Motif ID: RUNX1..3.p2

Z-value: 2.824


Transcription factors associated with RUNX1..3.p2:

Gene SymbolEntrez IDGene Name
RUNX1 861 runt-related transcription factor 1
RUNX2 860 runt-related transcription factor 2
RUNX3 864 runt-related transcription factor 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RUNX3chr1_-_251640610.792.8e-04Click!
RUNX1chr21_-_35182842-0.647.2e-03Click!
RUNX2chr6_+_45498354,
chr6_+_45498262
0.175.3e-01Click!


Activity profile for motif RUNX1..3.p2.

activity profile for motif RUNX1..3.p2


Sorted Z-values histogram for motif RUNX1..3.p2

Sorted Z-values for motif RUNX1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RUNX1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_+_23754822 10.379 PRKCB
protein kinase C, beta
chr1_-_25164061 9.516 NM_001031680
RUNX3
runt-related transcription factor 3
chr16_+_23754772 9.276 NM_002738
NM_212535
PRKCB

protein kinase C, beta

chr17_-_26665220 6.611 NM_006495
EVI2B
ecotropic viral integration site 2B
chr17_-_26665144 6.424 EVI2B
ecotropic viral integration site 2B
chr17_-_26665213 6.281 EVI2B
ecotropic viral integration site 2B
chr17_-_26665194 6.069 EVI2B
ecotropic viral integration site 2B
chr16_+_23754860 5.891 PRKCB
protein kinase C, beta
chr2_-_158008763 5.729 NM_004288
CYTIP
cytohesin 1 interacting protein
chr8_-_102872372 5.549 NCALD
neurocalcin delta
chr8_-_102872354 5.548 NCALD
neurocalcin delta
chr8_-_102872614 5.461 NM_032041
NCALD
neurocalcin delta
chr13_-_45654296 4.582 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr1_+_196874759 4.546 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr10_+_70517863 4.500 SRGN
serglycin
chr4_-_71751070 4.479 IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr22_+_21116283 4.262


chr9_-_122728173 4.230 TRAF1
TNF receptor-associated factor 1
chr10_+_70517823 4.223 NM_002727
SRGN
serglycin
chr4_-_84254873 4.135 PLAC8
placenta-specific 8
chr4_-_71751205 4.065 NM_144646
IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr1_+_196874839 4.049 PTPRC
protein tyrosine phosphatase, receptor type, C
chr16_+_30102426 4.028 CORO1A
coronin, actin binding protein, 1A
chr17_-_31441390 3.958 NM_002983
CCL3
chemokine (C-C motif) ligand 3
chr4_-_84254932 3.899 NM_001130715
NM_016619
PLAC8

placenta-specific 8

chr17_-_31548167 3.845 NM_001001437
NM_021006
CCL3L3
CCL3
CCL3L1
chemokine (C-C motif) ligand 3-like 3
chemokine (C-C motif) ligand 3
chemokine (C-C motif) ligand 3-like 1
chr4_-_84254912 3.813 PLAC8
placenta-specific 8
chr1_+_190811479 3.792 NM_002922
RGS1
regulator of G-protein signaling 1
chrX_+_48427103 3.706 NM_000377
WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr1_+_196874867 3.568 PTPRC
protein tyrosine phosphatase, receptor type, C
chr11_+_22652894 3.509 NM_005256
GAS2
growth arrest-specific 2
chr22_+_21552897 3.473 LOC100290481
immunoglobulin lambda light chain-like
chr1_+_207995999 3.429 NM_025228
TRAF3IP3
TRAF3 interacting protein 3
chr6_+_12825818 3.376 NM_030948
PHACTR1
phosphatase and actin regulator 1
chr6_-_32271277 3.181 NM_022107
GPSM3
G-protein signaling modulator 3
chr12_-_101396459 3.177 NM_001111284
IGF1
insulin-like growth factor 1 (somatomedin C)
chr14_+_75058518 3.064 NM_006399
BATF
basic leucine zipper transcription factor, ATF-like
chr14_+_75058591 2.929 BATF
basic leucine zipper transcription factor, ATF-like
chr12_+_25096472 2.879 NM_006152
LRMP
lymphoid-restricted membrane protein
chr13_-_45654292 2.858 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr2_-_88946767 2.735


chr1_-_114215768 2.708 NM_001193431
NM_012411
NM_015967
PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chr7_+_116447499 2.658 ST7
suppression of tumorigenicity 7
chr7_+_116447527 2.649 ST7
suppression of tumorigenicity 7
chr1_+_32489426 2.613 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chr12_+_25096755 2.496 LRMP
lymphoid-restricted membrane protein
chr4_-_38482805 2.449 NM_003263
TLR1
toll-like receptor 1
chr6_+_31651319 2.405 NM_000594
TNF
tumor necrosis factor
chr11_-_5232480 2.402 NM_000184
HBG1
HBG2
hemoglobin, gamma A
hemoglobin, gamma G
chrX_+_78087484 2.358 NM_014499
NM_198333
P2RY10

purinergic receptor P2Y, G-protein coupled, 10

chr5_-_88155360 2.350 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr22_+_38627031 2.336 NM_004810
GRAP2
GRB2-related adaptor protein 2
chr2_-_175170674 2.331 WIPF1
WAS/WASL interacting protein family, member 1
chr11_-_66961709 2.328 NM_005608
PTPRCAP
protein tyrosine phosphatase, receptor type, C-associated protein
chrX_-_30505804 2.293 NM_025159
CXorf21
chromosome X open reading frame 21
chrX_-_135690770 2.289 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr19_-_40925151 2.264 NM_024660
TMEM149
transmembrane protein 149
chr3_+_4510030 2.262 NM_001099952
NM_001168272
NM_002222
ITPR1


inositol 1,4,5-triphosphate receptor, type 1


chrX_-_135690699 2.262 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr22_+_21384862 2.262 IGLV3-21
IGLJ3
IGLC1
immunoglobulin lambda variable 3-21
immunoglobulin lambda joining 3
immunoglobulin lambda constant 1 (Mcg marker)
chr22_+_38627129 2.244 GRAP2
GRB2-related adaptor protein 2
chr17_+_69974116 2.229 NM_007261
CD300A
CD300a molecule
chr6_+_31647854 2.216 NM_001159740
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr11_+_1846478 2.209 NM_001013253
LSP1
lymphocyte-specific protein 1
chrX_-_48655978 2.189 PIM2
pim-2 oncogene
chr6_+_31648071 2.163 NM_000595
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr17_-_76622967 2.114 FLJ90757
hypothetical LOC440465
chr6_-_33028790 2.110 NM_006120
HLA-DMA
major histocompatibility complex, class II, DM alpha
chr17_-_26672757 2.085 NM_001003927
NM_014210
EVI2A

ecotropic viral integration site 2A

chrX_-_135691168 2.063 NM_004840
ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr1_-_9040141 2.052 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chrX_-_78509662 2.016 NM_001171581
NM_004867
ITM2A

integral membrane protein 2A

chrX_+_49047068 1.963 NM_001098413
GAGE10
G antigen 10
chr16_+_29582065 1.963 SPN
sialophorin
chr22_+_21464980 1.948


chrX_+_9391314 1.926 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr1_-_30977931 1.819 LAPTM5
lysosomal protein transmembrane 5
chr19_-_45947667 1.805 NM_198476
C19orf54
chromosome 19 open reading frame 54
chr3_+_99733432 1.804 NM_005290
GPR15
G protein-coupled receptor 15
chr5_+_75734759 1.801 NM_006633
IQGAP2
IQ motif containing GTPase activating protein 2
chr6_-_31954795 1.699 NM_001178044
NM_025257
SLC44A4

solute carrier family 44, member 4

chr2_+_74610039 1.698 NM_013247
NM_145074
HTRA2

HtrA serine peptidase 2

chr1_+_39694849 1.693 MACF1
microtubule-actin crosslinking factor 1
chr14_-_105565211 1.686 IGHV4-31
IGHA1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
chr13_-_45654327 1.686 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chrX_-_118889603 1.676 NM_006978
RNF113A
ring finger protein 113A
chr6_-_32892705 1.672 NM_002120
HLA-DOB
major histocompatibility complex, class II, DO beta
chr1_-_157313179 1.669 NM_004833
AIM2
absent in melanoma 2
chr1_-_205161821 1.667 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr1_+_32512298 1.653 NM_001042771
LCK
lymphocyte-specific protein tyrosine kinase
chr4_-_88531245 1.635 HSD17B11
hydroxysteroid (17-beta) dehydrogenase 11
chrX_-_78509367 1.604 ITM2A
integral membrane protein 2A
chr2_+_74610333 1.587 HTRA2
HtrA serine peptidase 2
chr2_+_68445936 1.531 PLEK
pleckstrin
chr6_-_31954745 1.529 SLC44A4
solute carrier family 44, member 4
chr6_-_31954730 1.528 SLC44A4
solute carrier family 44, member 4
chrX_-_31436335 1.524 NM_004014
DMD
dystrophin
chr9_-_122728993 1.521 NM_005658
TRAF1
TNF receptor-associated factor 1
chr5_-_137099361 1.521 KLHL3
kelch-like 3 (Drosophila)
chrX_-_70755023 1.515 NM_001142797
NM_001504
CXCR3

chemokine (C-X-C motif) receptor 3

chr5_+_156628929 1.515 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr15_+_73281249 1.513 NM_015492
C15orf39
chromosome 15 open reading frame 39
chr4_-_88531353 1.512 NM_016245
HSD17B11
hydroxysteroid (17-beta) dehydrogenase 11
chr3_+_114733907 1.507 NM_017699
SIDT1
SID1 transmembrane family, member 1
chr22_+_21042091 1.499 IGLV1-44
IGL@
immunoglobulin lambda variable 1-44
immunoglobulin lambda locus
chr12_+_92295738 1.496 NM_019094
NM_199040
NUDT4

NUDT4P1
nudix (nucleoside diphosphate linked moiety X)-type motif 4

nudix (nucleoside diphosphate linked moiety X)-type motif 4 pseudogene 1
chr14_-_105900687 1.489 IGHA1
IGHD
IGHG3
IGHM
SKAP2
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
src kinase associated phosphoprotein 2
chr15_+_73281286 1.453 C15orf39
chromosome 15 open reading frame 39
chr2_+_68445821 1.436 NM_002664
PLEK
pleckstrin
chr14_+_99601517 1.424 EVL
Enah/Vasp-like
chr15_-_53350383 1.420 NM_183236
RAB27A
RAB27A, member RAS oncogene family
chr14_+_99601498 1.414 NM_016337
EVL
Enah/Vasp-like
chr7_+_120415958 1.414 NM_024913
C7orf58
chromosome 7 open reading frame 58
chr2_+_33554824 1.398 NM_001139488
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr16_+_27346079 1.397 NM_021798
IL21R
interleukin 21 receptor
chr11_-_56951628 1.394 NM_017611
SLC43A3
solute carrier family 43, member 3
chr15_+_73281288 1.371 C15orf39
chromosome 15 open reading frame 39
chr15_-_35180656 1.369 NM_002399
MEIS2
Meis homeobox 2
chr7_+_120416103 1.369 C7orf58
chromosome 7 open reading frame 58
chr2_-_89223666 1.345 IGKC
IGK@
immunoglobulin kappa constant
immunoglobulin kappa locus
chr17_+_43540124 1.344 SNX11
sorting nexin 11
chr17_-_23928041 1.332 ALDOC
aldolase C, fructose-bisphosphate
chr21_+_41655786 1.288 NM_002463
LOC100131190
MX2
hypothetical protein LOC100131190
myxovirus (influenza virus) resistance 2 (mouse)
chr15_-_19974402 1.282


chr1_-_167947301 1.268 NM_000655
SELL
selectin L
chr13_-_40491405 1.259 ELF1
E74-like factor 1 (ets domain transcription factor)
chr14_+_100270222 1.256 DLK1
delta-like 1 homolog (Drosophila)
chr6_+_45404031 1.251 NM_001015051
NM_001024630
RUNX2

runt-related transcription factor 2

chr12_+_13240983 1.239 EMP1
epithelial membrane protein 1
chrX_-_39921525 1.226 NM_001123383
NM_001123384
BCOR

BCL6 corepressor

chr10_+_11087280 1.221 CELF2
CUGBP, Elav-like family member 2
chr4_+_39874921 1.213 NM_004310
RHOH
ras homolog gene family, member H
chr17_-_23927973 1.210 ALDOC
aldolase C, fructose-bisphosphate
chr2_-_200033445 1.194 SATB2
SATB homeobox 2
chrX_+_48427137 1.161 WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr17_-_23928048 1.158 NM_005165
ALDOC
aldolase C, fructose-bisphosphate
chrX_-_15782803 1.156 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr2_+_102401580 1.151 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr1_+_177317841 1.136 TOR3A
torsin family 3, member A
chr16_+_166678 1.133 NM_000558
HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chr22_+_21318779 1.111 NM_199127
GGTLC2
gamma-glutamyltransferase light chain 2
chr12_-_23995220 1.110 SOX5
SRY (sex determining region Y)-box 5
chr2_-_213723298 1.102 NM_016260
IKZF2
IKAROS family zinc finger 2 (Helios)
chr1_-_159099090 1.094 NM_001166663
NM_001166664
NM_016382
CD244


CD244 molecule, natural killer cell receptor 2B4


chr7_+_149699185 1.094 NM_014374
REPIN1
replication initiator 1
chr2_+_228386800 1.091 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr10_-_64698831 1.089 NM_004241
JMJD1C
jumonji domain containing 1C
chr22_+_37708350 1.087 NM_004900
APOBEC3B
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
chr6_+_32713160 1.075 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr17_+_69974375 1.056 CD300A
CD300a molecule
chr1_+_177317827 1.053 TOR3A
torsin family 3, member A
chr16_+_142853 1.044 NM_005332
HBZ
hemoglobin, zeta
chr19_+_13736352 1.043 MRI1
methylthioribose-1-phosphate isomerase homolog (S. cerevisiae)
chr22_+_20326572 1.042 SDF2L1
stromal cell-derived factor 2-like 1
chr12_-_23995109 1.040 SOX5
SRY (sex determining region Y)-box 5
chr3_+_134601479 1.037 NM_003571
BFSP2
beaded filament structural protein 2, phakinin
chr22_+_20101661 1.033 NM_015094
HIC2
hypermethylated in cancer 2
chr17_+_69974361 1.030 CD300A
CD300a molecule
chr22_+_20326541 1.023 NM_022044
SDF2L1
stromal cell-derived factor 2-like 1
chr10_+_11087259 1.019 NM_001025077
CELF2
CUGBP, Elav-like family member 2
chr13_-_40491491 1.019 NM_172373
ELF1
E74-like factor 1 (ets domain transcription factor)
chrX_-_15782859 1.015 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr1_+_177317734 1.011 NM_022371
TOR3A
torsin family 3, member A
chr11_-_67207112 1.005 RPL37
ribosomal protein L37
chr14_-_106084519 1.005 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr2_+_127130148 1.004 NM_002101
NM_016815
GYPC

glycophorin C (Gerbich blood group)

chr15_-_70455355 1.000 NM_000520
HEXA
hexosaminidase A (alpha polypeptide)
chr10_-_11614279 0.998 NM_001080491
USP6NL
USP6 N-terminal like
chrX_-_118610880 0.991 NM_001173488
NKRF
NFKB repressing factor
chr1_+_202000906 0.990 NM_001136190
NM_017773
LAX1

lymphocyte transmembrane adaptor 1

chr22_+_20326591 0.985 SDF2L1
stromal cell-derived factor 2-like 1
chr1_+_11256089 0.982 UBIAD1
UbiA prenyltransferase domain containing 1
chr2_+_74610395 0.975 HTRA2
HtrA serine peptidase 2
chr22_+_20326615 0.969 SDF2L1
stromal cell-derived factor 2-like 1
chr7_+_20653490 0.965 NM_001163942
NM_001163993
NM_178559
ABCB5


ATP-binding cassette, sub-family B (MDR/TAP), member 5


chrX_-_111953009 0.955 NM_001113490
AMOT
angiomotin
chr12_-_56432292 0.954 CDK4
cyclin-dependent kinase 4
chr19_+_13736345 0.951 MRI1
methylthioribose-1-phosphate isomerase homolog (S. cerevisiae)
chr12_-_9804682 0.950 NM_001781
CD69
CD69 molecule
chr5_+_176807931 0.949 NM_001174102
PRR7
proline rich 7 (synaptic)
chr4_+_68107039 0.946 NM_012108
STAP1
signal transducing adaptor family member 1
chr17_-_36451189 0.927 NM_030967
KRTAP1-3
KRTAP1-1
keratin associated protein 1-3
keratin associated protein 1-1
chr14_-_105762742 0.919


chr12_+_9713472 0.914 NM_001197318
NM_013269
NM_001004419
NM_001197317
NM_001197319
CLEC2D




C-type lectin domain family 2, member D




chr1_-_148475086 0.913 NM_001136478
NM_030920
ANP32E

acidic (leucine-rich) nuclear phosphoprotein 32 family, member E

chr2_+_74610751 0.908 HTRA2
HtrA serine peptidase 2
chr15_-_70455794 0.906 HEXA
hexosaminidase A (alpha polypeptide)
chr1_-_205012348 0.902 NM_000572
IL10
interleukin 10
chr1_-_149004879 0.902 CTSS
cathepsin S
chr19_-_13909877 0.887 PODNL1
podocan-like 1
chr22_-_18807805 0.884 PI4KAP2
PI4KAP1
phosphatidylinositol 4-kinase, catalytic, alpha pseudogene 2
phosphatidylinositol 4-kinase, catalytic, alpha pseudogene 1
chr1_-_149004916 0.883 NM_004079
CTSS
cathepsin S
chr2_+_74610635 0.874 HTRA2
HtrA serine peptidase 2
chr6_-_30818198 0.866 NM_005803
FLOT1
flotillin 1
chr17_+_61729193 0.864 PRKCA
protein kinase C, alpha
chr7_-_63660766 0.863 ZNF680
zinc finger protein 680
chr4_-_77147625 0.856 NM_002416
CXCL9
chemokine (C-X-C motif) ligand 9
chr6_+_16251260 0.855 MYLIP
myosin regulatory light chain interacting protein
chr1_-_182273451 0.854 NM_015101
GLT25D2
glycosyltransferase 25 domain containing 2
chr17_-_59363352 0.852 NM_000626
NM_001039933
NM_021602
CD79B


CD79b molecule, immunoglobulin-associated beta



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.50 5.70e-04 GO:0002376 immune system process
1.59 7.53e-03 GO:0006955 immune response
1.75 9.01e-03 GO:0001775 cell activation

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.52 2.25e-02 GO:0003823 antigen binding