Motif ID: IKZF1.p2

Z-value: 1.848


Transcription factors associated with IKZF1.p2:

Gene SymbolEntrez IDGene Name
IKZF1 10320 IKAROS family zinc finger 1 (Ikaros)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
IKZF1chr7_+_50314801-0.194.9e-01Click!


Activity profile for motif IKZF1.p2.

activity profile for motif IKZF1.p2


Sorted Z-values histogram for motif IKZF1.p2

Sorted Z-values for motif IKZF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of IKZF1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_151855413 3.023 NM_020672
S100A14
S100 calcium binding protein A14
chr2_-_113310796 2.967 NM_000576
IL1B
interleukin 1, beta
chr4_-_155753272 2.393 FGG
fibrinogen gamma chain
chr4_-_155753207 2.384 FGG
fibrinogen gamma chain
chr4_-_155753287 2.381 FGG
fibrinogen gamma chain
chr4_-_155753249 2.376 FGG
fibrinogen gamma chain
chr1_-_228916470 2.361 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr2_+_47449790 2.338 NM_002354
EPCAM
epithelial cell adhesion molecule
chr1_+_26728827 2.337 NM_002953
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr4_-_155753332 2.322 NM_000509
NM_021870
FGG

fibrinogen gamma chain

chr1_-_207892420 2.312 NM_000228
LAMB3
laminin, beta 3
chr1_+_26728839 2.308 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr12_-_56447090 2.209 NM_000785
CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chr1_-_228916486 2.209 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr2_-_21120398 2.083 APOB
apolipoprotein B (including Ag(x) antigen)
chr1_+_26728846 2.027 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr19_-_10558906 1.999 NM_005498
AP1M2
adaptor-related protein complex 1, mu 2 subunit
chr12_+_64504408 1.972 NM_003483
NM_003484
HMGA2

high mobility group AT-hook 2

chr12_-_109424260 1.866 NM_016226
NM_057180
VPS29

vacuolar protein sorting 29 homolog (S. cerevisiae)

chr1_-_207892296 1.841 NM_001127641
LAMB3
laminin, beta 3
chr20_+_55569542 1.840 NM_002591
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr19_-_6643953 1.779 C3
complement component 3
chr15_+_38923470 1.734 NM_003710
NM_181642
SPINT1

serine peptidase inhibitor, Kunitz type 1

chr2_+_17585287 1.716 NM_003385
VSNL1
visinin-like 1
chr12_+_50913274 1.688 KRT7
keratin 7
chr2_+_17585462 1.655 VSNL1
visinin-like 1
chr2_-_21120314 1.623 APOB
apolipoprotein B (including Ag(x) antigen)
chr14_-_23106779 1.613 AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chrX_+_130984912 1.595 NM_001042453
NM_016542
MST4

serine/threonine protein kinase MST4

chr18_+_53865455 1.581 NM_001144964
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr1_+_39229474 1.547 NM_001136275
NM_024595
AKIRIN1

akirin 1

chr19_+_43447262 1.543 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr19_+_43447078 1.527 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr19_+_43446937 1.508 NM_001166103
NM_021102
SPINT2

serine peptidase inhibitor, Kunitz type, 2

chr1_+_31814709 1.477 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr1_+_153366559 1.462 EFNA1
ephrin-A1
chr1_+_27062215 1.450 NM_006142
SFN
stratifin
chr16_-_11587647 1.445 NM_004862
LITAF
lipopolysaccharide-induced TNF factor
chr17_-_37181636 1.444 JUP
junction plakoglobin
chr11_+_62405736 1.429 SLC3A2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
chr14_-_23107106 1.413 NM_003917
AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chr12_+_50913220 1.394 NM_005556
KRT7
keratin 7
chr1_+_31814672 1.389 NM_022164
TINAGL1
tubulointerstitial nephritis antigen-like 1
chr12_-_51153788 1.381 NM_173086
KRT6C
keratin 6C
chr11_+_62405801 1.380 SLC3A2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
chr8_-_81246215 1.341 NM_001025253
NM_005079
TPD52

tumor protein D52

chr8_-_17787342 1.341 FGL1
fibrinogen-like 1
chr11_+_46697345 1.309 F2
coagulation factor II (thrombin)
chr19_-_56147971 1.303 NM_001077491
NM_001077492
NM_012427
KLK5


kallikrein-related peptidase 5


chr8_+_101239686 1.290 NM_003114
SPAG1
sperm associated antigen 1
chr18_-_26935883 1.288 NM_004949
NM_024422
DSC2

desmocollin 2

chr22_+_36531246 1.217 H1F0
H1 histone family, member 0
chr1_+_181421796 1.174 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr1_+_1971762 1.149 NM_002744
PRKCZ
protein kinase C, zeta
chr1_+_31814712 1.123 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr1_-_117011824 1.116 NM_001007237
NM_001542
IGSF3

immunoglobulin superfamily, member 3

chr2_-_165133239 1.114 GRB14
growth factor receptor-bound protein 14
chr22_+_36531059 1.094 NM_005318
H1F0
H1 histone family, member 0
chr2_-_238164042 1.090 RAB17
RAB17, member RAS oncogene family
chr2_-_98646367 1.087 NM_001160154
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr1_+_35020425 1.083 NM_001005752
GJB3
gap junction protein, beta 3, 31kDa
chr17_+_46067114 1.076 NM_001144070
NM_003786
ABCC3

ATP-binding cassette, sub-family C (CFTR/MRP), member 3

chr18_+_3441589 1.068 NM_170695
NM_173210
TGIF1

TGFB-induced factor homeobox 1

chr2_-_238164452 1.031 NM_022449
RAB17
RAB17, member RAS oncogene family
chr16_-_23559978 1.016 NM_024675
PALB2
partner and localizer of BRCA2
chr20_-_23566325 1.015 NM_000099
CST3
cystatin C
chr11_+_22646229 1.011 NM_177553
GAS2
growth arrest-specific 2
chr19_+_447453 0.995 NM_130760
NM_130762
MADCAM1

mucosal vascular addressin cell adhesion molecule 1

chr4_+_74496660 0.964 ALB
albumin
chr18_-_17538624 0.961 ABHD3
abhydrolase domain containing 3
chr22_+_36531178 0.957 H1F0
H1 histone family, member 0
chr17_+_24394043 0.946 NM_016518
PIPOX
pipecolic acid oxidase
chr12_-_51585004 0.938 NM_002273
KRT8
keratin 8
chr19_+_40431122 0.927 LSR
lipolysis stimulated lipoprotein receptor
chr8_+_95722516 0.920 NM_001034915
NM_001122825
NM_001122826
NM_001122827
NM_017697
ESRP1




epithelial splicing regulatory protein 1




chr3_+_195336631 0.916 HES1
hairy and enhancer of split 1, (Drosophila)
chr9_-_73573121 0.907 NM_001135820
NM_013390
TMEM2

transmembrane protein 2

chr10_-_52315436 0.906 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr10_-_52315390 0.901 A1CF
APOBEC1 complementation factor
chr5_+_76150588 0.880 NM_005242
F2RL1
coagulation factor II (thrombin) receptor-like 1
chr7_+_47661366 0.872 NM_001123065
C7orf65
chromosome 7 open reading frame 65
chr17_-_7434113 0.864 NM_006942
SOX15
SRY (sex determining region Y)-box 15
chr5_+_66160359 0.857 NM_015183
MAST4
microtubule associated serine/threonine kinase family member 4
chr5_+_5475766 0.851


chr3_+_46594079 0.847 NM_003212
TDGF1
teratocarcinoma-derived growth factor 1
chrX_+_115481774 0.843 NM_007231
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr9_+_129951552 0.842 NM_005564
LCN2
lipocalin 2
chr16_-_86460529 0.828 NM_003486
SLC7A5
solute carrier family 7 (cationic amino acid transporter, y+ system), member 5
chr14_+_64240902 0.828 NM_015549
PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr17_-_24425342 0.826 TIAF1
TGFB1-induced anti-apoptotic factor 1
chr4_+_74496575 0.816 ALB
albumin
chr8_+_95722575 0.813 ESRP1
epithelial splicing regulatory protein 1
chr3_+_191714533 0.790 NM_001167928
NM_001167929
NM_001167930
NM_001167931
NM_002182
NM_134470
IL1RAP





interleukin 1 receptor accessory protein





chr17_+_4621924 0.787 NM_003963
TM4SF5
transmembrane 4 L six family member 5
chr18_+_54489597 0.784 NM_006785
NM_173844
MALT1

mucosa associated lymphoid tissue lymphoma translocation gene 1

chr4_-_69852090 0.782 NM_024743
UGT2A3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr7_+_48095464 0.776 UPP1
uridine phosphorylase 1
chr11_+_73034870 0.775 NM_001130033
NM_021200
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr1_+_6767968 0.769 NM_001195563
NM_015215
CAMTA1

calmodulin binding transcription activator 1

chr8_+_38007147 0.749 NM_004095
EIF4EBP1
eukaryotic translation initiation factor 4E binding protein 1
chr4_+_1764802 0.739 NM_000142
NM_001163213
NM_022965
FGFR3


fibroblast growth factor receptor 3


chr17_-_24425716 0.735 TIAF1
TGFB1-induced anti-apoptotic factor 1
chr3_+_51992339 0.731 NM_000666
NM_001198895
NM_001198896
NM_001198897
NM_001198898
ACY1




aminoacylase 1




chr13_+_112808102 0.724 NM_000131
NM_019616
F7

coagulation factor VII (serum prothrombin conversion accelerator)

chr5_-_150441150 0.723 NM_006058
TNIP1
TNFAIP3 interacting protein 1
chr16_+_55217180 0.718 MT1E
metallothionein 1E
chr18_+_59295123 0.716 NM_002639
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr11_+_22652894 0.716 NM_005256
GAS2
growth arrest-specific 2
chr10_+_124124196 0.713 PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr2_-_43306650 0.713 ZFP36L2
zinc finger protein 36, C3H type-like 2
chr18_+_54489798 0.709 MALT1
mucosa associated lymphoid tissue lymphoma translocation gene 1
chr3_+_173240983 0.708 NM_001135095
FNDC3B
fibronectin type III domain containing 3B
chr18_+_54489658 0.707 MALT1
mucosa associated lymphoid tissue lymphoma translocation gene 1
chr8_+_126511739 0.703 NM_025195
TRIB1
tribbles homolog 1 (Drosophila)
chr8_+_22280731 0.696 SLC39A14
solute carrier family 39 (zinc transporter), member 14
chr16_+_55217085 0.686 NM_175617
MT1E
metallothionein 1E
chr8_+_95722448 0.685 ESRP1
epithelial splicing regulatory protein 1
chr19_+_50004134 0.684 NM_001013257
NM_005581
BCAM

basal cell adhesion molecule (Lutheran blood group)

chr8_+_22280703 0.678 NM_001128431
NM_001135154
NM_015359
SLC39A14


solute carrier family 39 (zinc transporter), member 14


chr3_-_121295663 0.669 NM_001146156
NM_002093
GSK3B

glycogen synthase kinase 3 beta

chr10_+_47875229 0.668 NM_001040084
NM_001098845
ANXA8L2
ANXA8
ANXA8L1
annexin A8-like 2
annexin A8
annexin A8-like 1
chrY_-_19613948 0.668 NM_013230
CD24
CD24P4
CD24 molecule
CD24 molecule pseudogene 4
chr18_+_18767764 0.664 NM_203291
NM_203292
RBBP8

retinoblastoma binding protein 8

chr10_-_46593923 0.662 NM_001040084
NM_001098845
ANXA8L2
LOC653110
ANXA8
ANXA8L1
annexin A8-like 2
hypothetical LOC653110
annexin A8
annexin A8-like 1
chr11_-_18214891 0.661 NM_006512
SAA4
serum amyloid A4, constitutive
chr2_-_39201066 0.660 NM_005633
SOS1
son of sevenless homolog 1 (Drosophila)
chr3_-_69517913 0.653 FRMD4B
FERM domain containing 4B
chrX_-_71709335 0.650 HDAC8
histone deacetylase 8
chr14_-_23847024 0.645 CIDEB
cell death-inducing DFFA-like effector b
chr1_-_180622083 0.644 GLUL
glutamate-ammonia ligase
chr20_+_43874654 0.641 NM_007019
NM_181799
NM_181800
NM_181802
NM_181803
UBE2C




ubiquitin-conjugating enzyme E2C




chr8_-_125809831 0.630 NM_014751
MTSS1
metastasis suppressor 1
chr1_+_207915282 0.620 NM_015714
G0S2
G0/G1switch 2
chr1_-_159257486 0.619 F11R
F11 receptor
chr18_+_54489763 0.614 MALT1
mucosa associated lymphoid tissue lymphoma translocation gene 1
chr2_+_101974737 0.614 NM_004633
IL1R2
interleukin 1 receptor, type II
chr13_-_110011866 0.612 NM_017817
RAB20
RAB20, member RAS oncogene family
chr11_+_66580861 0.610 NM_014578
RHOD
ras homolog gene family, member D
chr9_+_114953048 0.606 NM_001860
SLC31A2
solute carrier family 31 (copper transporters), member 2
chrX_+_30581377 0.605 NM_000167
NM_001128127
NM_203391
GK


glycerol kinase


chr9_+_114953087 0.601 SLC31A2
solute carrier family 31 (copper transporters), member 2
chr1_-_198905619 0.599 DDX59
DEAD (Asp-Glu-Ala-Asp) box polypeptide 59
chr14_-_23493169 0.597 C14orf167
chromosome 14 open reading frame 167
chr2_-_220144254 0.583 OBSL1
obscurin-like 1
chr19_-_50601406 0.583 NM_001142502
PPP1R13L
protein phosphatase 1, regulatory (inhibitor) subunit 13 like
chr12_-_55168168 0.571 NM_013267
GLS2
glutaminase 2 (liver, mitochondrial)
chr3_+_42176662 0.568 NM_014965
TRAK1
trafficking protein, kinesin binding 1
chr6_-_76259976 0.562 NM_015687
FILIP1
filamin A interacting protein 1
chr2_-_43307241 0.561 NM_006887
ZFP36L2
zinc finger protein 36, C3H type-like 2
chr1_+_218930542 0.560 C1orf115
chromosome 1 open reading frame 115
chr3_+_143858428 0.549 NM_001172312
PLS1
plastin 1
chr10_+_124135574 0.537 NM_001195608
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr14_+_22845851 0.531 NM_004050
BCL2L2-PABPN1
BCL2L2
BCL2L2-PABPN1 read-through transcript
BCL2-like 2
chr5_+_76150637 0.531 F2RL1
coagulation factor II (thrombin) receptor-like 1
chr18_+_3443771 0.528 NM_173211
TGIF1
TGFB-induced factor homeobox 1
chrX_-_133620103 0.528 NM_021796
PLAC1
placenta-specific 1
chr5_-_125958503 0.526 NM_001182
ALDH7A1
aldehyde dehydrogenase 7 family, member A1
chr3_+_195336625 0.519 NM_005524
HES1
hairy and enhancer of split 1, (Drosophila)
chr17_+_45965044 0.514 NM_017957
EPN3
epsin 3
chr1_+_153366928 0.509 NM_004428
NM_182685
EFNA1

ephrin-A1

chr19_-_43955984 0.508 NM_002307
LGALS7
LGALS7B
lectin, galactoside-binding, soluble, 7
lectin, galactoside-binding, soluble, 7B
chr8_-_146173531 0.506 ZNF252
zinc finger protein 252
chr16_+_55261226 0.504 NM_005951
MT1H
metallothionein 1H
chr22_+_23333610 0.504 NM_001032365
GGT1
gamma-glutamyltransferase 1
chr16_+_27232745 0.503 NM_000418
NM_001008699
IL4R

interleukin 4 receptor

chr2_+_96845704 0.498 NM_017623
NM_199078
CNNM3

cyclin M3

chr3_-_69518119 0.494 NM_015123
FRMD4B
FERM domain containing 4B
chr1_+_15123165 0.494 NM_001018000
KAZN
kazrin, periplakin interacting protein
chr22_+_36928972 0.492 NM_001161573
MAFF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr6_+_31234093 0.489 NM_001077511
NM_007109
TCF19

transcription factor 19

chr1_-_199635057 0.487 LAD1
ladinin 1
chr15_-_48766275 0.484 NM_017672
TRPM7
transient receptor potential cation channel, subfamily M, member 7
chr2_+_27163114 0.480 NM_000221
NM_006488
KHK

ketohexokinase (fructokinase)

chr17_+_45900688 0.480 ACSF2
acyl-CoA synthetase family member 2
chr2_-_171998681 0.478 METTL8
methyltransferase like 8
chr2_+_96295715 0.471 CIAO1
cytosolic iron-sulfur protein assembly 1
chr1_-_180627934 0.471 NM_001033044
NM_002065
GLUL

glutamate-ammonia ligase

chr1_-_199635339 0.466 LAD1
ladinin 1
chr4_-_35922288 0.464 NM_015230
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr18_+_18767275 0.463 NM_002894
RBBP8
retinoblastoma binding protein 8
chr19_+_10242516 0.463 NM_000201
ICAM1
intercellular adhesion molecule 1
chr11_-_110755366 0.459 NM_006235
POU2AF1
POU class 2 associating factor 1
chr17_+_45965076 0.459 EPN3
epsin 3
chr11_+_61276576 0.455 NM_001127392
C11orf9
chromosome 11 open reading frame 9
chr21_+_39117064 0.453 ETS2
v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
chr2_-_37312199 0.452 NM_005760
CEBPZ
CCAAT/enhancer binding protein (C/EBP), zeta
chr7_+_89621624 0.451 NM_012449
STEAP1
six transmembrane epithelial antigen of the prostate 1
chr14_+_64240996 0.450 PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr17_-_37022465 0.448 NM_005557
KRT16
keratin 16
chr1_-_180626804 0.445 GLUL
glutamate-ammonia ligase
chr7_+_148523486 0.443 NM_003575
ZNF282
zinc finger protein 282
chr15_-_50375143 0.441 NM_018728
MYO5C
myosin VC
chr12_-_9123126 0.441 A2M
alpha-2-macroglobulin
chr19_+_10242763 0.441 ICAM1
intercellular adhesion molecule 1
chr19_-_14501048 0.439 DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr10_+_53744043 0.438 NM_012242
DKK1
dickkopf homolog 1 (Xenopus laevis)
chr7_+_7188667 0.437 NM_020156
C1GALT1
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1
chr20_+_34635362 0.435 NM_021809
TGIF2
TGFB-induced factor homeobox 2
chr15_+_56511466 0.434 NM_000236
LIPC
lipase, hepatic
chr1_+_203740391 0.433 CDK18
cyclin-dependent kinase 18

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.96 2.61e-02 GO:0046578 regulation of Ras protein signal transduction

Nothing significant found in compartment category.

Nothing significant found in function category.