Motif ID: HES1.p2

Z-value: 2.143


Transcription factors associated with HES1.p2:

Gene SymbolEntrez IDGene Name
HES1 3280 hairy and enhancer of split 1, (Drosophila)



Activity profile for motif HES1.p2.

activity profile for motif HES1.p2


Sorted Z-values histogram for motif HES1.p2

Sorted Z-values for motif HES1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HES1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr18_+_18969724 3.279 NM_001100619
CABLES1
Cdk5 and Abl enzyme substrate 1
chr16_+_66153810 1.836 NM_001191022
NM_006565
CTCF

CCCTC-binding factor (zinc finger protein)

chr21_-_45786709 1.636 NM_194255
SLC19A1
solute carrier family 19 (folate transporter), member 1
chr3_+_129690735 1.605


chr22_-_27405708 1.535 NM_001145418
TTC28
tetratricopeptide repeat domain 28
chr17_+_37941715 1.501 NAGLU
N-acetylglucosaminidase, alpha
chr10_+_92912676 1.409 PCGF5
polycomb group ring finger 5
chr19_-_10474767 1.399 NM_203500
KEAP1
kelch-like ECH-associated protein 1
chr17_+_37941790 1.340 NAGLU
N-acetylglucosaminidase, alpha
chr19_-_10475083 1.329 KEAP1
kelch-like ECH-associated protein 1
chr7_+_98084531 1.323 NM_002523
NPTX2
neuronal pentraxin II
chr17_+_37941476 1.279 NM_000263
NAGLU
N-acetylglucosaminidase, alpha
chr3_+_51403760 1.264 NM_013286
RBM15B
RNA binding motif protein 15B
chr7_+_149696263 1.262 REPIN1
replication initiator 1
chr2_-_10506033 1.262 ODC1
ornithine decarboxylase 1
chr5_+_75734759 1.256 NM_006633
IQGAP2
IQ motif containing GTPase activating protein 2
chr2_+_10101822 1.238 NM_001177718
KLF11
Kruppel-like factor 11
chr2_-_10505902 1.168 NM_002539
ODC1
ornithine decarboxylase 1
chr11_-_67645246 1.166 CHKA
choline kinase alpha
chr12_+_6893751 1.160 NM_001975
ENO2
enolase 2 (gamma, neuronal)
chr2_+_242289983 1.160 NM_032329
ING5
inhibitor of growth family, member 5
chr10_+_92970487 1.150 PCGF5
polycomb group ring finger 5
chr10_+_92970302 1.148 NM_032373
PCGF5
polycomb group ring finger 5
chr17_-_77094426 1.118 ACTG1
actin, gamma 1
chr11_-_67153959 1.109 NM_181843
NUDT8
nudix (nucleoside diphosphate linked moiety X)-type motif 8
chr19_+_1199548 1.094 NM_177401
MIDN
midnolin
chr19_-_10474266 1.075 NM_012289
KEAP1
kelch-like ECH-associated protein 1
chr2_+_75039273 1.061 NM_019896
POLE4
polymerase (DNA-directed), epsilon 4 (p12 subunit)
chr9_-_135922912 1.057 NM_007371
BRD3
bromodomain containing 3
chr7_+_149696792 1.053 NM_001099695
NM_001099696
NM_013400
REPIN1


replication initiator 1


chr6_-_125664913 1.026 NM_016063
HDDC2
HD domain containing 2
chr11_+_67836575 1.016 NM_002335
LRP5
low density lipoprotein receptor-related protein 5
chr16_+_30617962 1.015 NM_006662
SRCAP
Snf2-related CREBBP activator protein
chr7_-_5536704 1.014 NM_001101
ACTB
actin, beta
chr19_-_1352474 1.014 NM_000156
NM_138924
GAMT

guanidinoacetate N-methyltransferase

chr20_-_62151216 1.010 NM_018419
SOX18
SRY (sex determining region Y)-box 18
chr20_-_61728866 1.002 GMEB2
glucocorticoid modulatory element binding protein 2
chr6_-_13922525 0.995 NM_001031713
CCDC90A
coiled-coil domain containing 90A
chr7_-_23476156 0.994


chr16_-_67723971 0.985 CHTF8
CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae)
chr1_+_9522107 0.984 NM_032315
SLC25A33
solute carrier family 25, member 33
chr6_-_163754903 0.981 LOC100526820
hypothetical LOC100526820
chr2_+_128175413 0.963 SFT2D3
SFT2 domain containing 3
chr7_-_47588266 0.951 TNS3
tensin 3
chr19_-_48815853 0.945 NM_182498
ZNF428
zinc finger protein 428
chr16_-_87244896 0.943 NM_000101
CYBA
cytochrome b-245, alpha polypeptide
chr7_-_47588160 0.940 TNS3
tensin 3
chr3_+_38470782 0.930 NM_001106
ACVR2B
activin A receptor, type IIB
chr7_+_93977267 0.913 CASD1
CAS1 domain containing 1
chr7_+_149696901 0.906 REPIN1
replication initiator 1
chr5_-_32480486 0.899 ZFR
zinc finger RNA binding protein
chr4_-_10068055 0.896 NM_053042
ZNF518B
zinc finger protein 518B
chr11_-_74740298 0.896 NM_004041
NM_020251
ARRB1

arrestin, beta 1

chr6_+_57145292 0.895 BAG2
BCL2-associated athanogene 2
chr1_+_9522133 0.893 SLC25A33
solute carrier family 25, member 33
chr1_-_32574185 0.889 NM_023009
MARCKSL1
MARCKS-like 1
chr21_-_43368963 0.888 NM_000071
CBS
cystathionine-beta-synthase
chr7_-_150408785 0.885 FASTK
Fas-activated serine/threonine kinase
chr17_-_77094375 0.884 NM_001614
ACTG1
actin, gamma 1
chr1_+_165865953 0.883 NM_052862
RCSD1
RCSD domain containing 1
chr2_-_45090025 0.879 NM_016932
SIX2
SIX homeobox 2
chr6_+_17708483 0.878 NM_016255
FAM8A1
family with sequence similarity 8, member A1
chr12_-_105057940 0.858 NM_014840
NUAK1
NUAK family, SNF1-like kinase, 1
chr4_+_57469122 0.856 REST
RE1-silencing transcription factor
chr15_+_39573363 0.855 NM_002220
ITPKA
inositol 1,4,5-trisphosphate 3-kinase A
chr6_-_143874463 0.854 NM_032020
FUCA2
fucosidase, alpha-L- 2, plasma
chr20_+_55399847 0.853 NM_017495
NM_183425
RBM38

RNA binding motif protein 38

chr6_-_35216981 0.852 NM_001093728
NM_018679
TCP11

t-complex 11 homolog (mouse)

chr7_-_148212310 0.848 EZH2
enhancer of zeste homolog 2 (Drosophila)
chr7_-_148212336 0.844 NM_004456
NM_152998
EZH2

enhancer of zeste homolog 2 (Drosophila)

chr7_-_148212312 0.836 EZH2
enhancer of zeste homolog 2 (Drosophila)
chr19_+_1055614 0.833 NM_001039848
GPX4
glutathione peroxidase 4 (phospholipid hydroperoxidase)
chr20_+_34635362 0.825 NM_021809
TGIF2
TGFB-induced factor homeobox 2
chr5_-_32480586 0.824 NM_016107
ZFR
zinc finger RNA binding protein
chr7_-_148212230 0.821 EZH2
enhancer of zeste homolog 2 (Drosophila)
chr20_-_34635091 0.817


chr17_+_63799228 0.809 ARSG
arylsulfatase G
chr17_-_1341599 0.809 NM_033375
MYO1C
myosin IC
chr16_+_30015243 0.801


chr10_-_95350949 0.800 NM_006744
RBP4
retinol binding protein 4, plasma
chr16_-_85974810 0.793 NM_024735
FBXO31
F-box protein 31
chr20_-_62081434 0.790 NM_080621
SAMD10
sterile alpha motif domain containing 10
chr22_-_20419975 0.787 NM_013313
YPEL1
yippee-like 1 (Drosophila)
chr16_+_85982884 0.785 MAP1LC3B
microtubule-associated protein 1 light chain 3 beta
chr16_+_2465109 0.785 NM_020705
TBC1D24
TBC1 domain family, member 24
chr3_-_127558747 0.783 NM_014079
KLF15
Kruppel-like factor 15
chr20_+_34667624 0.775 C20orf24
chromosome 20 open reading frame 24
chr5_+_95093267 0.772


chr15_-_72513311 0.771 NM_001146029
NM_003612
SEMA7A

semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)

chr16_-_1369613 0.767 NM_001193389
NM_023076
UNKL

unkempt homolog (Drosophila)-like

chr18_+_2645885 0.762 NM_015295
SMCHD1
structural maintenance of chromosomes flexible hinge domain containing 1
chr11_+_63337498 0.762 NM_138471
C11orf84
chromosome 11 open reading frame 84
chr4_+_57469907 0.757 REST
RE1-silencing transcription factor
chr19_+_3310138 0.753 NM_205843
NFIC
nuclear factor I/C (CCAAT-binding transcription factor)
chr17_+_72880831 0.753 NM_001113493
SEPT9
septin 9
chr10_-_43464157 0.747 NM_001005368
ZNF32
zinc finger protein 32
chr17_-_1478859 0.746 NM_152346
SLC43A2
solute carrier family 43, member 2
chr2_+_176702667 0.740 NM_019558
HOXD8
homeobox D8
chr18_+_586997 0.738 NM_014410
CLUL1
clusterin-like 1 (retinal)
chr5_-_132194488 0.734 NM_001172700
SHROOM1
shroom family member 1
chr16_+_67723988 0.733 NM_032830
CIRH1A
cirrhosis, autosomal recessive 1A (cirhin)
chr21_-_37284351 0.732 NM_000411
HLCS
holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
chr1_+_164063276 0.729 NM_012474
UCK2
uridine-cytidine kinase 2
chr12_-_31635089 0.726 NM_144973
DENND5B
DENN/MADD domain containing 5B
chr16_+_15397120 0.725 MPV17L
MPV17 mitochondrial membrane protein-like
chr16_-_4406608 0.725 CORO7
coronin 7
chr5_+_176806401 0.724 NM_001174101
NM_030567
PRR7

proline rich 7 (synaptic)

chr20_-_61728774 0.723 NM_012384
GMEB2
glucocorticoid modulatory element binding protein 2
chr17_-_73636362 0.723 TMC6
transmembrane channel-like 6
chr16_-_4406596 0.720 CORO7
coronin 7
chr6_-_125664770 0.720 HDDC2
HD domain containing 2
chr16_+_67724023 0.719 CIRH1A
cirrhosis, autosomal recessive 1A (cirhin)
chr20_-_31725821 0.719 NECAB3
N-terminal EF-hand calcium binding protein 3
chr12_+_2939250 0.713 TEAD4
TEA domain family member 4
chr9_+_130504782 0.708 PKN3
protein kinase N3
chr17_+_43374021 0.706 PNPO
pyridoxamine 5'-phosphate oxidase
chr20_-_61317891 0.704 NM_017798
YTHDF1
YTH domain family, member 1
chr3_-_129690056 0.703 NM_001145661
GATA2
GATA binding protein 2
chr17_-_73636386 0.701 NM_001127198
TMC6
transmembrane channel-like 6
chr2_-_242096673 0.694 NM_006374
STK25
serine/threonine kinase 25
chr20_+_30871357 0.692 NM_012325
MAPRE1
microtubule-associated protein, RP/EB family, member 1
chr19_+_748448 0.690 PTBP1
polypyrimidine tract binding protein 1
chr19_-_44032202 0.688 HNRNPL
heterogeneous nuclear ribonucleoprotein L
chr19_+_34994701 0.684 NM_001238
CCNE1
cyclin E1
chr9_-_85761451 0.681 C9orf64
chromosome 9 open reading frame 64
chr16_-_960982 0.681 NM_022773
LMF1
lipase maturation factor 1
chr16_-_4604895 0.680 NM_145253
FAM100A
family with sequence similarity 100, member A
chr22_-_37481925 0.680 SUN2
Sad1 and UNC84 domain containing 2
chr14_+_102313566 0.680 NM_003300
NM_145725
NM_145726
TRAF3


TNF receptor-associated factor 3


chr16_+_387176 0.680 NM_005009
NME4
non-metastatic cells 4, protein expressed in
chr5_-_132141368 0.679 NM_001098813
SEPT8
septin 8
chr2_+_223244606 0.678 NM_058165
MOGAT1
monoacylglycerol O-acyltransferase 1
chr7_-_150408824 0.676 NM_006712
NM_033015
FASTK

Fas-activated serine/threonine kinase

chr20_+_30871438 0.675 MAPRE1
microtubule-associated protein, RP/EB family, member 1
chr20_-_31725915 0.672 NM_031231
NM_031232
NECAB3

N-terminal EF-hand calcium binding protein 3

chr13_-_19997914 0.669 NM_015974
CRYL1
crystallin, lambda 1
chr19_+_54309423 0.665 NM_022165
LIN7B
lin-7 homolog B (C. elegans)
chr17_-_77422526 0.665 ARHGDIA
Rho GDP dissociation inhibitor (GDI) alpha
chr5_+_95092384 0.661 NM_014899
RHOBTB3
Rho-related BTB domain containing 3
chr11_-_67645433 0.660 NM_001277
NM_212469
CHKA

choline kinase alpha

chr16_-_4604781 0.659 FAM100A
family with sequence similarity 100, member A
chr16_-_65775326 0.658 NM_001040715
KIAA0895L
KIAA0895-like
chr20_-_7948370 0.657 NM_021156
TMX4
thioredoxin-related transmembrane protein 4
chr7_+_93976927 0.651 NM_022900
CASD1
CAS1 domain containing 1
chr9_-_85761472 0.651 NM_032307
C9orf64
chromosome 9 open reading frame 64
chr19_+_35124951 0.646 NM_003796
NM_134447
C19orf2

chromosome 19 open reading frame 2

chr20_+_34667605 0.643 C20orf24
chromosome 20 open reading frame 24
chr17_-_3546108 0.643 P2RX5-TAX1BP3
P2RX5
P2RX5-TAX1BP3 read-through transcript
purinergic receptor P2X, ligand-gated ion channel, 5
chr7_-_45927263 0.642 NM_000598
NM_001013398
IGFBP3

insulin-like growth factor binding protein 3

chr2_+_61146866 0.639 NM_032506
KIAA1841
KIAA1841
chr8_-_11242408 0.639 LOC100129129
hypothetical LOC100129129
chr22_-_22440054 0.638 NM_213720
CHCHD10
coiled-coil-helix-coiled-coil-helix domain containing 10
chr1_+_36046373 0.638 NM_017629
EIF2C4
eukaryotic translation initiation factor 2C, 4
chr16_-_88084387 0.635 NM_013275
ANKRD11
ankyrin repeat domain 11
chr1_-_1700088 0.627 NM_001198993
NADK
NAD kinase
chr19_+_748452 0.627 PTBP1
polypyrimidine tract binding protein 1
chr16_-_4406571 0.625 CORO7-PAM16
CORO7
CORO7-PAM16 read-through transcript
coronin 7
chr21_+_44377913 0.625 NM_004649
NM_198155
C21orf33

chromosome 21 open reading frame 33

chr15_+_83160914 0.623 NM_020778
ALPK3
alpha-kinase 3
chr22_-_37481403 0.623 SUN2
Sad1 and UNC84 domain containing 2
chr19_+_54309443 0.622 LIN7B
lin-7 homolog B (C. elegans)
chr20_+_34667597 0.621 C20orf24
chromosome 20 open reading frame 24
chr5_-_133368288 0.621 VDAC1
voltage-dependent anion channel 1
chr16_+_2742677 0.618 SRRM2
serine/arginine repetitive matrix 2
chr11_+_63337421 0.614 C11orf84
chromosome 11 open reading frame 84
chr16_-_65774904 0.613 KIAA0895L
KIAA0895-like
chr22_-_37481857 0.612 NM_015374
SUN2
Sad1 and UNC84 domain containing 2
chr1_-_233879617 0.612 NM_001098722
GNG4
guanine nucleotide binding protein (G protein), gamma 4
chr5_-_172594691 0.612 NM_001166175
NM_001166176
NM_004387
NKX2-5


NK2 transcription factor related, locus 5 (Drosophila)


chr22_-_49311439 0.609 NM_001169110
SCO2
SCO cytochrome oxidase deficient homolog 2 (yeast)
chr16_+_83291055 0.608 NM_005153
USP10
ubiquitin specific peptidase 10
chr6_+_31976754 0.605 NM_001178063
C2
complement component 2
chr8_-_12657339 0.603 NM_152271
LONRF1
LON peptidase N-terminal domain and ring finger 1
chrX_-_18282698 0.602 NM_006089
SCML2
sex comb on midleg-like 2 (Drosophila)
chr19_+_59385930 0.601 NM_024075
TSEN34
tRNA splicing endonuclease 34 homolog (S. cerevisiae)
chr7_-_149651594 0.600 NM_001164458
ACTR3C
ARP3 actin-related protein 3 homolog C (yeast)
chr4_-_2233606 0.597 MXD4
MAX dimerization protein 4
chr2_+_10360471 0.597 NM_002149
HPCAL1
hippocalcin-like 1
chr5_-_1547872 0.597 LPCAT1
lysophosphatidylcholine acyltransferase 1
chr7_+_149651202 0.595 NM_001142928
NM_023942
LRRC61

leucine rich repeat containing 61

chr17_+_43373887 0.594 NM_018129
PNPO
pyridoxamine 5'-phosphate oxidase
chr21_-_39642880 0.594 NM_004965
HMGN1
high-mobility group nucleosome binding domain 1
chr20_+_34667566 0.592 NM_018840
NM_199483
C20orf24

chromosome 20 open reading frame 24

chr9_+_36126710 0.591 NM_022343
GLIPR2
GLI pathogenesis-related 2
chr15_+_83326317 0.591 PDE8A
phosphodiesterase 8A
chr17_-_77422561 0.589 NM_001185078
NM_004309
ARHGDIA

Rho GDP dissociation inhibitor (GDI) alpha

chrX_-_7076146 0.588 NM_001135565
NM_001178135
NM_001178136
NM_012080
HDHD1



haloacid dehalogenase-like hydrolase domain containing 1



chr12_+_100615530 0.588 NM_020244
CHPT1
choline phosphotransferase 1
chr19_+_55045754 0.584 PTOV1
prostate tumor overexpressed 1
chr6_+_89912464 0.583 NM_001010853
PM20D2
peptidase M20 domain containing 2
chr7_+_149651481 0.583 LRRC61
leucine rich repeat containing 61
chr20_+_34667590 0.577 C20orf24
chromosome 20 open reading frame 24
chr17_-_77411803 0.577 NM_000918
P4HB
prolyl 4-hydroxylase, beta polypeptide
chr9_+_36126667 0.576 GLIPR2
GLI pathogenesis-related 2
chr2_-_236741352 0.576 NM_001485
GBX2
gastrulation brain homeobox 2
chr7_+_142205266 0.575


chr14_+_99507848 0.574 EVL
Enah/Vasp-like
chr17_-_77488258 0.574 NM_006907
NM_153824
PYCR1

pyrroline-5-carboxylate reductase 1

chr17_-_59131210 0.573 NM_030576
LIMD2
LIM domain containing 2
chr4_+_57468792 0.571 NM_005612
REST
RE1-silencing transcription factor

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.28 4.11e-24 GO:0044237 cellular metabolic process
1.23 3.19e-20 GO:0008152 metabolic process
1.25 1.29e-18 GO:0044238 primary metabolic process
1.32 4.08e-18 GO:0044260 cellular macromolecule metabolic process
1.12 5.45e-15 GO:0009987 cellular process
1.26 3.02e-14 GO:0043170 macromolecule metabolic process
1.42 4.72e-14 GO:0044249 cellular biosynthetic process
1.35 6.10e-14 GO:0034641 cellular nitrogen compound metabolic process
1.34 1.16e-13 GO:0006807 nitrogen compound metabolic process
1.39 4.45e-13 GO:0009058 biosynthetic process
2.13 1.46e-12 GO:0016568 chromatin modification
1.35 3.86e-11 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.31 4.00e-11 GO:0060255 regulation of macromolecule metabolic process
1.92 6.99e-11 GO:0006325 chromatin organization
1.43 1.21e-10 GO:0006464 protein modification process
1.78 3.34e-10 GO:0051276 chromosome organization
1.41 3.78e-10 GO:0043412 macromolecule modification
1.37 2.30e-09 GO:0090304 nucleic acid metabolic process
1.25 5.54e-09 GO:0019222 regulation of metabolic process
1.60 1.14e-08 GO:0006351 transcription, DNA-dependent
1.27 1.25e-08 GO:0080090 regulation of primary metabolic process
1.26 1.51e-08 GO:0031323 regulation of cellular metabolic process
1.41 1.88e-08 GO:0034645 cellular macromolecule biosynthetic process
1.56 1.89e-08 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.41 2.16e-08 GO:0009059 macromolecule biosynthetic process
1.32 2.25e-08 GO:0010468 regulation of gene expression
1.39 1.14e-07 GO:0016070 RNA metabolic process
1.32 1.54e-07 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.52 3.47e-07 GO:0032774 RNA biosynthetic process
1.30 5.60e-07 GO:0044267 cellular protein metabolic process
1.30 7.73e-07 GO:0010556 regulation of macromolecule biosynthetic process
1.25 8.95e-07 GO:0016043 cellular component organization
1.32 9.68e-07 GO:0051252 regulation of RNA metabolic process
1.14 2.45e-06 GO:0050789 regulation of biological process
1.14 2.49e-06 GO:0050794 regulation of cellular process
1.37 2.59e-06 GO:0006996 organelle organization
1.23 3.35e-06 GO:0071840 cellular component organization or biogenesis
1.64 3.71e-06 GO:0010629 negative regulation of gene expression
1.62 5.48e-06 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.27 5.53e-06 GO:0031326 regulation of cellular biosynthetic process
1.27 6.98e-06 GO:0009889 regulation of biosynthetic process
1.13 9.49e-06 GO:0065007 biological regulation
1.28 1.02e-05 GO:0048522 positive regulation of cellular process
1.49 1.09e-05 GO:0010605 negative regulation of macromolecule metabolic process
1.61 1.72e-05 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.26 1.76e-05 GO:0048518 positive regulation of biological process
1.58 1.85e-05 GO:0007167 enzyme linked receptor protein signaling pathway
1.58 2.09e-05 GO:0010558 negative regulation of macromolecule biosynthetic process
1.60 2.19e-05 GO:0051172 negative regulation of nitrogen compound metabolic process
1.26 2.20e-05 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.64 2.24e-05 GO:0051253 negative regulation of RNA metabolic process
2.12 2.49e-05 GO:0016569 covalent chromatin modification
1.46 2.61e-05 GO:0009892 negative regulation of metabolic process
2.12 3.37e-05 GO:0016570 histone modification
1.32 3.56e-05 GO:0010467 gene expression
1.63 4.28e-05 GO:0045892 negative regulation of transcription, DNA-dependent
1.25 5.14e-05 GO:0051171 regulation of nitrogen compound metabolic process
1.28 7.43e-05 GO:0006355 regulation of transcription, DNA-dependent
1.54 8.65e-05 GO:0009890 negative regulation of biosynthetic process
1.23 9.49e-05 GO:0019538 protein metabolic process
1.36 9.63e-05 GO:0009966 regulation of signal transduction
1.33 1.01e-04 GO:0023051 regulation of signaling
1.54 1.14e-04 GO:0031327 negative regulation of cellular biosynthetic process
1.24 3.30e-04 GO:0071842 cellular component organization at cellular level
1.41 4.62e-04 GO:0032268 regulation of cellular protein metabolic process
1.67 5.88e-04 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.25 6.08e-04 GO:0048519 negative regulation of biological process
1.70 6.15e-04 GO:0044419 interspecies interaction between organisms
1.39 6.24e-04 GO:0051246 regulation of protein metabolic process
1.80 7.87e-04 GO:0010608 posttranscriptional regulation of gene expression
1.26 9.99e-04 GO:0048523 negative regulation of cellular process
1.42 1.07e-03 GO:0031324 negative regulation of cellular metabolic process
1.37 1.28e-03 GO:0010604 positive regulation of macromolecule metabolic process
1.40 1.33e-03 GO:0006793 phosphorus metabolic process
1.40 1.33e-03 GO:0006796 phosphate metabolic process
1.22 1.45e-03 GO:0071841 cellular component organization or biogenesis at cellular level
1.57 1.58e-03 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.36 1.66e-03 GO:0031325 positive regulation of cellular metabolic process
1.62 2.24e-03 GO:0040008 regulation of growth
1.38 2.35e-03 GO:0007049 cell cycle
1.34 2.86e-03 GO:0009893 positive regulation of metabolic process
1.59 4.14e-03 GO:0032583 regulation of gene-specific transcription
1.65 6.10e-03 GO:0018193 peptidyl-amino acid modification
1.42 7.31e-03 GO:0031399 regulation of protein modification process
1.40 1.29e-02 GO:0051128 regulation of cellular component organization
1.61 1.32e-02 GO:0090066 regulation of anatomical structure size
2.10 1.79e-02 GO:0051188 cofactor biosynthetic process
1.39 1.81e-02 GO:0031328 positive regulation of cellular biosynthetic process
1.60 2.19e-02 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.41 2.28e-02 GO:0010557 positive regulation of macromolecule biosynthetic process
1.38 2.38e-02 GO:0016310 phosphorylation
1.45 2.48e-02 GO:0001932 regulation of protein phosphorylation
1.37 2.62e-02 GO:0050793 regulation of developmental process
2.16 2.94e-02 GO:0040029 regulation of gene expression, epigenetic
1.37 3.28e-02 GO:0009891 positive regulation of biosynthetic process
1.42 3.71e-02 GO:0045595 regulation of cell differentiation
1.39 3.94e-02 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.42 3.96e-02 GO:0051254 positive regulation of RNA metabolic process
1.61 4.16e-02 GO:0032535 regulation of cellular component size
1.42 4.18e-02 GO:0010628 positive regulation of gene expression
1.24 4.90e-02 GO:0044281 small molecule metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.19 1.38e-43 GO:0044424 intracellular part
1.18 1.79e-43 GO:0005622 intracellular
1.23 5.93e-35 GO:0043227 membrane-bounded organelle
1.23 8.28e-35 GO:0043231 intracellular membrane-bounded organelle
1.20 2.00e-32 GO:0043226 organelle
1.20 2.74e-32 GO:0043229 intracellular organelle
1.30 1.91e-25 GO:0005634 nucleus
1.19 3.50e-19 GO:0005737 cytoplasm
1.45 9.74e-16 GO:0044428 nuclear part
1.42 7.71e-15 GO:0031974 membrane-enclosed lumen
1.42 1.26e-14 GO:0070013 intracellular organelle lumen
1.23 3.99e-14 GO:0044446 intracellular organelle part
1.41 4.74e-14 GO:0043233 organelle lumen
1.46 1.80e-13 GO:0031981 nuclear lumen
1.22 2.90e-13 GO:0044422 organelle part
1.20 2.90e-12 GO:0044444 cytoplasmic part
1.50 4.01e-11 GO:0005654 nucleoplasm
1.33 5.83e-08 GO:0005829 cytosol
1.05 3.17e-07 GO:0044464 cell part
1.05 3.36e-07 GO:0005623 cell
1.49 3.77e-05 GO:0044451 nucleoplasm part
2.49 4.46e-05 GO:0016585 chromatin remodeling complex
1.32 3.55e-04 GO:0005739 mitochondrion
1.18 4.25e-04 GO:0032991 macromolecular complex
1.19 1.74e-03 GO:0043234 protein complex
4.44 1.24e-02 GO:0016581 NuRD complex
1.68 1.26e-02 GO:0000785 chromatin
1.43 1.40e-02 GO:0005694 chromosome
3.71 1.71e-02 GO:0031519 PcG protein complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.11 7.34e-16 GO:0005488 binding
1.31 1.07e-12 GO:0003676 nucleic acid binding
1.18 1.28e-12 GO:0005515 protein binding
1.37 1.62e-11 GO:0003677 DNA binding
1.38 2.04e-08 GO:0016740 transferase activity
1.51 4.55e-08 GO:0030528 transcription regulator activity
1.58 1.27e-07 GO:0019899 enzyme binding
1.18 2.40e-07 GO:0003824 catalytic activity
1.86 2.68e-06 GO:0016564 transcription repressor activity
1.84 3.05e-06 GO:0016563 transcription activator activity
1.28 4.22e-06 GO:0000166 nucleotide binding
1.33 3.01e-05 GO:0032559 adenyl ribonucleotide binding
1.33 3.57e-05 GO:0030554 adenyl nucleotide binding
1.63 5.95e-05 GO:0016874 ligase activity
1.41 7.52e-05 GO:0001071 nucleic acid binding transcription factor activity
1.41 7.52e-05 GO:0003700 sequence-specific DNA binding transcription factor activity
1.99 9.42e-05 GO:0003682 chromatin binding
1.32 1.00e-04 GO:0005524 ATP binding
2.55 5.94e-04 GO:0042393 histone binding
1.17 8.60e-04 GO:0046872 metal ion binding
1.17 9.17e-04 GO:0043167 ion binding
1.17 1.04e-03 GO:0043169 cation binding
1.25 1.42e-03 GO:0008270 zinc ion binding
1.38 1.74e-03 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.71 2.65e-03 GO:0016881 acid-amino acid ligase activity
1.55 3.01e-03 GO:0019904 protein domain specific binding
1.24 4.01e-03 GO:0032553 ribonucleotide binding
1.24 4.01e-03 GO:0032555 purine ribonucleotide binding
1.22 4.17e-03 GO:0046914 transition metal ion binding
1.24 4.99e-03 GO:0017076 purine nucleotide binding
1.65 5.01e-03 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.24 7.38e-03 GO:0035639 purine ribonucleoside triphosphate binding
1.64 7.42e-03 GO:0008134 transcription factor binding
1.38 7.58e-03 GO:0016301 kinase activity
4.81 7.82e-03 GO:0042974 retinoic acid receptor binding
5.13 1.20e-02 GO:0046965 retinoid X receptor binding
1.39 1.43e-02 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.67 2.90e-02 GO:0019787 small conjugating protein ligase activity
1.38 4.17e-02 GO:0043565 sequence-specific DNA binding