Motif ID: NKX6-1,2.p2

Z-value: 1.215


Transcription factors associated with NKX6-1,2.p2:

Gene SymbolEntrez IDGene Name
NKX6-1 4825 NK6 homeobox 1
NKX6-2 84504 NK6 homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX6-1chr4_-_856384100.078.0e-01Click!


Activity profile for motif NKX6-1,2.p2.

activity profile for motif NKX6-1,2.p2


Sorted Z-values histogram for motif NKX6-1,2.p2

Sorted Z-values for motif NKX6-1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX6-1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_169654742 5.202 NM_001166108
NM_016081
PALLD

palladin, cytoskeletal associated protein

chr2_-_151052391 3.416 NM_005168
RND3
Rho family GTPase 3
chr2_-_237987579 3.305 NM_004369
NM_057164
NM_057165
NM_057166
NM_057167
COL6A3




collagen, type VI, alpha 3




chr2_-_237987554 2.666 COL6A3
collagen, type VI, alpha 3
chr12_-_90029328 2.657 LUM
lumican
chr12_-_90029672 2.603 NM_002345
LUM
lumican
chr4_+_54790020 2.549 NM_006206
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr4_+_40953652 2.447 NM_004181
UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr13_-_37070862 2.444 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chrX_+_135058402 2.381 NM_001159700
FHL1
four and a half LIM domains 1
chr5_-_111119846 2.373 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr3_-_79899748 2.176 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr9_+_115303527 2.064 NM_130795
RGS3
regulator of G-protein signaling 3
chr20_+_19863716 2.006 RIN2
Ras and Rab interactor 2
chr7_+_93862137 1.882 COL1A2
PLAG1
collagen, type I, alpha 2
pleiomorphic adenoma gene 1
chr7_-_136679045 1.846 NM_002825
PTN
pleiotrophin
chr8_-_122722674 1.839 NM_005328
HAS2
hyaluronan synthase 2
chr6_+_114285209 1.832 NM_002356
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr21_+_29439768 1.823 C21orf7
chromosome 21 open reading frame 7
chrX_-_100759562 1.790 NM_001009584
NM_001184768
NM_019007
ARMCX6


armadillo repeat containing, X-linked 6


chrX_+_55951280 1.773


chrX_-_10495476 1.772 NM_001193278
NM_001193279
NM_001193280
NM_001193281
MID1



midline 1 (Opitz/BBB syndrome)



chr8_+_79591074 1.638 PKIA
protein kinase (cAMP-dependent, catalytic) inhibitor alpha
chr7_+_102340579 1.610 NM_001031692
NM_005824
LRRC17

leucine rich repeat containing 17

chr13_-_32658215 1.512 NM_178007
STARD13
StAR-related lipid transfer (START) domain containing 13
chr2_-_217268492 1.507 NM_000599
IGFBP5
insulin-like growth factor binding protein 5
chr5_+_140709907 1.450 NM_018922
NM_032095
PCDHGB1

protocadherin gamma subfamily B, 1

chrX_+_102727068 1.416 NM_001006935
NM_001006937
NM_024863
TCEAL4


transcription elongation factor A (SII)-like 4


chr4_+_40953698 1.388 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr8_+_79590890 1.369 NM_006823
NM_181839
PKIA

protein kinase (cAMP-dependent, catalytic) inhibitor alpha

chr9_+_81376666 1.348 NM_007005
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr17_-_7248137 1.334 NM_152766
C17orf61-PLSCR3
C17orf61
C17orf61-PLSCR3 read-through transcript
chromosome 17 open reading frame 61
chrX_-_10504852 1.304 NM_001193277
MID1
midline 1 (Opitz/BBB syndrome)
chr8_+_133060353 1.273 EFR3A
EFR3 homolog A (S. cerevisiae)
chr1_-_110735158 1.199 NM_004696
SLC16A4
solute carrier family 16, member 4 (monocarboxylic acid transporter 5)
chr4_-_16509446 1.193 NM_001130834
NM_001290
LDB2

LIM domain binding 2

chr1_+_185064654 1.192 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr4_-_16509126 1.179 LDB2
LIM domain binding 2
chr1_+_154120170 1.163 SYT11
synaptotagmin XI
chrX_+_47326746 1.155 TIMP1
TIMP metallopeptidase inhibitor 1
chr7_+_23252945 1.144 GPNMB
glycoprotein (transmembrane) nmb
chr7_+_23252909 1.074 GPNMB
glycoprotein (transmembrane) nmb
chr1_-_161380562 1.065 RGS5
regulator of G-protein signaling 5
chr1_+_208568218 1.061 NM_001122834
NM_001170564
HHAT

hedgehog acyltransferase

chr3_-_116272911 1.061 NM_001164343
ZBTB20
zinc finger and BTB domain containing 20
chr18_+_71051713 1.049 NM_005786
TSHZ1
teashirt zinc finger homeobox 1
chr10_+_31650069 1.048 NM_001128128
NM_001174094
ZEB1

zinc finger E-box binding homeobox 1

chr5_+_35892747 1.041 NM_002185
IL7R
interleukin 7 receptor
chr12_+_118100977 1.037 NM_014365
HSPB8
heat shock 22kDa protein 8
chrX_+_47326594 1.027 NM_003254
TIMP1
TIMP metallopeptidase inhibitor 1
chr6_+_26548678 1.012 NM_006994
NM_197974
BTN3A3

butyrophilin, subfamily 3, member A3

chr5_+_140719773 1.012 NM_018923
NM_032096
PCDHGB2

protocadherin gamma subfamily B, 2

chr8_-_131483395 0.989 NM_018482
ASAP1
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
chr10_-_14412813 0.979 NM_018027
FRMD4A
FERM domain containing 4A
chr12_-_6103945 0.971 NM_000552
VWF
von Willebrand factor
chr7_+_23252915 0.970 GPNMB
glycoprotein (transmembrane) nmb
chr7_+_23252911 0.969 GPNMB
glycoprotein (transmembrane) nmb
chrX_-_114158388 0.966 NM_000640
IL13RA2
interleukin 13 receptor, alpha 2
chr18_-_490583 0.939 NM_130386
COLEC12
collectin sub-family member 12
chrX_+_80343958 0.913 NM_003022
SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr19_-_53450953 0.905 NM_001184902
NM_001184904
CARD8

caspase recruitment domain family, member 8

chr15_+_22619886 0.862 NM_022806
NM_022807
NM_022808
SNRPN


small nuclear ribonucleoprotein polypeptide N


chr4_+_54790190 0.859 PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr7_-_136678815 0.840 PTN
pleiotrophin
chr1_+_78888064 0.817 NM_006417
IFI44
interferon-induced protein 44
chr11_-_27637771 0.816 NM_001143816
NM_170735
BDNF

brain-derived neurotrophic factor

chr7_-_41709191 0.805 NM_002192
INHBA
inhibin, beta A
chr14_+_100365390 0.801 MEG3
maternally expressed 3 (non-protein coding)
chr4_-_71751070 0.794 IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr3_-_150903749 0.779 NM_001168278
WWTR1
WW domain containing transcription regulator 1
chr3_-_106903734 0.757 CBLB
Cas-Br-M (murine) ecotropic retroviral transforming sequence b
chr7_+_23252802 0.721 NM_001005340
NM_002510
GPNMB

glycoprotein (transmembrane) nmb

chr15_-_91078307 0.713 FAM174B
family with sequence similarity 174, member B
chr15_+_97990705 0.706 NM_001130928
MEF2A
myocyte enhancer factor 2A
chr11_+_1830763 0.705 NM_002339
LSP1
lymphocyte-specific protein 1
chr5_+_155686333 0.697 NM_000337
NM_001128209
NM_172244
SGCD


sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)


chr12_-_51887266 0.696 NM_000889
ITGB7
integrin, beta 7
chr6_-_76027286 0.691 TMEM30A
transmembrane protein 30A
chr4_+_41395493 0.677 LIMCH1
LIM and calponin homology domains 1
chr13_-_109600709 0.674 COL4A1
collagen, type IV, alpha 1
chr2_-_144711375 0.661 NM_024659
GTDC1
glycosyltransferase-like domain containing 1
chr2_-_190635566 0.646 NM_005259
MSTN
myostatin
chr7_-_83662152 0.636 NM_006080
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr1_-_219982081 0.615 NM_007207
NM_144729
DUSP10

dual specificity phosphatase 10

chr6_+_26071255 0.603 TRIM38
tripartite motif containing 38
chr22_-_34892170 0.594 NM_145641
NM_145642
APOL3

apolipoprotein L, 3

chr7_+_28305464 0.589 NM_182899
CREB5
cAMP responsive element binding protein 5
chrX_+_80344215 0.587 SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr1_-_219982016 0.575 DUSP10
dual specificity phosphatase 10
chr6_+_26070957 0.570 NM_006355
TRIM38
tripartite motif containing 38
chr7_-_136678901 0.568 PTN
pleiotrophin
chr15_+_22772545 0.561 SNRPN
small nuclear ribonucleoprotein polypeptide N
chr1_+_207944807 0.561 NM_005525
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr20_-_18425811 0.556 NM_006606
RBBP9
retinoblastoma binding protein 9
chr9_+_34642125 0.549 NM_001142784
IL11RA
interleukin 11 receptor, alpha
chrX_+_80344253 0.549 SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr7_+_94135384 0.543 PEG10
paternally expressed 10
chr9_-_13240313 0.539 NM_003829
MPDZ
multiple PDZ domain protein
chr8_-_82557956 0.536 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr12_-_51887318 0.535 ITGB7
integrin, beta 7
chr2_+_33213111 0.534 NM_000627
NM_001166264
NM_001166265
NM_001166266
LTBP1



latent transforming growth factor beta binding protein 1



chr5_+_140730014 0.530 NM_018924
NM_032097
PCDHGB3

protocadherin gamma subfamily B, 3

chr16_+_31391998 0.529 NM_015927
TGFB1I1
transforming growth factor beta 1 induced transcript 1
chr9_+_81377419 0.517 TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr14_+_87921818 0.510 SPATA7
spermatogenesis associated 7
chr2_-_168812132 0.500 NM_013233
STK39
serine threonine kinase 39
chr18_+_41560915 0.491 NM_001146037
SLC14A1
solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
chr3_+_133518900 0.487 NM_001099
NM_001134194
ACPP

acid phosphatase, prostate

chr2_-_217267742 0.487 IGFBP5
insulin-like growth factor binding protein 5
chr7_-_137337354 0.483 NM_194071
CREB3L2
cAMP responsive element binding protein 3-like 2
chr8_-_13018123 0.473 NM_001164271
DLC1
deleted in liver cancer 1
chrY_+_13525412 0.468 NM_001122665
DDX3Y
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chr4_-_16509354 0.460 LDB2
LIM domain binding 2
chr4_-_186969041 0.459 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chr1_-_21249974 0.459 EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr1_+_203179976 0.455 NM_001160331
NFASC
neurofascin
chr2_-_188127430 0.454 NM_001032281
NM_006287
TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

chr4_-_71751205 0.453 NM_144646
IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr1_+_194887630 0.451 NM_000186
NM_001014975
CFH

complement factor H

chr1_-_205161821 0.433 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr16_-_68317868 0.430 NQO1
NAD(P)H dehydrogenase, quinone 1
chr5_+_140790310 0.429 NM_003735
NM_032094
PCDHGA12

protocadherin gamma subfamily A, 12

chr1_-_120413798 0.428 NM_024408
NOTCH2
notch 2
chr5_+_49997489 0.427 NM_001178055
PARP8
poly (ADP-ribose) polymerase family, member 8
chr21_-_26175068 0.426 APP
amyloid beta (A4) precursor protein
chr2_+_66516196 0.421 MEIS1
Meis homeobox 1
chr15_-_75135496 0.419 TSPAN3
tetraspanin 3
chr3_+_133518966 0.418 ACPP
acid phosphatase, prostate
chr3_-_150578103 0.415 TM4SF1
transmembrane 4 L six family member 1
chr8_+_110443881 0.414 NM_177531
PKHD1L1
polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1
chrX_+_102517909 0.413 NM_206915
NM_206917
NGFRAP1

nerve growth factor receptor (TNFRSF16) associated protein 1

chr21_+_37496616 0.412 TTC3
tetratricopeptide repeat domain 3
chrX_-_119550402 0.410 CUL4B
cullin 4B
chr8_-_93181091 0.406 NM_001198628
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr2_-_210876560 0.406 NM_079422
MYL1
myosin, light chain 1, alkali; skeletal, fast
chrX_+_51503219 0.406 NM_018094
GSPT2
G1 to S phase transition 2
chr1_-_30977931 0.404 LAPTM5
lysosomal protein transmembrane 5
chr12_+_46799279 0.402 NM_000289
PFKM
phosphofructokinase, muscle
chr8_-_23768242 0.398 NM_003155
STC1
stanniocalcin 1
chr10_-_69422391 0.398 HERC4
hect domain and RLD 4
chr7_-_136678973 0.398 PTN
pleiotrophin
chr3_+_150065732 0.395 NM_001870
CPA3
carboxypeptidase A3 (mast cell)
chr1_+_84402962 0.393 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chrX_+_55760774 0.392 NM_006064
NM_016656
RRAGB

Ras-related GTP binding B

chr5_+_140790365 0.392 PCDHGA12
protocadherin gamma subfamily A, 12
chrX_-_10605726 0.391 NM_001098624
MID1
midline 1 (Opitz/BBB syndrome)
chr3_-_15357878 0.388 NM_001018009
SH3BP5
SH3-domain binding protein 5 (BTK-associated)
chr5_+_140848905 0.368 NM_018929
NM_032407
PCDHGC5

protocadherin gamma subfamily C, 5

chr14_-_60185659 0.365 NM_005982
SIX1
SIX homeobox 1
chr2_+_102136833 0.361 NM_000877
IL1R1
interleukin 1 receptor, type I
chr12_+_27288344 0.357 NM_015000
STK38L
serine/threonine kinase 38 like
chr10_+_91142301 0.352 NM_001548
IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr9_-_26937172 0.351 PLAA
phospholipase A2-activating protein
chr16_-_68317855 0.351 NQO1
NAD(P)H dehydrogenase, quinone 1
chr16_+_31178778 0.349 NM_000632
NM_001145808
ITGAM

integrin, alpha M (complement component 3 receptor 3 subunit)

chrX_+_66705407 0.349 NM_001011645
AR
androgen receptor
chr3_+_137224266 0.346 NM_181897
PPP2R3A
protein phosphatase 2, regulatory subunit B'', alpha
chr1_+_170656450 0.341 NM_139240
C1orf105
chromosome 1 open reading frame 105
chr4_+_84175262 0.339 NM_016129
COPS4
COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)
chr1_+_156229686 0.337 NM_018240
KIRREL
kin of IRRE like (Drosophila)
chr6_+_32713160 0.337 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr1_-_199613427 0.334 NM_000364
NM_001001430
NM_001001431
NM_001001432
TNNT2



troponin T type 2 (cardiac)



chr9_+_96528764 0.333 NM_001193331
NM_032823
C9orf3

chromosome 9 open reading frame 3

chr18_+_59705918 0.333 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr16_+_15503623 0.331 NM_001142469
C16orf45
chromosome 16 open reading frame 45
chr21_-_26269298 0.324 APP
amyloid beta (A4) precursor protein
chr9_-_26937234 0.322 PLAA
phospholipase A2-activating protein
chr5_-_136862786 0.318 NM_004598
SPOCK1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
chr18_+_64616296 0.317 NM_024781
CCDC102B
coiled-coil domain containing 102B
chr9_+_96528814 0.316 C9orf3
chromosome 9 open reading frame 3
chr4_+_40953666 0.309 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr3_-_47932479 0.309


chr2_-_136590210 0.306 NM_001008540
CXCR4
chemokine (C-X-C motif) receptor 4
chr5_-_88235624 0.304 NM_001131005
NM_001193347
MEF2C

myocyte enhancer factor 2C

chr2_-_162808123 0.300 NM_004460
FAP
fibroblast activation protein, alpha
chr5_+_32824701 0.299 NM_024563
NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr3_-_150578023 0.297 TM4SF1
transmembrane 4 L six family member 1
chr16_+_31178812 0.290 ITGAM
integrin, alpha M (complement component 3 receptor 3 subunit)
chr4_-_186970366 0.289 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr2_+_210152399 0.286 MAP2
microtubule-associated protein 2
chr16_+_31178828 0.284 ITGAM
integrin, alpha M (complement component 3 receptor 3 subunit)
chr20_+_9146036 0.283 NM_182797
PLCB4
phospholipase C, beta 4
chr19_-_53444733 0.283 NM_001184901
NM_001184903
NM_014959
CARD8


caspase recruitment domain family, member 8


chr15_+_62467055 0.283 NM_016213
TRIP4
thyroid hormone receptor interactor 4
chr6_-_116553918 0.282 NM_000493
COL10A1
collagen, type X, alpha 1
chr14_+_59628381 0.281 NM_022495
C14orf135
chromosome 14 open reading frame 135
chr3_+_101694244 0.281 TMEM45A
transmembrane protein 45A
chr1_+_84382529 0.281 NM_182948
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr7_+_149895390 0.273 NM_018326
GIMAP4
GTPase, IMAP family member 4
chr12_+_54832470 0.267 NM_002475
MYL6B
myosin, light chain 6B, alkali, smooth muscle and non-muscle
chr1_+_111571803 0.265 NM_001025197
NM_004000
CHI3L2

chitinase 3-like 2

chr19_+_46503524 0.261 HNRNPUL1
heterogeneous nuclear ribonucleoprotein U-like 1
chr2_+_228064531 0.261 AGFG1
ArfGAP with FG repeats 1
chr11_+_5597749 0.260 NM_001003827
TRIM34
tripartite motif containing 34
chr11_+_17289030 0.258


chr1_-_149004916 0.258 NM_004079
CTSS
cathepsin S
chr6_+_26473376 0.258 NM_001197247
NM_001197249
NM_007047
NM_001197248
BTN3A2



butyrophilin, subfamily 3, member A2



chr1_-_199613406 0.257 TNNT2
troponin T type 2 (cardiac)
chr16_-_31412748 0.256 C16orf58
chromosome 16 open reading frame 58
chr14_+_87921740 0.254 NM_001040428
NM_018418
SPATA7

spermatogenesis associated 7


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.14 1.93e-03 GO:0007517 muscle organ development
3.28 2.71e-02 GO:0007156 homophilic cell adhesion

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.33 2.27e-03 GO:0071944 cell periphery
1.33 3.24e-03 GO:0005886 plasma membrane
14.91 1.47e-02 GO:0016011 dystroglycan complex
1.64 1.86e-02 GO:0044421 extracellular region part
1.39 3.63e-02 GO:0044459 plasma membrane part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.94 5.25e-03 GO:0005509 calcium ion binding