Motif ID: LEF1_TCF7_TCF7L1,2.p2

Z-value: 3.021


Transcription factors associated with LEF1_TCF7_TCF7L1,2.p2:

Gene SymbolEntrez IDGene Name
LEF1 51176 lymphoid enhancer-binding factor 1
TCF7 6932 transcription factor 7 (T-cell specific, HMG-box)
TCF7L1 83439 transcription factor 7-like 1 (T-cell specific, HMG-box)
TCF7L2 6934 transcription factor 7-like 2 (T-cell specific, HMG-box)



Activity profile for motif LEF1_TCF7_TCF7L1,2.p2.

activity profile for motif LEF1_TCF7_TCF7L1,2.p2


Sorted Z-values histogram for motif LEF1_TCF7_TCF7L1,2.p2

Sorted Z-values for motif LEF1_TCF7_TCF7L1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of LEF1_TCF7_TCF7L1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_11597530 8.747 NM_148903
GREB1
growth regulation by estrogen in breast cancer 1
chr17_-_76985538 6.997


chr6_-_128883125 6.708 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chr12_-_120781002 6.613 NM_002150
HPD
4-hydroxyphenylpyruvate dioxygenase
chr17_-_60986905 6.036 AXIN2
axin 2
chr3_+_152970904 4.570 LOC201651
arylacetamide deacetylase (esterase) pseudogene
chr3_-_150422474 4.388 NM_000096
CP
ceruloplasmin (ferroxidase)
chr14_-_22521544 4.330 NM_032876
JUB
jub, ajuba homolog (Xenopus laevis)
chr6_+_167624792 4.308 NM_001143947
NM_018974
UNC93A

unc-93 homolog A (C. elegans)

chr2_+_228386800 4.269 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr5_-_16791346 4.190 MYO10
myosin X
chr10_+_7785347 3.905 ITIH2
inter-alpha (globulin) inhibitor H2
chr10_+_7785360 3.661 ITIH2
inter-alpha (globulin) inhibitor H2
chr11_+_101488380 3.633 NM_001195045
YAP1
Yes-associated protein 1
chr2_+_171280046 3.630 NM_001003845
SP5
Sp5 transcription factor
chr8_+_121892719 3.583


chr10_+_53744043 3.550 NM_012242
DKK1
dickkopf homolog 1 (Xenopus laevis)
chr2_-_75641587 3.515 NM_001135032
FAM176A
family with sequence similarity 176, member A
chr10_+_7785331 3.509 ITIH2
inter-alpha (globulin) inhibitor H2
chr2_-_75641535 3.470 FAM176A
family with sequence similarity 176, member A
chr2_+_233443237 3.433 NM_206895
C2orf82
chromosome 2 open reading frame 82
chr9_+_96806235 3.313 C9orf3
chromosome 9 open reading frame 3
chr2_+_171280182 3.248


chr13_+_75232797 3.228 NM_015842
LMO7
LIM domain 7
chr5_-_58370693 3.064 NM_001197221
NM_001197222
PDE4D

phosphodiesterase 4D, cAMP-specific

chr15_-_63457378 2.992 NM_004884
IGDCC3
immunoglobulin superfamily, DCC subclass, member 3
chr15_+_38082041 2.992 EIF2AK4
eukaryotic translation initiation factor 2 alpha kinase 4
chr8_-_121893196 2.953


chr6_-_138935359 2.929 NM_020464
NHSL1
NHS-like 1
chr10_+_7785235 2.928 NM_002216
ITIH2
inter-alpha (globulin) inhibitor H2
chr18_-_24010944 2.908 CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr20_-_42457717 2.905


chr19_+_59061422 2.900 NM_001020820
MYADM
myeloid-associated differentiation marker
chr8_-_121892877 2.900 SNTB1
syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
chr17_+_72795567 2.856 NM_001113492
SEPT9
septin 9
chr10_+_114144512 2.789 ACSL5
acyl-CoA synthetase long-chain family member 5
chr10_+_7785290 2.755 ITIH2
inter-alpha (globulin) inhibitor H2
chr6_-_2785682 2.747 SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr6_+_144649142 2.709 UTRN
utrophin
chr6_+_131190237 2.707 NM_001195597
LOC285733
hypothetical LOC285733
chr22_+_18330049 2.673 NM_007310
COMT
catechol-O-methyltransferase
chr18_-_24011349 2.534 NM_001792
CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr17_+_69939806 2.516 GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr17_+_7900926 2.500


chr10_+_114699953 2.463 NM_001146274
NM_001146283
NM_001146284
NM_001146285
NM_001146286
NM_001198525
NM_001198526
NM_001198527
NM_001198528
NM_001198529
NM_001198530
NM_001198531
NM_030756
TCF7L2












transcription factor 7-like 2 (T-cell specific, HMG-box)












chr6_-_11340886 2.423 NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr7_+_72883128 2.422 NM_001305
CLDN4
claudin 4
chr9_-_14858974 2.380 FREM1
FRAS1 related extracellular matrix 1
chr16_-_71639670 2.358 NM_006885
ZFHX3
zinc finger homeobox 3
chr6_-_11340887 2.349 NM_006403
NM_182966
NEDD9

neural precursor cell expressed, developmentally down-regulated 9

chr7_+_29200636 2.347 NM_004067
CHN2
chimerin (chimaerin) 2
chr2_+_219354948 2.292 CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1
chr6_-_11340869 2.275 NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr1_+_9222489 2.192 H6PD
hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
chr13_+_23042722 2.189 NM_148957
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr1_+_16203317 2.173 NM_178840
C1orf64
chromosome 1 open reading frame 64
chr11_+_69165065 2.166 CCND1
cyclin D1
chr17_-_60988226 2.079 AXIN2
axin 2
chr17_-_60988077 2.065 NM_004655
AXIN2
axin 2
chr11_+_69165119 2.062 CCND1
cyclin D1
chr9_-_98185815 2.050 SLC35D2
solute carrier family 35, member D2
chr11_+_69165018 2.045 NM_053056
CCND1
cyclin D1
chr14_+_105012106 2.027 NM_001312
CRIP2
cysteine-rich protein 2
chr14_-_64479198 2.018 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr11_+_69165159 1.993 CCND1
cyclin D1
chrX_-_105169370 1.973 NM_000354
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr9_-_98185613 1.930 NM_007001
SLC35D2
solute carrier family 35, member D2
chr10_+_73393998 1.877 NM_004273
CHST3
carbohydrate (chondroitin 6) sulfotransferase 3
chr3_-_150858274 1.847 NM_001168280
NM_015472
WWTR1

WW domain containing transcription regulator 1

chr1_-_229071957 1.784 NM_001136494
C1orf198
chromosome 1 open reading frame 198
chr1_-_95165089 1.783 NM_001839
CNN3
calponin 3, acidic
chr11_+_46697312 1.762 NM_000506
F2
coagulation factor II (thrombin)
chr5_+_34720368 1.757 NM_001145521
NM_001145525
RAI14

retinoic acid induced 14

chr3_-_127258299 1.747 NM_001008487
SLC41A3
solute carrier family 41, member 3
chr9_-_126309510 1.745 NM_004959
NR5A1
nuclear receptor subfamily 5, group A, member 1
chr2_+_101680594 1.732 NM_004834
NM_145686
NM_145687
MAP4K4


mitogen-activated protein kinase kinase kinase kinase 4


chr18_-_44723116 1.716 NM_001190823
SMAD7
SMAD family member 7
chr2_-_98714020 1.716 NM_012214
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr9_+_115265827 1.709 NM_017790
RGS3
regulator of G-protein signaling 3
chr11_+_46697345 1.695 F2
coagulation factor II (thrombin)
chr2_+_11600238 1.688 GREB1
growth regulation by estrogen in breast cancer 1
chr2_+_54537842 1.677 SPTBN1
spectrin, beta, non-erythrocytic 1
chr10_-_116434364 1.656 NM_001003407
NM_001003408
ABLIM1

actin binding LIM protein 1

chr7_-_107430566 1.642 NM_002291
LAMB1
laminin, beta 1
chr11_+_46697335 1.638 F2
coagulation factor II (thrombin)
chr12_-_49076658 1.638 NM_001145475
FAM186A
family with sequence similarity 186, member A
chr7_-_27186400 1.634 NM_153715
HOXA10
homeobox A10
chr16_+_56259657 1.631 NM_170776
GPR97
G protein-coupled receptor 97
chr17_-_36347197 1.607 NM_015515
KRT23
keratin 23 (histone deacetylase inducible)
chr1_+_48460943 1.606 NM_001011547
NM_001135181
SLC5A9

solute carrier family 5 (sodium/glucose cotransporter), member 9

chr7_-_158304062 1.593 ESYT2
extended synaptotagmin-like protein 2
chr1_+_57093030 1.589 NM_000562
C8A
complement component 8, alpha polypeptide
chr12_-_15833383 1.585 EPS8
epidermal growth factor receptor pathway substrate 8
chr20_-_32363268 1.550 NM_001161766
AHCY
adenosylhomocysteinase
chr3_-_115826481 1.547 NM_001164346
ZBTB20
zinc finger and BTB domain containing 20
chr9_+_111927601 1.539 NM_001136562
AKAP2
A kinase (PRKA) anchor protein 2
chr2_-_98713862 1.515 MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr11_+_74548472 1.514 NM_001145211
SLCO2B1
solute carrier organic anion transporter family, member 2B1
chr2_-_74606819 1.506 NM_133637
DQX1
DEAQ box RNA-dependent ATPase 1
chr14_-_30746577 1.477


chr2_+_11600287 1.476 NM_033090
GREB1
growth regulation by estrogen in breast cancer 1
chr4_+_90252990 1.455 NM_145715
TIGD2
tigger transposable element derived 2
chrX_-_2857351 1.451 NM_001669
NM_009589
ARSD

arylsulfatase D

chr13_+_75108450 1.425 LMO7
LIM domain 7
chr6_+_64339869 1.422 NM_003463
PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr3_-_65999548 1.409 NM_001033057
NM_004742
NM_015520
MAGI1


membrane associated guanylate kinase, WW and PDZ domain containing 1


chrX_-_2857315 1.393 ARSD
arylsulfatase D
chr16_+_49139694 1.392 NM_033119
NKD1
naked cuticle homolog 1 (Drosophila)
chr2_+_69093641 1.390 NM_018153
NM_032208
NM_053034
ANTXR1


anthrax toxin receptor 1


chr17_-_23721468 1.384 VTN
vitronectin
chr4_+_69996780 1.384 NM_001074
UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr10_-_52315390 1.377 A1CF
APOBEC1 complementation factor
chr8_-_145613034 1.362 SLC39A4
solute carrier family 39 (zinc transporter), member 4
chr16_+_70646008 1.361 NM_001126102
NM_005143
HP

haptoglobin

chr6_-_26038817 1.354 NM_005835
SLC17A2
solute carrier family 17 (sodium phosphate), member 2
chr14_-_30746431 1.346 NM_015382
HECTD1
HECT domain containing 1
chr10_+_24795446 1.343 KIAA1217
KIAA1217
chrX_+_49718954 1.330 NM_000084
CLCN5
chloride channel 5
chr6_+_123151669 1.310 NM_006714
SMPDL3A
sphingomyelin phosphodiesterase, acid-like 3A
chr11_-_124311106 1.307 HEPACAM
hepatic and glial cell adhesion molecule
chr1_+_99884018 1.261 NM_017734
PALMD
palmdelphin
chr1_-_176329357 1.259 LOC100302401
hypothetical LOC100302401
chr4_-_158111504 1.239 PDGFC
platelet derived growth factor C
chr18_+_66107222 1.227 SOCS6
suppressor of cytokine signaling 6
chr17_-_36346240 1.221 KRT23
keratin 23 (histone deacetylase inducible)
chr16_-_12805194 1.217 NM_001099455
NM_018340
CPPED1

calcineurin-like phosphoesterase domain containing 1

chr1_+_93686154 1.210 NM_001024948
NM_001164473
NM_017737
FNBP1L


formin binding protein 1-like


chr8_+_103889733 1.208 FLJ45248
FLJ45248 protein
chr2_-_38683119 1.199 HNRPLL
heterogeneous nuclear ribonucleoprotein L-like
chr4_-_158111916 1.197 PDGFC
platelet derived growth factor C
chr6_+_123152044 1.197 SMPDL3A
sphingomyelin phosphodiesterase, acid-like 3A
chr18_+_3439972 1.194 NM_173209
NM_173208
NM_003244
TGIF1


TGFB-induced factor homeobox 1


chr19_-_6671585 1.193 NM_000064
C3
complement component 3
chr3_+_142569988 1.183 ZBTB38
zinc finger and BTB domain containing 38
chr10_+_102722275 1.174 NM_017893
SEMA4G
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr4_-_158111995 1.168 NM_016205
PDGFC
platelet derived growth factor C
chr17_-_53420595 1.162 NM_007146
VEZF1
vascular endothelial zinc finger 1
chr10_+_24795465 1.143 KIAA1217
KIAA1217
chr17_+_72958920 1.131 SEPT9
septin 9
chr10_-_99436889 1.113 NM_021732
AVPI1
arginine vasopressin-induced 1
chrX_+_46822751 1.091 RGN
regucalcin (senescence marker protein-30)
chr13_+_100902942 1.087 NM_004791
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr7_-_27180398 1.085 NM_018951
HOXA10
homeobox A10
chr4_-_7991992 1.083 NM_001134647
NM_198595
AFAP1

actin filament associated protein 1

chr16_+_30314276 1.067


chr13_-_98428244 1.057 NM_001130048
NM_001130050
DOCK9

dedicator of cytokinesis 9

chr2_+_233961538 1.055 NM_003648
DGKD
diacylglycerol kinase, delta 130kDa
chr17_-_36475652 1.054 NM_033184
KRTAP2-4
keratin associated protein 2-4
chr10_-_52315436 1.054 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr3_+_187813405 1.050 AHSG
alpha-2-HS-glycoprotein
chr16_-_12805133 1.028 CPPED1
calcineurin-like phosphoesterase domain containing 1
chrX_+_54852217 1.024 NM_201222
MAGED2
melanoma antigen family D, 2
chr17_-_53420473 1.017 VEZF1
vascular endothelial zinc finger 1
chr17_-_53849888 1.013 RNF43
ring finger protein 43
chr11_+_62813947 1.012 NM_001039752
SLC22A10
solute carrier family 22, member 10
chr1_-_11029737 1.002 NM_006610
NM_139208
MASP2

mannan-binding lectin serine peptidase 2

chr3_-_115960807 1.002 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr19_-_18578467 0.998 CRLF1
cytokine receptor-like factor 1
chr17_+_28279040 0.997 NM_001033504
NM_015544
TMEM98

transmembrane protein 98

chr4_-_159311959 0.996 FAM198B
family with sequence similarity 198, member B
chr6_-_112001590 0.995 NM_001164282
TRAF3IP2
TRAF3 interacting protein 2
chr10_+_135010833 0.995 NM_001145201
NM_145202
PRAP1

proline-rich acidic protein 1

chr3_+_9919511 0.994 NM_001193380
NM_153480
IL17RE

interleukin 17 receptor E

chr3_-_135575925 0.993 NM_016201
AMOTL2
angiomotin like 2
chr10_-_101831579 0.983 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr10_-_116382089 0.973 ABLIM1
actin binding LIM protein 1
chrX_+_70359780 0.965 NM_000166
GJB1
gap junction protein, beta 1, 32kDa
chr20_+_39199542 0.962 NM_002660
NM_182811
PLCG1

phospholipase C, gamma 1

chr1_-_110108048 0.958 NM_024526
NM_133181
NM_139053
EPS8L3


EPS8-like 3


chr7_-_139523187 0.954 NM_030647
JHDM1D
jumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae)
chr5_-_73973004 0.953 NM_003633
ENC1
ectodermal-neural cortex 1 (with BTB-like domain)
chr7_+_142692165 0.951 NM_153345
TMEM139
transmembrane protein 139
chr14_-_20642629 0.948 NM_001102454
ZNF219
zinc finger protein 219
chr1_+_149437602 0.943 NM_001135636
NM_001135637
NM_001135638
NM_003557
PIP5K1A



phosphatidylinositol-4-phosphate 5-kinase, type I, alpha



chr17_-_44226595 0.942 NM_173623
TTLL6
tubulin tyrosine ligase-like family, member 6
chr4_-_40911212 0.939 NM_001166050
NM_004307
NM_173075
APBB2


amyloid beta (A4) precursor protein-binding, family B, member 2


chr3_-_121883647 0.926 HGD
homogentisate 1,2-dioxygenase
chr1_+_67923660 0.920 GADD45A
growth arrest and DNA-damage-inducible, alpha
chr14_-_38642029 0.918 SEC23A
Sec23 homolog A (S. cerevisiae)
chr17_+_28279283 0.911 TMEM98
transmembrane protein 98
chr19_-_18578577 0.911 CRLF1
cytokine receptor-like factor 1
chr1_+_2026014 0.906 NM_001033582
PRKCZ
protein kinase C, zeta
chr5_+_60663842 0.887 NM_020928
ZSWIM6
zinc finger, SWIM-type containing 6
chr17_-_53849929 0.881 NM_017763
RNF43
ring finger protein 43
chr11_+_22646229 0.877 NM_177553
GAS2
growth arrest-specific 2
chr7_-_98643024 0.877 NM_001145715
KPNA7
karyopherin alpha 7 (importin alpha 8)
chr16_-_11274952 0.875 NM_021247
PRM3
protamine 3
chr1_+_59535074 0.874 NM_001113411
NM_018291
FGGY

FGGY carbohydrate kinase domain containing

chr17_+_35425139 0.870 NM_000759
NM_001178147
NM_172219
NM_172220
CSF3



colony stimulating factor 3 (granulocyte)



chr7_+_128615948 0.868 NM_005631
SMO
smoothened homolog (Drosophila)
chr11_-_46572160 0.865 AMBRA1
autophagy/beclin-1 regulator 1
chr1_-_172153087 0.865 NM_000488
SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr17_+_77289804 0.863 SLC25A10
solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
chr5_+_66160359 0.856 NM_015183
MAST4
microtubule associated serine/threonine kinase family member 4
chr19_-_18578631 0.850 NM_004750
CRLF1
cytokine receptor-like factor 1
chrX_+_46822688 0.850 NM_004683
NM_152869
RGN

regucalcin (senescence marker protein-30)

chr17_+_19377732 0.849 NM_018242
SLC47A1
solute carrier family 47, member 1
chr16_+_55963883 0.839 CX3CL1
chemokine (C-X3-C motif) ligand 1
chr13_+_109936080 0.839 COL4A2
collagen, type IV, alpha 2
chr3_-_71196696 0.828 FOXP1
forkhead box P1

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.14 1.40e-02 GO:0005515 protein binding