Motif ID: LHX3,4.p2

Z-value: 1.089


Transcription factors associated with LHX3,4.p2:

Gene SymbolEntrez IDGene Name
LHX3 8022 LIM homeobox 3
LHX4 89884 LIM homeobox 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
LHX3chr9_-_138234707,
chr9_-_138236775
-0.136.4e-01Click!


Activity profile for motif LHX3,4.p2.

activity profile for motif LHX3,4.p2


Sorted Z-values histogram for motif LHX3,4.p2

Sorted Z-values for motif LHX3,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of LHX3,4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_+_94135384 2.753 PEG10
paternally expressed 10
chr4_+_74497998 2.151 ALB
albumin
chr4_+_74498042 2.110 ALB
albumin
chr11_+_22646229 2.069 NM_177553
GAS2
growth arrest-specific 2
chr1_+_196874839 1.795 PTPRC
protein tyrosine phosphatase, receptor type, C
chr14_-_105997732 1.673 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr6_+_12825022 1.616 PHACTR1
phosphatase and actin regulator 1
chr6_-_29635680 1.530 NM_006398
UBD
ubiquitin D
chr16_+_11966464 1.517 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr7_-_25234582 1.504 NM_022150
NPVF
neuropeptide VF precursor
chr6_+_12825818 1.502 NM_030948
PHACTR1
phosphatase and actin regulator 1
chr17_-_61655915 1.406 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr7_-_87180499 1.387 NM_000927
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr16_+_2593351 1.255 LOC652276
hypothetical LOC652276
chr14_-_106249999 1.249 IGHA1
immunoglobulin heavy constant alpha 1
chr3_-_57209319 1.121 NM_003865
HESX1
HESX homeobox 1
chr17_-_36347197 1.101 NM_015515
KRT23
keratin 23 (histone deacetylase inducible)
chr11_-_114593838 1.054 CADM1
cell adhesion molecule 1
chr17_-_36346240 1.024 KRT23
keratin 23 (histone deacetylase inducible)
chr4_+_74520796 1.014 NM_001134
AFP
alpha-fetoprotein
chr18_-_72857665 1.001 MBP
myelin basic protein
chr20_-_51633042 0.976 NM_006526
ZNF217
zinc finger protein 217
chr5_+_67622242 0.950 NM_181504
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr10_+_91142301 0.922 NM_001548
IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr5_-_88155360 0.903 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr11_+_59979857 0.878 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr6_+_32021831 0.861 CFB
complement factor B
chr6_+_32021687 0.861 NM_001710
CFB
complement factor B
chr12_-_9123126 0.857 A2M
alpha-2-macroglobulin
chr6_+_32021742 0.835 CFB
complement factor B
chr6_+_32021793 0.825 CFB
complement factor B
chr4_+_74499651 0.824 ALB
albumin
chr3_-_69254226 0.791 NM_198271
LMOD3
leiomodin 3 (fetal)
chr2_-_216654708 0.773 NM_018441
PECR
peroxisomal trans-2-enoyl-CoA reductase
chr2_-_175170674 0.772 WIPF1
WAS/WASL interacting protein family, member 1
chr14_+_38653177 0.770 NM_001009182
NM_001009183
NM_003616
SIP1


survival of motor neuron protein interacting protein 1


chr4_+_89115862 0.744 SPP1
secreted phosphoprotein 1
chr12_-_101396459 0.743 NM_001111284
IGF1
insulin-like growth factor 1 (somatomedin C)
chr5_+_59819761 0.723 PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr13_-_98708549 0.719 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chr17_-_38087366 0.707 NM_016602
CCR10
chemokine (C-C motif) receptor 10
chr1_+_196874759 0.692 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr4_+_74493174 0.690 ALB
albumin
chr19_-_40996040 0.674 NM_021232
PRODH2
proline dehydrogenase (oxidase) 2
chr4_+_89115923 0.672 SPP1
secreted phosphoprotein 1
chr4_-_23500706 0.664 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr4_+_89115892 0.646 SPP1
secreted phosphoprotein 1
chr1_-_149004852 0.645 CTSS
cathepsin S
chr1_-_195818927 0.644 DENND1B
DENN/MADD domain containing 1B
chr1_-_92725017 0.642 NM_005263
GFI1
growth factor independent 1 transcription repressor
chr19_-_40995606 0.640 PRODH2
proline dehydrogenase (oxidase) 2
chr1_+_196874867 0.636 PTPRC
protein tyrosine phosphatase, receptor type, C
chr4_+_155703581 0.622 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr2_-_158008763 0.618 NM_004288
CYTIP
cytohesin 1 interacting protein
chr1_+_166516901 0.602 NM_005149
TBX19
T-box 19
chrX_+_37524190 0.586 NM_000397
CYBB
cytochrome b-245, beta polypeptide
chr2_-_166638376 0.580 NM_001165963
NM_001165964
NM_006920
SCN1A


sodium channel, voltage-gated, type I, alpha subunit


chr11_-_58099884 0.578 NM_004811
LPXN
leupaxin
chr6_-_32265489 0.570 NM_002586
PBX2
pre-B-cell leukemia homeobox 2
chr3_-_79899748 0.562 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr12_-_51887266 0.557 NM_000889
ITGB7
integrin, beta 7
chr7_-_36991189 0.550 NM_001039459
ELMO1
engulfment and cell motility 1
chr4_+_140806536 0.547 MGST2
microsomal glutathione S-transferase 2
chr8_-_110762409 0.539 NM_001099745
NM_001099746
SYBU

syntabulin (syntaxin-interacting)

chr5_+_156628929 0.537 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr2_+_161981138 0.536 TBR1
T-box, brain, 1
chr22_+_38627031 0.535 NM_004810
GRAP2
GRB2-related adaptor protein 2
chr4_-_176970895 0.534 GPM6A
glycoprotein M6A
chr22_+_38627129 0.530 GRAP2
GRB2-related adaptor protein 2
chr4_-_155731288 0.530 NM_000508
NM_021871
FGA

fibrinogen alpha chain

chr8_-_110730183 0.529 NM_001099747
NM_001099748
NM_001099749
NM_001099750
NM_017786
SYBU




syntabulin (syntaxin-interacting)




chrX_+_70682204 0.527 OGT
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
chr12_-_16652202 0.524 NM_001001395
LMO3
LIM domain only 3 (rhombotin-like 2)
chr7_+_137795387 0.517 NM_003852
NM_015905
TRIM24

tripartite motif containing 24

chr12_-_101398429 0.515 IGF1
insulin-like growth factor 1 (somatomedin C)
chr8_-_102872372 0.509 NCALD
neurocalcin delta
chr7_-_7724762 0.509 NM_002947
RPA3
replication protein A3, 14kDa
chrM_+_1670 0.507 USP47
ubiquitin specific peptidase 47
chr12_-_51887318 0.506 ITGB7
integrin, beta 7
chr3_+_63928459 0.503 NM_001128149
ATXN7
ataxin 7
chr2_+_161981046 0.499 TBR1
T-box, brain, 1
chr10_-_52315390 0.480 A1CF
APOBEC1 complementation factor
chr6_+_31538934 0.479 NM_006674
HCP5
HLA complex P5
chr3_-_12561962 0.476 NM_001195279
LOC100129480
hypothetical protein LOC100129480
chr3_+_73193499 0.475 NM_018029
EBLN2
endogenous Borna-like N element-2
chr10_+_102722275 0.472 NM_017893
SEMA4G
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr3_-_12916547 0.466 IQSEC1
IQ motif and Sec7 domain 1
chr6_-_22405708 0.461 NM_000948
PRL
prolactin
chr4_+_74496660 0.453 ALB
albumin
chr10_-_52315436 0.453 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr1_-_149004916 0.449 NM_004079
CTSS
cathepsin S
chr1_+_205329206 0.448 NM_000716
NM_001017364
NM_001017367
C4BPB


complement component 4 binding protein, beta


chr3_-_106903734 0.448 CBLB
Cas-Br-M (murine) ecotropic retroviral transforming sequence b
chr4_+_74500748 0.444 ALB
albumin
chr4_-_176970407 0.442 GPM6A
glycoprotein M6A
chr15_-_31147376 0.440 NM_001103184
FMN1
formin 1
chr15_-_58706934 0.436 NM_002943
NM_134260
RORA

RAR-related orphan receptor A

chr8_-_81155564 0.429 NM_001025252
TPD52
tumor protein D52
chr12_-_52281050 0.426 NM_001130059
ATF7
activating transcription factor 7
chr2_-_121875610 0.424 CLASP1
cytoplasmic linker associated protein 1
chr4_+_89115825 0.422 NM_000582
NM_001040058
NM_001040060
SPP1


secreted phosphoprotein 1


chr1_-_149681265 0.421 NM_207171
POGZ
pogo transposable element with ZNF domain
chr6_+_155579788 0.416 NM_001010927
TIAM2
T-cell lymphoma invasion and metastasis 2
chr20_-_18425811 0.413 NM_006606
RBBP9
retinoblastoma binding protein 9
chr3_+_179759181 0.411 NM_005832
KCNMB2
potassium large conductance calcium-activated channel, subfamily M, beta member 2
chr20_+_30161173 0.397 TM9SF4
transmembrane 9 superfamily protein member 4
chrX_+_107174855 0.396 NM_001170553
NM_182607
VSIG1

V-set and immunoglobulin domain containing 1

chrX_+_37524250 0.395 CYBB
cytochrome b-245, beta polypeptide
chr1_-_149004879 0.385 CTSS
cathepsin S
chr19_-_40995564 0.382 PRODH2
proline dehydrogenase (oxidase) 2
chr8_-_102872354 0.381 NCALD
neurocalcin delta
chr7_+_128802719 0.377 NM_001130722
AHCYL2
adenosylhomocysteinase-like 2
chr16_+_68284252 0.377 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr16_+_10430225 0.377 NM_024997
ATF7IP2
activating transcription factor 7 interacting protein 2
chr1_+_111215343 0.374 NM_001040033
CD53
CD53 molecule
chr8_+_123863224 0.373 ZHX2
zinc fingers and homeoboxes 2
chr14_-_106084519 0.373 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr1_+_148726537 0.370 NM_025150
TARS2
threonyl-tRNA synthetase 2, mitochondrial (putative)
chr4_+_74493301 0.365 ALB
albumin
chr3_-_78749633 0.365 ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr1_+_148726497 0.362 TARS2
threonyl-tRNA synthetase 2, mitochondrial (putative)
chr1_-_114215768 0.360 NM_001193431
NM_012411
NM_015967
PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chr12_+_8224056 0.359 FAM66C
family with sequence similarity 66, member C
chr5_-_22889192 0.359 CDH12
cadherin 12, type 2 (N-cadherin 2)
chr12_-_101398503 0.359 NM_000618
NM_001111283
NM_001111285
IGF1


insulin-like growth factor 1 (somatomedin C)


chrX_-_110542040 0.355 NM_178151
NM_001195553
NM_178152
NM_178153
DCX



doublecortin



chr6_-_33016561 0.350 NM_002118
HLA-DMB
major histocompatibility complex, class II, DM beta
chr14_+_101346032 0.349 PPP2R5C
protein phosphatase 2, regulatory subunit B', gamma
chr10_+_57028755 0.348 NM_001190478
MTRNR2L5
MT-RNR2-like 5
chr14_-_105610144 0.346 IGHA1
IGHG1
IGHG3
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
chr3_+_99733432 0.343 NM_005290
GPR15
G protein-coupled receptor 15
chr16_-_30841938 0.340 NCRNA00095
non-protein coding RNA 95
chr1_+_100089118 0.340 NM_000646
AGL
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
chr6_-_79732391 0.338 PHIP
pleckstrin homology domain interacting protein
chr8_+_67505091 0.334 RRS1
RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
chr2_+_161980865 0.333 NM_006593
TBR1
T-box, brain, 1
chr3_+_12304332 0.329 NM_005037
NM_138712
PPARG

peroxisome proliferator-activated receptor gamma

chr3_-_143230124 0.326 NM_001178141
NM_001178142
NM_006286
TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr7_-_37454933 0.325 NM_014800
ELMO1
engulfment and cell motility 1
chr2_-_199922047 0.323 SATB2
SATB homeobox 2
chr9_+_102987137 0.323 NM_017753
LPPR1
lipid phosphate phosphatase-related protein type 1
chr14_+_69307914 0.321 SRSF5
serine/arginine-rich splicing factor 5
chrX_+_23982992 0.321 EIF2S3
eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
chr11_+_86710076 0.321 TMEM135
transmembrane protein 135
chr13_-_34948758 0.320 NM_005584
MAB21L1
mab-21-like 1 (C. elegans)
chrX_+_99726445 0.313 NM_022144
TNMD
tenomodulin
chr12_+_52696908 0.309 NM_014620
NM_153693
HOXC4
HOXC6
homeobox C4
homeobox C6
chr5_+_150380173 0.309 NM_002084
GPX3
glutathione peroxidase 3 (plasma)
chr6_-_24985432 0.309 NM_015864
FAM65B
family with sequence similarity 65, member B
chr12_-_101398451 0.307 IGF1
insulin-like growth factor 1 (somatomedin C)
chr4_+_38740246 0.305 NM_015990
NM_199039
KLHL5

kelch-like 5 (Drosophila)

chr14_+_69306019 0.304 SRSF5
serine/arginine-rich splicing factor 5
chr4_+_88790477 0.303 NM_001079911
NM_004407
DMP1

dentin matrix acidic phosphoprotein 1

chr12_-_101036407 0.303 NM_024057
NUP37
nucleoporin 37kDa
chr4_+_74493266 0.302 ALB
albumin
chr15_+_79276273 0.302 NM_001172128
IL16
interleukin 16 (lymphocyte chemoattractant factor)
chr2_+_47449951 0.298 EPCAM
epithelial cell adhesion molecule
chr4_-_116254381 0.298 NM_022569
NDST4
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4
chr10_-_101831579 0.297 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr10_+_35466715 0.293 NM_183011
NM_183012
CREM

cAMP responsive element modulator

chr20_-_6052056 0.289 NM_017671
FERMT1
fermitin family member 1
chr6_+_43846372 0.288 VEGFA
vascular endothelial growth factor A
chr14_+_94097513 0.283 NM_006215
SERPINA4
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
chr12_+_28301399 0.282 NM_018318
CCDC91
coiled-coil domain containing 91
chr2_-_20390601 0.280 NM_015317
PUM2
pumilio homolog 2 (Drosophila)
chr7_-_44547382 0.280 NM_001101648
NM_013389
NPC1L1

NPC1 (Niemann-Pick disease, type C1, gene)-like 1

chr8_-_17811750 0.279 FGL1
fibrinogen-like 1
chr20_-_19984685 0.279 NM_016652
CRNKL1
crooked neck pre-mRNA splicing factor-like 1 (Drosophila)
chr3_-_54937001 0.278 NM_020678
LRTM1
leucine-rich repeats and transmembrane domains 1
chr4_-_77163609 0.277 NM_001565
CXCL10
chemokine (C-X-C motif) ligand 10
chr5_-_1935764 0.276 NM_016358
IRX4
iroquois homeobox 4
chr4_+_74493331 0.275 ALB
albumin
chr14_-_105623358 0.275 IGHA1
IGHD
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 1 (G1m marker)
chr1_-_233880676 0.274 NM_001098721
NM_004485
GNG4

guanine nucleotide binding protein (G protein), gamma 4

chr11_+_22652894 0.274 NM_005256
GAS2
growth arrest-specific 2
chr1_+_157067729 0.271 NM_002432
MNDA
myeloid cell nuclear differentiation antigen
chr3_-_121065112 0.270


chr4_+_74493218 0.269 ALB
albumin
chr3_+_39399770 0.269 NM_017875
SLC25A38
solute carrier family 25, member 38
chr12_+_25096755 0.267 LRMP
lymphoid-restricted membrane protein
chr4_+_74496575 0.264 ALB
albumin
chr4_-_46605980 0.263 NM_130902
COX7B2
cytochrome c oxidase subunit VIIb2
chr1_+_242281199 0.260 ZNF238
zinc finger protein 238
chr12_-_10173947 0.259 NM_022570
NM_197947
NM_197948
NM_197949
NM_197950
NM_197954
CLEC7A





C-type lectin domain family 7, member A





chrM_+_12283 0.258


chr2_-_215711313 0.257 NM_173076
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12
chr2_-_200033445 0.253 SATB2
SATB homeobox 2
chr6_-_87861492 0.253 NM_000735
CGA
glycoprotein hormones, alpha polypeptide
chrX_-_105169370 0.251 NM_000354
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chrX_-_24600661 0.251 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr17_+_31195760 0.250 TAF15
TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
chr9_-_111230926 0.249 NM_001145371
NM_001145372
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr6_-_133076873 0.248 NM_004666
VNN1
vanin 1
chr8_+_22900863 0.247 NM_001160036
RHOBTB2
Rho-related BTB domain containing 2
chr6_+_32003380 0.247 C2
complement component 2
chr12_-_101398470 0.247 IGF1
insulin-like growth factor 1 (somatomedin C)
chr6_+_31691745 0.245 NM_032955
AIF1
allograft inflammatory factor 1
chr12_-_101398288 0.245 IGF1
insulin-like growth factor 1 (somatomedin C)
chr14_-_94669547 0.244 NM_001195573
DICER1
dicer 1, ribonuclease type III
chr6_+_32003180 0.243 NM_000063
NM_001145903
C2

complement component 2


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.17 2.00e-02 GO:0065007 biological regulation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
3.13 7.66e-03 GO:0034703 cation channel complex
2.54 2.27e-02 GO:0034702 ion channel complex

Nothing significant found in function category.