Motif ID: ZBTB6.p2

Z-value: 1.120


Transcription factors associated with ZBTB6.p2:

Gene SymbolEntrez IDGene Name
ZBTB6 10773 zinc finger and BTB domain containing 6

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ZBTB6chr9_-_1247153920.048.7e-01Click!


Activity profile for motif ZBTB6.p2.

activity profile for motif ZBTB6.p2


Sorted Z-values histogram for motif ZBTB6.p2

Sorted Z-values for motif ZBTB6.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ZBTB6.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_51200347 4.598 NM_000424
KRT5
keratin 5
chr12_-_51132129 3.672 NM_005555
KRT6B
keratin 6B
chr12_-_51173238 2.378 NM_005554
KRT6A
keratin 6A
chr12_-_51153788 2.300 NM_173086
KRT6C
keratin 6C
chr11_-_78829342 1.434 NM_001098816
ODZ4
odz, odd Oz/ten-m homolog 4 (Drosophila)
chr2_-_235070431 1.392 NM_005737
ARL4C
ADP-ribosylation factor-like 4C
chr1_-_151804929 1.329 NM_005978
S100A2
S100 calcium binding protein A2
chr7_+_143683365 1.171 NM_005435
ARHGEF5
Rho guanine nucleotide exchange factor (GEF) 5
chr11_-_11987458 1.160 NM_013253
DKK3
dickkopf homolog 3 (Xenopus laevis)
chr5_-_72780107 1.116 NM_004472
FOXD1
forkhead box D1
chr11_-_11987414 1.112 DKK3
dickkopf homolog 3 (Xenopus laevis)
chr10_+_47875229 1.102 NM_001040084
NM_001098845
ANXA8L2
ANXA8
ANXA8L1
annexin A8-like 2
annexin A8
annexin A8-like 1
chr12_-_51298599 1.088 NM_175068
KRT73
keratin 73
chr2_-_20288108 1.048 NM_002997
SDC1
syndecan 1
chr10_-_46593923 1.030 NM_001040084
NM_001098845
ANXA8L2
LOC653110
ANXA8
ANXA8L1
annexin A8-like 2
hypothetical LOC653110
annexin A8
annexin A8-like 1
chr12_-_51253875 1.015 NM_175053
KRT74
keratin 74
chr11_-_11987115 0.996 DKK3
dickkopf homolog 3 (Xenopus laevis)
chr12_+_54612055 0.991 NM_201444
NM_201445
NM_201554
DGKA


diacylglycerol kinase, alpha 80kDa


chr19_+_43447262 0.964 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr11_-_11987198 0.949 NM_015881
DKK3
dickkopf homolog 3 (Xenopus laevis)
chr10_+_75343352 0.927 PLAU
plasminogen activator, urokinase
chr10_+_47216925 0.904 NM_001630
ANXA8L2
ANXA8
annexin A8-like 2
annexin A8
chr3_-_191321367 0.889 LEPREL1
leprecan-like 1
chrX_+_130984912 0.863 NM_001042453
NM_016542
MST4

serine/threonine protein kinase MST4

chr12_-_28016182 0.799 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr20_-_55718982 0.791 NM_199169
NM_199170
PMEPA1

prostate transmembrane protein, androgen induced 1

chr8_+_104582151 0.778 NM_001100117
RIMS2
regulating synaptic membrane exocytosis 2
chr18_+_27332024 0.760 NM_001943
DSG2
desmoglein 2
chr16_+_22733307 0.733 NM_006043
HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr1_+_26728827 0.730 NM_002953
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr1_+_26728839 0.718 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr17_+_45965044 0.680 NM_017957
EPN3
epsin 3
chr1_+_26728846 0.669 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr19_+_43447078 0.660 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr22_+_29819343 0.659 SMTN
smoothelin
chr3_-_191321601 0.645 NM_018192
LEPREL1
leprecan-like 1
chr5_+_52812236 0.635 NM_006350
NM_013409
FST

follistatin

chr15_+_43209422 0.623 NM_017434
NM_175940
DUOX1

dual oxidase 1

chr22_+_31527678 0.612 TIMP3
TIMP metallopeptidase inhibitor 3
chr17_-_37022465 0.603 NM_005557
KRT16
keratin 16
chrX_+_73557809 0.602 NM_006517
SLC16A2
solute carrier family 16, member 2 (monocarboxylic acid transporter 8)
chr2_-_20288647 0.589 NM_001006946
SDC1
syndecan 1
chr22_-_45311730 0.588 NM_014246
CELSR1
cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)
chr1_+_13782838 0.585 NM_006474
NM_198389
PDPN

podoplanin

chr5_+_131621287 0.584 PDLIM4
PDZ and LIM domain 4
chr11_-_11986704 0.576 NM_001018057
DKK3
dickkopf homolog 3 (Xenopus laevis)
chr7_+_115926855 0.562 CAV2
caveolin 2
chr8_-_49996353 0.553 NM_003068
SNAI2
snail homolog 2 (Drosophila)
chr18_-_26876622 0.547 NM_001941
NM_024423
DSC3

desmocollin 3

chr5_+_52812165 0.547 FST
follistatin
chr17_+_62804036 0.546 PITPNC1
phosphatidylinositol transfer protein, cytoplasmic 1
chr5_+_131621276 0.534 PDLIM4
PDZ and LIM domain 4
chr16_+_22732982 0.524 HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr10_+_88718167 0.522 NM_006829
C10orf116
chromosome 10 open reading frame 116
chr6_-_10520592 0.518 NM_001032280
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr4_+_30330963 0.514 NM_001173523
NM_002589
NM_032456
NM_032457
PCDH7



protocadherin 7



chr10_-_105604942 0.512 NM_014631
SH3PXD2A
SH3 and PX domains 2A
chr12_+_51628921 0.510 NM_199187
NM_000224
KRT18

keratin 18

chr21_+_38566298 0.502 NM_170737
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr17_+_45965076 0.502 EPN3
epsin 3
chrX_-_51256035 0.482 NUDT11
nudix (nucleoside diphosphate linked moiety X)-type motif 11
chr16_+_55273879 0.479 NM_005952
MT1X
metallothionein 1X
chr22_+_31527744 0.476 TIMP3
TIMP metallopeptidase inhibitor 3
chr6_+_30958672 0.466 DDR1
discoidin domain receptor tyrosine kinase 1
chr2_-_224612177 0.455 NM_001136528
NM_006216
SERPINE2

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2

chr3_-_52065130 0.445 NM_001947
DUSP7
dual specificity phosphatase 7
chr12_+_51629164 0.428 KRT18
keratin 18
chr20_-_55719946 0.421 NM_199171
PMEPA1
prostate transmembrane protein, androgen induced 1
chr10_-_95231933 0.419 NM_013451
NM_133337
MYOF

myoferlin

chr5_+_135392482 0.416 NM_000358
TGFBI
transforming growth factor, beta-induced, 68kDa
chr19_+_45915122 0.412 ITPKC
inositol 1,4,5-trisphosphate 3-kinase C
chr12_-_42486314 0.411 NM_002822
TWF1
twinfilin, actin-binding protein, homolog 1 (Drosophila)
chr5_+_17270474 0.410 NM_006317
BASP1
brain abundant, membrane attached signal protein 1
chr3_-_45162901 0.407 NM_022842
NM_178181
CDCP1

CUB domain containing protein 1

chr1_+_160797973 0.394 UAP1
UDP-N-acteylglucosamine pyrophosphorylase 1
chr8_+_15442100 0.387 NM_006765
NM_178234
TUSC3

tumor suppressor candidate 3

chr1_-_93199586 0.387 NM_001006605
FAM69A
family with sequence similarity 69, member A
chr16_-_31121555 0.386 NM_013258
NM_145182
PYCARD

PYD and CARD domain containing

chr1_+_160797853 0.385 NM_003115
UAP1
UDP-N-acteylglucosamine pyrophosphorylase 1
chr5_+_17270781 0.382 BASP1
brain abundant, membrane attached signal protein 1
chr8_+_15442106 0.381 TUSC3
tumor suppressor candidate 3
chr16_+_55217085 0.374 NM_175617
MT1E
metallothionein 1E
chr16_-_31121504 0.371 PYCARD
PYD and CARD domain containing
chr3_-_13896618 0.369 NM_004625
WNT7A
wingless-type MMTV integration site family, member 7A
chr5_-_57791544 0.368 NM_006622
PLK2
polo-like kinase 2
chr11_+_129534873 0.363 NM_021978
ST14
suppression of tumorigenicity 14 (colon carcinoma)
chr8_+_61592278 0.361 RAB2A
RAB2A, member RAS oncogene family
chr5_+_131621230 0.359 NM_001131027
NM_003687
PDLIM4

PDZ and LIM domain 4

chr3_-_45162847 0.357 CDCP1
CUB domain containing protein 1
chr9_-_99994704 0.356 NM_052820
CORO2A
coronin, actin binding protein, 2A
chr17_-_36996611 0.347 NM_000526
KRT14
keratin 14
chr1_-_143232344 0.344 LOC728855
hypothetical LOC728855
chr2_+_218790364 0.342 NM_005731
ARPC2
actin related protein 2/3 complex, subunit 2, 34kDa
chr5_+_86599800 0.342 RASA1
RAS p21 protein activator (GTPase activating protein) 1
chr3_-_45242808 0.341 NM_015444
TMEM158
transmembrane protein 158 (gene/pseudogene)
chr5_+_86599902 0.341 NM_002890
RASA1
RAS p21 protein activator (GTPase activating protein) 1
chr8_-_145099963 0.337 NM_201379
PLEC
plectin
chr1_-_142535878 0.336 LOC100286793
FLJ39739
hypothetical LOC100286793
hypothetical FLJ39739
chr15_-_81744469 0.334 NM_001717
BNC1
basonuclin 1
chr1_-_143232275 0.331 LOC728855
hypothetical LOC728855
chr4_+_30331289 0.328 PCDH7
protocadherin 7
chr6_-_136829705 0.317 NM_001198615
MAP7
microtubule-associated protein 7
chr8_+_61592105 0.317 NM_002865
RAB2A
RAB2A, member RAS oncogene family
chr19_-_14490235 0.316 DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr10_+_53744043 0.316 NM_012242
DKK1
dickkopf homolog 1 (Xenopus laevis)
chr1_+_156417302 0.315 CD1D
CD1d molecule
chr17_+_2627099 0.313 RAP1GAP2
RAP1 GTPase activating protein 2
chr4_-_177950658 0.313 NM_005429
VEGFC
vascular endothelial growth factor C
chr6_-_30820264 0.312 NM_003897
IER3
immediate early response 3
chr2_-_216586488 0.307 NM_018000
MREG
melanoregulin
chr17_+_62804385 0.307 NM_012417
NM_181671
PITPNC1

phosphatidylinositol transfer protein, cytoplasmic 1

chr15_+_68971835 0.305 NM_001199017
NM_017691
NM_001199018
LRRC49


leucine rich repeat containing 49


chr5_+_49998677 0.304 PARP8
poly (ADP-ribose) polymerase family, member 8
chr1_+_109594163 0.302 NM_001408
CELSR2
cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)
chr4_+_87734489 0.301 NM_006264
NM_080683
NM_080684
NM_080685
PTPN13



protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)



chr12_+_54498129 0.300 ORMDL2
ORM1-like 2 (S. cerevisiae)
chr12_+_54497985 0.299 NM_014182
ORMDL2
ORM1-like 2 (S. cerevisiae)
chr8_+_15442123 0.299 TUSC3
tumor suppressor candidate 3
chrX_-_51256166 0.296 NM_018159
NUDT11
nudix (nucleoside diphosphate linked moiety X)-type motif 11
chr6_-_84197573 0.294 NM_002395
ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr16_+_67236730 0.292 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr5_-_140978751 0.292 NM_001079812
NM_005219
DIAPH1

diaphanous homolog 1 (Drosophila)

chr5_+_49998528 0.288 NM_001178056
NM_024615
PARP8

poly (ADP-ribose) polymerase family, member 8

chr4_+_85723080 0.286 NM_001263
CDS1
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
chr22_+_41877470 0.283 NM_000714
NM_007311
TSPO

translocator protein (18kDa)

chr16_-_4927057 0.282 NM_002705
PPL
periplakin
chr11_+_65443452 0.281 DRAP1
DR1-associated protein 1 (negative cofactor 2 alpha)
chr5_+_50714996 0.280 ISL1
ISL LIM homeobox 1
chr12_-_6354650 0.279 NM_001159576
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr3_-_38040999 0.279 PLCD1
phospholipase C, delta 1
chr1_-_6585268 0.278 KLHL21
kelch-like 21 (Drosophila)
chr11_+_65443303 0.278 NM_006442
DRAP1
DR1-associated protein 1 (negative cofactor 2 alpha)
chr10_-_121286034 0.278 NM_002925
RGS10
regulator of G-protein signaling 10
chr10_-_61139328 0.276 NM_194298
LOC100129721
SLC16A9
hypothetical protein LOC100129721
solute carrier family 16, member 9 (monocarboxylic acid transporter 9)
chr5_+_50714714 0.276 NM_002202
ISL1
ISL LIM homeobox 1
chr11_+_129534983 0.275 ST14
suppression of tumorigenicity 14 (colon carcinoma)
chr2_+_201384880 0.273 BZW1
basic leucine zipper and W2 domains 1
chr22_+_29808845 0.270 SMTN
smoothelin
chrX_-_54538591 0.269 FGD1
FYVE, RhoGEF and PH domain containing 1
chr3_+_157874898 0.269 NM_015508
TIPARP
TCDD-inducible poly(ADP-ribose) polymerase
chr16_-_11588257 0.265 NM_001136472
NM_001136473
LITAF

lipopolysaccharide-induced TNF factor

chr3_-_191522886 0.262 NM_021101
CLDN1
claudin 1
chr22_+_41877502 0.261 TSPO
translocator protein (18kDa)
chr10_-_121292139 0.260 NM_001005339
RGS10
regulator of G-protein signaling 10
chr2_-_97978421 0.258 NM_015348
TMEM131
transmembrane protein 131
chr11_+_65443484 0.258 DRAP1
DR1-associated protein 1 (negative cofactor 2 alpha)
chr9_-_88159143 0.256 NM_001185059
NM_001185074
NM_024617
ZCCHC6


zinc finger, CCHC domain containing 6


chr8_+_67503798 0.253 NM_015169
RRS1
RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
chr15_-_70288071 0.253 PKM2
pyruvate kinase, muscle
chr2_+_201384842 0.252 BZW1
basic leucine zipper and W2 domains 1
chr8_+_98725505 0.251 NM_178812
MTDH
metadherin
chr8_+_54956069 0.251 RGS20
regulator of G-protein signaling 20
chr8_-_48813256 0.250 NM_005195
CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr16_-_86460529 0.250 NM_003486
SLC7A5
solute carrier family 7 (cationic amino acid transporter, y+ system), member 5
chr7_+_55054416 0.250 EGFR
epidermal growth factor receptor
chr8_+_25098296 0.249 DOCK5
dedicator of cytokinesis 5
chr10_+_70748581 0.248 NM_000188
HK1
hexokinase 1
chr8_+_100025806 0.247 NM_001142462
NM_053001
OSR2

odd-skipped related 2 (Drosophila)

chr17_+_46067114 0.247 NM_001144070
NM_003786
ABCC3

ATP-binding cassette, sub-family C (CFTR/MRP), member 3

chr20_+_6696744 0.245 NM_001200
BMP2
bone morphogenetic protein 2
chr8_-_48813236 0.243 CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr18_+_40514772 0.242 NM_015559
SETBP1
SET binding protein 1
chr6_-_33276416 0.241 RXRB
retinoid X receptor, beta
chr12_-_94135154 0.241 NM_018351
FGD6
FYVE, RhoGEF and PH domain containing 6
chr4_-_56107725 0.241 NM_004898
CLOCK
clock homolog (mouse)
chr11_+_63510478 0.240 OTUB1
OTU domain, ubiquitin aldehyde binding 1
chr10_+_103815114 0.240 NM_024747
HPS6
Hermansky-Pudlak syndrome 6
chr6_-_136889302 0.239 MAP7
microtubule-associated protein 7
chr20_+_61622545 0.238 NM_024299
PPDPF
pancreatic progenitor cell differentiation and proliferation factor homolog (zebrafish)
chr19_+_43446937 0.237 NM_001166103
NM_021102
SPINT2

serine peptidase inhibitor, Kunitz type, 2

chr11_-_124871258 0.237 NM_005103
NM_022549
FEZ1

fasciculation and elongation protein zeta 1 (zygin I)

chr2_+_113119985 0.237 NM_005415
SLC20A1
solute carrier family 20 (phosphate transporter), member 1
chr19_+_45914755 0.235 NM_025194
ITPKC
inositol 1,4,5-trisphosphate 3-kinase C
chrX_+_117364055 0.232 NM_001184965
NM_001184966
NM_019045
WDR44


WD repeat domain 44


chr1_-_93919789 0.230 NM_003567
BCAR3
breast cancer anti-estrogen resistance 3
chr11_+_63510403 0.229 OTUB1
OTU domain, ubiquitin aldehyde binding 1
chr6_+_111242516 0.228 AMD1
adenosylmethionine decarboxylase 1
chr1_-_94147537 0.226 GCLM
glutamate-cysteine ligase, modifier subunit
chr10_+_27026563 0.226 NM_014317
PDSS1
prenyl (decaprenyl) diphosphate synthase, subunit 1
chr6_+_29799095 0.225 NM_001098478
NM_001098479
NM_018950
HLA-F


major histocompatibility complex, class I, F


chr6_+_86216020 0.225 NM_002526
NT5E
5'-nucleotidase, ecto (CD73)
chr4_-_647424 0.224


chr11_-_61491684 0.224 NM_002032
FTH1
ferritin, heavy polypeptide 1
chr4_+_4439750 0.224 D4S234E
DNA segment on chromosome 4 (unique) 234 expressed sequence
chr2_+_201384505 0.224 BZW1
basic leucine zipper and W2 domains 1
chr1_+_148089251 0.221 NM_001040874
NM_003516
HIST2H2AA4
HIST2H2AA3
histone cluster 2, H2aa4
histone cluster 2, H2aa3
chr16_+_67236699 0.219 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr1_-_94147574 0.219 NM_002061
GCLM
glutamate-cysteine ligase, modifier subunit
chr3_+_157875063 0.219 TIPARP
TCDD-inducible poly(ADP-ribose) polymerase
chr6_-_84197477 0.217 ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr16_-_11588525 0.217 LITAF
lipopolysaccharide-induced TNF factor
chr6_-_84197463 0.217 ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr19_-_14490227 0.216 DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr2_+_218790143 0.215 ARPC2
actin related protein 2/3 complex, subunit 2, 34kDa
chr1_+_26480134 0.215 SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
chr1_-_203557379 0.214 NM_030952
NUAK2
NUAK family, SNF1-like kinase, 2
chrX_-_54539043 0.213 NM_004463
FGD1
FYVE, RhoGEF and PH domain containing 1
chr17_-_39265965 0.213 NM_001932
MPP3
membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
chr22_-_44015424 0.212 KIAA0930
KIAA0930
chr1_+_45738442 0.212 NM_015506
MMACHC
methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.39 4.65e-04 GO:0007399 nervous system development
1.20 1.09e-02 GO:0023052 signaling
1.07 1.34e-02 GO:0009987 cellular process
1.46 1.60e-02 GO:0048699 generation of neurons
1.60 2.04e-02 GO:0032990 cell part morphogenesis
1.53 3.43e-02 GO:0000902 cell morphogenesis
1.32 4.24e-02 GO:0009653 anatomical structure morphogenesis

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.81 2.05e-02 GO:0016791 phosphatase activity