Motif ID: PBX1.p2

Z-value: 0.504


Transcription factors associated with PBX1.p2:

Gene SymbolEntrez IDGene Name
PBX1 5087 pre-B-cell leukemia homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PBX1chr1_+_162795538-0.185.2e-01Click!


Activity profile for motif PBX1.p2.

activity profile for motif PBX1.p2


Sorted Z-values histogram for motif PBX1.p2

Sorted Z-values for motif PBX1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PBX1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_-_45577144 1.314 NM_001872
NM_016413
CPB2

carboxypeptidase B2 (plasma)

chr4_+_74496575 0.859 ALB
albumin
chr17_+_16225130 0.829


chr4_+_74499651 0.829 ALB
albumin
chr22_-_27467776 0.763 NM_001005735
NM_007194
NM_145862
CHEK2


CHK2 checkpoint homolog (S. pombe)


chr9_-_115880366 0.755 AMBP
alpha-1-microglobulin/bikunin precursor
chr9_-_115880281 0.746 AMBP
alpha-1-microglobulin/bikunin precursor
chr9_-_115880425 0.716 AMBP
alpha-1-microglobulin/bikunin precursor
chr14_+_23654161 0.683 DCAF11
DDB1 and CUL4 associated factor 11
chr2_+_20510312 0.614 NM_004040
RHOB
ras homolog gene family, member B
chr4_+_74496660 0.591 ALB
albumin
chr20_-_45410033 0.578 ZMYND8
zinc finger, MYND-type containing 8
chr2_-_200030944 0.531 NM_001172509
SATB2
SATB homeobox 2
chr5_+_162797149 0.517 NM_004060
NM_199246
CCNG1

cyclin G1

chr4_+_69716298 0.483 NM_001075
NM_001144767
UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr15_-_35179185 0.467 MEIS2
Meis homeobox 2
chr9_-_98421894 0.440 NM_003671
NM_033331
CDC14B

CDC14 cell division cycle 14 homolog B (S. cerevisiae)

chr15_-_35178888 0.440 NM_172316
MEIS2
Meis homeobox 2
chr15_-_35180656 0.421 NM_002399
MEIS2
Meis homeobox 2
chr1_+_15862887 0.419


chr9_-_115880372 0.412 AMBP
alpha-1-microglobulin/bikunin precursor
chr14_+_23653848 0.404 DCAF11
DDB1 and CUL4 associated factor 11
chr14_+_23653819 0.398 NM_025230
DCAF11
DDB1 and CUL4 associated factor 11
chr2_-_174538197 0.397 SP3
Sp3 transcription factor
chr14_+_23008723 0.376 NM_001042635
NM_015514
NGDN

neuroguidin, EIF4E binding protein

chr12_+_79995927 0.376 NM_024560
ACSS3
acyl-CoA synthetase short-chain family member 3
chr11_+_95163256 0.374 NM_014679
CEP57
centrosomal protein 57kDa
chr4_-_174492029 0.366 NM_001130688
NM_002129
HMGB2

high-mobility group box 2

chr2_-_88208650 0.365 NM_001443
FABP1
fatty acid binding protein 1, liver
chr1_-_180627512 0.360 GLUL
glutamate-ammonia ligase
chrX_+_9391314 0.350 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr6_-_31938572 0.350 NM_000434
NEU1
sialidase 1 (lysosomal sialidase)
chr2_-_21079145 0.349 APOB
apolipoprotein B (including Ag(x) antigen)
chr14_+_23653745 0.346 NM_001163484
DCAF11
DDB1 and CUL4 associated factor 11
chr9_-_115880494 0.342 NM_001633
AMBP
alpha-1-microglobulin/bikunin precursor
chr12_+_12761085 0.333 NM_004064
CDKN1B
cyclin-dependent kinase inhibitor 1B (p27, Kip1)
chr11_+_95163457 0.326 CEP57
centrosomal protein 57kDa
chr3_+_195336631 0.307 HES1
hairy and enhancer of split 1, (Drosophila)
chr14_+_23008742 0.306 NGDN
neuroguidin, EIF4E binding protein
chr11_+_22646229 0.305 NM_177553
GAS2
growth arrest-specific 2
chr6_+_26307691 0.305 NM_003522
HIST1H2BF
histone cluster 1, H2bf
chr4_-_70115037 0.286 NM_001073
UGT2B11
UDP glucuronosyltransferase 2 family, polypeptide B11
chr3_+_195336625 0.285 NM_005524
HES1
hairy and enhancer of split 1, (Drosophila)
chr3_-_150286812 0.271 NM_003071
NM_139048
HLTF

helicase-like transcription factor

chr6_-_31938530 0.267 NEU1
sialidase 1 (lysosomal sialidase)
chr16_+_18986459 0.267 COQ7
coenzyme Q7 homolog, ubiquinone (yeast)
chr16_+_2593351 0.260 LOC652276
hypothetical LOC652276
chrY_+_15145019 0.260 NM_014893
NLGN4Y
neuroligin 4, Y-linked
chr4_+_70180805 0.258 NM_053039
UGT2B28
UDP glucuronosyltransferase 2 family, polypeptide B28
chr5_-_171814026 0.256 NM_001017995
SH3PXD2B
SH3 and PX domains 2B
chr19_-_54646837 0.255 NM_017916
PIH1D1
PIH1 domain containing 1
chr4_+_89115892 0.247 SPP1
secreted phosphoprotein 1
chr2_+_238540361 0.243 UBE2F
ubiquitin-conjugating enzyme E2F (putative)
chr2_+_44249487 0.241 NM_001033556
NM_001033557
NM_002706
NM_177968
NM_177969
PPM1B




protein phosphatase, Mg2+/Mn2+ dependent, 1B




chr16_+_18986417 0.240 NM_016138
COQ7
coenzyme Q7 homolog, ubiquinone (yeast)
chr4_+_6322459 0.239 NM_001145853
NM_006005
WFS1

Wolfram syndrome 1 (wolframin)

chr5_-_149515613 0.232 NM_002609
PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr4_-_155731288 0.226 NM_000508
NM_021871
FGA

fibrinogen alpha chain

chr1_+_60053050 0.225 NM_015888
HOOK1
hook homolog 1 (Drosophila)
chr4_+_89115862 0.224 SPP1
secreted phosphoprotein 1
chr3_-_150422474 0.224 NM_000096
CP
ceruloplasmin (ferroxidase)
chr10_-_71812350 0.219 NM_018205
NM_018239
LRRC20

leucine rich repeat containing 20

chr16_+_3433606 0.214 NM_001083601
NAT15
N-acetyltransferase 15 (GCN5-related, putative)
chr6_+_151603201 0.214 AKAP12
A kinase (PRKA) anchor protein 12
chr15_+_57696016 0.214 GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr6_+_26232351 0.212 NM_003512
HIST1H2AC
histone cluster 1, H2ac
chr9_-_128910132 0.209 ANGPTL2
angiopoietin-like 2
chr4_+_89115825 0.204 NM_000582
NM_001040058
NM_001040060
SPP1


secreted phosphoprotein 1


chr2_-_46988449 0.202 MCFD2
multiple coagulation factor deficiency 2
chr18_-_58005268 0.200 NM_012327
NM_176787
PIGN

phosphatidylinositol glycan anchor biosynthesis, class N

chr22_+_27468018 0.200 NM_172002
HSCB
HscB iron-sulfur cluster co-chaperone homolog (E. coli)
chr17_+_50697319 0.198 NM_002126
HLF
hepatic leukemia factor
chr12_-_56200547 0.195 NM_001195053
NM_001195054
NM_001195055
NM_001195056
NM_001195057
NM_004083
DDIT3





DNA-damage-inducible transcript 3





chr4_+_6322489 0.195 WFS1
Wolfram syndrome 1 (wolframin)
chr4_-_84254912 0.195 PLAC8
placenta-specific 8
chr8_-_38127489 0.194 NM_000349
STAR
steroidogenic acute regulatory protein
chr19_+_46462113 0.193 HNRNPUL1
heterogeneous nuclear ribonucleoprotein U-like 1
chr15_-_62460622 0.192 NM_001029989
NM_014736
KIAA0101

KIAA0101

chr2_+_62786290 0.189 NM_001142616
NM_015252
EHBP1

EH domain binding protein 1

chr2_-_218843039 0.188 AAMP
angio-associated, migratory cell protein
chr2_-_218843109 0.180 NM_001087
AAMP
angio-associated, migratory cell protein
chr6_-_26307418 0.178 NM_021065
NM_003530
HIST1H2AD
HIST1H3D
histone cluster 1, H2ad
histone cluster 1, H3d
chrX_-_119550402 0.178 CUL4B
cullin 4B
chr1_+_148603208 0.178 RPRD2
regulation of nuclear pre-mRNA domain containing 2
chr10_-_44794146 0.176 NM_007021
C10orf10
chromosome 10 open reading frame 10
chrX_+_70420194 0.175 NONO
non-POU domain containing, octamer-binding
chr1_-_147665783 0.175 HIST2H2BF
histone cluster 2, H2bf
chr19_+_44573858 0.171 MED29
mediator complex subunit 29
chr4_-_84254873 0.170 PLAC8
placenta-specific 8
chr6_-_30792830 0.170 MDC1
mediator of DNA-damage checkpoint 1
chr16_-_68880844 0.169 AARS
alanyl-tRNA synthetase
chr6_+_26212082 0.169 NM_003542
HIST1H4C
histone cluster 1, H4c
chr12_+_63090008 0.165 XPOT
exportin, tRNA (nuclear export receptor for tRNAs)
chr20_-_54400628 0.162 NM_003600
NM_198433
NM_198434
NM_198435
NM_198436
NM_198437
AURKA





aurora kinase A





chr1_-_180627023 0.160 NM_001033056
GLUL
glutamate-ammonia ligase
chr16_+_29728932 0.159 MAZ
MYC-associated zinc finger protein (purine-binding transcription factor)
chr19_+_44573790 0.159 NM_017592
MED29
mediator complex subunit 29
chr16_-_68880908 0.158 NM_001605
AARS
alanyl-tRNA synthetase
chr8_+_107807415 0.158 NM_001198534
NM_001198535
OXR1

oxidation resistance 1

chr17_+_50697355 0.157 HLF
hepatic leukemia factor
chr18_-_58005159 0.156 PIGN
phosphatidylinositol glycan anchor biosynthesis, class N
chr3_+_173240126 0.156 FNDC3B
fibronectin type III domain containing 3B
chr16_+_80626331 0.156 NM_002153
HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr1_-_171442937 0.156 NM_003326
TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr6_+_111302679 0.155 NM_001634
NM_001033059
AMD1

adenosylmethionine decarboxylase 1

chr12_+_49728350 0.153 NM_001024668
NM_015416
LETMD1

LETM1 domain containing 1

chrX_+_70420221 0.151 NONO
non-POU domain containing, octamer-binding
chr1_-_58920315 0.151


chr16_-_57221240 0.150 NM_016284
NM_206999
CNOT1

CCR4-NOT transcription complex, subunit 1

chr5_-_149515331 0.150 PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr16_-_57221235 0.149 CNOT1
CCR4-NOT transcription complex, subunit 1
chr6_-_26232109 0.149 NM_003526
HIST1H2BG
HIST1H2BC
histone cluster 1, H2bg
histone cluster 1, H2bc
chr14_-_57834558 0.148 FLJ31306
hypothetical LOC379025
chr14_+_95071136 0.148 GLRX5
glutaredoxin 5
chr16_+_80626402 0.147 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr16_+_18986721 0.147 NM_001190983
COQ7
coenzyme Q7 homolog, ubiquinone (yeast)
chr17_+_78009895 0.145 NARF
nuclear prelamin A recognition factor
chr2_-_218843088 0.144 AAMP
angio-associated, migratory cell protein
chrX_+_70420237 0.144 NONO
non-POU domain containing, octamer-binding
chr3_+_122109716 0.144 NM_014980
STXBP5L
syntaxin binding protein 5-like
chr17_-_44058612 0.142 NM_024017
HOXB9
homeobox B9
chr1_+_148603613 0.141 NM_015203
RPRD2
regulation of nuclear pre-mRNA domain containing 2
chr10_-_101180191 0.141 NM_002079
GOT1
glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)
chr17_+_43480724 0.140 NFE2L1
nuclear factor (erythroid-derived 2)-like 1
chr19_+_46462125 0.140 HNRNPUL1
heterogeneous nuclear ribonucleoprotein U-like 1
chr7_+_106897737 0.139 NM_005295
GPR22
G protein-coupled receptor 22
chr6_+_151603346 0.139 AKAP12
A kinase (PRKA) anchor protein 12
chr17_-_36074812 0.139 NM_152349
KRT222
keratin 222
chr18_-_50776276 0.138 NM_001143829
CCDC68
coiled-coil domain containing 68
chr5_+_145807059 0.137 NM_001040006
NM_006706
TCERG1

transcription elongation regulator 1

chr1_-_19101603 0.136 NM_003748
NM_170726
ALDH4A1

aldehyde dehydrogenase 4 family, member A1

chr14_-_73620826 0.135 ALDH6A1
aldehyde dehydrogenase 6 family, member A1
chr1_-_180621272 0.133 GLUL
glutamate-ammonia ligase
chr2_+_162908828 0.133 NM_012198
GCA
grancalcin, EF-hand calcium binding protein
chr1_-_57204208 0.132 NM_000066
C8B
complement component 8, beta polypeptide
chr7_-_143230096 0.130 NM_014719
FAM115A
family with sequence similarity 115, member A
chr17_+_43328514 0.130 NM_003110
SP2
Sp2 transcription factor
chr14_+_22860547 0.127 PABPN1
poly(A) binding protein, nuclear 1
chr4_+_6322506 0.127 WFS1
Wolfram syndrome 1 (wolframin)
chr2_+_24660849 0.126 NM_003743
NM_147223
NM_147233
NCOA1


nuclear receptor coactivator 1


chr14_-_73620912 0.126 NM_005589
ALDH6A1
aldehyde dehydrogenase 6 family, member A1
chrX_+_70420259 0.125 NONO
non-POU domain containing, octamer-binding
chr12_+_100512877 0.124 NM_002465
NM_206819
NM_206820
NM_206821
MYBPC1



myosin binding protein C, slow type



chr12_-_120715937 0.123 NM_019034
RHOF
ras homolog gene family, member F (in filopodia)
chr15_+_41264607 0.122 NM_012142
CCNDBP1
cyclin D-type binding-protein 1
chr4_+_155703581 0.121 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr20_+_29790564 0.121 NM_012112
TPX2
TPX2, microtubule-associated, homolog (Xenopus laevis)
chr14_+_22860511 0.120 PABPN1
poly(A) binding protein, nuclear 1
chr12_+_119609305 0.119 NM_014730
MLEC
malectin
chr9_-_83494198 0.118 TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr19_+_55398680 0.118 NM_001077186
NM_001145809
NM_024729
MYH14


myosin, heavy chain 14, non-muscle


chr10_-_115923874 0.117 C10orf118
chromosome 10 open reading frame 118
chr1_+_212843117 0.117 NM_016343
CENPF
centromere protein F, 350/400kDa (mitosin)
chr19_-_3928840 0.114 EEF2
eukaryotic translation elongation factor 2
chr5_-_89741233 0.113 NM_004365
CETN3
centrin, EF-hand protein, 3
chr5_-_147191428 0.113 NM_003122
SPINK1
serine peptidase inhibitor, Kazal type 1
chr3_-_123036526 0.111 IQCB1
IQ motif containing B1
chr12_-_6586811 0.110 NM_001273
CHD4
chromodomain helicase DNA binding protein 4
chr11_+_57121602 0.108 NM_000062
SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr14_+_57834962 0.108 NM_002892
NM_023000
NM_023001
ARID4A


AT rich interactive domain 4A (RBP1-like)


chr5_+_43639044 0.107 NNT
nicotinamide nucleotide transhydrogenase
chr6_-_42821790 0.106 TBCC
tubulin folding cofactor C
chr12_+_6473519 0.106 NCAPD2
non-SMC condensin I complex, subunit D2
chr19_+_14501403 0.105 TECR
trans-2,3-enoyl-CoA reductase
chr1_-_148124738 0.104 NM_003528
HIST2H2BE
histone cluster 2, H2be
chr5_+_43638973 0.103 NM_182977
NNT
nicotinamide nucleotide transhydrogenase
chr10_+_114699953 0.103 NM_001146274
NM_001146283
NM_001146284
NM_001146285
NM_001146286
NM_001198525
NM_001198526
NM_001198527
NM_001198528
NM_001198529
NM_001198530
NM_001198531
NM_030756
TCF7L2












transcription factor 7-like 2 (T-cell specific, HMG-box)












chr10_+_76256305 0.103 NM_012330
MYST4
MYST histone acetyltransferase (monocytic leukemia) 4
chr3_+_52786642 0.102 NM_002215
ITIH1
inter-alpha (globulin) inhibitor H1
chr19_-_44032449 0.102 NM_001533
HNRNPL
heterogeneous nuclear ribonucleoprotein L
chr19_+_47416271 0.101 NM_133444
ZNF526
zinc finger protein 526
chr19_-_14108400 0.099 NM_018154
ASF1B
ASF1 anti-silencing function 1 homolog B (S. cerevisiae)
chr16_-_1816793 0.099 HAGH
hydroxyacylglutathione hydrolase
chr17_-_77411707 0.099 P4HB
prolyl 4-hydroxylase, beta polypeptide
chr19_-_14108267 0.098 ASF1B
ASF1 anti-silencing function 1 homolog B (S. cerevisiae)
chr17_+_16225117 0.097 UBB
ubiquitin B
chr17_-_77411659 0.097 P4HB
prolyl 4-hydroxylase, beta polypeptide
chr12_-_26877189 0.096 NM_002223
ITPR2
inositol 1,4,5-triphosphate receptor, type 2
chr4_+_129950222 0.096 NM_024900
NM_199320
PHF17

PHD finger protein 17

chr2_+_162908869 0.094 GCA
grancalcin, EF-hand calcium binding protein
chr19_+_14501406 0.094 TECR
trans-2,3-enoyl-CoA reductase
chr11_+_67984758 0.093 NM_001164160
NM_001164161
NM_001164162
NM_001164163
NM_001164164
NM_018312
PPP6R3





protein phosphatase 6, regulatory subunit 3





chr18_+_31074985 0.093 NM_001135178
NM_032347
ZNF397

zinc finger protein 397

chr2_+_27109341 0.093 TMEM214
transmembrane protein 214
chr5_+_139999182 0.093 NM_018502
TMCO6
transmembrane and coiled-coil domains 6
chr11_+_66140628 0.092 NM_001198845
NM_001198846
NM_001198836
NM_001198837
NM_006328
RBM14-RBM4

RBM14


RBM14-RBM4 readthrough

RNA binding motif protein 14


chr14_+_75197409 0.092 TTLL5
tubulin tyrosine ligase-like family, member 5
chr7_-_121571472 0.091 NM_005763
AASS
aminoadipate-semialdehyde synthase
chr5_+_43639069 0.090 NNT
nicotinamide nucleotide transhydrogenase
chr6_+_135544170 0.090 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr2_-_183439515 0.089 NM_001463
FRZB
frizzled-related protein
chr2_+_27109249 0.089 NM_001083590
NM_017727
TMEM214

transmembrane protein 214

chr17_-_77411803 0.089 NM_000918
P4HB
prolyl 4-hydroxylase, beta polypeptide
chr17_-_1534880 0.088 NM_006445
PRPF8
PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae)
chr7_-_135083906 0.088 NM_205855
FAM180A
family with sequence similarity 180, member A
chr17_-_1534848 0.087 PRPF8
PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae)
chr5_-_147191334 0.087 SPINK1
serine peptidase inhibitor, Kazal type 1
chr1_-_3702908 0.086 NM_020710
LRRC47
leucine rich repeat containing 47
chr4_-_140224794 0.086 ELF2
E74-like factor 2 (ets domain transcription factor)
chr12_-_118799457 0.086 NM_007174
CIT
citron (rho-interacting, serine/threonine kinase 21)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
5.88 1.73e-09 GO:0006333 chromatin assembly or disassembly
6.63 3.83e-09 GO:0065004 protein-DNA complex assembly
6.23 1.39e-08 GO:0071824 protein-DNA complex subunit organization
6.73 3.31e-08 GO:0031497 chromatin assembly
6.53 1.90e-07 GO:0006334 nucleosome assembly
5.54 4.08e-07 GO:0006323 DNA packaging
2.68 1.33e-06 GO:0051276 chromosome organization
5.81 1.44e-06 GO:0034728 nucleosome organization
4.66 9.62e-06 GO:0071103 DNA conformation change
2.74 6.38e-05 GO:0006325 chromatin organization
2.84 2.80e-04 GO:0034622 cellular macromolecular complex assembly
1.76 4.88e-04 GO:0006996 organelle organization
1.55 6.43e-04 GO:0071842 cellular component organization at cellular level
1.51 2.10e-03 GO:0071841 cellular component organization or biogenesis at cellular level
1.41 4.65e-03 GO:0071840 cellular component organization or biogenesis
1.42 4.73e-03 GO:0016043 cellular component organization
2.31 7.13e-03 GO:0034621 cellular macromolecular complex subunit organization
1.98 2.42e-02 GO:0071844 cellular component assembly at cellular level
2.70 4.23e-02 GO:0000280 nuclear division
2.70 4.23e-02 GO:0007067 mitosis
1.96 4.70e-02 GO:0065003 macromolecular complex assembly

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
7.62 4.55e-07 GO:0000786 nucleosome
2.66 1.17e-06 GO:0005694 chromosome
5.40 6.68e-06 GO:0032993 protein-DNA complex
3.53 7.89e-06 GO:0000785 chromatin
2.66 2.35e-05 GO:0044427 chromosomal part
1.19 3.12e-05 GO:0043229 intracellular organelle
1.18 4.13e-05 GO:0043226 organelle
1.34 4.63e-05 GO:0005634 nucleus
1.20 1.20e-04 GO:0043231 intracellular membrane-bounded organelle
1.20 1.40e-04 GO:0043227 membrane-bounded organelle
1.57 1.77e-04 GO:0043233 organelle lumen
1.13 2.09e-04 GO:0044424 intracellular part
1.54 4.08e-04 GO:0031974 membrane-enclosed lumen
1.54 7.11e-04 GO:0070013 intracellular organelle lumen
1.12 8.63e-04 GO:0005622 intracellular
1.28 9.73e-04 GO:0044422 organelle part
1.72 1.64e-03 GO:0005654 nucleoplasm
1.47 2.20e-03 GO:0043228 non-membrane-bounded organelle
1.47 2.20e-03 GO:0043232 intracellular non-membrane-bounded organelle
1.27 3.63e-03 GO:0044446 intracellular organelle part
1.54 8.26e-03 GO:0031981 nuclear lumen

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.53 3.26e-03 GO:0003677 DNA binding
1.42 3.45e-03 GO:0003676 nucleic acid binding