Motif ID: ALX1.p2

Z-value: 1.332


Transcription factors associated with ALX1.p2:

Gene SymbolEntrez IDGene Name
ALX1 8092 ALX homeobox 1



Activity profile for motif ALX1.p2.

activity profile for motif ALX1.p2


Sorted Z-values histogram for motif ALX1.p2

Sorted Z-values for motif ALX1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ALX1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_-_53444733 3.119 NM_001184901
NM_001184903
NM_014959
CARD8


caspase recruitment domain family, member 8


chr2_-_224974954 2.362 NM_001122779
NM_024785
FAM124B

family with sequence similarity 124B

chr21_-_38792173 1.570 NM_001136155
NM_182918
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr5_+_61910318 1.421 NM_181506
LRRC70
leucine rich repeat containing 70
chr5_+_147775652 1.373 FBXO38
F-box protein 38
chr4_-_38534802 1.271 NM_006068
TLR6
toll-like receptor 6
chr12_-_9913199 1.150 CLEC2B
C-type lectin domain family 2, member B
chr7_-_115458047 1.046 TFEC
transcription factor EC
chr7_-_115458010 1.044 NM_001018058
NM_012252
TFEC

transcription factor EC

chr7_+_22733290 0.982 NM_000600
IL6
interleukin 6 (interferon, beta 2)
chr17_+_63766874 0.950 NM_014960
ARSG
arylsulfatase G
chr2_+_102320148 0.926 NM_003856
IL1RL1
interleukin 1 receptor-like 1
chr7_+_143043871 0.914 NM_001130026
FAM115C
family with sequence similarity 115, member C
chr7_-_149960218 0.907 GIMAP6
GTPase, IMAP family member 6
chr12_-_9913724 0.903 NM_005127
CLEC2B
C-type lectin domain family 2, member B
chr1_-_197173159 0.844 LOC100131234
familial acute myelogenous leukemia related factor
chr12_-_52939584 0.842 NM_001127322
CBX5
chromobox homolog 5
chr14_-_19252330 0.839 NM_001197287
OR11H2
olfactory receptor, family 11, subfamily H, member 2
chr12_-_52939636 0.813 NM_001127321
CBX5
chromobox homolog 5
chr13_-_98757634 0.787 NM_004951
GPR183
G protein-coupled receptor 183
chr6_+_27215039 0.786 NM_003495
HIST1H4I
histone cluster 1, H4i
chr7_-_107667728 0.766 NM_001037132
NRCAM
neuronal cell adhesion molecule
chr20_+_31717964 0.763 NM_001024675
C20orf134
chromosome 20 open reading frame 134
chr5_+_162862808 0.724 NM_182796
MAT2B
methionine adenosyltransferase II, beta
chr5_+_76470829 0.691


chr6_+_153060722 0.690 NM_025107
MYCT1
myc target 1
chr4_+_43185 0.663 NM_182524
ZNF595
ZNF718
zinc finger protein 595
zinc finger protein 718
chr17_-_44006808 0.656 NM_002146
HOXB3
homeobox B3
chr3_-_170347019 0.645 NM_001105078
MECOM
MDS1 and EVI1 complex locus
chr10_+_94584449 0.643 NM_001013848
EXOC6
exocyst complex component 6
chr5_+_40877053 0.618 NM_032587
CARD6
caspase recruitment domain family, member 6
chr7_+_73826244 0.617 NM_000265
NCF1
NCF1B
NCF1C
neutrophil cytosolic factor 1
neutrophil cytosolic factor 1B pseudogene
neutrophil cytosolic factor 1C pseudogene
chr8_-_125252884 0.580 C8orf78
chromosome 8 open reading frame 78
chr1_-_114215768 0.570 NM_001193431
NM_012411
NM_015967
PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chr9_-_116608113 0.554 NM_005118
TNFSF15
tumor necrosis factor (ligand) superfamily, member 15
chrX_+_107174855 0.553 NM_001170553
NM_182607
VSIG1

V-set and immunoglobulin domain containing 1

chr21_-_26867138 0.545 NM_052954
CYYR1
cysteine/tyrosine-rich 1
chr17_-_26665220 0.538 NM_006495
EVI2B
ecotropic viral integration site 2B
chr17_-_26665194 0.537 EVI2B
ecotropic viral integration site 2B
chr9_+_124416768 0.537 NM_012364
OR1Q1
olfactory receptor, family 1, subfamily Q, member 1
chr7_-_149960612 0.533 NM_024711
GIMAP6
GTPase, IMAP family member 6
chr8_-_86477585 0.531 NM_001128829
NM_001128830
NM_001128831
NM_001738
CA1



carbonic anhydrase I



chr4_+_55956520 0.525


chr8_+_98772537 0.523 MTDH
metadherin
chr14_+_100365390 0.521 MEG3
maternally expressed 3 (non-protein coding)
chr10_-_21226536 0.518 NM_006393
NEBL
nebulette
chr10_+_35524060 0.515 NM_182717
NM_182718
NM_182719
NM_182720
CREM



cAMP responsive element modulator



chr3_-_170864111 0.515 NM_004991
MECOM
MDS1 and EVI1 complex locus
chr17_-_26665213 0.509 EVI2B
ecotropic viral integration site 2B
chr11_-_104274606 0.491 NM_001191016
CASP12
caspase 12 (gene/pseudogene)
chr19_-_4510713 0.490 SEMA6B
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
chr4_-_70661018 0.489 NM_014465
SULT1B1
sulfotransferase family, cytosolic, 1B, member 1
chr7_-_25234582 0.482 NM_022150
NPVF
neuropeptide VF precursor
chr12_+_9871343 0.476 NM_016523
KLRF1
killer cell lectin-like receptor subfamily F, member 1
chr11_+_5610060 0.474 NM_130390
TRIM34
tripartite motif containing 34
chr1_-_67039518 0.473 NM_005478
INSL5
insulin-like 5
chr7_+_77307382 0.470 NM_001127357
NM_001127359
NM_020432
PHTF2


putative homeodomain transcription factor 2


chr20_-_1420004 0.448 SIRPB2
signal-regulatory protein beta 2
chr18_+_28023984 0.446 NM_005925
MEP1B
meprin A, beta
chr5_-_139706357 0.442 NM_001945
HBEGF
heparin-binding EGF-like growth factor
chr7_-_115458064 0.437 TFEC
transcription factor EC
chrX_+_114734074 0.431 NM_001136025
NM_001172335
PLS3

plastin 3

chr8_-_130868315 0.426 NM_031415
GSDMC
gasdermin C
chr17_+_18566060 0.420 NM_001037330
TRIM16L
tripartite motif containing 16-like
chr2_+_37282516 0.419 LOC100505876
hypothetical LOC100505876
chr6_-_50045296 0.418 NM_001037729
DEFB113
defensin, beta 113
chr3_-_25654659 0.404 TOP2B
topoisomerase (DNA) II beta 180kDa
chr7_-_112545840 0.403 LOC401397
hypothetical LOC401397
chr17_-_26665144 0.402 EVI2B
ecotropic viral integration site 2B
chr14_+_19473606 0.401 NM_001004063
OR4K1
olfactory receptor, family 4, subfamily K, member 1
chr1_+_166516901 0.397 NM_005149
TBX19
T-box 19
chr3_+_184453907 0.387 B3GNT5
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
chr6_-_31007905 0.387 NM_205854
SFTA2
surfactant associated 2
chr19_+_49147219 0.384 NM_013359
ZNF221
zinc finger protein 221
chr14_-_34414603 0.376 NM_013448
NM_182648
BAZ1A

bromodomain adjacent to zinc finger domain, 1A

chr11_-_10546654 0.374 NM_006691
LYVE1
lymphatic vessel endothelial hyaluronan receptor 1
chrX_-_10504852 0.373 NM_001193277
MID1
midline 1 (Opitz/BBB syndrome)
chr4_-_91979113 0.373 NM_183049
TMSL3
thymosin-like 3
chr8_+_107807415 0.373 NM_001198534
NM_001198535
OXR1

oxidation resistance 1

chrX_-_23835868 0.371 NM_024122
APOO
apolipoprotein O
chr3_-_113495763 0.370 NM_183061
SLC9A10
solute carrier family 9, member 10
chr4_-_72868598 0.365 NM_000583
GC
group-specific component (vitamin D binding protein)
chr12_+_15590811 0.361 PTPRO
protein tyrosine phosphatase, receptor type, O
chr20_-_1420126 0.361 SIRPB2
signal-regulatory protein beta 2
chr16_-_4836198 0.355 GLYR1
glyoxylate reductase 1 homolog (Arabidopsis)
chr7_-_112545847 0.353 LOC401397
hypothetical LOC401397
chr16_+_28993770 0.349 RRN3P2
RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 2
chr9_+_27099138 0.344 NM_000459
TEK
TEK tyrosine kinase, endothelial
chr20_+_34019942 0.338 NM_080834
C20orf152
chromosome 20 open reading frame 152
chr6_+_26359805 0.338 NM_003524
HIST1H2BH
histone cluster 1, H2bh
chr1_-_156923111 0.337 NM_003126
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chrX_+_154764136 0.336 NM_001145149
NM_001185183
NM_005638
VAMP7


vesicle-associated membrane protein 7


chr11_+_5602782 0.336 NM_021616
TRIM34
tripartite motif containing 34
chr1_+_194887630 0.334 NM_000186
NM_001014975
CFH

complement factor H

chr19_+_15699833 0.333 NM_013939
OR10H2
olfactory receptor, family 10, subfamily H, member 2
chr4_-_123761615 0.328 NM_021803
IL21
interleukin 21
chr4_-_120462705 0.323 NM_000134
FABP2
fatty acid binding protein 2, intestinal
chr9_+_106496480 0.322 NM_001004484
OR13D1
olfactory receptor, family 13, subfamily D, member 1
chr12_+_53177758 0.321 NM_005337
NCKAP1L
NCK-associated protein 1-like
chr6_-_10939095 0.320 NM_005906
MAK
male germ cell-associated kinase
chr9_+_79158164 0.319 VPS13A
vacuolar protein sorting 13 homolog A (S. cerevisiae)
chr14_+_100365162 0.318 MEG3
maternally expressed 3 (non-protein coding)
chr10_-_42183441 0.316 LOC283027
hypothetical protein LOC283027
chr5_+_70980724 0.309 MCCC2
methylcrotonoyl-CoA carboxylase 2 (beta)
chr3_+_122769467 0.309 NM_001012659
ARGFX
arginine-fifty homeobox
chr19_+_57564981 0.305 NM_001145434
ZNF880
zinc finger protein 880
chr16_+_87687734 0.300 NM_001127214
NM_174917
ACSF3

acyl-CoA synthetase family member 3

chr7_-_102070473 0.300 NM_001114403
UPK3BL
POLR2J2
uroplakin 3B-like
polymerase (RNA) II (DNA directed) polypeptide J2
chr1_+_12149662 0.299 TNFRSF1B
tumor necrosis factor receptor superfamily, member 1B
chr11_+_5667494 0.298 NM_006074
TRIM22
tripartite motif containing 22
chr1_+_117345894 0.297 NM_004258
CD101
CD101 molecule
chr14_+_20306425 0.295 NM_022360
EDDM3B
epididymal protein 3B
chr10_+_49279647 0.295 NM_002750
NM_139046
NM_139047
NM_139049
MAPK8



mitogen-activated protein kinase 8



chr10_+_43187095 0.294 NM_001184963
NM_173160
FXYD4

FXYD domain containing ion transport regulator 4

chr7_+_143423073 0.293 NM_001004135
OR2A12
olfactory receptor, family 2, subfamily A, member 12
chr13_-_40454360 0.291 NM_001145353
ELF1
E74-like factor 1 (ets domain transcription factor)
chr2_-_207291364 0.290 NM_001093730
DYTN
dystrotelin
chr9_+_124835608 0.288 RABGAP1
GPR21
RAB GTPase activating protein 1
G protein-coupled receptor 21
chr19_-_34395947 0.287 NM_006003
UQCRFS1
ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
chr5_+_81636921 0.284 NM_001017971
ATP6AP1L
ATPase, H+ transporting, lysosomal accessory protein 1-like
chr6_-_31756119 0.280 NM_025262
LY6G5C
lymphocyte antigen 6 complex, locus G5C
chr11_-_5212168 0.279 NM_000519
HBD
hemoglobin, delta
chr1_+_190394214 0.277 NM_130782
RGS18
regulator of G-protein signaling 18
chr16_+_87687763 0.276 ACSF3
acyl-CoA synthetase family member 3
chr3_+_63238854 0.274 NM_001130003
SYNPR
synaptoporin
chr13_-_22905822 0.273 NM_014363
SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr2_-_63518589 0.268 NM_001042692
WDPCP
WD repeat containing planar cell polarity effector
chr1_-_42738535 0.268 TMSB4XP1
thymosin beta 4, X-linked pseudogene 1
chr1_-_155788775 0.266 NM_001195388
NM_031281
FCRL5

Fc receptor-like 5

chr12_-_25041639 0.263 NM_001101339
C12orf77
chromosome 12 open reading frame 77
chr5_+_57823017 0.261 NM_152687
GAPT
GRB2-binding adaptor protein, transmembrane
chr7_-_98983924 0.261 FAM200A
family with sequence similarity 200, member A
chr1_+_12149637 0.257 NM_001066
TNFRSF1B
tumor necrosis factor receptor superfamily, member 1B
chr21_-_44899003 0.256 NM_198698
KRTAP12-4
keratin associated protein 12-4
chr1_-_89414310 0.255 NM_207398
GBP7
guanylate binding protein 7
chr2_-_87102453 0.253 NM_002665
NM_001032392
PLGLB2
PLGLB1
plasminogen-like B2
plasminogen-like B1
chr3_-_197726587 0.250 NM_001077657
C3orf43
chromosome 3 open reading frame 43
chr11_-_123695302 0.249 NM_001002918
OR8D2
olfactory receptor, family 8, subfamily D, member 2
chr5_-_142795269 0.248 NM_001018074
NM_001018075
NM_001018077
NR3C1


nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


chr8_-_111056099 0.247 NM_014379
KCNV1
potassium channel, subfamily V, member 1
chr1_+_156991133 0.247 NM_001005184
OR6K6
olfactory receptor, family 6, subfamily K, member 6
chr10_+_90414125 0.245 NM_001198828
NM_001198829
NM_001198830
NM_004190
LIPF



lipase, gastric



chr1_-_156954528 0.244 NM_001005327
OR6K3
olfactory receptor, family 6, subfamily K, member 3
chr10_-_69095362 0.244 NM_001127384
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr18_+_45342398 0.244 NM_006033
LIPG
lipase, endothelial
chr1_+_559618 0.241


chr12_+_53177806 0.241 NCKAP1L
NCK-associated protein 1-like
chr12_+_53177789 0.241 NCKAP1L
NCK-associated protein 1-like
chr1_+_195010552 0.237 NM_001166624
NM_021023
CFHR3

complement factor H-related 3

chr9_-_27287106 0.236 NM_001161585
NM_020641
C9orf11

chromosome 9 open reading frame 11

chr3_+_8750485 0.233 NM_033337
NM_001234
CAV3

caveolin 3

chr7_-_113346284 0.229 NM_002711
PPP1R3A
protein phosphatase 1, regulatory (inhibitor) subunit 3A
chr11_+_63282639 0.229 RTN3
reticulon 3
chr12_+_9033403 0.229 NM_005810
KLRG1
killer cell lectin-like receptor subfamily G, member 1
chr14_-_105542441 0.228 IGLJ3
IGHA1
IGHG1
IGHM
immunoglobulin lambda joining 3
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr7_-_81237162 0.227 NM_000601
NM_001010931
NM_001010932
NM_001010933
NM_001010934
HGF




hepatocyte growth factor (hepapoietin A; scatter factor)




chr3_+_64645819 0.227 LOC100507098
hypothetical LOC100507098
chr20_+_57729659 0.226 NM_183244
NM_183246
PHACTR3

phosphatase and actin regulator 3

chr19_-_34395861 0.226 UQCRFS1
ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
chr9_-_106407728 0.225 NM_001004481
OR13C2
olfactory receptor, family 13, subfamily C, member 2
chrX_-_6156655 0.225 NM_181332
NLGN4X
neuroligin 4, X-linked
chr11_+_59580630 0.225 NM_001031666
NM_001031809
NM_006138
MS4A3


membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)


chr19_+_2279628 0.222 NM_001077238
NM_152988
SPPL2B

signal peptide peptidase-like 2B

chr2_+_225973845 0.220 NM_020864
KIAA1486
KIAA1486
chr13_-_37070862 0.220 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr7_-_92615593 0.219 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr2_-_144991556 0.218 ZEB2
zinc finger E-box binding homeobox 2
chr4_-_38710376 0.217 NM_024943
TMEM156
transmembrane protein 156
chr20_-_1420168 0.217 NM_001122962
NM_001134836
SIRPB2

signal-regulatory protein beta 2

chr7_-_107930170 0.215 PNPLA8
patatin-like phospholipase domain containing 8
chr18_+_20294590 0.215 NM_001143828
NM_001160166
NM_021624
HRH4


histamine receptor H4


chr9_+_102380156 0.215 NM_001018116
MURC
muscle-related coiled-coil protein
chr20_+_56912146 0.214 GNAS
GNAS complex locus
chr5_-_94442941 0.212 MCTP1
multiple C2 domains, transmembrane 1
chr3_+_35658852 0.209 NM_016300
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr4_-_164754106 0.209 NM_017923
MARCH1
membrane-associated ring finger (C3HC4) 1
chr4_-_186815116 0.209 NM_001145674
NM_001145675
SORBS2

sorbin and SH3 domain containing 2

chr11_+_120478584 0.207 NM_005422
TECTA
tectorin alpha
chr11_-_59707074 0.206 NM_022349
NM_152851
NM_152852
MS4A6A


membrane-spanning 4-domains, subfamily A, member 6A


chrX_+_51562894 0.206 NM_001005332
MAGED1
melanoma antigen family D, 1
chr9_-_21358005 0.205 NM_006900
IFNA1
IFNA13
interferon, alpha 1
interferon, alpha 13
chr16_+_4842077 0.205 NM_016936
UBN1
ubinuclein 1
chr11_+_93940121 0.205 NM_152431
PIWIL4
piwi-like 4 (Drosophila)
chr19_-_44518516 0.203 NM_004877
GMFG
glia maturation factor, gamma
chr17_+_31195760 0.202 TAF15
TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
chr2_-_188127430 0.200 NM_001032281
NM_006287
TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

chr4_-_186814852 0.198 SORBS2
sorbin and SH3 domain containing 2
chr1_-_191341866 0.198 NM_016066
GLRX2
glutaredoxin 2
chr11_+_113351006 0.195 NM_000869
NM_213621
HTR3A

5-hydroxytryptamine (serotonin) receptor 3A

chr4_-_100431093 0.195 NM_000667
ADH1A
alcohol dehydrogenase 1A (class I), alpha polypeptide
chr4_+_71713324 0.194 NM_031889
ENAM
enamelin
chr1_+_154120170 0.193 SYT11
synaptotagmin XI
chr17_+_59875623 0.192 NM_001085423
C17orf60
chromosome 17 open reading frame 60
chr20_+_33223434 0.192 NM_006404
PROCR
protein C receptor, endothelial
chr2_+_28572441 0.189 NM_001170585
NM_153021
PLB1

phospholipase B1

chr22_-_37211467 0.189 DDX17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chr11_-_76800525 0.187 PAK1
p21 protein (Cdc42/Rac)-activated kinase 1
chr1_+_234624266 0.187 NM_145861
EDARADD
EDAR-associated death domain
chr10_+_5976354 0.187 NM_032807
FBXO18
F-box protein, helicase, 18
chr12_-_29828958 0.186 NM_175861
TMTC1
transmembrane and tetratricopeptide repeat containing 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.37 1.75e-16 GO:0007606 sensory perception of chemical stimulus
3.45 2.01e-15 GO:0007608 sensory perception of smell
2.55 9.70e-14 GO:0007600 sensory perception
1.89 4.09e-08 GO:0050877 neurological system process
1.70 2.10e-06 GO:0003008 system process
1.78 2.35e-02 GO:0006955 immune response

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.35 8.31e-09 GO:0031224 intrinsic to membrane
1.36 1.29e-08 GO:0016021 integral to membrane
1.42 4.51e-08 GO:0005886 plasma membrane
1.41 4.59e-08 GO:0071944 cell periphery
1.26 5.83e-06 GO:0044425 membrane part
1.52 6.20e-05 GO:0005576 extracellular region
1.55 3.38e-02 GO:0044421 extracellular region part

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.62 3.97e-17 GO:0004984 olfactory receptor activity
2.04 5.39e-16 GO:0004872 receptor activity
2.59 1.04e-15 GO:0004930 G-protein coupled receptor activity
2.20 7.95e-15 GO:0004888 transmembrane receptor activity
1.83 4.02e-13 GO:0004871 signal transducer activity
1.83 4.02e-13 GO:0060089 molecular transducer activity
2.61 5.10e-03 GO:0005125 cytokine activity
12.98 5.78e-03 GO:0005132 interferon-alpha/beta receptor binding
2.58 1.34e-02 GO:0005126 cytokine receptor binding