Motif ID: SOX17.p2

Z-value: 1.707


Transcription factors associated with SOX17.p2:

Gene SymbolEntrez IDGene Name
SOX17 64321 SRY (sex determining region Y)-box 17

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SOX17chr8_+_555330470.523.8e-02Click!


Activity profile for motif SOX17.p2.

activity profile for motif SOX17.p2


Sorted Z-values histogram for motif SOX17.p2

Sorted Z-values for motif SOX17.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX17.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_149299490 3.856 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr1_+_149299504 3.740 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr1_+_149299530 3.631 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr1_+_149299307 2.927 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr1_-_26105477 2.344 NM_001145454
NM_005563
STMN1

stathmin 1

chr17_-_59817722 2.287 NM_000442
PECAM1
platelet/endothelial cell adhesion molecule
chr12_-_21701985 2.272 NM_001174097
LDHB
lactate dehydrogenase B
chr12_-_21702000 2.252 LDHB
lactate dehydrogenase B
chr12_-_21702021 2.247 LDHB
lactate dehydrogenase B
chr12_-_21702036 2.209 LDHB
lactate dehydrogenase B
chr10_+_17311242 2.190 VIM
vimentin
chr10_+_17311282 2.177 VIM
vimentin
chr12_-_21702046 2.150 NM_002300
LDHB
lactate dehydrogenase B
chr10_+_17311283 1.983 VIM
vimentin
chr14_-_22458220 1.952 NM_001077351
NM_001077352
NM_018107
RBM23


RNA binding motif protein 23


chr10_+_17311307 1.938 VIM
vimentin
chr14_-_22458199 1.919 RBM23
RNA binding motif protein 23
chr14_-_22458134 1.844 RBM23
RNA binding motif protein 23
chr11_-_122438054 1.791 HSPA8
heat shock 70kDa protein 8
chr11_+_113672378 1.785 NNMT
nicotinamide N-methyltransferase
chr17_-_59817575 1.725 PECAM1
platelet/endothelial cell adhesion molecule
chr1_-_26105230 1.710 NM_203401
STMN1
stathmin 1
chr11_+_113672407 1.692 NNMT
nicotinamide N-methyltransferase
chr17_-_59817654 1.673 PECAM1
platelet/endothelial cell adhesion molecule
chr1_-_151910080 1.656 ILF2
interleukin enhancer binding factor 2, 45kDa
chr12_-_6103945 1.651 NM_000552
VWF
von Willebrand factor
chr1_-_151910052 1.590 ILF2
interleukin enhancer binding factor 2, 45kDa
chr10_+_17312654 1.585 VIM
vimentin
chrX_+_15428820 1.583 NM_203281
BMX
BMX non-receptor tyrosine kinase
chr1_-_151910057 1.578 ILF2
interleukin enhancer binding factor 2, 45kDa
chr1_-_151910041 1.570 ILF2
interleukin enhancer binding factor 2, 45kDa
chr1_-_151910098 1.525 NM_004515
ILF2
interleukin enhancer binding factor 2, 45kDa
chr7_-_27171673 1.500 NM_152739
HOXA9
homeobox A9
chr17_-_59817456 1.491 PECAM1
platelet/endothelial cell adhesion molecule
chr13_-_29938029 1.491 NM_002128
HMGB1
high-mobility group box 1
chr7_-_27171648 1.486 HOXA9
homeobox A9
chr8_+_26491507 1.483 DPYSL2
dihydropyrimidinase-like 2
chr13_-_29937966 1.480 HMGB1
HMGB1P6
high-mobility group box 1
high-mobility group box 1 pseudogene 6
chr1_+_149298774 1.448 NM_006818
MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr7_-_44854188 1.415 H2AFV
H2A histone family, member V
chr11_-_122438016 1.362 NM_006597
NM_153201
HSPA8

heat shock 70kDa protein 8

chr7_-_130891861 1.349 NM_001018111
NM_005397
PODXL

podocalyxin-like

chr10_+_70748581 1.314 NM_000188
HK1
hexokinase 1
chr10_+_17311347 1.297 VIM
vimentin
chr2_-_37752272 1.243 CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr1_-_26105954 1.231 NM_203399
STMN1
stathmin 1
chr2_-_175578156 1.206 NM_001025201
NM_001822
CHN1

chimerin (chimaerin) 1

chr22_-_17892859 1.161 NM_001130861
NM_003277
CLDN5

claudin 5

chr15_-_32875040 1.120 NM_005159
ACTC1
actin, alpha, cardiac muscle 1
chr8_+_55533047 1.118 NM_022454
SOX17
SRY (sex determining region Y)-box 17
chr10_+_17311962 1.087 VIM
vimentin
chr5_+_177564102 1.085 NM_004499
NM_031266
HNRNPAB

heterogeneous nuclear ribonucleoprotein A/B

chr13_+_51927495 1.077 NM_001098525
NM_018204
CKAP2

cytoskeleton associated protein 2

chr5_+_177564139 1.068 HNRNPAB
heterogeneous nuclear ribonucleoprotein A/B
chr17_+_42641712 1.066 NM_002476
MYL4
myosin, light chain 4, alkali; atrial, embryonic
chr3_-_122862447 1.066 NM_005335
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr3_+_158637273 1.057 NM_002852
PTX3
pentraxin 3, long
chr17_-_70662088 1.052 HN1
hematological and neurological expressed 1
chr2_-_188021117 1.029 NM_005795
CALCRL
calcitonin receptor-like
chr5_+_177564140 1.018 HNRNPAB
heterogeneous nuclear ribonucleoprotein A/B
chr7_-_44854222 0.996 NM_012412
NM_138635
NM_201436
NM_201516
NM_201517
H2AFV




H2A histone family, member V




chr10_+_3099708 0.990 NM_002627
PFKP
phosphofructokinase, platelet
chr10_+_124210980 0.979 NM_002775
HTRA1
HtrA serine peptidase 1
chr10_+_17311788 0.968 VIM
vimentin
chr6_+_80771108 0.955 TTK
TTK protein kinase
chr12_+_74160779 0.954 NM_006851
GLIPR1
GLI pathogenesis-related 1
chr8_-_102034272 0.932 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr10_+_124211353 0.928 HTRA1
HtrA serine peptidase 1
chr3_-_122862391 0.922 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr14_+_85066207 0.916 NM_013231
FLRT2
fibronectin leucine rich transmembrane protein 2
chr2_-_9688450 0.910 YWHAQ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
chr1_+_100957883 0.907 NM_001078
NM_080682
VCAM1

vascular cell adhesion molecule 1

chr5_+_148717762 0.905 NM_024028
PCYOX1L
prenylcysteine oxidase 1 like
chr10_+_11087259 0.904 NM_001025077
CELF2
CUGBP, Elav-like family member 2
chr8_+_1759502 0.891 NM_014629
ARHGEF10
Rho guanine nucleotide exchange factor (GEF) 10
chr10_+_11087280 0.881 CELF2
CUGBP, Elav-like family member 2
chr21_-_14840506 0.879 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr10_+_70418482 0.871 NM_015634
KIAA1279
KIAA1279
chr5_+_148717806 0.870 PCYOX1L
prenylcysteine oxidase 1 like
chr5_+_40715778 0.868 NM_000958
PTGER4
prostaglandin E receptor 4 (subtype EP4)
chr16_-_43557 0.867 NM_016310
POLR3K
polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
chr14_-_87529600 0.855 NM_000153
NM_001037525
GALC

galactosylceramidase

chrX_+_12903145 0.846 NM_021109
NM_183049
TMSB4X
TMSL3
thymosin beta 4, X-linked
thymosin-like 3
chr12_-_6830667 0.845 NM_031299
CDCA3
cell division cycle associated 3
chr3_+_48482625 0.831 TREX1
three prime repair exonuclease 1
chr2_-_37752731 0.827 NM_006449
CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr2_-_9688552 0.816 NM_006826
YWHAQ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
chr5_+_68498704 0.812 CCNB1
cyclin B1
chr1_+_43888391 0.811 KDM4A
lysine (K)-specific demethylase 4A
chr14_+_85066265 0.800 FLRT2
fibronectin leucine rich transmembrane protein 2
chr1_-_219982049 0.798 DUSP10
dual specificity phosphatase 10
chr1_+_201541241 0.792 BTG2
BTG family, member 2
chr6_+_80771040 0.784 NM_001166691
NM_003318
TTK

TTK protein kinase

chr1_+_24944493 0.782 CLIC4
chloride intracellular channel 4
chr12_+_97433536 0.782 TMPO
thymopoietin
chr7_-_44854145 0.776 H2AFV
H2A histone family, member V
chr12_+_97433541 0.774 TMPO
thymopoietin
chr7_-_44854183 0.771 H2AFV
H2A histone family, member V
chr4_-_103485600 0.771 NM_001135146
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr14_+_102870431 0.767 EIF5
eukaryotic translation initiation factor 5
chr5_+_76047536 0.765 NM_001992
F2R
coagulation factor II (thrombin) receptor
chrX_-_15782826 0.764


chr5_+_68498741 0.760 CCNB1
cyclin B1
chr7_+_120378052 0.759 NM_019071
NM_198267
ING3

inhibitor of growth family, member 3

chr1_-_219982081 0.759 NM_007207
NM_144729
DUSP10

dual specificity phosphatase 10

chr4_+_154606900 0.759 NM_001131007
NM_015196
KIAA0922

KIAA0922

chr11_-_66877519 0.759 NM_021173
POLD4
polymerase (DNA-directed), delta 4
chr19_+_50086299 0.758 NM_001128916
NM_001128917
NM_006114
TOMM40


translocase of outer mitochondrial membrane 40 homolog (yeast)


chr1_-_219982016 0.753 DUSP10
dual specificity phosphatase 10
chr8_+_82355322 0.751 NM_001444
FABP5
fatty acid binding protein 5 (psoriasis-associated)
chr7_-_44854092 0.750 H2AFV
H2A histone family, member V
chr8_+_133856793 0.743 PHF20L1
PHD finger protein 20-like 1
chr14_-_87529222 0.742 GALC
galactosylceramidase
chr17_+_78009819 0.737 NM_001083608
NM_012336
NM_031968
NARF


nuclear prelamin A recognition factor


chr14_+_23711044 0.735 NM_001048205
NM_005132
REC8

REC8 homolog (yeast)

chr1_-_195382189 0.734 NM_018136
ASPM
asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
chr11_-_6633427 0.733 NM_003737
DCHS1
dachsous 1 (Drosophila)
chr17_-_8054587 0.732 NM_004217
AURKB
aurora kinase B
chrX_-_15782842 0.724 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr2_-_61618898 0.713 NM_003400
XPO1
exportin 1 (CRM1 homolog, yeast)
chr12_-_21545751 0.710 NM_002907
NM_032941
RECQL

RecQ protein-like (DNA helicase Q1-like)

chr1_+_24944554 0.709 CLIC4
chloride intracellular channel 4
chr14_+_102870287 0.706 EIF5
eukaryotic translation initiation factor 5
chr10_-_75080784 0.701 NM_024875
SYNPO2L
synaptopodin 2-like
chr17_+_78009895 0.696 NARF
nuclear prelamin A recognition factor
chr3_+_48482213 0.694 NM_016381
NM_033629
TREX1

three prime repair exonuclease 1

chr13_-_98428244 0.687 NM_001130048
NM_001130050
DOCK9

dedicator of cytokinesis 9

chr20_-_55718982 0.684 NM_199169
NM_199170
PMEPA1

prostate transmembrane protein, androgen induced 1

chr5_+_102493155 0.684 NM_015216
PPIP5K2
diphosphoinositol pentakisphosphate kinase 2
chr14_+_20007377 0.681 NM_000270
PNP
purine nucleoside phosphorylase
chr14_-_87529212 0.681 GALC
galactosylceramidase
chr3_+_51397756 0.676 MANF
mesencephalic astrocyte-derived neurotrophic factor
chr16_-_74086779 0.675


chr4_-_122964232 0.665 CCNA2
cyclin A2
chr17_+_42641426 0.664 NM_001002841
MYL4
myosin, light chain 4, alkali; atrial, embryonic
chr10_+_70748634 0.661 HK1
hexokinase 1
chr12_-_21545473 0.661 RECQL
RecQ protein-like (DNA helicase Q1-like)
chr11_+_128068982 0.657 NM_002017
FLI1
Friend leukemia virus integration 1
chr7_-_120823556 0.656 FAM3C
family with sequence similarity 3, member C
chr4_-_40631397 0.655 APBB2
amyloid beta (A4) precursor protein-binding, family B, member 2
chr19_+_50086362 0.652 TOMM40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr11_-_71501385 0.641 NM_014042
C11orf51
chromosome 11 open reading frame 51
chr7_-_99612757 0.638 NM_152742
GPC2
glypican 2
chr10_+_31650069 0.635 NM_001128128
NM_001174094
ZEB1

zinc finger E-box binding homeobox 1

chr7_-_120823591 0.631 NM_001040020
NM_014888
FAM3C

family with sequence similarity 3, member C

chr15_+_37660568 0.630 NM_003246
THBS1
thrombospondin 1
chr12_+_97433462 0.627 NM_001032283
NM_001032284
NM_003276
TMPO


thymopoietin


chr3_+_51397731 0.624 NM_006010
MANF
mesencephalic astrocyte-derived neurotrophic factor
chr7_-_5535349 0.624 ACTB
actin, beta
chr1_+_43597185 0.620 NM_001255
CDC20
cell division cycle 20 homolog (S. cerevisiae)
chr1_+_201541269 0.619 NM_006763
BTG2
BTG family, member 2
chrX_-_15782859 0.618 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr14_+_23710924 0.616 REC8
REC8 homolog (yeast)
chr3_-_170347019 0.613 NM_001105078
MECOM
MDS1 and EVI1 complex locus
chr19_+_54723044 0.610 RCN3
reticulocalbin 3, EF-hand calcium binding domain
chr17_+_16886491 0.608 NM_015134
NM_201274
MPRIP

myosin phosphatase Rho interacting protein

chr19_+_50086357 0.608 TOMM40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr1_+_153213771 0.604 CKS1B
CDC28 protein kinase regulatory subunit 1B
chr5_+_53787187 0.603 NM_006308
HSPB3
heat shock 27kDa protein 3
chr16_+_30102426 0.602 CORO1A
coronin, actin binding protein, 1A
chr1_-_154913712 0.601 NM_006617
NES
nestin
chr7_+_149895390 0.599 NM_018326
GIMAP4
GTPase, IMAP family member 4
chrX_-_15782803 0.599 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr16_+_30102231 0.595 NM_001193333
NM_007074
CORO1A

coronin, actin binding protein, 1A

chr9_+_102275310 0.593 NM_003692
TMEFF1
transmembrane protein with EGF-like and two follistatin-like domains 1
chr19_+_750281 0.592 PTBP1
polypyrimidine tract binding protein 1
chr5_+_68498624 0.592 NM_031966
CCNB1
cyclin B1
chr2_-_9687817 0.586 YWHAQ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
chr19_-_60611136 0.580 NM_014501
UBE2S
ubiquitin-conjugating enzyme E2S
chr1_+_24944346 0.573 NM_013943
CLIC4
chloride intracellular channel 4
chr19_-_60610971 0.571 UBE2S
ubiquitin-conjugating enzyme E2S
chr5_-_137099602 0.569 NM_017415
KLHL3
kelch-like 3 (Drosophila)
chr1_+_170017452 0.568 METTL13
methyltransferase like 13
chr2_+_33592445 0.562 NM_015376
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr14_+_102870245 0.560 NM_001969
EIF5
eukaryotic translation initiation factor 5
chr14_-_106289751 0.558 IGHA1
IGHG1
IGHM
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr1_-_43692134 0.557 NM_001190880
NM_031207
HYI

hydroxypyruvate isomerase (putative)

chr9_+_89302574 0.556 NM_004938
DAPK1
death-associated protein kinase 1
chr1_+_170017430 0.556 METTL13
methyltransferase like 13
chr4_-_186969041 0.555 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chr17_+_1680013 0.555 NM_002945
RPA1
replication protein A1, 70kDa
chr1_+_153213740 0.555 NM_001826
CKS1B
CDC28 protein kinase regulatory subunit 1B
chr4_-_40553838 0.554 NM_001166051
NM_001166052
NM_001166053
NM_001166054
APBB2



amyloid beta (A4) precursor protein-binding, family B, member 2



chr4_-_186969202 0.552 NM_001145671
SORBS2
sorbin and SH3 domain containing 2
chr15_+_39412183 0.548 NM_001129897
NM_016359
NM_018454
NUSAP1


nucleolar and spindle associated protein 1


chr15_-_43457916 0.548 GATM
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr16_+_43827 0.546 NM_024571
SNRNP25
small nuclear ribonucleoprotein 25kDa (U11/U12)
chr7_+_99613282 0.544 STAG3
stromal antigen 3
chr13_-_45654296 0.543 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr8_-_95976599 0.537 NM_057749
CCNE2
cyclin E2
chr15_-_66900266 0.536 ANP32A
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
chr9_-_35101534 0.536 KIAA1539
KIAA1539
chr6_-_31805932 0.535 DDAH2
dimethylarginine dimethylaminohydrolase 2
chr7_+_44754700 0.534 ZMIZ2
zinc finger, MIZ-type containing 2
chr17_+_1680063 0.534 RPA1
replication protein A1, 70kDa
chr1_+_234372454 0.533 NM_003272
GPR137B
G protein-coupled receptor 137B
chr5_+_112340326 0.532 NM_152624
DCP2
DCP2 decapping enzyme homolog (S. cerevisiae)
chr11_-_4585947 0.530 NM_018073
TRIM68
tripartite motif containing 68
chr2_+_85619802 0.529 MAT2A
methionine adenosyltransferase II, alpha
chr6_+_12398514 0.526 NM_001168319
NM_001955
EDN1

endothelin 1


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.93 1.11e-04 GO:0034622 cellular macromolecular complex assembly
2.76 3.36e-04 GO:0065004 protein-DNA complex assembly
2.44 6.09e-04 GO:0071103 DNA conformation change
2.85 6.76e-04 GO:0006334 nucleosome assembly
2.78 1.18e-03 GO:0031497 chromatin assembly
2.59 1.56e-03 GO:0071824 protein-DNA complex subunit organization
1.56 2.95e-03 GO:0071844 cellular component assembly at cellular level
1.67 4.90e-03 GO:0034621 cellular macromolecular complex subunit organization
2.42 7.64e-03 GO:0006323 DNA packaging
2.54 8.92e-03 GO:0034728 nucleosome organization
1.27 2.61e-02 GO:0090304 nucleic acid metabolic process
3.02 2.78e-02 GO:0030048 actin filament-based movement
1.51 3.26e-02 GO:0065003 macromolecular complex assembly
2.21 4.09e-02 GO:0006333 chromatin assembly or disassembly

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.21 1.50e-06 GO:0005634 nucleus
1.30 6.75e-04 GO:0044428 nuclear part
3.01 2.54e-03 GO:0000786 nucleosome
1.25 2.54e-03 GO:0043228 non-membrane-bounded organelle
1.25 2.54e-03 GO:0043232 intracellular non-membrane-bounded organelle
1.30 4.23e-03 GO:0031981 nuclear lumen
2.91 1.31e-02 GO:0000794 condensed nuclear chromosome
1.31 4.97e-02 GO:0005654 nucleoplasm

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.25 5.67e-04 GO:0003676 nucleic acid binding
1.70 4.16e-02 GO:0003779 actin binding