphate aldolase (putative)
chr6_+_32713160 0.452 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr3_+_101720753 0.451 TMEM45A
transmembrane protein 45A
chrX_-_10761729 0.449 NM_033290
MID1
midline 1 (Opitz/BBB syndrome)
chr6_+_76515690 0.446 MYO6
myosin VI
chr22_+_29808845 0.446 SMTN
smoothelin
chr20_+_56318245 0.444 RAB22A
RAB22A, member RAS oncogene family
chr5_-_150517528 0.444 NM_001155
ANXA6
annexin A6
chr3_+_48482625 0.443 TREX1
three prime repair exonuclease 1
chr6_-_32742265 0.441 NM_002123
HLA-DQB1
major histocompatibility complex, class II, DQ beta 1
chr20_+_44180296 0.439 NM_001250
NM_152854
CD40

CD40 molecule, TNF receptor superfamily member 5

chr6_-_112033752 0.435 TRAF3IP2
TRAF3 interacting protein 2
chr4_-_90977149 0.434 NM_001146054
NM_007308
NM_000345
SNCA


synuclein, alpha (non A4 component of amyloid precursor)


chr22_-_44015248 0.430 NM_001009880
KIAA0930
KIAA0930
chr12_+_74160779 0.430 NM_006851
GLIPR1
GLI pathogenesis-related 1
chr7_-_87687276 0.429 SRI
sorcin
chr6_-_112186977 0.427 NM_153048
FYN
FYN oncogene related to SRC, FGR, YES
chr17_-_1037312 0.425 NM_001159746
ABR
active BCR-related gene
chr14_+_64240902 0.423 NM_015549
PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr12_-_94135154 0.422 NM_018351
FGD6
FYVE, RhoGEF and PH domain containing 6
chr7_-_120285245 0.422 TSPAN12
tetraspanin 12
chr11_+_66827563 0.421 SSH3
slingshot homolog 3 (Drosophila)
chr16_+_31390567 0.421 NM_001042454
NM_001164719
TGFB1I1

transforming growth factor beta 1 induced transcript 1

chr3_+_101694098 0.419 NM_018004
TMEM45A
transmembrane protein 45A
chr20_+_33223434 0.418 NM_006404
PROCR
protein C receptor, endothelial
chr16_-_10581944 0.414 NM_001424
EMP2
epithelial membrane protein 2
chr10_+_63803921 0.411 NM_014951
NM_199450
NM_199451
ZNF365


zinc finger protein 365


chr5_+_96023926 0.410 CAST
calpastatin
chr6_+_76515608 0.410 NM_004999
MYO6
myosin VI
chr14_+_64041257 0.408 ZBTB1
zinc finger and BTB domain containing 1
chr3_-_55496607 0.404 WNT5A
wingless-type MMTV integration site family, member 5A
chr17_-_3518568 0.402 TAX1BP3
Tax1 (human T-cell leukemia virus type I) binding protein 3
chr11_+_66827494 0.401 NM_017857
SSH3
slingshot homolog 3 (Drosophila)
chr5_+_96023479 0.400 NM_001190442
CAST
calpastatin
chr15_-_40052041 0.398 NM_139265
EHD4
EH-domain containing 4
chr3_+_48482213 0.398 NM_016381
NM_033629
TREX1

three prime repair exonuclease 1

chr14_-_105308531 0.398


chr3_+_189425886 0.397 NM_001167671
LPP
LIM domain containing preferred translocation partner in lipoma
chr1_+_167342493 0.397 NM_001677
ATP1B1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr17_-_3518628 0.396 TAX1BP3
Tax1 (human T-cell leukemia virus type I) binding protein 3
chr22_+_36472201 0.395 TRIOBP
TRIO and F-actin binding protein
chr3_-_45162865 0.393 CDCP1
CUB domain containing protein 1
chr6_+_32515596 0.390 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr3_-_45162847 0.389 CDCP1
CUB domain containing protein 1
chr15_-_40051979 0.387 EHD4
EH-domain containing 4
chr9_+_115382990 0.386 RGS3
regulator of G-protein signaling 3
chr5_+_96023627 0.386 NM_001042440
CAST
calpastatin
chr7_-_87687302 0.383 NM_003130
SRI
sorcin
chr1_+_154297588 0.379 NM_020387
RAB25
RAB25, member RAS oncogene family
chr10_-_116408046 0.373 NM_002313
ABLIM1
actin binding LIM protein 1
chr7_-_150960086 0.373 NM_024429
PRKAG2
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chr14_-_52487022 0.373 FERMT2
fermitin family member 2
chr3_-_180272291 0.372 NM_022470
NM_152240
ZMAT3

zinc finger, matrin-type 3

chr11_+_66580861 0.372 NM_014578
RHOD
ras homolog gene family, member D
chr1_+_163867057 0.370 NM_004528
MGST3
microsomal glutathione S-transferase 3
chr6_-_32605898 0.370 NM_002125
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr10_+_123744131 0.368 TACC2
transforming, acidic coiled-coil containing protein 2
chr3_-_109292444 0.367 NM_001777
NM_198793
CD47

CD47 molecule

chr20_+_56318155 0.366 NM_020673
RAB22A
RAB22A, member RAS oncogene family
chr11_+_19328846 0.366 NM_001111018
NAV2
neuron navigator 2
chrX_-_10605726 0.363 NM_001098624
MID1
midline 1 (Opitz/BBB syndrome)
chr3_-_122951200 0.361 NM_004487
GOLGB1
golgin B1
chr5_-_150517454 0.360 ANXA6
annexin A6
chr14_-_105796665 0.360 IGHV4-31
IGHV3-23
IGHA1
IGHG1
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy variable 3-23
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr6_-_33028790 0.358 NM_006120
HLA-DMA
major histocompatibility complex, class II, DM alpha
chr10_+_75340921 0.355 PLAU
plasminogen activator, urokinase
chr1_-_151333624 0.355 NM_001024209
SPRR2E
small proline-rich protein 2E
chr14_-_22358752 0.353 NM_001126106
SLC7A7
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
chr6_-_16869579 0.347 NM_000332
NM_001128164
ATXN1

ataxin 1

chr2_+_102345528 0.345 NM_003855
IL18R1
interleukin 18 receptor 1
chr20_+_42537927 0.344 NM_001039199
NM_024331
TTPAL

tocopherol (alpha) transfer protein-like

chr6_-_109883639 0.343 MICAL1
microtubule associated monoxygenase, calponin and LIM domain containing 1
chr5_+_172343415 0.343 ATP6V0E1
ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
chr8_-_42184350 0.342 NM_000930
NM_033011
PLAT

plasminogen activator, tissue

chr14_-_54025414 0.340 GMFB
glia maturation factor, beta
chr12_-_8706746 0.340 MFAP5
microfibrillar associated protein 5
chr13_-_37070862 0.340 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr19_+_48772791 0.339 NM_001193621
LOC390940
hypothetical protein LOC390940
chr1_-_85816520 0.339 NM_001134445
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr13_-_32658215 0.338 NM_178007
STARD13
StAR-related lipid transfer (START) domain containing 13
chr2_-_110230642 0.336 MALL
mal, T-cell differentiation protein-like
chr19_-_11549508 0.335 NM_001611
ACP5
acid phosphatase 5, tartrate resistant
chr5_+_36642213 0.335 NM_001166696
NM_004172
SLC1A3

solute carrier family 1 (glial high affinity glutamate transporter), member 3

chr3_+_123256902 0.334 NM_175862
CD86
CD86 molecule
chr3_-_45162901 0.332 NM_022842
NM_178181
CDCP1

CUB domain containing protein 1

chr3_-_180272229 0.332 ZMAT3
zinc finger, matrin-type 3
chr20_-_1321702 0.332 FKBP1A-SDCBP2
FKBP1A
FKBP1A-SDCBP2 read-through transcript
FK506 binding protein 1A, 12kDa
chr12_-_55791443 0.332 NM_001178078
NM_001178080
NM_001178081
NM_003153
STAT6



signal transducer and activator of transcription 6, interleukin-4 induced



chr14_-_105181939 0.330 IGHG2
immunoglobulin heavy constant gamma 2 (G2m marker)
chr10_+_123862430 0.330 TACC2
transforming, acidic coiled-coil containing protein 2
chr14_-_54025464 0.328 NM_004124
GMFB
glia maturation factor, beta
chr15_-_57452361 0.326 NM_004998
MYO1E
myosin IE
chr16_-_11588257 0.326 NM_001136472
NM_001136473
LITAF

lipopolysaccharide-induced TNF factor

chr3_-_152517204 0.326 NM_023915
GPR87
G protein-coupled receptor 87
chr17_-_3518654 0.325 NM_014604
TAX1BP3
Tax1 (human T-cell leukemia virus type I) binding protein 3
chr1_-_85515174 0.324 NM_003921
BCL10
B-cell CLL/lymphoma 10
chr2_+_64535114 0.324 HSPC159
galectin-related protein
chr16_-_66827449 0.323 NM_024939
ESRP2
epithelial splicing regulatory protein 2
chrX_+_51562894 0.323 NM_001005332
MAGED1
melanoma antigen family D, 1
chr12_+_52618815 0.323 NM_017410
HOXC13
homeobox C13
chr12_-_52960168 0.319 NM_012117
CBX5
chromobox homolog 5
chr2_+_64534774 0.319 NM_014181
HSPC159
galectin-related protein
chr12_-_8706637 0.319 NM_003480
MFAP5
microfibrillar associated protein 5
chr19_-_8548232 0.319 MYO1F
myosin IF
chr19_+_627346 0.318 NM_005860
FSTL3
follistatin-like 3 (secreted glycoprotein)
chr20_-_1321571 0.318 FKBP1A
FK506 binding protein 1A, 12kDa
chr22_+_40559070 0.317 SREBF2
sterol regulatory element binding transcription factor 2
chr6_-_109883635 0.316 MICAL1
microtubule associated monoxygenase, calponin and LIM domain containing 1
chr11_+_13255913 0.316 ARNTL
aryl hydrocarbon receptor nuclear translocator-like
chr15_-_57452345 0.316 MYO1E
myosin IE
chr1_-_85703198 0.315 DDAH1
dimethylarginine dimethylaminohydrolase 1
chr2_-_85969527 0.315 NM_003896
ST3GAL5
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
chr6_-_30289092 0.313 NM_003449
TRIM26
tripartite motif containing 26
chr5_+_172343429 0.313 ATP6V0E1
ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
chr7_+_90063543 0.312 CDK14
cyclin-dependent kinase 14
chr6_-_31658044 0.312 NM_002341
NM_009588
LTB

lymphotoxin beta (TNF superfamily, member 3)

chr13_+_113023938 0.307 LAMP1
lysosomal-associated membrane protein 1
chrX_-_70067650 0.305 NM_001048164
NM_032803
SLC7A3

solute carrier family 7 (cationic amino acid transporter, y+ system), member 3

chr1_-_25164061 0.304 NM_001031680
RUNX3
runt-related transcription factor 3
chr11_+_13255948 0.304 ARNTL
aryl hydrocarbon receptor nuclear translocator-like

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.33 7.56e-05 GO:0048731 system development
1.31 8.44e-05 GO:0048856 anatomical structure development
1.26 5.90e-04 GO:0032502 developmental process
1.39 1.17e-03 GO:0048583 regulation of response to stimulus
1.27 1.46e-03 GO:0007275 multicellular organismal development
1.47 1.50e-03 GO:0002376 immune system process
1.35 3.34e-03 GO:0048869 cellular developmental process
1.56 4.52e-03 GO:0040011 locomotion
1.35 7.94e-03 GO:0030154 cell differentiation
1.71 9.36e-03 GO:0006935 chemotaxis
1.71 9.36e-03 GO:0042330 taxis
1.86 2.43e-02 GO:0007411 axon guidance
2.25 2.73e-02 GO:0050900 leukocyte migration
1.69 2.98e-02 GO:0000904 cell morphogenesis involved in differentiation
1.18 3.34e-02 GO:0032501 multicellular organismal process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.26 3.36e-05 GO:0071944 cell periphery
1.26 5.31e-05 GO:0005886 plasma membrane
1.16 1.97e-04 GO:0016020 membrane
1.36 9.75e-04 GO:0005576 extracellular region
1.17 2.00e-03 GO:0044425 membrane part
1.30 3.18e-03 GO:0044459 plasma membrane part
5.77 6.41e-03 GO:0042613 MHC class II protein complex
2.99 1.78e-02 GO:0015934 large ribosomal subunit
1.41 2.56e-02 GO:0044421 extracellular region part
2.06 3.93e-02 GO:0070161 anchoring junction

Nothing significant found in function category.