Motif ID: NFE2L1.p2

Z-value: 2.507


Transcription factors associated with NFE2L1.p2:

Gene SymbolEntrez IDGene Name
NFE2L1 4779 nuclear factor (erythroid-derived 2)-like 1



Activity profile for motif NFE2L1.p2.

activity profile for motif NFE2L1.p2


Sorted Z-values histogram for motif NFE2L1.p2

Sorted Z-values for motif NFE2L1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFE2L1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_-_16717887 3.398 BNC2
basonuclin 2
chr15_+_65205107 2.879 NM_001145102
SMAD3
SMAD family member 3
chr20_+_19903778 2.735 RIN2
Ras and Rab interactor 2
chr7_-_27153892 2.727 NM_024014
HOXA6
homeobox A6
chr5_+_148186348 2.486 NM_000024
ADRB2
adrenergic, beta-2-, receptor, surface
chr3_+_29297806 2.338 NM_001003792
NM_001003793
NM_001177711
NM_001177712
NM_014483
RBMS3




RNA binding motif, single stranded interacting protein 3




chr10_-_92671005 2.260 NM_014391
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr1_-_197173159 2.222 LOC100131234
familial acute myelogenous leukemia related factor
chr8_-_108579270 2.171 NM_001146
ANGPT1
angiopoietin 1
chrX_+_86659370 2.131 NM_019117
NM_057162
KLHL4

kelch-like 4 (Drosophila)

chr13_-_98428244 2.069 NM_001130048
NM_001130050
DOCK9

dedicator of cytokinesis 9

chr10_-_92670764 2.023 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr11_-_123353607 2.003 NM_001004474
OR10S1
olfactory receptor, family 10, subfamily S, member 1
chr18_-_63333487 1.957 DSEL
dermatan sulfate epimerase-like
chr12_-_50871953 1.955 NM_001081492
NM_182507
KRT80

keratin 80

chr9_-_14303509 1.913 NFIB
nuclear factor I/B
chr1_-_59020875 1.882 JUN
jun proto-oncogene
chr7_-_27149750 1.826 NM_019102
HOXA5
homeobox A5
chr20_-_22978141 1.802 NM_000361
THBD
thrombomodulin
chr2_-_164300758 1.798 NM_018086
FIGN
fidgetin
chr5_-_54317102 1.794 NM_001135604
NM_007036
ESM1

endothelial cell-specific molecule 1

chr8_-_37847095 1.789 RAB11FIP1
RAB11 family interacting protein 1 (class I)
chr2_-_105381855 1.777 NM_001039492
NM_001450
NM_201555
FHL2


four and a half LIM domains 2


chr16_+_81218074 1.763 NM_001257
CDH13
cadherin 13, H-cadherin (heart)
chr5_-_94443300 1.712 NM_001002796
MCTP1
multiple C2 domains, transmembrane 1
chr9_+_119506446 1.706 TLR4
toll-like receptor 4
chr9_+_119506428 1.643 TLR4
toll-like receptor 4
chr16_+_56219802 1.593 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr1_-_68470585 1.592 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr7_+_150442652 1.571 AGAP3
ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
chr11_-_65860450 1.570 NM_004292
RIN1
Ras and Rab interactor 1
chr11_-_8788765 1.568 NM_213618
ST5
suppression of tumorigenicity 5
chr17_-_37034288 1.558 NM_000422
KRT17
keratin 17
chr16_+_81218142 1.541 CDH13
cadherin 13, H-cadherin (heart)
chr9_+_119506274 1.540 NM_138554
TLR4
toll-like receptor 4
chr2_+_201182187 1.535 AOX1
aldehyde oxidase 1
chr7_-_27108826 1.530 NM_006735
HOXA2
homeobox A2
chr10_+_128583984 1.491 NM_001380
DOCK1
dedicator of cytokinesis 1
chr8_-_102029997 1.468 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr9_-_14303899 1.461 NFIB
nuclear factor I/B
chr3_+_25445071 1.461 RARB
retinoic acid receptor, beta
chr9_-_14303943 1.460 NFIB
nuclear factor I/B
chr12_+_13240987 1.409 EMP1
epithelial membrane protein 1
chr7_+_134114912 1.402 CALD1
caldesmon 1
chr12_+_13240868 1.385 NM_001423
EMP1
epithelial membrane protein 1
chr12_+_13240983 1.382 EMP1
epithelial membrane protein 1
chr3_+_171619346 1.368 NM_005602
CLDN11
claudin 11
chr10_+_123862430 1.363 TACC2
transforming, acidic coiled-coil containing protein 2
chr5_+_34720368 1.360 NM_001145521
NM_001145525
RAI14

retinoic acid induced 14

chr4_+_183302105 1.344 ODZ3
odz, odd Oz/ten-m homolog 3 (Drosophila)
chr6_-_10527772 1.334 NM_001042425
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr12_+_12829807 1.332 NM_030817
APOLD1
apolipoprotein L domain containing 1
chr5_+_52320660 1.327 NM_002203
ITGA2
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
chr11_+_7574992 1.285 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr17_-_36475652 1.263 NM_033184
KRTAP2-4
keratin associated protein 2-4
chr1_-_23393808 1.253 NM_000864
HTR1D
5-hydroxytryptamine (serotonin) receptor 1D
chr5_+_36644187 1.251 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr18_-_51219880 1.225 TCF4
transcription factor 4
chr21_-_35343065 1.215 RUNX1
runt-related transcription factor 1
chrX_+_99786044 1.214 SRPX2
sushi-repeat containing protein, X-linked 2
chr11_+_12652427 1.211 NM_021961
TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr19_-_55008172 1.210 NM_001171937
NM_025129
FUZ

fuzzy homolog (Drosophila)

chrX_+_99785818 1.200 NM_014467
SRPX2
sushi-repeat containing protein, X-linked 2
chr2_-_160764819 1.195 NM_000888
ITGB6
integrin, beta 6
chr12_-_51173238 1.190 NM_005554
KRT6A
keratin 6A
chr4_-_177950658 1.188 NM_005429
VEGFC
vascular endothelial growth factor C
chr17_-_37828643 1.187 NM_012232
PTRF
polymerase I and transcript release factor
chr2_-_101457596 1.172 NM_001145664
RFX8
regulatory factor X, 8
chr15_-_37999519 1.157


chr11_+_12355600 1.140 NM_018222
PARVA
parvin, alpha
chr18_+_54681657 1.133 ZNF532
zinc finger protein 532
chrX_+_106956115 1.123 MID2
midline 2
chr1_-_154205675 1.111 ARHGEF2
Rho/Rac guanine nucleotide exchange factor (GEF) 2
chr3_-_116272911 1.101 NM_001164343
ZBTB20
zinc finger and BTB domain containing 20
chr4_-_75183860 1.087 NM_002089
CXCL2
chemokine (C-X-C motif) ligand 2
chr5_+_35892747 1.068 NM_002185
IL7R
interleukin 7 receptor
chr13_-_32658215 1.054 NM_178007
STARD13
StAR-related lipid transfer (START) domain containing 13
chr9_+_35528628 1.045 NM_001135999
RUSC2
RUN and SH3 domain containing 2
chr7_-_78920806 1.036 NM_012301
MAGI2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr11_-_119504726 1.034 TRIM29
tripartite motif containing 29
chr7_+_116447527 1.031 ST7
suppression of tumorigenicity 7
chr3_-_113842652 1.030 NM_199511
NM_199512
CCDC80

coiled-coil domain containing 80

chr17_-_36996611 1.027 NM_000526
KRT14
keratin 14
chr7_-_27158726 1.022


chr12_+_13045702 1.020 HTR7P1
5-hydroxytryptamine (serotonin) receptor 7 pseudogene 1
chr12_-_119172339 1.009 NM_025157
PXN
paxillin
chr10_+_75343352 1.009 PLAU
plasminogen activator, urokinase
chr3_-_64647325 1.006 ADAMTS9
ADAM metallopeptidase with thrombospondin type 1 motif, 9
chr1_-_58815415 1.002 TACSTD2
tumor-associated calcium signal transducer 2
chr12_+_79625538 1.002 NM_002469
MYF6
myogenic factor 6 (herculin)
chr5_-_58607673 1.000 NM_001197220
PDE4D
phosphodiesterase 4D, cAMP-specific
chr10_-_116434364 0.982 NM_001003407
NM_001003408
ABLIM1

actin binding LIM protein 1

chr13_-_32757835 0.973 NM_178006
STARD13
StAR-related lipid transfer (START) domain containing 13
chr11_-_85107569 0.971 NM_206929
SYTL2
synaptotagmin-like 2
chr5_-_16561936 0.951 NM_019000
FAM134B
family with sequence similarity 134, member B
chr9_+_108665168 0.950 NM_021224
ZNF462
zinc finger protein 462
chr7_+_129720209 0.941 NM_001163446
NM_016352
CPA4

carboxypeptidase A4

chr3_-_113842553 0.941 CCDC80
coiled-coil domain containing 80
chr12_-_94135154 0.935 NM_018351
FGD6
FYVE, RhoGEF and PH domain containing 6
chr3_+_25444837 0.928 NM_000965
RARB
retinoic acid receptor, beta
chr15_+_73728402 0.927 NM_153271
SNX33
sorting nexin 33
chr18_+_44319365 0.925 NM_001142397
NM_014772
CTIF

CBP80/20-dependent translation initiation factor

chr7_+_27191534 0.922 HOXA11-AS1
HOXA11 antisense RNA 1 (non-protein coding)
chr6_-_112682573 0.921 LAMA4
laminin, alpha 4
chr17_-_35510074 0.921 NR1D1
nuclear receptor subfamily 1, group D, member 1
chr7_-_27162688 0.918 NM_006896
HOXA7
homeobox A7
chr7_+_134114701 0.915 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chr3_+_191588354 0.907 NM_006580
CLDN16
claudin 16
chr5_+_102229425 0.901 NM_000919
NM_001177306
NM_138766
NM_138821
NM_138822
PAM




peptidylglycine alpha-amidating monooxygenase




chr3_+_69895310 0.899 NM_001184967
MITF
microphthalmia-associated transcription factor
chr11_+_34599163 0.893 NM_012153
EHF
ets homologous factor
chr6_+_116939500 0.885 NM_153711
FAM26E
family with sequence similarity 26, member E
chr4_+_86918882 0.881 ARHGAP24
Rho GTPase activating protein 24
chr4_+_30331289 0.878 PCDH7
protocadherin 7
chr14_-_49932366 0.871 NM_004196
CDKL1
cyclin-dependent kinase-like 1 (CDC2-related kinase)
chr4_-_159311959 0.871 FAM198B
family with sequence similarity 198, member B
chr4_+_126457016 0.866 NM_024582
FAT4
FAT tumor suppressor homolog 4 (Drosophila)
chr9_-_131555111 0.861 NM_004878
PTGES
prostaglandin E synthase
chr5_+_60663842 0.861 NM_020928
ZSWIM6
zinc finger, SWIM-type containing 6
chr3_+_25444753 0.859 NM_016152
RARB
retinoic acid receptor, beta
chrX_+_142794838 0.857 NM_001012989
UBE2NL
ubiquitin-conjugating enzyme E2N-like
chr1_-_58815753 0.853 NM_002353
TACSTD2
tumor-associated calcium signal transducer 2
chr1_+_68070573 0.853


chr9_+_27514311 0.851 NM_020124
IFNK
interferon, kappa
chr6_-_112682459 0.851 NM_001105206
NM_001105207
NM_001105208
NM_001105209
NM_002290
LAMA4




laminin, alpha 4




chr17_-_36469869 0.847 NM_001165252
LOC730755
keratin associated protein 2-4-like
chr3_-_48576204 0.846 NM_033199
UCN2
urocortin 2
chr4_+_74825138 0.846 NM_000584
IL8
interleukin 8
chr9_+_35528890 0.845 RUSC2
RUN and SH3 domain containing 2
chr1_-_153209625 0.841 NM_001130040
NM_183001
SHC1

SHC (Src homology 2 domain containing) transforming protein 1

chr15_-_37999717 0.838 GPR176
G protein-coupled receptor 176
chr15_+_60838053 0.837 TLN2
talin 2
chr7_-_41709191 0.833 NM_002192
INHBA
inhibin, beta A
chr14_+_20580224 0.828 NM_032572
RNASE7
ribonuclease, RNase A family, 7
chr7_-_27191287 0.823 NM_005523
HOXA11
homeobox A11
chr10_-_33663305 0.820 NRP1
neuropilin 1
chr6_-_56615544 0.817 NM_001723
NM_015548
DST

dystonin

chr10_+_5556923 0.810 NM_005185
CALML3
calmodulin-like 3
chr11_-_5946299 0.803 NM_001146033
OR56A5
olfactory receptor, family 56, subfamily A, member 5
chr1_+_84382575 0.795 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr4_+_30331543 0.794 PCDH7
protocadherin 7
chrX_-_10548458 0.790 NM_000381
NM_033289
MID1

midline 1 (Opitz/BBB syndrome)

chr17_+_7289086 0.788 NM_000747
CHRNB1
cholinergic receptor, nicotinic, beta 1 (muscle)
chr22_+_36927884 0.782 NM_001161572
NM_001161574
NM_012323
MAFF


v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)


chrX_-_99778340 0.781 NM_003270
TSPAN6
tetraspanin 6
chr7_+_134114957 0.777 CALD1
caldesmon 1
chr1_+_84382529 0.777 NM_182948
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr11_+_19691397 0.773 NM_145117
NM_182964
NAV2

neuron navigator 2

chr13_-_73605914 0.770 NM_007249
KLF12
Kruppel-like factor 12
chr18_+_54682261 0.763 ZNF532
zinc finger protein 532
chr9_+_676640 0.757


chr1_-_95165089 0.755 NM_001839
CNN3
calponin 3, acidic
chr9_+_88953378 0.752 NM_001001709
C9orf170
chromosome 9 open reading frame 170
chr19_+_51804260 0.750 CALM3
calmodulin 3 (phosphorylase kinase, delta)
chrX_+_153423652 0.746 NM_001099856
IKBKG
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
chr19_+_12996745 0.743 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr2_+_132890616 0.743 NM_001508
GPR39
G protein-coupled receptor 39
chr11_+_101485946 0.740 NM_001130145
NM_001195044
NM_006106
YAP1


Yes-associated protein 1


chr8_+_70541631 0.739 SULF1
sulfatase 1
chr17_-_7434113 0.737 NM_006942
SOX15
SRY (sex determining region Y)-box 15
chr1_-_95165037 0.737 CNN3
calponin 3, acidic
chr3_-_110155237 0.737 NM_005459
GUCA1C
guanylate cyclase activator 1C
chr3_+_158637273 0.734 NM_002852
PTX3
pentraxin 3, long
chr3_+_190147633 0.729 TPRG1
tumor protein p63 regulated 1
chr1_+_84382562 0.728 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr6_+_1556543 0.728 FOXC1
forkhead box C1
chr11_+_101290930 0.722 NM_020802
KIAA1377
KIAA1377
chrX_+_106955737 0.722 NM_012216
NM_052817
MID2

midline 2

chr6_+_74462226 0.716 NM_001159587
NM_001159588
NM_133493
CD109


CD109 molecule


chr15_-_31147376 0.711 NM_001103184
FMN1
formin 1
chr8_-_145090892 0.710 NM_201381
PLEC
plectin
chr4_-_152368492 0.708 SH3D19
SH3 domain containing 19
chr11_-_85115105 0.708 NM_206927
NM_206928
SYTL2

synaptotagmin-like 2

chr2_+_206255597 0.706 NRP2
neuropilin 2
chr10_+_11100111 0.706 CELF2
CUGBP, Elav-like family member 2
chr9_+_35032222 0.695 NM_001040410
NM_203299
C9orf131

chromosome 9 open reading frame 131

chr10_+_124211353 0.694 HTRA1
HtrA serine peptidase 1
chr14_-_75517844 0.693 NM_003239
TGFB3
transforming growth factor, beta 3
chr5_+_125786975 0.688 GRAMD3
GRAM domain containing 3
chr8_-_122722674 0.685 NM_005328
HAS2
hyaluronan synthase 2
chr6_+_142665057 0.684 GPR126
G protein-coupled receptor 126
chr6_-_134537637 0.684 SGK1
serum/glucocorticoid regulated kinase 1
chr17_+_71174993 0.684 NM_013260
SAP30BP
SAP30 binding protein
chr4_-_75123193 0.683 NM_002090
CXCL3
chemokine (C-X-C motif) ligand 3
chr1_+_199519202 0.680 NM_000299
NM_001005337
PKP1

plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)

chr10_-_33663984 0.676 NRP1
neuropilin 1
chr4_-_75183700 0.676 CXCL2
chemokine (C-X-C motif) ligand 2
chr6_-_134537699 0.674 NM_005627
SGK1
serum/glucocorticoid regulated kinase 1
chr18_-_57711283 0.672 NM_173557
RNF152
ring finger protein 152
chr22_+_36928011 0.672 MAFF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr21_-_38792173 0.671 NM_001136155
NM_182918
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr14_+_54104099 0.671 SAMD4A
sterile alpha motif domain containing 4A
chr18_+_45342398 0.670 NM_006033
LIPG
lipase, endothelial
chr11_-_85108030 0.667 NM_001162952
NM_206930
SYTL2

synaptotagmin-like 2

chr5_+_147775652 0.666 FBXO38
F-box protein 38
chr1_+_183970093 0.664 NM_031935
HMCN1
hemicentin 1
chr11_+_101291134 0.664 KIAA1377
KIAA1377
chr15_-_68971665 0.663 NM_020147
THAP10
THAP domain containing 10
chr9_+_77695334 0.663 NM_001190482
NM_006200
PCSK5

proprotein convertase subtilisin/kexin type 5

chr3_-_71262405 0.662 FOXP1
forkhead box P1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.51 4.39e-32 GO:0007608 sensory perception of smell
2.31 2.15e-27 GO:0007606 sensory perception of chemical stimulus
1.89 9.86e-24 GO:0007600 sensory perception
1.56 9.28e-21 GO:0003008 system process
1.60 1.89e-18 GO:0050877 neurological system process
1.24 1.13e-14 GO:0032501 multicellular organismal process
1.19 1.40e-11 GO:0050896 response to stimulus
1.30 1.91e-04 GO:0023051 regulation of signaling
1.30 4.64e-04 GO:0009653 anatomical structure morphogenesis
1.19 7.26e-04 GO:0048856 anatomical structure development
1.21 8.09e-04 GO:0048731 system development
1.31 9.55e-04 GO:0009966 regulation of signal transduction
1.35 1.51e-03 GO:0010646 regulation of cell communication
1.53 2.96e-03 GO:0072358 cardiovascular system development
1.53 2.96e-03 GO:0072359 circulatory system development
1.16 3.02e-03 GO:0032502 developmental process
1.17 5.42e-03 GO:0007275 multicellular organismal development
1.42 1.46e-02 GO:0030030 cell projection organization
1.26 1.53e-02 GO:0007399 nervous system development
1.43 2.78e-02 GO:0048666 neuron development
1.63 2.92e-02 GO:0001568 blood vessel development
1.60 3.74e-02 GO:0001944 vasculature development
1.41 3.78e-02 GO:0042060 wound healing

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.29 2.55e-18 GO:0071944 cell periphery
1.29 5.94e-18 GO:0005886 plasma membrane
1.13 2.11e-08 GO:0016020 membrane
1.46 3.18e-04 GO:0030054 cell junction
1.37 4.51e-04 GO:0042995 cell projection
1.11 5.42e-04 GO:0044425 membrane part
1.27 5.99e-04 GO:0005856 cytoskeleton
1.51 3.37e-03 GO:0043005 neuron projection
1.76 4.35e-03 GO:0030424 axon
1.11 1.53e-02 GO:0016021 integral to membrane
1.10 2.27e-02 GO:0031224 intrinsic to membrane
1.76 2.46e-02 GO:0005912 adherens junction
1.69 4.56e-02 GO:0070161 anchoring junction

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.58 4.00e-34 GO:0004984 olfactory receptor activity
1.78 1.75e-19 GO:0004930 G-protein coupled receptor activity
1.44 2.03e-09 GO:0004888 transmembrane receptor activity
1.30 2.41e-07 GO:0004871 signal transducer activity
1.30 2.41e-07 GO:0060089 molecular transducer activity
1.32 1.25e-06 GO:0004872 receptor activity