Motif ID: NANOG.p2

Z-value: 1.015


Transcription factors associated with NANOG.p2:

Gene SymbolEntrez IDGene Name
NANOG 79923 Nanog homeobox

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NANOGchr12_+_7833261-0.505.0e-02Click!


Activity profile for motif NANOG.p2.

activity profile for motif NANOG.p2


Sorted Z-values histogram for motif NANOG.p2

Sorted Z-values for motif NANOG.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NANOG.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_30977931 2.595 LAPTM5
lysosomal protein transmembrane 5
chr12_-_15005761 2.549 NM_001175
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr1_+_196874759 2.260 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr15_-_53349775 2.225 NM_183234
NM_004580
RAB27A

RAB27A, member RAS oncogene family

chr6_-_32605898 2.184 NM_002125
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr11_-_56951628 2.181 NM_017611
SLC43A3
solute carrier family 43, member 3
chr1_+_196874839 2.117 PTPRC
protein tyrosine phosphatase, receptor type, C
chr15_-_53350383 1.838 NM_183236
RAB27A
RAB27A, member RAS oncogene family
chr12_+_25096472 1.699 NM_006152
LRMP
lymphoid-restricted membrane protein
chr12_+_25096755 1.436 LRMP
lymphoid-restricted membrane protein
chr7_-_36992221 1.436 NM_130442
ELMO1
engulfment and cell motility 1
chr11_-_110755112 1.384 POU2AF1
POU class 2 associating factor 1
chr6_-_32665409 1.349 NM_002124
HLA-DRB1
HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1
major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr13_-_40491405 1.313 ELF1
E74-like factor 1 (ets domain transcription factor)
chr13_-_40491491 1.225 NM_172373
ELF1
E74-like factor 1 (ets domain transcription factor)
chr3_-_126325132 1.198 SLC12A8
solute carrier family 12 (potassium/chloride transporters), member 8
chr7_+_116447527 1.154 ST7
suppression of tumorigenicity 7
chr1_-_149004852 1.153 CTSS
cathepsin S
chr8_-_82557956 1.150 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr7_-_25234582 1.142 NM_022150
NPVF
neuropeptide VF precursor
chr10_+_11246934 1.091 NM_001025076
NM_001083591
CELF2

CUGBP, Elav-like family member 2

chr6_-_26343139 1.090 NM_005320
HIST1H1D
histone cluster 1, H1d
chr11_+_59979857 1.049 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr7_-_13992351 1.026 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr6_+_34314545 1.022 NM_145905
HMGA1
high mobility group AT-hook 1
chr13_-_98708549 1.001 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chr12_-_101398451 0.994 IGF1
insulin-like growth factor 1 (somatomedin C)
chr3_-_57209319 0.947 NM_003865
HESX1
HESX homeobox 1
chr10_+_35524835 0.931 NM_182721
NM_182722
NM_182723
NM_182724
NM_182725
CREM




cAMP responsive element modulator




chr9_-_5294579 0.912 NM_005059
NM_134441
RLN2

relaxin 2

chr1_-_153109349 0.911 NM_002249
KCNN3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr1_-_149004916 0.891 NM_004079
CTSS
cathepsin S
chr13_-_93929719 0.889 NM_001129889
NM_001922
DCT

dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)

chr3_-_122862447 0.889 NM_005335
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr6_+_32713160 0.876 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr3_-_122862391 0.869 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr6_+_34312906 0.868 HMGA1
high mobility group AT-hook 1
chr12_+_14429499 0.865 ATF7IP
activating transcription factor 7 interacting protein
chr13_+_108079570 0.842 NM_001198950
MYO16
myosin XVI
chr22_+_38652555 0.810 GRAP2
GRB2-related adaptor protein 2
chr12_-_101398503 0.804 NM_000618
NM_001111283
NM_001111285
IGF1


insulin-like growth factor 1 (somatomedin C)


chr2_+_169465995 0.798 NM_001081686
NM_021176
G6PC2

glucose-6-phosphatase, catalytic, 2

chr8_+_26206648 0.789 NM_001177591
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr10_+_70517863 0.773 SRGN
serglycin
chr1_+_50342168 0.760 NM_001144776
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr6_+_135544214 0.734 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr1_+_165564904 0.729 NM_001198783
POU2F1
POU class 2 homeobox 1
chr12_-_101398429 0.724 IGF1
insulin-like growth factor 1 (somatomedin C)
chr10_-_14412813 0.711 NM_018027
FRMD4A
FERM domain containing 4A
chr1_+_165565006 0.709 POU2F1
POU class 2 homeobox 1
chr1_+_50347188 0.707 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr3_+_123279439 0.706 NM_006889
CD86
CD86 molecule
chr5_-_88215034 0.697 NM_001193350
NM_002397
MEF2C

myocyte enhancer factor 2C

chr6_+_88026338 0.683 ZNF292
zinc finger protein 292
chr17_-_1195096 0.681 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr6_+_34312979 0.676 HMGA1
high mobility group AT-hook 1
chr11_-_118405288 0.674 NM_001164280
SLC37A4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr12_-_69434330 0.674 PTPRR
protein tyrosine phosphatase, receptor type, R
chr11_+_7574992 0.672 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr7_+_128802719 0.664 NM_001130722
AHCYL2
adenosylhomocysteinase-like 2
chr5_+_169713458 0.650 NM_001034838
KCNIP1
Kv channel interacting protein 1
chr18_+_55718171 0.645 NM_021127
PMAIP1
phorbol-12-myristate-13-acetate-induced protein 1
chrX_-_137649180 0.642 NM_033642
FGF13
fibroblast growth factor 13
chr9_-_85773899 0.634 HNRNPK
heterogeneous nuclear ribonucleoprotein K
chr12_-_101398470 0.631 IGF1
insulin-like growth factor 1 (somatomedin C)
chr1_-_116185215 0.629 NM_005599
NHLH2
nescient helix loop helix 2
chr20_+_30831298 0.619 NM_175850
DNMT3B
DNA (cytosine-5-)-methyltransferase 3 beta
chr10_-_13789628 0.618 FRMD4A
FERM domain containing 4A
chr17_-_39094787 0.615 NM_001040002
MEOX1
mesenchyme homeobox 1
chr14_+_69307914 0.610 SRSF5
serine/arginine-rich splicing factor 5
chr1_-_149004879 0.610 CTSS
cathepsin S
chr6_+_34312633 0.605 HMGA1
high mobility group AT-hook 1
chr5_-_88235624 0.595 NM_001131005
NM_001193347
MEF2C

myocyte enhancer factor 2C

chr15_-_91078307 0.593 FAM174B
family with sequence similarity 174, member B
chr4_+_114433551 0.569 ANK2
ankyrin 2, neuronal
chr3_+_157877146 0.560 NM_001184718
TIPARP
TCDD-inducible poly(ADP-ribose) polymerase
chr6_-_87861492 0.548 NM_000735
CGA
glycoprotein hormones, alpha polypeptide
chrX_-_135690699 0.547 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr5_+_128468785 0.545 ISOC1
isochorismatase domain containing 1
chr12_-_101398288 0.535 IGF1
insulin-like growth factor 1 (somatomedin C)
chr15_+_56217686 0.518 NM_020980
AQP9
aquaporin 9
chr1_+_196874867 0.516 PTPRC
protein tyrosine phosphatase, receptor type, C
chr4_-_123761615 0.515 NM_021803
IL21
interleukin 21
chr1_-_150653351 0.510 NM_016190
CRNN
cornulin
chr6_+_32515596 0.505 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr11_+_75203859 0.503 NM_003369
UVRAG
UV radiation resistance associated gene
chr11_+_75203884 0.498 UVRAG
UV radiation resistance associated gene
chr12_+_52105131 0.496 AMHR2
anti-Mullerian hormone receptor, type II
chr5_-_169657395 0.492 NM_005565
LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr9_+_12683385 0.491 NM_000550
TYRP1
tyrosinase-related protein 1
chr6_+_34312641 0.479 HMGA1
high mobility group AT-hook 1
chr1_+_50347176 0.478 NM_001144774
NM_021952
ELAVL4

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)

chr20_+_2224612 0.465 NM_003245
TGM3
transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)
chrX_+_119622570 0.463 NM_001137554
MCTS1
malignant T cell amplified sequence 1
chr10_-_101680645 0.459 DNMBP
dynamin binding protein
chr12_-_101036407 0.458 NM_024057
NUP37
nucleoporin 37kDa
chr3_+_89239494 0.454 EPHA3
EPH receptor A3
chr12_-_23995109 0.449 SOX5
SRY (sex determining region Y)-box 5
chr4_+_146250978 0.449 ABCE1
ATP-binding cassette, sub-family E (OABP), member 1
chr6_+_34313007 0.447 HMGA1
high mobility group AT-hook 1
chr6_-_154719560 0.439 NM_001130700
NM_015553
IPCEF1

interaction protein for cytohesin exchange factors 1

chr2_+_161980865 0.439 NM_006593
TBR1
T-box, brain, 1
chr17_-_46479127 0.438 SPAG9
sperm associated antigen 9
chr1_+_154386358 0.435 NM_001193301
SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr12_-_6103945 0.435 NM_000552
VWF
von Willebrand factor
chr16_+_55373241 0.429 NUP93
nucleoporin 93kDa
chr4_-_151990061 0.423 LRBA
LPS-responsive vesicle trafficking, beach and anchor containing
chr3_+_195336625 0.422 NM_005524
HES1
hairy and enhancer of split 1, (Drosophila)
chr3_+_88270951 0.421 NM_018293
ZNF654
zinc finger protein 654
chr4_-_176970895 0.418 GPM6A
glycoprotein M6A
chr8_-_40874485 0.417 NM_001135731
NM_024645
ZMAT4

zinc finger, matrin-type 4

chr2_+_161981046 0.416 TBR1
T-box, brain, 1
chrX_+_28515479 0.411 NM_014271
IL1RAPL1
interleukin 1 receptor accessory protein-like 1
chr6_+_34312625 0.398 NM_145901
NM_145902
HMGA1

high mobility group AT-hook 1

chr5_+_137701122 0.398 NM_001135647
FAM53C
family with sequence similarity 53, member C
chr15_+_87432699 0.396 ABHD2
abhydrolase domain containing 2
chr6_-_32742265 0.390 NM_002123
HLA-DQB1
major histocompatibility complex, class II, DQ beta 1
chr2_+_161981138 0.380 TBR1
T-box, brain, 1
chr18_+_30812205 0.378 NM_001143827
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr8_-_102029997 0.378 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr3_+_154362726 0.377 RAP2B
RAP2B, member of RAS oncogene family
chr12_+_8167494 0.373 NM_016184
NM_194447
NM_194448
NM_194450
CLEC4A



C-type lectin domain family 4, member A



chr1_+_42934910 0.370 YBX1
Y box binding protein 1
chr18_-_30057166 0.368 NOL4
nucleolar protein 4
chr12_+_49155798 0.368 LARP4
La ribonucleoprotein domain family, member 4
chr14_+_100365162 0.365 MEG3
maternally expressed 3 (non-protein coding)
chr6_+_26212082 0.363 NM_003542
HIST1H4C
histone cluster 1, H4c
chr11_+_58146721 0.363 NM_000614
CNTF
ciliary neurotrophic factor
chr6_-_55848346 0.362 BMP5
bone morphogenetic protein 5
chr20_+_42463419 0.362 HNF4A
hepatocyte nuclear factor 4, alpha
chr15_-_68177283 0.358 NM_001105192
NM_005078
NM_020908
TLE3


transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)


chr11_+_10433241 0.356 NM_001025389
AMPD3
adenosine monophosphate deaminase 3
chr11_-_33870411 0.355 NM_005574
LMO2
LIM domain only 2 (rhombotin-like 1)
chr15_+_87432735 0.355 ABHD2
abhydrolase domain containing 2
chr14_+_91859289 0.348 NM_153647
SLC24A4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr3_-_120861959 0.340 NM_022135
POPDC2
popeye domain containing 2
chr4_-_176971175 0.339 NM_201591
GPM6A
glycoprotein M6A
chr7_+_68702252 0.339 AUTS2
autism susceptibility candidate 2
chr1_-_198643885 0.336 ZNF281
zinc finger protein 281
chr4_-_41445693 0.335 NM_003924
PHOX2B
paired-like homeobox 2b
chr9_+_117955890 0.334 NM_002581
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr18_+_19826734 0.334 NM_153211
TTC39C
tetratricopeptide repeat domain 39C
chr20_+_42463387 0.331 HNF4A
hepatocyte nuclear factor 4, alpha
chr6_-_112033752 0.329 TRAF3IP2
TRAF3 interacting protein 2
chr13_+_48582389 0.329 NM_014923
FNDC3A
fibronectin type III domain containing 3A
chr3_+_63859114 0.325 NM_001177387
ATXN7
ataxin 7
chr14_+_91858677 0.319 NM_153648
SLC24A4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr6_-_161614962 0.318 NM_020133
AGPAT4
1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)
chr1_-_42157077 0.318 NM_001127714
NM_024503
HIVEP3

human immunodeficiency virus type I enhancer binding protein 3

chr2_-_40510923 0.316 NM_001112800
NM_001112801
NM_021097
SLC8A1


solute carrier family 8 (sodium/calcium exchanger), member 1


chr15_+_87432629 0.315 ABHD2
abhydrolase domain containing 2
chr1_+_50348052 0.315 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr5_+_176744037 0.313 NM_001167579
NM_003052
SLC34A1

solute carrier family 34 (sodium phosphate), member 1

chr12_+_84792203 0.313 NM_006183
NTS
neurotensin
chr7_+_28692122 0.312 NM_001011666
CREB5
cAMP responsive element binding protein 5
chr4_-_83566246 0.306 HNRPDL
heterogeneous nuclear ribonucleoprotein D-like
chr16_-_21221872 0.305 NM_001014444
NM_001888
CRYM

crystallin, mu

chr18_+_13601664 0.300 NM_001003674
NM_001003675
C18orf1

chromosome 18 open reading frame 1

chr1_+_51208499 0.299 CDKN2C
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
chr14_+_31868229 0.294 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6
chr22_+_21006814 0.290


chr12_-_107551783 0.288 NM_003006
SELPLG
selectin P ligand
chr13_+_30207668 0.288 NM_001629
ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr9_-_8723893 0.288 NM_001040712
NM_001171025
NM_130391
NM_130392
NM_130393
PTPRD




protein tyrosine phosphatase, receptor type, D




chr10_-_115603848 0.285 NM_014881
DCLRE1A
DNA cross-link repair 1A
chr11_+_88550687 0.284 NM_000372
TYR
tyrosinase (oculocutaneous albinism IA)
chr1_-_198644111 0.284 ZNF281
zinc finger protein 281
chr20_+_42463350 0.283 HNF4A
hepatocyte nuclear factor 4, alpha
chr12_+_50981915 0.281 NM_002284
KRT86
keratin 86
chr17_-_9870292 0.279 NM_001130831
GAS7
growth arrest-specific 7
chr5_+_140790141 0.275 PCDHGA12
protocadherin gamma subfamily A, 12
chr5_+_176786279 0.273 NM_001004105
NM_001004106
NM_002082
GRK6


G protein-coupled receptor kinase 6


chr4_-_26100986 0.273 NM_000730
CCKAR
cholecystokinin A receptor
chr2_+_128119908 0.271 NM_001161415
NM_001161416
NM_001161417
NM_005291
GPR17



G protein-coupled receptor 17



chr7_+_50318801 0.270 IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr5_-_169657312 0.269 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr16_+_55950195 0.269 NM_002990
CCL22
chemokine (C-C motif) ligand 22
chr20_+_42463279 0.266 NM_000457
NM_178849
NM_178850
HNF4A


hepatocyte nuclear factor 4, alpha


chr6_+_49575629 0.265 NM_001010904
GLYATL3
glycine-N-acyltransferase-like 3
chr8_-_102872372 0.264 NCALD
neurocalcin delta
chr11_-_102001259 0.262 NM_004771
MMP20
matrix metallopeptidase 20
chr12_-_52281050 0.262 NM_001130059
ATF7
activating transcription factor 7
chr7_+_150321771 0.259 NM_001160109
NM_001160110
NM_001160111
NOS3


nitric oxide synthase 3 (endothelial cell)


chr10_+_35456095 0.258 CREM
cAMP responsive element modulator
chr11_+_20577521 0.256 NM_004211
SLC6A5
solute carrier family 6 (neurotransmitter transporter, glycine), member 5
chr7_+_18501876 0.253 NM_014707
NM_178423
HDAC9

histone deacetylase 9

chr10_+_35456393 0.253 NM_181571
NM_183060
CREM

cAMP responsive element modulator

chr3_-_102522093 0.252 NM_016247
IMPG2
interphotoreceptor matrix proteoglycan 2
chr14_-_22496098 0.252 NM_001166269
NM_001166270
NM_017815
HAUS4


HAUS augmin-like complex, subunit 4


chr9_+_115265827 0.252 NM_017790
RGS3
regulator of G-protein signaling 3
chr7_+_115650240 0.251 NM_152829
TES
testis derived transcript (3 LIM domains)
chr6_-_24827265 0.249 NM_030939
C6orf62
chromosome 6 open reading frame 62
chr3_+_138132006 0.248 NM_001190796
NCK1
NCK adaptor protein 1
chr20_+_36365965 0.246 NM_001725
BPI
bactericidal/permeability-increasing protein
chr6_+_16251260 0.245 MYLIP
myosin regulatory light chain interacting protein
chr6_-_112034166 0.242 NM_001164281
NM_147686
TRAF3IP2

TRAF3 interacting protein 2

chr1_+_74473672 0.242 NM_015978
TNNI3K
TNNI3 interacting kinase
chrX_-_123925343 0.242 NM_001163278
NM_001163279
NM_014253
ODZ1


odz, odd Oz/ten-m homolog 1(Drosophila)


chr18_-_30057512 0.240 NM_001198546
NM_001198548
NM_003787
NOL4


nucleolar protein 4


chr6_-_55848317 0.239 NM_021073
BMP5
bone morphogenetic protein 5

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.36 7.60e-05 GO:0032501 multicellular organismal process
1.42 3.14e-04 GO:0032502 developmental process
1.75 8.66e-04 GO:0003008 system process
1.42 1.48e-03 GO:0007275 multicellular organismal development
1.40 9.75e-03 GO:0048856 anatomical structure development
1.43 1.05e-02 GO:0048731 system development
2.20 3.47e-02 GO:0007600 sensory perception
1.74 4.57e-02 GO:0050877 neurological system process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
10.21 3.44e-03 GO:0042613 MHC class II protein complex
13.62 2.78e-02 GO:0033162 melanosome membrane
13.62 2.78e-02 GO:0045009 chitosome

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.92 2.24e-04 GO:0001071 nucleic acid binding transcription factor activity
1.92 2.24e-04 GO:0003700 sequence-specific DNA binding transcription factor activity
1.98 3.77e-03 GO:0043565 sequence-specific DNA binding
1.43 4.71e-02 GO:0003677 DNA binding