Motif ID: FOXP3.p2

Z-value: 0.825


Transcription factors associated with FOXP3.p2:

Gene SymbolEntrez IDGene Name
FOXP3 50943 forkhead box P3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOXP3chrX_-_490081150.077.9e-01Click!


Activity profile for motif FOXP3.p2.

activity profile for motif FOXP3.p2


Sorted Z-values histogram for motif FOXP3.p2

Sorted Z-values for motif FOXP3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXP3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_-_26665220 2.275 NM_006495
EVI2B
ecotropic viral integration site 2B
chr17_-_26665213 2.264 EVI2B
ecotropic viral integration site 2B
chr17_-_26665144 2.159 EVI2B
ecotropic viral integration site 2B
chr17_-_26665194 2.138 EVI2B
ecotropic viral integration site 2B
chr6_-_32605898 2.073 NM_002125
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chrX_-_100527799 1.900 NM_000061
BTK
Bruton agammaglobulinemia tyrosine kinase
chr4_+_39874921 1.835 NM_004310
RHOH
ras homolog gene family, member H
chr6_-_32665409 1.735 NM_002124
HLA-DRB1
HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1
major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr2_-_158008763 1.625 NM_004288
CYTIP
cytohesin 1 interacting protein
chr6_-_154719560 1.343 NM_001130700
NM_015553
IPCEF1

interaction protein for cytohesin exchange factors 1

chr4_+_74493918 1.301 ALB
albumin
chr2_-_21079145 1.167 APOB
apolipoprotein B (including Ag(x) antigen)
chr1_+_15862887 1.164


chr17_+_64922420 1.013 NM_002758
MAP2K6
mitogen-activated protein kinase kinase 6
chr1_+_205694237 0.962 NM_001006658
NM_001877
CR2

complement component (3d/Epstein Barr virus) receptor 2

chr22_+_19458378 0.951 NM_000185
SERPIND1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr6_+_64414389 0.884 NM_015153
PHF3
PHD finger protein 3
chr10_+_114125003 0.876 NM_203380
ACSL5
acyl-CoA synthetase long-chain family member 5
chr1_-_205161821 0.870 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr15_-_78050515 0.798 NM_001114735
NM_004049
BCL2A1

BCL2-related protein A1

chr9_-_115880425 0.759 AMBP
alpha-1-microglobulin/bikunin precursor
chr11_+_116205830 0.703 NM_000040
APOC3
apolipoprotein C-III
chr16_+_70646008 0.698 NM_001126102
NM_005143
HP

haptoglobin

chr1_+_190811479 0.682 NM_002922
RGS1
regulator of G-protein signaling 1
chrX_-_76824726 0.679 ATRX
alpha thalassemia/mental retardation syndrome X-linked
chr11_+_124329222 0.657 NM_025004
CCDC15
coiled-coil domain containing 15
chr9_-_36365965 0.655 RNF38
ring finger protein 38
chr15_-_91078307 0.630 FAM174B
family with sequence similarity 174, member B
chr1_-_149004852 0.602 CTSS
cathepsin S
chr9_-_115880366 0.574 AMBP
alpha-1-microglobulin/bikunin precursor
chr4_+_89115825 0.553 NM_000582
NM_001040058
NM_001040060
SPP1


secreted phosphoprotein 1


chr11_+_124329286 0.526 CCDC15
coiled-coil domain containing 15
chr9_-_115880372 0.517 AMBP
alpha-1-microglobulin/bikunin precursor
chr4_+_70180805 0.500 NM_053039
UGT2B28
UDP glucuronosyltransferase 2 family, polypeptide B28
chr12_+_6424293 0.493 NM_001242
CD27
CD27 molecule
chr5_+_157090900 0.483 NM_017872
THG1L
tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
chr1_+_173111306 0.452 NM_001035230
RABGAP1L
RAB GTPase activating protein 1-like
chr12_+_99391870 0.452 NR1H4
nuclear receptor subfamily 1, group H, member 4
chr4_+_89115862 0.446 SPP1
secreted phosphoprotein 1
chr17_+_38306339 0.443 NM_000151
G6PC
glucose-6-phosphatase, catalytic subunit
chr8_+_107807415 0.436 NM_001198534
NM_001198535
OXR1

oxidation resistance 1

chr1_-_149004916 0.425 NM_004079
CTSS
cathepsin S
chr3_+_142175329 0.414 SLC25A36
solute carrier family 25, member 36
chr16_+_70654625 0.407 NM_020995
HPR
haptoglobin-related protein
chr9_-_115880281 0.407 AMBP
alpha-1-microglobulin/bikunin precursor
chr1_+_154390939 0.401 SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr4_-_123596921 0.400 NM_000586
IL2
interleukin 2
chr16_+_14976333 0.397 NM_015027
PDXDC1
pyridoxal-dependent decarboxylase domain containing 1
chr6_+_106653429 0.385 NM_182907
PRDM1
PR domain containing 1, with ZNF domain
chr12_+_99391681 0.385 NM_005123
NR1H4
nuclear receptor subfamily 1, group H, member 4
chr14_-_20969706 0.380 NM_001170629
CHD8
chromodomain helicase DNA binding protein 8
chr4_+_89115923 0.377 SPP1
secreted phosphoprotein 1
chr6_+_88026338 0.366 ZNF292
zinc finger protein 292
chr17_-_59825221 0.359


chr17_+_72692889 0.359 NM_001144001
SEC14L1
SEC14-like 1 (S. cerevisiae)
chr7_+_21434818 0.357


chr19_-_6671585 0.351 NM_000064
C3
complement component 3
chr9_-_115880494 0.345 NM_001633
AMBP
alpha-1-microglobulin/bikunin precursor
chr6_+_33151703 0.339 NM_002121
HLA-DPB1
major histocompatibility complex, class II, DP beta 1
chr2_-_215605054 0.338 NM_015657
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12
chr2_-_110319866 0.335 NM_000272
NM_001128178
NM_001128179
NM_207181
NPHP1



nephronophthisis 1 (juvenile)



chr10_+_97505398 0.318 NM_001164178
NM_001164181
NM_001164179
NM_001164182
NM_001164183
NM_001776
ENTPD1





ectonucleoside triphosphate diphosphohydrolase 1





chr1_+_196874759 0.301 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr2_-_89400935 0.300 IGKC
immunoglobulin kappa constant
chr19_+_47073029 0.283 NM_001783
NM_021601
CD79A

CD79a molecule, immunoglobulin-associated alpha

chr17_+_24394043 0.279 NM_016518
PIPOX
pipecolic acid oxidase
chr1_-_172153087 0.278 NM_000488
SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr5_-_32424352 0.266 ZFR
zinc finger RNA binding protein
chr12_+_49604782 0.266 NM_014033
METTL7A
methyltransferase like 7A
chr14_-_34414603 0.263 NM_013448
NM_182648
BAZ1A

bromodomain adjacent to zinc finger domain, 1A

chr2_-_110319828 0.258 NPHP1
nephronophthisis 1 (juvenile)
chr21_-_33107813 0.253 NM_001162495
NM_001162496
NM_019596
C21orf62


chromosome 21 open reading frame 62


chrX_-_105169370 0.249 NM_000354
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr1_-_158815850 0.245 CD84
CD84 molecule
chr13_-_98708549 0.242 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chr16_+_2807228 0.241 PRSS21
protease, serine, 21 (testisin)
chr1_-_159459999 0.240 NM_001643
APOA2
apolipoprotein A-II
chr1_+_116727514 0.234 NM_001160234
ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr1_-_172153024 0.232 SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chrX_+_78087484 0.227 NM_014499
NM_198333
P2RY10

purinergic receptor P2Y, G-protein coupled, 10

chr2_+_33592445 0.226 NM_015376
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr15_+_83467295 0.222 PDE8A
phosphodiesterase 8A
chr4_-_103464491 0.215 NM_001135148
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr6_-_11490487 0.215 NM_001142393
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr6_-_76259976 0.210 NM_015687
FILIP1
filamin A interacting protein 1
chr1_-_159099090 0.206 NM_001166663
NM_001166664
NM_016382
CD244


CD244 molecule, natural killer cell receptor 2B4


chr19_-_60458915 0.203 PPP6R1
protein phosphatase 6, regulatory subunit 1
chr8_-_17797127 0.202 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chr12_+_15366712 0.196 NM_002848
NM_030667
PTPRO

protein tyrosine phosphatase, receptor type, O

chr16_+_2807164 0.195 NM_006799
NM_144956
NM_144957
PRSS21


protease, serine, 21 (testisin)


chr22_-_43987010 0.193 NM_015264
KIAA0930
KIAA0930
chr12_+_51783540 0.192 NM_003578
SOAT2
sterol O-acyltransferase 2
chr2_+_143351536 0.190 NM_001032998
NM_003937
KYNU

kynureninase

chr1_+_66570363 0.168 NM_001037339
PDE4B
phosphodiesterase 4B, cAMP-specific
chr4_-_70115037 0.165 NM_001073
UGT2B11
UDP glucuronosyltransferase 2 family, polypeptide B11
chr6_+_144654565 0.162 NM_007124
UTRN
utrophin
chr6_+_37895244 0.158 NM_021943
ZFAND3
zinc finger, AN1-type domain 3
chr4_+_100714995 0.155 MTTP
microsomal triglyceride transfer protein
chr2_+_170149092 0.155 NM_004792
PPIG
peptidylprolyl isomerase G (cyclophilin G)
chr3_+_63859114 0.155 NM_001177387
ATXN7
ataxin 7
chr2_+_165860528 0.155 NM_001040143
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr4_+_114433551 0.153 ANK2
ankyrin 2, neuronal
chr4_+_71096830 0.150 NM_017855
ODAM
odontogenic, ameloblast asssociated
chr11_-_112851051 0.148 NM_000795
NM_016574
DRD2

dopamine receptor D2

chr1_-_158815895 0.148 NM_001184879
NM_001184881
NM_001184882
NM_003874
CD84



CD84 molecule



chr1_-_78217360 0.147 NM_003902
FUBP1
far upstream element (FUSE) binding protein 1
chr14_-_105948734 0.144 LOC100126583
IGHV4-31
IGHA1
IGHA2
IGHG1
IGHG4
IGHM
hypothetical LOC100126583
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 4 (G4m marker)
immunoglobulin heavy constant mu
chr15_+_56511466 0.144 NM_000236
LIPC
lipase, hepatic
chr5_-_94442941 0.140 MCTP1
multiple C2 domains, transmembrane 1
chr8_+_124263932 0.140 NM_032899
NM_207006
FAM83A

family with sequence similarity 83, member A

chr2_+_102401580 0.140 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr6_+_31648071 0.138 NM_000595
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr4_-_186934059 0.136 NM_001145673
SORBS2
sorbin and SH3 domain containing 2
chr3_-_122747470 0.136 NM_199420
POLQ
polymerase (DNA directed), theta
chr6_-_109795925 0.135 CD164
CD164 molecule, sialomucin
chr19_+_47416271 0.133 NM_133444
ZNF526
zinc finger protein 526
chr5_+_67622242 0.132 NM_181504
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr17_-_35327318 0.132 NM_018530
GSDMB
gasdermin B
chr11_+_86710076 0.125 TMEM135
transmembrane protein 135
chr9_+_12683385 0.124 NM_000550
TYRP1
tyrosinase-related protein 1
chr8_+_92184022 0.124 NM_001129890
LRRC69
leucine rich repeat containing 69
chr13_+_48582389 0.123 NM_014923
FNDC3A
fibronectin type III domain containing 3A
chr5_-_94443300 0.119 NM_001002796
MCTP1
multiple C2 domains, transmembrane 1
chr22_-_43986896 0.118 KIAA0930
KIAA0930
chr19_+_39402167 0.114 LSM14A
LSM14A, SCD6 homolog A (S. cerevisiae)
chr1_+_51968191 0.113 OSBPL9
oxysterol binding protein-like 9
chr15_-_63199228 0.110 PDCD7
programmed cell death 7
chr4_-_140280031 0.109 NM_201999
ELF2
E74-like factor 2 (ets domain transcription factor)
chr6_+_31838751 0.108 NM_001039651
C6orf26
chromosome 6 open reading frame 26
chr6_-_112147946 0.107 NM_153047
FYN
FYN oncogene related to SRC, FGR, YES
chr9_-_103237851 0.105 NM_000035
ALDOB
aldolase B, fructose-bisphosphate
chr6_+_31623331 0.104 NM_001144961
NM_005007
NFKBIL1

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1

chr21_+_42946719 0.104 NM_001001567
NM_001001568
NM_001001569
NM_001001570
NM_001001571
NM_001001572
NM_001001573
NM_001001574
NM_001001575
NM_001001576
NM_001001577
NM_001001578
NM_001001579
NM_001001580
NM_001001581
NM_001001582
NM_001001583
NM_001001584
NM_001001585
NM_002606
PDE9A



















phosphodiesterase 9A



















chr1_-_78217278 0.098 FUBP1
far upstream element (FUSE) binding protein 1
chr16_+_14976422 0.098 PDXDC1
pyridoxal-dependent decarboxylase domain containing 1
chr5_+_161210280 0.096 NM_001127648
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr4_-_151990061 0.093 LRBA
LPS-responsive vesicle trafficking, beach and anchor containing
chr15_+_46285789 0.092 NM_000338
NM_001184832
SLC12A1

solute carrier family 12 (sodium/potassium/chloride transporters), member 1

chr14_+_101346032 0.091 PPP2R5C
protein phosphatase 2, regulatory subunit B', gamma
chr16_-_12805194 0.089 NM_001099455
NM_018340
CPPED1

calcineurin-like phosphoesterase domain containing 1

chr2_-_166638376 0.089 NM_001165963
NM_001165964
NM_006920
SCN1A


sodium channel, voltage-gated, type I, alpha subunit


chr10_+_124904269 0.089 BUB3
budding uninhibited by benzimidazoles 3 homolog (yeast)
chr18_-_72857951 0.087 MBP
myelin basic protein
chr2_-_74235860 0.087


chr3_-_173723754 0.084 NM_001190943
NM_001190942
NM_003810
TNFSF10


tumor necrosis factor (ligand) superfamily, member 10


chr17_-_10362583 0.084 NM_005963
MYH1
myosin, heavy chain 1, skeletal muscle, adult
chr11_+_58668827 0.081 NM_022074
NM_198847
FAM111A

family with sequence similarity 111, member A

chr13_+_94883853 0.080 NM_001160100
NM_182848
CLDN10

claudin 10

chr8_-_146173531 0.080 ZNF252
zinc finger protein 252
chr8_+_17874128 0.079 PCM1
pericentriolar material 1
chr12_-_131725848 0.079 POLE
polymerase (DNA directed), epsilon
chr6_-_17814596 0.077 NM_005124
NUP153
nucleoporin 153kDa
chr10_-_44794146 0.076 NM_007021
C10orf10
chromosome 10 open reading frame 10
chr4_-_70396167 0.075 NM_021139
UGT2B4
UDP glucuronosyltransferase 2 family, polypeptide B4
chr15_+_62578671 0.074 NM_015042
ZNF609
zinc finger protein 609
chr12_+_54646814 0.074 NM_001798
NM_052827
CDK2

cyclin-dependent kinase 2

chr19_-_44060729 0.074 NM_001195833
NM_198445
RINL

Ras and Rab interactor-like

chr16_-_68657256 0.073 PDXDC2P
pyridoxal-dependent decarboxylase domain containing 2, pseudogene
chr8_-_37847095 0.072 RAB11FIP1
RAB11 family interacting protein 1 (class I)
chr19_-_40996040 0.071 NM_021232
PRODH2
proline dehydrogenase (oxidase) 2
chr15_-_80428760 0.070 NM_001164465
GOLGA6L10
golgin A6 family-like 10
chr19_+_56958452 0.069 NM_001462
FPR2
formyl peptide receptor 2
chr11_+_62231689 0.066 NM_012202
GNG3
guanine nucleotide binding protein (G protein), gamma 3
chr16_+_68890559 0.065 NM_001014449
NM_001014451
NM_007242
DDX19B


DEAD (Asp-Glu-Ala-As) box polypeptide 19B


chr19_-_40995606 0.064 PRODH2
proline dehydrogenase (oxidase) 2
chr1_+_67404756 0.064 NM_144701
IL23R
interleukin 23 receptor
chr11_-_47502115 0.062 NM_001172639
CELF1
CUGBP, Elav-like family member 1
chr1_-_45868775 0.062 GPBP1L1
GC-rich promoter binding protein 1-like 1
chr11_+_30209138 0.060 NM_000510
NM_001018080
FSHB

follicle stimulating hormone, beta polypeptide

chr3_-_180467483 0.060 NM_001163677
NM_171828
KCNMB3

potassium large conductance calcium-activated channel, subfamily M beta member 3

chr15_+_75074743 0.059 PSTPIP1
proline-serine-threonine phosphatase interacting protein 1
chr3_-_172227152 0.059 SLC2A2
solute carrier family 2 (facilitated glucose transporter), member 2
chr4_+_71261066 0.058 NM_012390
SMR3B
SMR3A
submaxillary gland androgen regulated protein 3B
submaxillary gland androgen regulated protein 3A
chr8_-_91065961 0.058 NBN
nibrin
chr5_+_43645018 0.057 NNT
nicotinamide nucleotide transhydrogenase
chr10_+_112334066 0.054 SMC3
structural maintenance of chromosomes 3
chr13_+_110637173 0.054 NM_001113513
ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr1_-_89364273 0.053 NM_004120
GBP2
guanylate binding protein 2, interferon-inducible
chr3_+_170974745 0.053 NM_001185119
MYNN
myoneurin
chr11_+_10433241 0.051 NM_001025389
AMPD3
adenosine monophosphate deaminase 3
chr4_+_88790477 0.050 NM_001079911
NM_004407
DMP1

dentin matrix acidic phosphoprotein 1

chr9_-_21067804 0.049 NM_002176
IFNB1
interferon, beta 1, fibroblast
chr6_-_30748760 0.048 NM_001164239
NM_003587
DHX16

DEAH (Asp-Glu-Ala-His) box polypeptide 16

chr22_+_16423147 0.048 NM_031481
SLC25A18
solute carrier family 25 (mitochondrial carrier), member 18
chrX_-_135690770 0.048 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr15_+_75074793 0.047 PSTPIP1
proline-serine-threonine phosphatase interacting protein 1
chr6_-_131426080 0.046 NM_001135555
NM_001135554
NM_001431
EPB41L2


erythrocyte membrane protein band 4.1-like 2


chr17_+_7402788 0.045 TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chr10_+_69539255 0.045 NM_032578
MYPN
myopalladin
chr17_-_59327602 0.045 NM_001317
NM_022640
NM_022641
CSH1


CSH2
chorionic somatomammotropin hormone 1 (placental lactogen)


chorionic somatomammotropin hormone 2
chr3_+_153468518 0.045 NM_021038
NM_207292
MBNL1

muscleblind-like (Drosophila)

chr11_-_66201794 0.044 NM_031492
RBM4B
RNA binding motif protein 4B
chr22_+_27998367 0.044 EWSR1
Ewing sarcoma breakpoint region 1
chr18_-_72858037 0.043 NM_001025081
NM_001025090
NM_001025092
NM_002385
MBP



myelin basic protein



chr7_+_141124710 0.043 NM_016944
TAS2R4
taste receptor, type 2, member 4
chr5_+_140546839 0.043 NM_019119
PCDHB9
protocadherin beta 9
chr16_+_2672476 0.042 NM_018992
KCTD5
potassium channel tetramerisation domain containing 5
chr3_+_150675169 0.042 TM4SF4
transmembrane 4 L six family member 4
chr3_-_121065112 0.042


chr5_+_180348450 0.042 NM_197975
BTNL3
butyrophilin-like 3

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.19 1.63e-04 GO:0002376 immune system process
2.60 1.67e-04 GO:0006955 immune response
6.20 2.01e-04 GO:0002429 immune response-activating cell surface receptor signaling pathway
6.01 2.88e-04 GO:0002768 immune response-regulating cell surface receptor signaling pathway
3.62 8.93e-04 GO:0050778 positive regulation of immune response
3.05 9.26e-04 GO:0002684 positive regulation of immune system process
3.00 1.23e-03 GO:0050776 regulation of immune response
3.89 2.32e-03 GO:0002253 activation of immune response
4.64 5.79e-03 GO:0006869 lipid transport
4.25 7.01e-03 GO:0051251 positive regulation of lymphocyte activation
3.99 1.45e-02 GO:0002757 immune response-activating signal transduction
11.21 1.45e-02 GO:0071825 protein-lipid complex subunit organization
11.21 1.45e-02 GO:0071827 plasma lipoprotein particle organization
4.25 1.52e-02 GO:0010876 lipid localization
3.97 1.56e-02 GO:0002696 positive regulation of leukocyte activation
8.60 1.73e-02 GO:0030301 cholesterol transport
3.92 1.79e-02 GO:0002764 immune response-regulating signaling pathway
3.89 1.91e-02 GO:0050867 positive regulation of cell activation
8.38 2.07e-02 GO:0015918 sterol transport
13.74 2.75e-02 GO:0044269 glycerol ether catabolic process
13.74 2.75e-02 GO:0046461 neutral lipid catabolic process
13.74 2.75e-02 GO:0046464 acylglycerol catabolic process
5.19 2.76e-02 GO:0050851 antigen receptor-mediated signaling pathway
6.44 3.83e-02 GO:0055088 lipid homeostasis
7.60 4.03e-02 GO:0042632 cholesterol homeostasis
7.60 4.03e-02 GO:0055092 sterol homeostasis
6.23 4.93e-02 GO:0006641 triglyceride metabolic process
18.68 4.93e-02 GO:0034374 low-density lipoprotein particle remodeling

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.46 8.04e-03 GO:0071944 cell periphery
1.45 1.35e-02 GO:0005886 plasma membrane
1.66 3.91e-02 GO:0005576 extracellular region

Nothing significant found in function category.