Motif ID: ZFP161.p2

Z-value: 1.733


Transcription factors associated with ZFP161.p2:

Gene SymbolEntrez IDGene Name
ZFP161 7541 zinc finger protein 161 homolog (mouse)



Activity profile for motif ZFP161.p2.

activity profile for motif ZFP161.p2


Sorted Z-values histogram for motif ZFP161.p2

Sorted Z-values for motif ZFP161.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ZFP161.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_31635089 2.759 NM_144973
DENND5B
DENN/MADD domain containing 5B
chr10_-_725522 2.512 NM_014974
DIP2C
DIP2 disco-interacting protein 2 homolog C (Drosophila)
chr9_+_126060063 2.274 NEK6
NIMA (never in mitosis gene a)-related kinase 6
chr9_+_126060108 2.128 NEK6
NIMA (never in mitosis gene a)-related kinase 6
chr9_+_126060072 2.022 NEK6
NIMA (never in mitosis gene a)-related kinase 6
chr9_+_126059603 1.743 NM_001166167
NM_001145001
NM_014397
NEK6


NIMA (never in mitosis gene a)-related kinase 6


chr2_+_28469850 1.675 FOSL2
FOS-like antigen 2
chr18_-_21184824 1.647


chr10_+_11099860 1.606 NM_006561
CELF2
CUGBP, Elav-like family member 2
chr16_-_71639670 1.603 NM_006885
ZFHX3
zinc finger homeobox 3
chr2_+_28469864 1.525 FOSL2
FOS-like antigen 2
chr2_+_56264627 1.475 NM_001080433
CCDC85A
coiled-coil domain containing 85A
chr2_+_71547325 1.445 NM_001130455
NM_001130982
NM_001130983
NM_001130984
NM_001130985
NM_001130986
NM_001130987
DYSF






dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)






chr10_+_11100111 1.413 CELF2
CUGBP, Elav-like family member 2
chr10_+_11100075 1.399 CELF2
CUGBP, Elav-like family member 2
chr2_+_56265260 1.396


chr20_+_8997791 1.372 PLCB4
phospholipase C, beta 4
chr10_+_124210980 1.347 NM_002775
HTRA1
HtrA serine peptidase 1
chr3_+_61522310 1.340 PTPRG
protein tyrosine phosphatase, receptor type, G
chr10_-_131652007 1.320 NM_001005463
EBF3
early B-cell factor 3
chr9_+_126060283 1.312 NM_001166168
NEK6
NIMA (never in mitosis gene a)-related kinase 6
chr1_+_229829143 1.277 NM_001012957
NM_001012958
NM_001012959
NM_001164537
NM_001164538
NM_001164539
NM_001164540
NM_001164541
NM_001164542
NM_001164544
NM_001164545
NM_001164546
NM_001164547
NM_001164548
NM_001164549
NM_001164550
NM_001164551
NM_001164552
NM_001164553
NM_001164554
NM_001164555
NM_001164556
NM_018662
DISC1






















disrupted in schizophrenia 1






















chr3_-_55496607 1.268 WNT5A
wingless-type MMTV integration site family, member 5A
chr2_+_241586927 1.252 NM_001080437
SNED1
sushi, nidogen and EGF-like domains 1
chr3_-_55496370 1.229 NM_003392
WNT5A
wingless-type MMTV integration site family, member 5A
chr7_-_47588266 1.214 TNS3
tensin 3
chr16_-_71650034 1.209 NM_001164766
ZFHX3
zinc finger homeobox 3
chr15_+_29406335 1.196 NM_015995
KLF13
Kruppel-like factor 13
chr9_-_131845277 1.185 NM_015033
FNBP1
formin binding protein 1
chr2_+_207016525 1.171 NM_003812
ADAM23
ADAM metallopeptidase domain 23
chr18_-_16945763 1.169 NM_005406
ROCK1
Rho-associated, coiled-coil containing protein kinase 1
chr1_-_85703321 1.165 NM_012137
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr3_+_61522219 1.152 NM_002841
PTPRG
protein tyrosine phosphatase, receptor type, G
chr5_+_14493905 1.114 TRIO
triple functional domain (PTPRF interacting)
chr13_+_92677012 1.107 NM_005708
GPC6
glypican 6
chr2_+_54536780 1.102 NM_003128
SPTBN1
spectrin, beta, non-erythrocytic 1
chr7_-_27180398 1.098 NM_018951
HOXA10
homeobox A10
chr9_+_126060407 1.090


chr5_+_14196287 1.081 NM_007118
TRIO
triple functional domain (PTPRF interacting)
chrX_-_19815526 1.058 SH3KBP1
SH3-domain kinase binding protein 1
chr13_+_112911055 1.057 NM_003589
CUL4A
cullin 4A
chr6_-_143307976 1.054 NM_006734
HIVEP2
human immunodeficiency virus type I enhancer binding protein 2
chr9_+_127549437 1.054 NM_006195
PBX3
pre-B-cell leukemia homeobox 3
chr22_-_30072329 1.053 PATZ1
POZ (BTB) and AT hook containing zinc finger 1
chr7_-_35044177 1.044 NM_015283
DPY19L1
dpy-19-like 1 (C. elegans)
chr12_-_123617962 1.032 NM_001077261
NM_006312
NCOR2

nuclear receptor corepressor 2

chr7_-_55607625 1.026 VOPP1
vesicular, overexpressed in cancer, prosurvival protein 1
chrX_-_142549984 1.025 NM_001184750
SLITRK4
SLIT and NTRK-like family, member 4
chr2_-_236740710 1.024


chr7_-_55607692 1.020 NM_030796
VOPP1
vesicular, overexpressed in cancer, prosurvival protein 1
chr16_-_73842884 1.019 NM_001170717
NM_014567
BCAR1

breast cancer anti-estrogen resistance 1

chrX_-_34585287 0.995 NM_031442
TMEM47
transmembrane protein 47
chr1_-_85703198 0.995 DDAH1
dimethylarginine dimethylaminohydrolase 1
chr9_-_133605037 0.992 RAPGEF1
Rap guanine nucleotide exchange factor (GEF) 1
chr19_-_1518875 0.987 NM_001174118
NM_203304
MEX3D

mex-3 homolog D (C. elegans)

chr12_+_88627601 0.981 LOC338758
hypothetical LOC338758
chr7_-_525336 0.975 PDGFA
platelet-derived growth factor alpha polypeptide
chr20_-_43996980 0.974 FLJ40606
hypothetical protein LOC643549
chr7_-_45927263 0.964 NM_000598
NM_001013398
IGFBP3

insulin-like growth factor binding protein 3

chr15_-_32118477 0.963 NM_020371
AVEN
apoptosis, caspase activation inhibitor
chr22_+_22459143 0.958 NM_001007468
NM_003073
SMARCB1

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1

chr5_-_88215034 0.952 NM_001193350
NM_002397
MEF2C

myocyte enhancer factor 2C

chr5_-_58370693 0.948 NM_001197221
NM_001197222
PDE4D

phosphodiesterase 4D, cAMP-specific

chr12_+_50271283 0.927 NM_014191
SCN8A
sodium channel, voltage gated, type VIII, alpha subunit
chrX_-_19815370 0.919 SH3KBP1
SH3-domain kinase binding protein 1
chr11_+_133444029 0.916 NM_032801
JAM3
junctional adhesion molecule 3
chr2_-_37752272 0.911 CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr19_-_2378581 0.909 TIMM13
translocase of inner mitochondrial membrane 13 homolog (yeast)
chr13_-_32822759 0.909 STARD13
StAR-related lipid transfer (START) domain containing 13
chr16_+_415630 0.908 NM_014700
RAB11FIP3
RAB11 family interacting protein 3 (class II)
chr11_+_133444175 0.889 JAM3
junctional adhesion molecule 3
chr9_+_101623957 0.885 NM_006981
NM_173199
NR4A3

nuclear receptor subfamily 4, group A, member 3

chr18_-_16945613 0.884 ROCK1
Rho-associated, coiled-coil containing protein kinase 1
chr2_-_40532651 0.883 SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr15_-_88446543 0.882 IDH2
isocitrate dehydrogenase 2 (NADP+), mitochondrial
chr11_+_17697685 0.877 NM_002478
MYOD1
myogenic differentiation 1
chr20_-_43997091 0.877 FLJ40606
hypothetical protein LOC643549
chr13_-_112910945 0.871 NM_001127202
NM_001127203
NM_018386
PCID2


PCI domain containing 2


chr21_-_27261276 0.862 NM_007038
ADAMTS5
ADAM metallopeptidase with thrombospondin type 1 motif, 5
chr7_-_55607598 0.857 VOPP1
vesicular, overexpressed in cancer, prosurvival protein 1
chr9_+_89302239 0.854 DAPK1
death-associated protein kinase 1
chr13_-_43259032 0.854 NM_017993
ENOX1
ecto-NOX disulfide-thiol exchanger 1
chr14_-_73106243 0.853


chr20_+_11819364 0.852 NM_181443
BTBD3
BTB (POZ) domain containing 3
chr10_+_90629880 0.831 NM_020799
STAMBPL1
STAM binding protein-like 1
chr6_-_163754903 0.828 LOC100526820
hypothetical LOC100526820
chr5_-_88214720 0.824 MEF2C
myocyte enhancer factor 2C
chr19_-_2378530 0.813 TIMM13
translocase of inner mitochondrial membrane 13 homolog (yeast)
chr2_+_149895274 0.807 NM_194317
LYPD6
LY6/PLAUR domain containing 6
chr6_-_86409701 0.803 NM_001159677
NM_006372
SYNCRIP

synaptotagmin binding, cytoplasmic RNA interacting protein

chr17_+_58058774 0.795 MRC2
mannose receptor, C type 2
chr20_+_8997660 0.795 NM_001172646
PLCB4
phospholipase C, beta 4
chr7_-_47588652 0.795 TNS3
tensin 3
chr17_-_77649322 0.793 FASN
fatty acid synthase
chr7_-_150576957 0.790 SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr6_-_38715567 0.789 BTBD9
BTB (POZ) domain containing 9
chr9_-_16860719 0.787 NM_017637
BNC2
basonuclin 2
chr7_-_5535726 0.787 ACTB
actin, beta
chr17_-_77649393 0.785 NM_004104
FASN
fatty acid synthase
chr16_-_46976649 0.777 NM_003031
SIAH1
seven in absentia homolog 1 (Drosophila)
chr7_-_525556 0.773 PDGFA
platelet-derived growth factor alpha polypeptide
chr3_+_171558143 0.770 NM_001145098
NM_005414
SKIL

SKI-like oncogene

chr11_+_101485946 0.769 NM_001130145
NM_001195044
NM_006106
YAP1


Yes-associated protein 1


chr14_+_73105618 0.769 ACOT2
acyl-CoA thioesterase 2
chr16_+_415606 0.768 RAB11FIP3
RAB11 family interacting protein 3 (class II)
chr2_+_239000395 0.760 ASB1
ankyrin repeat and SOCS box containing 1
chr17_-_77411695 0.754 P4HB
prolyl 4-hydroxylase, beta polypeptide
chr1_-_212791597 0.750 NM_005401
PTPN14
protein tyrosine phosphatase, non-receptor type 14
chr3_+_151171755 0.750 LOC646903
hypothetical LOC646903
chr11_+_86189138 0.750 NM_007173
PRSS23
protease, serine, 23
chr11_+_66381077 0.740 LRFN4
leucine rich repeat and fibronectin type III domain containing 4
chr21_+_45118353 0.738


chr17_+_42963442 0.734 NM_006310
NPEPPS
aminopeptidase puromycin sensitive
chr13_-_31900218 0.724 NM_001079691
NM_052818
N4BP2L1

NEDD4 binding protein 2-like 1

chr10_-_131652364 0.721 EBF3
early B-cell factor 3
chr8_+_121892719 0.719


chr17_+_58058479 0.715 NM_006039
MRC2
mannose receptor, C type 2
chr3_-_151171190 0.713 NM_002628
NM_053024
PFN2

profilin 2

chr9_-_21984414 0.712 NM_058195
CDKN2A
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
chr17_-_77411707 0.712 P4HB
prolyl 4-hydroxylase, beta polypeptide
chr17_-_1341599 0.702 NM_033375
MYO1C
myosin IC
chr2_-_45090025 0.699 NM_016932
SIX2
SIX homeobox 2
chr5_-_83716346 0.696 NM_005711
EDIL3
EGF-like repeats and discoidin I-like domains 3
chr7_-_5536704 0.696 NM_001101
ACTB
actin, beta
chr6_-_56816403 0.695 DST
dystonin
chr10_+_129595349 0.692 PTPRE
protein tyrosine phosphatase, receptor type, E
chr10_+_129595289 0.690 NM_006504
PTPRE
protein tyrosine phosphatase, receptor type, E
chr2_+_30307900 0.688 NM_030915
LBH
limb bud and heart development homolog (mouse)
chr1_-_59020875 0.688 JUN
jun proto-oncogene
chr9_+_81377289 0.687 TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr21_-_45118037 0.686 NM_004339
PTTG1IP
pituitary tumor-transforming 1 interacting protein
chr7_-_47588160 0.684 TNS3
tensin 3
chr15_-_88446708 0.680 NM_002168
IDH2
isocitrate dehydrogenase 2 (NADP+), mitochondrial
chr2_+_239000306 0.680 NM_001040445
ASB1
ankyrin repeat and SOCS box containing 1
chr10_+_124211353 0.679 HTRA1
HtrA serine peptidase 1
chr6_-_38715613 0.678 BTBD9
BTB (POZ) domain containing 9
chr10_+_94598204 0.677 NM_019053
EXOC6
exocyst complex component 6
chr11_+_65594361 0.675 NM_018026
PACS1
phosphofurin acidic cluster sorting protein 1
chr9_-_35062545 0.673 VCP
valosin containing protein
chr9_-_135922912 0.673 NM_007371
BRD3
bromodomain containing 3
chr13_-_76358433 0.672 NM_138444
KCTD12
potassium channel tetramerisation domain containing 12
chr17_+_58058783 0.667 MRC2
mannose receptor, C type 2
chr21_-_45118026 0.666 PTTG1IP
pituitary tumor-transforming 1 interacting protein
chr9_-_13269562 0.663 MPDZ
multiple PDZ domain protein
chr21_-_45117989 0.662 PTTG1IP
pituitary tumor-transforming 1 interacting protein
chr2_+_28469275 0.661 NM_005253
FOSL2
FOS-like antigen 2
chr10_+_98582648 0.659 NM_032440
LCOR
ligand dependent nuclear receptor corepressor
chr1_+_226336983 0.654 NM_001024226
NM_001658
ARF1

ADP-ribosylation factor 1

chr7_-_150576634 0.653 SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr17_-_77411607 0.648 P4HB
prolyl 4-hydroxylase, beta polypeptide
chr20_+_43996717 0.645 NM_022104
PCIF1
PDX1 C-terminal inhibiting factor 1
chr6_-_86409415 0.642 SYNCRIP
synaptotagmin binding, cytoplasmic RNA interacting protein
chr19_+_37588355 0.642 NM_001172774
DPY19L3
dpy-19-like 3 (C. elegans)
chr14_+_44436176 0.640 NM_001017923
C14orf28
chromosome 14 open reading frame 28
chr14_+_76297885 0.639 NM_014909
VASH1
vasohibin 1
chr10_+_121400881 0.638 BAG3
BCL2-associated athanogene 3
chr7_-_55607564 0.638 VOPP1
vesicular, overexpressed in cancer, prosurvival protein 1
chr1_+_181259317 0.638


chr8_+_1937711 0.636 KBTBD11
kelch repeat and BTB (POZ) domain containing 11
chr1_+_109827975 0.635 NM_153340
ATXN7L2
ataxin 7-like 2
chr15_-_88446713 0.635 IDH2
isocitrate dehydrogenase 2 (NADP+), mitochondrial
chr9_-_16860664 0.634 BNC2
basonuclin 2
chr6_-_166960690 0.632 NM_021135
RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr1_+_181258952 0.632 NM_002293
LAMC1
laminin, gamma 1 (formerly LAMB2)
chr9_-_35062596 0.624 VCP
valosin containing protein
chr19_+_1358664 0.623 DAZAP1
DAZ associated protein 1
chr8_+_143805595 0.622 NM_016647
C8orf55
chromosome 8 open reading frame 55
chr21_-_45117960 0.621 PTTG1IP
pituitary tumor-transforming 1 interacting protein
chr1_-_1198920 0.621 UBE2J2
ubiquitin-conjugating enzyme E2, J2 (UBC6 homolog, yeast)
chr7_-_72574528 0.619 NM_032408
BAZ1B
bromodomain adjacent to zinc finger domain, 1B
chr14_+_70178126 0.616 NM_015351
TTC9
tetratricopeptide repeat domain 9
chr2_-_161058120 0.614 RBMS1
RNA binding motif, single stranded interacting protein 1
chr17_-_77411659 0.613 P4HB
prolyl 4-hydroxylase, beta polypeptide
chr5_-_37285160 0.611 NM_023073
C5orf42
chromosome 5 open reading frame 42
chr7_-_150576660 0.611 NM_001003801
SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr13_-_76358370 0.608 KCTD12
potassium channel tetramerisation domain containing 12
chr20_-_20641122 0.606 NM_020343
RALGAPA2
Ral GTPase activating protein, alpha subunit 2 (catalytic)
chr10_-_118022965 0.604 NM_005264
GFRA1
GDNF family receptor alpha 1
chr10_-_17699371 0.601 NM_014241
PTPLA
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
chr9_-_35062578 0.601 VCP
valosin containing protein
chr11_+_66381451 0.601 NM_024036
LRFN4
leucine rich repeat and fibronectin type III domain containing 4
chr2_+_232281491 0.600 PTMA
prothymosin, alpha
chr8_+_26491317 0.599 NM_001386
DPYSL2
dihydropyrimidinase-like 2
chr18_+_9903954 0.597 NM_003574
NM_194434
VAPA

VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa

chr4_-_141896920 0.596 NM_015130
TBC1D9
TBC1 domain family, member 9 (with GRAM domain)
chr10_+_170423 0.596 NM_001161482
NM_006624
NM_212479
ZMYND11


zinc finger, MYND-type containing 11


chr15_+_61127367 0.594 NM_001018008
TPM1
tropomyosin 1 (alpha)
chr13_-_73605914 0.588 NM_007249
KLF12
Kruppel-like factor 12
chr9_-_83493415 0.587 NM_005077
TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr2_+_238432925 0.587 NM_005855
RAMP1
receptor (G protein-coupled) activity modifying protein 1
chr9_-_4289915 0.587 GLIS3
GLIS family zinc finger 3
chr2_-_216008689 0.586 FN1
fibronectin 1
chr2_-_175255717 0.583 NM_001077269
WIPF1
WAS/WASL interacting protein family, member 1
chr16_-_86460529 0.582 NM_003486
SLC7A5
solute carrier family 7 (cationic amino acid transporter, y+ system), member 5
chr17_+_4841923 0.582 NM_006612
KIF1C
kinesin family member 1C
chr21_+_36993302 0.581


chr3_-_49424413 0.579 RHOA
ras homolog gene family, member A
chr18_+_9904032 0.579 VAPA
VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
chr3_+_23219490 0.578 UBE2E2
ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast)
chr17_-_33667003 0.576 LOC440434
aminopeptidase puromycin sensitive pseudogene

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.28 3.77e-16 GO:0044260 cellular macromolecule metabolic process
1.19 1.14e-14 GO:0050794 regulation of cellular process
1.18 9.20e-14 GO:0050789 regulation of biological process
1.11 4.05e-13 GO:0009987 cellular process
1.30 5.04e-13 GO:0060255 regulation of macromolecule metabolic process
1.43 9.38e-13 GO:0006464 protein modification process
1.36 1.10e-12 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.19 1.93e-12 GO:0044237 cellular metabolic process
1.29 2.04e-12 GO:0007275 multicellular organismal development
1.27 2.98e-12 GO:0032502 developmental process
1.40 1.19e-11 GO:0043412 macromolecule modification
1.28 1.67e-11 GO:0080090 regulation of primary metabolic process
1.34 1.69e-11 GO:0010556 regulation of macromolecule biosynthetic process
1.46 1.92e-11 GO:0007399 nervous system development
1.27 2.33e-11 GO:0031323 regulation of cellular metabolic process
1.60 2.35e-11 GO:0022008 neurogenesis
1.15 2.49e-11 GO:0065007 biological regulation
1.21 2.25e-10 GO:0043170 macromolecule metabolic process
1.32 2.27e-10 GO:0010468 regulation of gene expression
1.59 3.35e-10 GO:0048699 generation of neurons
1.69 3.36e-10 GO:0007167 enzyme linked receptor protein signaling pathway
1.31 4.78e-10 GO:0031326 regulation of cellular biosynthetic process
1.30 8.86e-10 GO:0009889 regulation of biosynthetic process
1.35 1.35e-09 GO:0030154 cell differentiation
1.32 1.53e-09 GO:0048522 positive regulation of cellular process
1.30 1.57e-09 GO:0071842 cellular component organization at cellular level
1.33 1.98e-09 GO:0051252 regulation of RNA metabolic process
1.34 4.73e-09 GO:0048869 cellular developmental process
1.29 7.43e-09 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.29 1.01e-08 GO:0071841 cellular component organization or biogenesis at cellular level
1.23 1.80e-08 GO:0019222 regulation of metabolic process
1.16 2.14e-08 GO:0044238 primary metabolic process
1.72 3.86e-08 GO:0031175 neuron projection development
1.28 4.62e-08 GO:0051171 regulation of nitrogen compound metabolic process
1.32 5.63e-08 GO:0006355 regulation of transcription, DNA-dependent
1.27 6.23e-08 GO:0048731 system development
1.29 1.08e-07 GO:0044267 cellular protein metabolic process
1.25 1.21e-07 GO:0048856 anatomical structure development
1.76 1.30e-07 GO:0007409 axonogenesis
1.74 1.46e-07 GO:0048812 neuron projection morphogenesis
1.64 1.62e-07 GO:0048666 neuron development
1.62 1.76e-07 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.69 1.95e-07 GO:0000904 cell morphogenesis involved in differentiation
1.58 2.19e-07 GO:0030182 neuron differentiation
1.27 2.31e-07 GO:0048518 positive regulation of biological process
1.48 2.50e-07 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.60 2.84e-07 GO:0030030 cell projection organization
1.59 3.49e-07 GO:0010558 negative regulation of macromolecule biosynthetic process
1.73 3.87e-07 GO:0048667 cell morphogenesis involved in neuron differentiation
1.14 5.09e-07 GO:0008152 metabolic process
1.23 6.29e-07 GO:0016043 cellular component organization
1.66 7.55e-07 GO:0032990 cell part morphogenesis
1.66 7.80e-07 GO:0048858 cell projection morphogenesis
1.63 1.12e-06 GO:0051253 negative regulation of RNA metabolic process
1.36 1.46e-06 GO:0009653 anatomical structure morphogenesis
1.37 1.69e-06 GO:0009966 regulation of signal transduction
1.47 1.77e-06 GO:0048468 cell development
1.55 1.92e-06 GO:0031327 negative regulation of cellular biosynthetic process
1.64 2.00e-06 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.58 3.02e-06 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.62 3.34e-06 GO:0045892 negative regulation of transcription, DNA-dependent
1.54 3.42e-06 GO:0009890 negative regulation of biosynthetic process
1.56 3.82e-06 GO:0032989 cellular component morphogenesis
1.58 3.83e-06 GO:0010629 negative regulation of gene expression
1.58 4.01e-06 GO:0000902 cell morphogenesis
1.78 5.26e-06 GO:0007411 axon guidance
1.21 5.29e-06 GO:0071840 cellular component organization or biogenesis
1.47 5.44e-06 GO:0006351 transcription, DNA-dependent
1.33 6.34e-06 GO:0023051 regulation of signaling
1.48 6.47e-06 GO:0051128 regulation of cellular component organization
1.28 6.67e-06 GO:0048523 negative regulation of cellular process
1.43 6.70e-06 GO:0006793 phosphorus metabolic process
1.43 6.70e-06 GO:0006796 phosphate metabolic process
1.56 8.13e-06 GO:0051172 negative regulation of nitrogen compound metabolic process
1.43 3.43e-05 GO:0010605 negative regulation of macromolecule metabolic process
1.89 5.31e-05 GO:0048011 nerve growth factor receptor signaling pathway
1.42 1.34e-04 GO:0031324 negative regulation of cellular metabolic process
1.63 1.35e-04 GO:0009968 negative regulation of signal transduction
1.43 1.51e-04 GO:0040011 locomotion
1.24 1.51e-04 GO:0048519 negative regulation of biological process
1.71 2.09e-04 GO:0060284 regulation of cell development
1.38 2.75e-04 GO:0032268 regulation of cellular protein metabolic process
1.62 3.44e-04 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.47 3.46e-04 GO:0045595 regulation of cell differentiation
1.58 4.30e-04 GO:0023057 negative regulation of signaling
1.38 4.54e-04 GO:0009892 negative regulation of metabolic process
1.58 4.96e-04 GO:0010648 negative regulation of cell communication
1.67 5.59e-04 GO:0045597 positive regulation of cell differentiation
1.62 8.37e-04 GO:0016568 chromatin modification
1.20 9.79e-04 GO:0019538 protein metabolic process
1.18 1.23e-03 GO:0007165 signal transduction
1.38 1.74e-03 GO:0050793 regulation of developmental process
1.36 2.20e-03 GO:0032774 RNA biosynthetic process
1.20 2.39e-03 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.41 2.61e-03 GO:2000026 regulation of multicellular organismal development
1.33 3.88e-03 GO:0051246 regulation of protein metabolic process
1.16 3.94e-03 GO:0023052 signaling
1.41 4.52e-03 GO:0006468 protein phosphorylation
1.98 5.75e-03 GO:0006470 protein dephosphorylation
1.24 5.90e-03 GO:0048583 regulation of response to stimulus
1.15 6.75e-03 GO:0051716 cellular response to stimulus
1.50 8.91e-03 GO:0072358 cardiovascular system development
1.50 8.91e-03 GO:0072359 circulatory system development
1.97 1.10e-02 GO:0010769 regulation of cell morphogenesis involved in differentiation
1.25 1.14e-02 GO:0009059 macromolecule biosynthetic process
1.69 1.15e-02 GO:0050767 regulation of neurogenesis
1.17 1.18e-02 GO:0034641 cellular nitrogen compound metabolic process
1.25 1.27e-02 GO:0034645 cellular macromolecule biosynthetic process
1.36 1.29e-02 GO:0016310 phosphorylation
1.38 1.29e-02 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.21 1.29e-02 GO:0090304 nucleic acid metabolic process
2.73 1.31e-02 GO:0030509 BMP signaling pathway
1.96 1.41e-02 GO:0022604 regulation of cell morphogenesis
1.37 1.61e-02 GO:0051173 positive regulation of nitrogen compound metabolic process
1.17 2.06e-02 GO:0006807 nitrogen compound metabolic process
2.25 2.09e-02 GO:0007173 epidermal growth factor receptor signaling pathway
1.24 2.32e-02 GO:0016070 RNA metabolic process
1.46 2.33e-02 GO:0048585 negative regulation of response to stimulus
1.31 2.44e-02 GO:0010646 regulation of cell communication
1.39 2.55e-02 GO:0051254 positive regulation of RNA metabolic process
1.41 2.62e-02 GO:0001932 regulation of protein phosphorylation
1.48 2.72e-02 GO:0051094 positive regulation of developmental process
1.45 2.91e-02 GO:0006935 chemotaxis
1.45 2.91e-02 GO:0042330 taxis
1.73 3.00e-02 GO:0045664 regulation of neuron differentiation
1.24 3.32e-02 GO:0006996 organelle organization
1.50 3.36e-02 GO:0007243 intracellular protein kinase cascade
1.50 3.36e-02 GO:0023014 signal transduction via phosphorylation event
1.60 4.16e-02 GO:0051960 regulation of nervous system development
2.00 4.40e-02 GO:0010720 positive regulation of cell development
1.38 4.54e-02 GO:0042325 regulation of phosphorylation
1.98 4.67e-02 GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
1.84 4.81e-02 GO:0016311 dephosphorylation
1.60 4.84e-02 GO:0010608 posttranscriptional regulation of gene expression

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.14 8.75e-27 GO:0044424 intracellular part
1.13 2.69e-25 GO:0005622 intracellular
1.28 5.93e-25 GO:0005634 nucleus
1.17 9.33e-22 GO:0043227 membrane-bounded organelle
1.17 1.08e-21 GO:0043231 intracellular membrane-bounded organelle
1.15 7.69e-19 GO:0043226 organelle
1.15 8.06e-19 GO:0043229 intracellular organelle
1.15 2.40e-13 GO:0005737 cytoplasm
1.35 2.71e-11 GO:0044428 nuclear part
1.37 3.76e-10 GO:0031981 nuclear lumen
1.38 2.23e-07 GO:0005654 nucleoplasm
1.28 4.80e-07 GO:0070013 intracellular organelle lumen
1.27 5.86e-07 GO:0043233 organelle lumen
1.27 8.66e-07 GO:0031974 membrane-enclosed lumen
1.04 1.18e-06 GO:0044464 cell part
1.04 1.25e-06 GO:0005623 cell
1.25 3.81e-05 GO:0005829 cytosol
1.13 4.76e-05 GO:0044444 cytoplasmic part
1.13 2.62e-04 GO:0044446 intracellular organelle part
1.41 4.13e-04 GO:0044451 nucleoplasm part
2.10 1.40e-03 GO:0005925 focal adhesion
1.12 1.46e-03 GO:0044422 organelle part
2.05 2.03e-03 GO:0005924 cell-substrate adherens junction
2.03 2.19e-03 GO:0030055 cell-substrate junction
1.83 3.97e-03 GO:0005912 adherens junction
2.00 1.91e-02 GO:0016585 chromatin remodeling complex
1.69 3.97e-02 GO:0070161 anchoring junction

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.19 1.20e-18 GO:0005515 protein binding
1.11 4.93e-17 GO:0005488 binding
1.49 2.54e-09 GO:0030528 transcription regulator activity
1.30 1.48e-08 GO:0003677 DNA binding
1.44 5.02e-07 GO:0001071 nucleic acid binding transcription factor activity
1.44 5.02e-07 GO:0003700 sequence-specific DNA binding transcription factor activity
1.64 3.04e-06 GO:0019904 protein domain specific binding
1.21 6.98e-06 GO:0003676 nucleic acid binding
1.49 1.48e-05 GO:0043565 sequence-specific DNA binding
1.79 5.36e-05 GO:0016791 phosphatase activity
1.96 1.33e-04 GO:0004721 phosphoprotein phosphatase activity
1.58 5.11e-04 GO:0000988 protein binding transcription factor activity
1.58 5.11e-04 GO:0000989 transcription factor binding transcription factor activity
1.41 5.17e-04 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.39 5.88e-04 GO:0016301 kinase activity
1.57 8.20e-04 GO:0003712 transcription cofactor activity
2.13 1.12e-03 GO:0005057 receptor signaling protein activity
1.21 1.22e-03 GO:0000166 nucleotide binding
1.91 1.47e-03 GO:0003714 transcription corepressor activity
1.39 1.51e-03 GO:0019899 enzyme binding
1.35 1.56e-03 GO:0016772 transferase activity, transferring phosphorus-containing groups
4.92 2.07e-03 GO:0005072 transforming growth factor beta receptor, cytoplasmic mediator activity
1.59 2.87e-03 GO:0016563 transcription activator activity
1.73 3.53e-03 GO:0000975 regulatory region DNA binding
1.73 3.53e-03 GO:0001067 regulatory region nucleic acid binding
1.73 3.53e-03 GO:0044212 transcription regulatory region DNA binding
1.75 3.64e-03 GO:0010843 promoter binding
1.55 4.86e-03 GO:0042578 phosphoric ester hydrolase activity
2.16 7.35e-03 GO:0019199 transmembrane receptor protein kinase activity
1.57 1.08e-02 GO:0008134 transcription factor binding
1.39 1.13e-02 GO:0004672 protein kinase activity
1.22 1.35e-02 GO:0016740 transferase activity
1.55 1.49e-02 GO:0016564 transcription repressor activity
1.64 2.28e-02 GO:0004842 ubiquitin-protein ligase activity
1.57 3.18e-02 GO:0016881 acid-amino acid ligase activity
4.78 4.93e-02 GO:0030332 cyclin binding