Motif ID: BACH2.p2

Z-value: 1.483


Transcription factors associated with BACH2.p2:

Gene SymbolEntrez IDGene Name
BACH2 60468 BTB and CNC homology 1, basic leucine zipper transcription factor 2



Activity profile for motif BACH2.p2.

activity profile for motif BACH2.p2


Sorted Z-values histogram for motif BACH2.p2

Sorted Z-values for motif BACH2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of BACH2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr18_+_19706979 7.057 NM_000227
NM_001127718
LAMA3

laminin, alpha 3

chr1_+_221955876 6.456 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chr3_+_11153778 5.225 NM_001098213
HRH1
histamine receptor H1
chr10_-_88720908 4.549 LOC100133190
hypothetical LOC100133190
chr7_+_116099648 4.487 NM_000245
NM_001127500
MET

met proto-oncogene (hepatocyte growth factor receptor)

chr4_+_108965167 4.137 NM_001136258
SGMS2
sphingomyelin synthase 2
chr11_-_6298284 3.975 NM_145040
PRKCDBP
protein kinase C, delta binding protein
chr1_-_6474346 3.753 NM_020631
PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr19_+_43486640 3.735 NM_033520
C19orf33
chromosome 19 open reading frame 33
chr1_-_177378801 3.671 NM_001136000
NM_001168239
NM_005158
ABL2


v-abl Abelson murine leukemia viral oncogene homolog 2


chr12_-_68369322 3.606 NM_152439
BEST3
bestrophin 3
chr14_+_104218487 3.579


chr2_+_113591940 3.574 NM_000577
NM_173841
NM_173843
IL1RN


interleukin 1 receptor antagonist


chr6_+_31190505 3.573 NM_014068
PSORS1C1
psoriasis susceptibility 1 candidate 1
chr6_+_74462226 3.550 NM_001159587
NM_001159588
NM_133493
CD109


CD109 molecule


chr1_-_207891264 3.418 NM_001017402
LAMB3
laminin, beta 3
chr21_+_29439768 3.411 C21orf7
chromosome 21 open reading frame 7
chr8_-_38505331 3.194 NM_207412
C8orf86
chromosome 8 open reading frame 86
chr17_-_36996611 3.180 NM_000526
KRT14
keratin 14
chr6_+_74462654 3.164 CD109
CD109 molecule
chr6_+_74462630 3.155 CD109
CD109 molecule
chr6_+_74462485 3.149 CD109
CD109 molecule
chr9_+_102231616 3.003 NM_001198806
C9orf30
chromosome 9 open reading frame 30
chr6_+_74462577 2.975 CD109
CD109 molecule
chr9_+_676640 2.962


chr3_-_11585264 2.908 NM_001128221
VGLL4
vestigial like 4 (Drosophila)
chr11_+_12265022 2.810 NM_032867
MICALCL
MICAL C-terminal like
chr8_+_22900863 2.741 NM_001160036
RHOBTB2
Rho-related BTB domain containing 2
chr18_+_59593591 2.718 NM_003784
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr16_+_56219802 2.712 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr11_-_119499188 2.672 TRIM29
tripartite motif containing 29
chr17_+_18566060 2.638 NM_001037330
TRIM16L
tripartite motif containing 16-like
chr11_-_2907169 2.594 NM_003311
PHLDA2
pleckstrin homology-like domain, family A, member 2
chr3_-_48607596 2.587 NM_000094
COL7A1
collagen, type VII, alpha 1
chr11_-_117640166 2.499 MPZL2
myelin protein zero-like 2
chr5_-_141041982 2.486 NM_022481
ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr15_-_58477407 2.467 NM_001002857
NM_001002858
NM_001136015
NM_004039
ANXA2



annexin A2



chr3_-_152517204 2.456 NM_023915
GPR87
G protein-coupled receptor 87
chr5_-_141041933 2.444 ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr5_+_150000394 2.417 NM_001109974
NM_007286
SYNPO

synaptopodin

chr11_-_117640078 2.385


chr11_-_117640407 2.343 NM_005797
NM_144765
MPZL2

myelin protein zero-like 2

chr1_+_181421984 2.323 LAMC2
laminin, gamma 2
chr3_+_175641340 2.305 NAALADL2
N-acetylated alpha-linked acidic dipeptidase-like 2
chr3_+_161877640 2.218 NM_025047
ARL14
ADP-ribosylation factor-like 14
chr11_-_117640196 2.206 MPZL2
myelin protein zero-like 2
chr1_-_36589744 2.200


chr1_+_221966951 2.172 CAPN2
calpain 2, (m/II) large subunit
chr1_-_108032645 2.171 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr11_-_65860450 2.170 NM_004292
RIN1
Ras and Rab interactor 1
chr1_+_154351162 2.151 LMNA
lamin A/C
chr1_+_154351082 2.121 NM_005572
NM_170707
NM_170708
LMNA


lamin A/C


chr1_-_150276114 2.108 NM_005620
S100A11
S100 calcium binding protein A11
chr18_+_59788242 2.070 NM_001031848
NM_002640
NM_198833
SERPINB8


serpin peptidase inhibitor, clade B (ovalbumin), member 8


chr19_-_48866111 2.065 NM_001005376
NM_001005377
NM_002659
PLAUR


plasminogen activator, urokinase receptor


chr18_+_50646616 2.047 NM_004163
RAB27B
RAB27B, member RAS oncogene family
chr17_-_37022465 2.028 NM_005557
KRT16
keratin 16
chr19_-_3920736 1.998 NM_001348
DAPK3
death-associated protein kinase 3
chr6_+_41712907 1.996 MDFI
MyoD family inhibitor
chr6_+_1556543 1.988 FOXC1
forkhead box C1
chr12_-_15005761 1.968 NM_001175
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr3_-_12775718 1.955 NM_018306
TMEM40
transmembrane protein 40
chr18_+_59295123 1.938 NM_002639
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr7_+_1543644 1.856 MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr1_+_891739 1.789 NM_001160184
NM_032129
PLEKHN1

pleckstrin homology domain containing, family N member 1

chr12_+_10256682 1.761 NM_031412
GABARAPL1
GABA(A) receptor-associated protein like 1
chr4_-_177950658 1.759 NM_005429
VEGFC
vascular endothelial growth factor C
chr6_+_47774247 1.758 NM_153838
GPR115
G protein-coupled receptor 115
chr1_+_181422016 1.746 LAMC2
laminin, gamma 2
chr19_-_48661563 1.738 NM_014400
LYPD3
LY6/PLAUR domain containing 3
chr15_-_38417564 1.736 C15orf52
chromosome 15 open reading frame 52
chr20_-_17487480 1.726 NM_001161705
BFSP1
beaded filament structural protein 1, filensin
chr1_-_94779727 1.685 NM_001178096
NM_001993
F3

coagulation factor III (thromboplastin, tissue factor)

chr17_+_71229110 1.682 NM_000213
NM_001005731
ITGB4

integrin, beta 4

chr18_-_45630154 1.671 MYO5B
myosin VB
chr1_+_221966835 1.620 CAPN2
calpain 2, (m/II) large subunit
chr11_+_67107641 1.614 NM_000852
GSTP1
glutathione S-transferase pi 1
chr20_-_1257809 1.594 NM_080489
SDCBP2
syndecan binding protein (syntenin) 2
chr1_+_221966684 1.594 NM_001748
CAPN2
calpain 2, (m/II) large subunit
chr11_+_67107852 1.586 GSTP1
glutathione S-transferase pi 1
chr1_+_221966849 1.578 CAPN2
calpain 2, (m/II) large subunit
chr20_-_1257782 1.562 SDCBP2
syndecan binding protein (syntenin) 2
chr1_-_151788341 1.562 NM_002960
S100A3
S100 calcium binding protein A3
chr20_+_19903778 1.530 RIN2
Ras and Rab interactor 2
chr17_+_71229151 1.519 ITGB4
integrin, beta 4
chr16_+_55199978 1.509 NM_005953
MT2A
metallothionein 2A
chr9_-_34652629 1.463 NM_006664
CCL27
chemokine (C-C motif) ligand 27
chr12_-_46439127 1.463 NM_001098531
RAPGEF3
Rap guanine nucleotide exchange factor (GEF) 3
chr1_+_54780515 1.454 ACOT11
acyl-CoA thioesterase 11
chr3_-_58175437 1.421 NM_004944
DNASE1L3
deoxyribonuclease I-like 3
chr19_+_43971689 1.417 NM_001042507
LGALS7B
lectin, galactoside-binding, soluble, 7B
chr3_+_48482213 1.416 NM_016381
NM_033629
TREX1

three prime repair exonuclease 1

chr2_-_73170290 1.416 RAB11FIP5
RAB11 family interacting protein 5 (class I)
chr5_+_35892747 1.414 NM_002185
IL7R
interleukin 7 receptor
chr8_+_120289735 1.409 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr5_-_175776137 1.401 NM_001834
NM_007097
CLTB

clathrin, light chain B

chr1_+_154351200 1.386 LMNA
lamin A/C
chr11_-_65424434 1.372 FOSL1
FOS-like antigen 1
chr12_-_46438447 1.361 NM_001098532
NM_006105
RAPGEF3

Rap guanine nucleotide exchange factor (GEF) 3

chr1_-_221919982 1.359 CAPN8
calpain 8
chr11_-_33701073 1.354 NM_001127227
CD59
CD59 molecule, complement regulatory protein
chr7_-_158304062 1.327 ESYT2
extended synaptotagmin-like protein 2
chr11_-_65424385 1.327 FOSL1
FOS-like antigen 1
chr1_-_221920023 1.317 NM_001143962
CAPN8
calpain 8
chr3_+_48482625 1.302 TREX1
three prime repair exonuclease 1
chr19_-_43955984 1.291 NM_002307
LGALS7
LGALS7B
lectin, galactoside-binding, soluble, 7
lectin, galactoside-binding, soluble, 7B
chr15_+_38849450 1.291 NM_001130448
C15orf62
chromosome 15 open reading frame 62
chr1_+_181421796 1.287 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr11_+_1812115 1.285 NM_138567
SYT8
synaptotagmin VIII
chr2_-_85494639 1.282 CAPG
capping protein (actin filament), gelsolin-like
chr12_-_10767115 1.263 NM_001145426
NM_003651
CSDA

cold shock domain protein A

chr3_-_123995216 1.252 NM_024610
HSPBAP1
HSPB (heat shock 27kDa) associated protein 1
chr9_-_129381086 1.249 NM_001035534
FAM129B
family with sequence similarity 129, member B
chr18_+_59405513 1.246 NM_012397
SERPINB13
serpin peptidase inhibitor, clade B (ovalbumin), member 13
chr1_-_17180659 1.238 NM_001135247
NM_017459
MFAP2

microfibrillar-associated protein 2

chr18_+_54039818 1.222 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr6_-_84197370 1.220 ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr17_+_71229191 1.203 ITGB4
integrin, beta 4
chr6_-_84197477 1.201 ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr1_+_27062215 1.195 NM_006142
SFN
stratifin
chr12_-_105057940 1.188 NM_014840
NUAK1
NUAK family, SNF1-like kinase, 1
chr6_-_84197463 1.181 ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr3_+_11242666 1.148 NM_001098211
HRH1
histamine receptor H1
chr18_+_54039779 1.144 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr1_-_155374756 1.124 ETV3
ets variant 3
chr22_-_35914200 1.124 NM_031910
NM_182486
C1QTNF6

C1q and tumor necrosis factor related protein 6

chr6_-_159159186 1.124 EZR
ezrin
chr6_-_84197573 1.121 NM_002395
ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr2_+_27705018 1.108 NM_001145047
NM_001145048
NM_001145049
GPN1


GPN-loop GTPase 1


chrX_-_15198093 1.102 NM_001031739
NM_001168530
NM_024087
ASB9


ankyrin repeat and SOCS box containing 9


chr16_-_62573 1.087 NM_022450
RHBDF1
rhomboid 5 homolog 1 (Drosophila)
chr17_-_3407780 1.076 TRPV3
transient receptor potential cation channel, subfamily V, member 3
chr6_-_159159242 1.075 EZR
ezrin
chr4_+_76700281 1.072 NM_178497
C4orf26
chromosome 4 open reading frame 26
chrX_+_12903145 1.069 NM_021109
NM_183049
TMSB4X
TMSL3
thymosin beta 4, X-linked
thymosin-like 3
chr3_-_51912376 1.064 NM_152397
IQCF1
IQ motif containing F1
chr11_+_384238 1.061 PKP3
plakophilin 3
chr5_-_175775966 1.042 CLTB
clathrin, light chain B
chr11_-_65424436 1.039 NM_005438
FOSL1
FOS-like antigen 1
chr3_+_69216747 1.033 NM_006407
ARL6IP5
ADP-ribosylation-like factor 6 interacting protein 5
chr18_+_54039730 1.032 NM_001144966
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr3_+_185499679 1.031 NM_002808
PSMD2
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
chr4_+_74825138 1.029 NM_000584
IL8
interleukin 8
chr6_-_138470160 1.021 NM_022121
PERP
PERP, TP53 apoptosis effector
chr5_+_145297490 1.016 SH3RF2
SH3 domain containing ring finger 2
chr11_+_10433241 1.016 NM_001025389
AMPD3
adenosine monophosphate deaminase 3
chr12_-_56445653 0.998 CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chr11_-_66898223 0.990 NM_001166212
CLCF1
cardiotrophin-like cytokine factor 1
chr9_-_90456824 0.989 NM_001100111
LOC286238
hypothetical protein LOC286238
chr11_-_47502115 0.985 NM_001172639
CELF1
CUGBP, Elav-like family member 1
chr6_-_159159257 0.980 NM_003379
EZR
ezrin
chr11_-_92570626 0.952


chr17_-_24068759 0.947 NM_001144942
NM_031934
RAB34

RAB34, member RAS oncogene family

chr17_-_36792161 0.944 NM_021013
KRT34
keratin 34
chr6_-_112033775 0.938 TRAF3IP2
TRAF3 interacting protein 2
chr17_+_7196151 0.937 KCTD11
potassium channel tetramerisation domain containing 11
chr19_-_60573552 0.930 NM_000641
IL11
interleukin 11
chr5_+_40877053 0.909 NM_032587
CARD6
caspase recruitment domain family, member 6
chr16_+_66121040 0.905 NM_001193523
FAM65A
family with sequence similarity 65, member A
chr4_+_152549776 0.899 NM_001109977
FAM160A1
family with sequence similarity 160, member A1
chr11_-_92570693 0.895 NM_152313
SLC36A4
solute carrier family 36 (proton/amino acid symporter), member 4
chr3_+_185499732 0.890 PSMD2
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
chr19_-_56215084 0.881 NM_002776
NM_001077500
KLK10

kallikrein-related peptidase 10

chr17_-_18102767 0.878 NM_002018
FLII
flightless I homolog (Drosophila)
chr3_+_64645819 0.878 LOC100507098
hypothetical LOC100507098
chr17_+_72827227 0.876 SEPT9
septin 9
chr21_-_35343065 0.876 RUNX1
runt-related transcription factor 1
chr16_-_2848106 0.873 NM_022119
PRSS22
protease, serine, 22
chr17_+_7195931 0.871 NM_001002914
KCTD11
potassium channel tetramerisation domain containing 11
chr6_+_107066422 0.871 NM_001624
AIM1
absent in melanoma 1
chr17_-_24069299 0.857 NM_001142624
NM_001142625
NM_001144943
RAB34


RAB34, member RAS oncogene family


chr17_-_7064092 0.855 NM_001365
DLG4
discs, large homolog 4 (Drosophila)
chr7_-_1465487 0.853 MICALL2
MICAL-like 2
chr7_+_48094750 0.840 NM_181597
UPP1
uridine phosphorylase 1
chr3_-_48576204 0.838 NM_033199
UCN2
urocortin 2
chr12_+_55018925 0.837 NM_016584
IL23A
interleukin 23, alpha subunit p19
chr17_-_18102594 0.826 FLII
flightless I homolog (Drosophila)
chr11_-_102174102 0.826 NM_001145938
NM_002421
MMP1

matrix metallopeptidase 1 (interstitial collagenase)

chr6_-_35804337 0.821 NM_001145775
FKBP5
FK506 binding protein 5
chrX_+_99785818 0.818 NM_014467
SRPX2
sushi-repeat containing protein, X-linked 2
chr17_+_77261457 0.817


chr1_-_155374793 0.814 NM_005240
NM_001145312
ETV3

ets variant 3

chr6_-_112033752 0.809 TRAF3IP2
TRAF3 interacting protein 2
chr11_+_384199 0.806 NM_007183
PKP3
plakophilin 3
chr3_-_197549640 0.799 NM_138461
TM4SF19
transmembrane 4 L six family member 19
chr1_+_151270301 0.799 NM_003125
SPRR1B
small proline-rich protein 1B
chr19_+_46416975 0.795 AXL
AXL receptor tyrosine kinase
chr17_+_72827185 0.789 NM_006640
SEPT9
septin 9
chr17_+_77261447 0.789 HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr12_-_10766965 0.782 CSDA
cold shock domain protein A
chr1_+_152644668 0.768 IL6R
interleukin 6 receptor
chr2_+_219852268 0.752 NM_001039550
NM_006736
DNAJB2

DnaJ (Hsp40) homolog, subfamily B, member 2

chr19_+_46416971 0.749 AXL
AXL receptor tyrosine kinase
chr17_-_18102743 0.748 FLII
flightless I homolog (Drosophila)
chr5_+_147562531 0.747 NM_001195290
NM_205841
SPINK6

serine peptidase inhibitor, Kazal type 6

chr11_-_102174032 0.744 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr17_+_77261477 0.737 HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chrX_-_129072152 0.734 NM_001421
ELF4
E74-like factor 4 (ets domain transcription factor)
chr7_+_39739690 0.723 NCRNA00265
non-protein coding RNA 265
chr17_-_7434113 0.719 NM_006942
SOX15
SRY (sex determining region Y)-box 15

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.79 4.62e-03 GO:0010740 positive regulation of intracellular protein kinase cascade
2.43 6.43e-03 GO:0010627 regulation of intracellular protein kinase cascade
1.65 1.71e-02 GO:0009966 regulation of signal transduction
2.70 1.92e-02 GO:0030334 regulation of cell migration
2.67 2.36e-02 GO:2000145 regulation of cell motility
1.73 3.38e-02 GO:0051246 regulation of protein metabolic process
1.73 4.16e-02 GO:0043067 regulation of programmed cell death
1.56 4.55e-02 GO:0023051 regulation of signaling
12.36 4.60e-02 GO:0031581 hemidesmosome assembly

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
4.32 2.54e-02 GO:0000502 proteasome complex

Nothing significant found in function category.