ISMARA results for ENCODE cell lines, H3K27ac, averaged replicates (Ernst 2011)

ISMARA - Integrated System for Motif Actitivity Response Analysis is a free online tool that recognizes most important transcription factors that are changing their activity in a set of samples.

Averaging sample configuration

Sample Condition
Rep1_GM12878 GM12878
Rep1_HMEC HMEC
Rep1_HSMM HSMM
Rep1_HepG2 HepG2
Rep1_Huvec Huvec
Rep1_K562 K562
Rep1_NHEK NHEK
Rep1_NHLF NHLF
Rep2_GM12878 GM12878
Rep2_HMEC HMEC
Rep2_HSMM HSMM
Rep2_HepG2 HepG2
Rep2_Huvec Huvec
Rep2_K562 K562
Rep2_NHEK NHEK
Rep2_NHLF NHLF

All motifs sorted by activity significance

Motif name Z-value Associated genes Profile Logo
RFX1..5_RFXANK_RFXAP.p2 10.466 RFX1 (EF-C)
RFXAP
RFX5
RFXANK (BLS, RFX-B, ANKRA1, F14150_1, MGC138628)
RFX4
RFX3
RFX2 (FLJ14226)
HNF1A.p2 9.830 HNF1A (HNF1, LFB1)
HNF4A_NR2F1,2.p2 8.856 NR2F1 (EAR-3, COUP-TFI, TCFCOUP1, SVP44)
NR2F2 (COUP-TFII, COUPTFB, SVP40)
HNF4A (NR2A1, HNF4)
IRF1,2,7.p3 8.627 IRF1 (MAR, IRF-1)
IRF2 (IRF-2, DKFZp686F0244)
IRF7 (IRF7A, IRF-7H)
SNAI1..3.p2 8.545 SNAI2 (SLUGH1)
SNAI1 (SNA, SLUGH2, SNAH)
SNAI3 (SMUC, Zfp293)
FOS_FOS{B,L1}_JUN{B,D}.p2 8.160 FOS (c-fos, AP-1)
JUNB
FOSL1 (fra-1)
JUND (AP-1)
FOSB (G0S3, GOSB, GOS3, AP-1, MGC42291, DKFZp686C0818)
TEAD1.p2 6.275 TEAD1 (TEF-1)
TEAD2 (ETF, TEF4, TEF-4, TEAD-2)
TEAD3 (TEF5, TEAD5, TEF-5, DTEF-1, ETFR-1, TEAD-3)
TEAD4 (TEF3, RTEF1, TEF-3, EFTR-2, TEFR-1, TCF13L1, hRTEF-1B)
GATA6.p2 5.916 GATA6
MYOD1.p2 5.593 MYOD1 (PUM, MYOD, bHLHc1)
PITX1..3.p2 5.571 PITX2 (IGDS, RS, Brx1, Otlx2, ARP1)
PITX3
PITX1 (PTX1, POTX)
NFKB1_REL_RELA.p2 5.506 RELA (p65)
REL (I-Rel)
NFKB1 (KBF1, p105)
RUNX1..3.p2 5.419 RUNX1 (PEBP2A2, AMLCR1)
RUNX3 (AML2, PEBP2A3)
RUNX2 (AML3, PEBP2A1, PEBP2aA1)
NRF1.p2 5.376 NRF1 (EWG, ALPHA-PAL)
SPIB.p2 5.014 SPIB (SPI-B)
KLF4.p3 4.930 KLF4 (EZF, GKLF)
SPI1.p2 4.917 SPI1 (PU.1, SPI-A, OF, SFPI1, SPI-1)
ZEB1.p2 4.591 ZEB1 (BZP, ZEB, AREB6, NIL-2-A, Zfhep, Zfhx1a)
ESRRA.p2 4.469 ESRRA (ERR1, ERRalpha, NR3B1, ERRa)
TLX1..3_NFIC{dimer}.p2 4.469 TLX1
TLX3 (RNX)
HBP1_HMGB_SSRP1_UBTF.p2 4.398 HMGB2
HMGB3 (HMG2A, MGC90319)
SSRP1 (FACT80)
UBTF (UBF, NOR-90)
HBP1
ZNF143.p2 4.204 ZNF143 (SBF, pHZ-1, STAF)
ATF5_CREB3.p2 4.172 ATF5
CREB3 (LZIP, Luman)
ELK1,4_GABP{A,B1}.p3 4.032 GABPA (E4TF1A, NFT2, NRF2, E4TF1-60, NRF2A)
GABPB1 (E4TF1-47, GABPB)
ELK4 (SAP1)
ELK1
NFY{A,B,C}.p2 3.886 NFYC (CBF-C)
NFYB (CBF-A, HAP3)
NFYA (HAP2, CBF-B)
HLF.p2 3.872 HLF (MGC33822)
E2F1..5.p2 3.814 E2F4 (E2F-4)
E2F5
E2F2 (E2F-2)
E2F1 (RBP3)
E2F3
HOX{A6,A7,B6,B7}.p2 3.795 HOXB6
HOXA7
HOXB7
HOXA6
MYB.p2 3.672 MYB (c-myb)
FOXA2.p3 3.642 FOXA2
SRF.p3 3.553 SRF (MCM1)
DMAP1_NCOR{1,2}_SMARC.p2 3.496 SMARCA1 (SNF2LB, NURF140, ISWI, SWI)
SMARCC2 (BAF170, Rsc8, CRACC2)
SMARCA5 (hSNF2H, hISWI, ISWI)
NCOR1 (N-CoR, hCIT529I10, TRAC1, hN-CoR, KIAA1047, MGC104216)
NCOR2 (SMRT, SMRTE, TRAC-1, CTG26, TNRC14)
DMAP1 (DNMAP1, FLJ11543, KIAA1425, DNMTAP1, EAF2, SWC4)
RXR{A,B,G}.p2 3.444 RXRA (NR2B1)
RXRB (NR2B2, H-2RIIBP, RCoR-1)
RXRG (NR2B3)
bHLH_family.p2 3.425 ARNTL (MOP3, JAP3, BMAL1, PASD3, bHLHe5)
MITF (WS2A, MI, bHLHe32)
MXI1 (MXD2, MAD2, MXI, bHLHc11)
TFE3 (TFEA, bHLHe33)
CLOCK (KIAA0334, KAT13D, bHLHe8)
OLIG2 (RACK17, OLIGO2, bHLHe19)
MXD4 (MAD4, MSTP149, MST149, bHLHc12)
HEY2 (bHLHb32)
HEY1 (HESR-1, CHF2, HESR1, HRT-1, CHF-2, HERP2, BHLHb31)
HEYL (bHLHb33)
MLXIPL (WS-bHLH, MIO, CHREBP, MONDOB)
HES6 (bHLHc23)
MXD3 (MAD3, bHLHc13)
ARNTL2 (BMAL2, MOP9, CLIF, PASD9, bHLHe6)
ID1 (dJ857M17.1.2, bHLHb24)
MNT (ROX, MXD6, MAD6, bHLHd3)
OLIG1 (BHLHB6, bHLHe21)
NPAS2 (MOP4, PASD4, bHLHe9)
ETS1,2.p2 3.308 ETS2
ETS1 (FLJ10768, ETS-1)
ARNT_ARNT2_BHLHB2_MAX_MYC_USF1.p2 3.234 ARNT (HIF-1beta, bHLHe2)
MAX (bHLHd4)
MYC (c-Myc, bHLHe39)
USF1 (UEF, MLTFI, bHLHb11)
BHLHB2 (DEC1, bHLHe40)
ARNT2 (KIAA0307, bHLHe1)
ATF6.p2 3.231 ATF6 (ATF6A)
PATZ1.p2 3.212 PATZ1 (MAZR, dJ400N23, ZBTB19, ZSG, RIAZ, PATZ)
MAZ.p2 3.202 MAZ (ZF87, Pur-1, Zif87, ZNF801)
PAX5.p2 3.199 PAX5 (BSAP)
POU2F1..3.p2 3.171 POU2F2 (OCT2)
POU2F1 (OCT1)
POU2F3 (OCT11, PLA-1, Skn-1a, Epoc-1)
TCF4_dimer.p2 3.143 TCF4 (E2-2, ITF2, PTHS, SEF2, SEF2-1, SEF2-1A, SEF2-1B, bHLHb19, MGC149723, MGC149724)
NFE2L2.p2 3.104 NFE2L2 (NRF2)
GATA1..3.p2 3.069 GATA1 (ERYF1, NFE1)
GATA2 (NFE1B)
GATA3 (HDR)
XBP1.p3 3.044 XBP1
EN1,2.p2 3.042 EN1
EN2
LEF1_TCF7_TCF7L1,2.p2 3.021 TCF7 (TCF-1)
TCF7L2 (TCF-4)
LEF1 (TCF1ALPHA)
TCF7L1
MTF1.p2 3.007 MTF1
LMO2.p2 2.984 LMO2 (TTG2, RHOM2, RBTN2)
NKX3-2.p2 2.968 NKX3-2 (NKX3B, NKX3.2)
PRDM1.p3 2.948 PRDM1 (PRDI-BF1)
ZIC1..3.p2 2.936 ZIC1 (ZIC, ZNF201)
ZIC2 (HPE5)
ZIC3 (HTX, ZNF203)
TFAP2{A,C}.p2 2.919 TFAP2C (AP2-GAMMA, ERF1, TFAP2G, hAP-2g)
TFAP2A (AP-2)
YY1.p2 2.906 YY1 (NF-E1, DELTA, UCRBP, YIN-YANG-1, INO80S)
RREB1.p2 2.851 RREB1 (HNT)
NHLH1,2.p2 2.837 NHLH1 (NSCL, NSCL1, bHLHa35)
NHLH2 (NSCL2, bHLHa34)
ONECUT1,2.p2 2.836 ONECUT2 (OC-2)
ONECUT1 (HNF-6)
GFI1B.p2 2.791 GFI1B
KLF12.p2 2.777 KLF12 (AP-2rep, HSPC122, AP2REP)
HAND1,2.p2 2.769 HAND1 (eHand, Thing1, Hxt, bHLHa27)
HAND2 (dHand, Thing2, Hed, bHLHa26)
EP300.p2 2.684 EP300 (p300, KAT3B)
FEV.p2 2.670 FEV (PET-1, HSRNAFEV)
NFATC1..3.p2 2.571 NFATC3 (NFAT4, NFATX)
NFATC2 (NF-ATP, NFATp, NFAT1)
NFATC1 (NF-ATC, NFATc, NFAT2)
NFIX.p2 2.565 NFIX (NF1A)
DBP.p2 2.533 DBP (DABP)
MAFB.p2 2.529 MAFB
ZNF238.p2 2.518 ZNF238 (C2H2-171, TAZ-1, RP58, ZBTB18)
NFE2L1.p2 2.507 NFE2L1 (NRF1, LCR-F1, FLJ00380, TCF11)
FOX{D1,D2}.p2 2.502 FOXD2 (FREAC9)
FOXD1 (FREAC4)
TFEB.p2 2.501 TFEB
MSX1,2.p2 2.470 MSX1 (HYD1, OFC5)
MSX2 (CRS2, FPP, HOX8, MSH, PFM)
CEBPA,B_DDIT3.p2 2.385 DDIT3 (CHOP10, GADD153, CHOP)
CEBPA (C/EBP-alpha)
CEBPB (LAP, CRP2, NFIL6, IL6DBP)
MZF1.p2 2.336 MZF1 (MZF1B, ZSCAN6, MZF-1, Zfp98)
NR5A1,2.p2 2.293 NR5A1 (FTZ1, SF-1, ELP, AD4BP)
NR5A2 (FTZ-F1beta, hB1F, LRH-1, FTZ-F1, hB1F-2, B1F2)
STAT2,4,6.p2 2.290 STAT2 (STAT113)
STAT4
STAT6 (D12S1644, IL-4-STAT)
GTF2I.p2 2.257 GTF2I (TFII-I, BAP-135, SPIN, BTKAP1, DIWS, IB291)
SOX{8,9,10}.p2 2.253 SOX9 (SRA1)
SOX8
SOX10 (DOM, WS4, WS2E)
ATF4.p2 2.228 ATF4 (TAXREB67, CREB-2)
CTCF.p2 2.167 CTCF
PBX1.p2 2.146 PBX1
HES1.p2 2.143 HES1 (FLJ20408, HES-1, Hes1, bHLHb39)
ELF1,2,4.p2 2.143 ELF2 (EU32, NERF, NERF-2, NERF-1A, NERF-1B)
ELF1
ELF4 (MEF, ELFR)
TBP.p2 2.109 TBP (TFIID)
EHF.p2 2.109 EHF
TGIF1.p2 2.083 TGIF1
MYFfamily.p2 2.075 MYOD1 (PUM, MYOD, bHLHc1)
MYF6 (MRF4, bHLHc4)
MYF5 (bHLHc2)
MYOG (bHLHc3)
ZNF384.p2 2.034 ZNF384 (CAGH1A, CIZ, NMP4, NP)
JUN.p2 2.033 JUN (c-Jun, AP-1)
JUND (AP-1)
JUNB
PAX2.p2 2.016 PAX2
TFAP2B.p2 2.010 TFAP2B (AP2-B)
CREB1.p2 1.986 CREB1
NFE2.p2 1.984 NFE2 (NF-E2)
ZNF423.p2 1.984 ZNF423 (KIAA0760, OAZ, Roaz, Ebfaz, Zfp104)
NR1H4.p2 1.973 NR1H4 (FXR, RIP14, HRR1, HRR-1)
FOXQ1.p2 1.957 FOXQ1 (HFH1)
GFI1.p2 1.933 GFI1
TFAP4.p2 1.931 TFAP4 (AP-4)
TBX4,5.p2 1.918 TBX5
TBX4
SMAD1..7,9.p2 1.891 SMAD5 (Dwfc, JV5-1)
SMAD1 (MADR1, JV4-1)
SMAD3 (JV15-2, HsT17436)
SMAD4 (DPC4)
SMAD2 (MADR2, JV18-1)
SMAD6 (HsT17432)
SMAD7
SMAD9
FOX{F1,F2,J1}.p2 1.882 FOXF2 (FREAC2)
FOXJ1 (HFH-4, HFH4)
FOXF1 (FREAC1)
BPTF.p2 1.881 BPTF (FAC1, NURF301)
FOX{I1,J2}.p2 1.874 FOXI1 (FREAC6)
FOXJ2 (FHX)
STAT5{A,B}.p2 1.873 STAT5B
STAT5A (MGF)
PAX4.p2 1.862 PAX4
FOXO1,3,4.p2 1.845 FOXO1 (FKH1)
FOXO4 (AFX1)
FOXO3 (AF6q21, FOXO2)
POU5F1.p2 1.828 POU5F1 (OCT3, Oct4, MGC22487)
MEF2{A,B,C,D}.p2 1.821 MEF2A (RSRFC4, RSRFC9)
MEF2C
MEF2D
MEF2BNB-MEF2B (MEF2B, LOC729991-MEF2B)
MEF2B (RSRFR2, FLJ32648)
RXRG_dimer.p3 1.821 NR1H2 (NER, NER-I, RIP15, LXR-b)
RXRA (NR2B1)
PPARG (PPARG1, PPARG2, NR1C3, PPARgamma)
PPARA (hPPAR, NR1C1)
RXRB (NR2B2, H-2RIIBP, RCoR-1)
RXRG (NR2B3)
FOSL2.p2 1.811 FOSL2 (FRA2, FLJ23306)
TFCP2.p2 1.789 TFCP2 (CP2, LSF, LBP-1C, TFCP2C)
ZNF148.p2 1.770 ZNF148 (BERF-1, ZBP-89, BFCOL1, HT-BETA, ZFP148, pHZ-52)
HIC1.p2 1.768 HIC1 (ZBTB29)
FOXN1.p2 1.753 FOXN1 (FKHL20)
ZFP161.p2 1.733 ZFP161 (ZNF478, ZBTB14)
HOX{A4,D4}.p2 1.731 HOXA4
HOXD4
HIF1A.p2 1.720 HIF1A (MOP1, HIF-1alpha, PASD8, HIF1)
FOXL1.p2 1.710 FOXL1 (FREAC7, FKH6)
TFDP1.p2 1.676 TFDP1 (Dp-1, DRTF1, DP1)
NANOG{mouse}.p2 1.647 NANOG (FLJ12581, FLJ40451)
EBF1.p2 1.646 EBF1 (OLF1)
SRY.p2 1.605 SRY (TDF)
GTF2A1,2.p2 1.602 GTF2A1 (TFIIA)
GTF2A2 (TFIIA, HsT18745)
EGR1..3.p2 1.596 EGR3 (PILOT)
EGR1 (TIS8, G0S30, NGFI-A, KROX-24, ZIF-268, AT225, ZNF225)
EGR2
PRRX1,2.p2 1.573 PRRX2 (PRX2, PMX2)
PRRX1 (PHOX1)
HOXA9_MEIS1.p2 1.548 MEIS1
HOXA9
POU5F1_SOX2{dimer}.p2 1.532 POU5F1 (OCT3, Oct4, MGC22487)
SOX2
SOX17.p2 1.516 SOX17
ESR1.p2 1.513 ESR1 (NR3A1, Era)
ZBTB16.p2 1.511 ZBTB16 (PLZF)
EOMES.p2 1.498 EOMES (TBR2)
BACH2.p2 1.483 BACH2
IKZF1.p2 1.475 IKZF1 (hIk-1, LyF-1, Hs.54452, IKAROS)
SOX5.p2 1.474 SOX5 (L-SOX5, MGC35153)
SREBF1,2.p2 1.473 SREBF1 (SREBP1, bHLHd1)
SREBF2 (SREBP2, bHLHd2)
CRX.p2 1.448 CRX (CRD, LCA7, OTX3)
NKX3-1.p2 1.428 NKX3-1 (NKX3.1, BAPX2)
POU1F1.p2 1.423 POU1F1 (GHF-1)
ZBTB6.p2 1.423 ZBTB6 (ZID)
RXRA_VDR{dimer}.p2 1.413 VDR (NR1I1)
FOXD3.p2 1.403 FOXD3 (Genesis, HFH2)
FOXP3.p2 1.400 FOXP3 (JM2, XPID, AIID, PIDX, DIETER, SCURFIN)
AIRE.p2 1.358 AIRE (PGA1, APS1)
HOX{A5,B5}.p2 1.345 HOXB5
HOXA5
IKZF2.p2 1.335 IKZF2 (Helios)
ALX1.p2 1.332 ALX1
NKX2-1,4.p2 1.331 NKX2-1 (TTF-1)
NKX2-4 (NKX2.4)
SP1.p2 1.331 SP1
NANOG.p2 1.329 NANOG (FLJ12581, FLJ40451)
STAT1,3.p3 1.329 STAT1 (STAT91, ISGF-3)
STAT3 (APRF)
HSF1,2.p2 1.300 HSF1 (HSTF1)
HSF2
ATF2.p2 1.271 ATF2 (TREB7, CRE-BP1, HB16)
HMX1.p2 1.241 HMX1 (H6, NKX5-3)
NR3C1.p2 1.232 NR3C1 (GR)
TP53.p2 1.217 TP53 (p53, LFS1)
EWSR1-FLI1.p2 1.213 FLI1 (EWSR2, SIC-1)
EWSR1 (EWS, K984G1.4)
ARID5B.p2 1.207 ARID5B (FLJ21150, MRF2)
MYBL2.p2 1.187 MYBL2 (BMYB, B-MYB)
EVI1.p2 1.187 EVI1 (MDS1-EVI1, PRDM3)
CDC5L.p2 1.184 CDC5L (PCDC5RP, hCDC5, CEF1)
SPZ1.p2 1.169 SPZ1 (NYD-TSP1, FLJ25709)
AHR_ARNT_ARNT2.p2 1.139 ARNT (HIF-1beta, bHLHe2)
AHR
ARNT2 (KIAA0307, bHLHe1)
T.p2 1.121 T
SOX2.p2 1.120 SOX2
POU3F1..4.p2 1.100 POU3F1 (OCT6, SCIP)
POU3F3 (BRN1, OTF8)
POU3F2 (POUF3, BRN2, OCT7)
POU3F4 (BRN4, OTF9)
NKX2-2,8.p2 1.100 NKX2-2 (NKX2.2)
NKX2-8 (NKX2.8, Nkx2-9)
FOX{C1,C2}.p2 1.069 FOXC1 (FREAC3, ARA, IGDA, IHG1)
FOXC2 (MFH-1)
GZF1.p2 1.061 GZF1 (dJ322G13.2, ZBTB23)
PPARG.p2 1.045 PPARG (PPARG1, PPARG2, NR1C3, PPARgamma)
NKX6-1,2.p2 1.027 NKX6-1 (Nkx6.1)
NKX6-2 (NKX6B, GTX, NKX6.1)
POU6F1.p2 1.015 POU6F1 (BRN5, MPOU, TCFB1)
CUX2.p2 1.006 CUX2 (KIAA0293, CDP2)
HMGA1,2.p2 0.958 HMGA1
HMGA2 (BABL, LIPO)
REST.p3 0.940 REST (NRSF, XBR)
NKX2-3_NKX2-5.p2 0.929 NKX2-5 (CSX1, NKX2.5, NKX4-1)
NKX2-3 (NKX2.3, CSX3, NKX4-3)
VSX1,2.p2 0.928 VSX2 (RET1)
VSX1 (PPD)
AR.p2 0.923 AR (AIS, NR3C4, SMAX1, HUMARA)
PDX1.p2 0.893 PDX1 (IDX-1, STF-1, PDX-1, MODY4)
ADNP_IRX_SIX_ZHX.p2 0.872 SIX5
ZHX1
IRX4
ADNP (KIAA0784, ADNP1)
ZHX3 (KIAA0395)
ZHX2 (KIAA0854)
IRX5 (IRX-2a)
SIX2
TAL1_TCF{3,4,12}.p2 0.859 TCF3 (E2A, ITF1, MGC129647, MGC129648, bHLHb21)
TCF4 (SEF2-1B, ITF2, bHLHb19)
TAL1 (SCL, bHLHa17)
TCF12 (HEB, HTF4, HsT17266, bHLHb20)
TLX2.p2 0.795 TLX2 (Enx, Tlx2, NCX)
CDX1,2,4.p2 0.775 CDX1
CDX2
CDX4
RBPJ.p2 0.734 RBPJ (SUH, IGKJRB, RBPJK, KBF2, RBP-J, CBF1)
GLI1..3.p2 0.716 GLI1
GLI2 (THP2, HPE9, THP1)
GLI3 (PAP-A, PAPA, PAPA1, PAPB, ACLS, PPDIV)
RORA.p2 0.655 RORA (RZRA, ROR1, ROR2, ROR3, NR1F1)
LHX3,4.p2 0.639 LHX3
LHX4 (Gsh4)
NFIL3.p2 0.563 NFIL3 (E4BP4, NFIL3A, NF-IL3A)
PAX6.p2 0.552 PAX6 (D11S812E, AN, WAGR)
NR6A1.p2 0.322 NR6A1 (GCNF1, RTR)
PAX3,7.p2 0.302 PAX7 (Hup1)
PAX3 (HUP2)
PAX8.p2 0.242 PAX8

All samples sorted alphabetically


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Sample name Condition Replicate/Batch
GM12878
HepG2
HMEC
HSMM
Huvec
K562
NHEK
NHLF