Motif ID: NFATC1..3.p2

Z-value: 2.571


Transcription factors associated with NFATC1..3.p2:

Gene SymbolEntrez IDGene Name
NFATC1 4772 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFATC2 4773 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFATC3 4775 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3



Activity profile for motif NFATC1..3.p2.

activity profile for motif NFATC1..3.p2


Sorted Z-values histogram for motif NFATC1..3.p2

Sorted Z-values for motif NFATC1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFATC1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_+_13240983 9.825 EMP1
epithelial membrane protein 1
chr12_+_13240987 9.559 EMP1
epithelial membrane protein 1
chr12_+_13240868 8.217 NM_001423
EMP1
epithelial membrane protein 1
chr10_-_116434364 6.670 NM_001003407
NM_001003408
ABLIM1

actin binding LIM protein 1

chr18_-_51219880 5.569 TCF4
transcription factor 4
chr10_-_116434102 5.049 ABLIM1
actin binding LIM protein 1
chr11_-_85115105 4.469 NM_206927
NM_206928
SYTL2

synaptotagmin-like 2

chr8_-_13416554 4.385 NM_024767
NM_182643
DLC1

deleted in liver cancer 1

chr6_-_128883125 4.054 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chr22_-_34566210 3.892 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr1_+_157246305 3.871 NM_005531
IFI16
interferon, gamma-inducible protein 16
chr9_+_676640 3.694


chr1_+_160868932 3.454 DDR2
discoidin domain receptor tyrosine kinase 2
chr15_-_40537002 3.363 NM_022473
ZFP106
zinc finger protein 106 homolog (mouse)
chr4_-_115120251 3.329 NM_024590
ARSJ
arylsulfatase family, member J
chr13_-_79810972 3.301 SPRY2
sprouty homolog 2 (Drosophila)
chr22_-_34566367 3.200 NM_001031695
NM_001082576
NM_001082577
NM_014309
RBFOX2



RNA binding protein, fox-1 homolog (C. elegans) 2



chr22_-_34566276 3.186 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr1_+_160868822 3.114 NM_001014796
NM_006182
DDR2

discoidin domain receptor tyrosine kinase 2

chr18_+_3443771 2.963 NM_173211
TGIF1
TGFB-induced factor homeobox 1
chr4_-_152366970 2.805 NM_001009555
NM_001128923
SH3D19

SH3 domain containing 19

chr12_-_50871953 2.803 NM_001081492
NM_182507
KRT80

keratin 80

chr11_+_65027721 2.791


chr4_-_153820535 2.729 NM_152680
TMEM154
transmembrane protein 154
chr12_+_118100977 2.726 NM_014365
HSPB8
heat shock 22kDa protein 8
chr14_+_62740878 2.701 NM_020663
RHOJ
ras homolog gene family, member J
chr3_+_185537969 2.677 NM_144635
FAM131A
family with sequence similarity 131, member A
chr2_-_202271598 2.670 NM_033066
MPP4
membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
chr2_-_188021117 2.658 NM_005795
CALCRL
calcitonin receptor-like
chr9_+_35528890 2.600 RUSC2
RUN and SH3 domain containing 2
chr9_+_74956494 2.588 NM_000700
ANXA1
annexin A1
chr4_-_141293572 2.544 MAML3
mastermind-like 3 (Drosophila)
chr12_+_32578513 2.507 FGD4
FYVE, RhoGEF and PH domain containing 4
chrX_-_19598912 2.474 NM_001184960
SH3KBP1
SH3-domain kinase binding protein 1
chr1_+_66772393 2.437 NM_032291
SGIP1
SH3-domain GRB2-like (endophilin) interacting protein 1
chrX_-_10504852 2.425 NM_001193277
MID1
midline 1 (Opitz/BBB syndrome)
chrX_+_100692071 2.422 NM_016608
ARMCX1
armadillo repeat containing, X-linked 1
chr17_+_7732759 2.409 NM_001005273
NM_005852
CHD3

chromodomain helicase DNA binding protein 3

chr20_+_12937616 2.392 NM_018327
SPTLC3
serine palmitoyltransferase, long chain base subunit 3
chr11_+_101290930 2.388 NM_020802
KIAA1377
KIAA1377
chr7_+_115952074 2.361 NM_001753
CAV1
caveolin 1, caveolae protein, 22kDa
chr6_+_116939500 2.349 NM_153711
FAM26E
family with sequence similarity 26, member E
chr6_-_152744022 2.309 SYNE1
spectrin repeat containing, nuclear envelope 1
chr15_+_37330176 2.299 NM_207445
C15orf54
chromosome 15 open reading frame 54
chr9_+_12764988 2.275 NM_203403
C9orf150
chromosome 9 open reading frame 150
chr2_+_66519949 2.266 MEIS1
Meis homeobox 1
chr3_-_150533948 2.236 NM_001184723
NM_138786
TM4SF18

transmembrane 4 L six family member 18

chr9_+_35528628 2.222 NM_001135999
RUSC2
RUN and SH3 domain containing 2
chr1_-_68470585 2.211 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr12_+_12829807 2.200 NM_030817
APOLD1
apolipoprotein L domain containing 1
chr10_-_31328426 2.183 NM_001143769
ZNF438
zinc finger protein 438
chr4_-_152368492 2.176 SH3D19
SH3 domain containing 19
chr7_+_93388951 2.146 NM_004126
GNG11
guanine nucleotide binding protein (G protein), gamma 11
chr20_+_42644633 2.142 PKIG
protein kinase (cAMP-dependent, catalytic) inhibitor gamma
chr3_-_194118321 2.121 MB21D2
Mab-21 domain containing 2
chr4_-_153493133 2.107 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chr13_+_100902942 2.100 NM_004791
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr5_-_54317102 2.094 NM_001135604
NM_007036
ESM1

endothelial cell-specific molecule 1

chrX_+_2680092 2.059 NM_001141919
NM_001141920
NM_175569
XGPY2
XG


Xg pseudogene, Y-linked 2
Xg blood group


chr3_-_113842553 2.040 CCDC80
coiled-coil domain containing 80
chr7_+_22733626 2.015 IL6
interleukin 6 (interferon, beta 2)
chr1_+_85819004 2.009 NM_001554
CYR61
cysteine-rich, angiogenic inducer, 61
chr17_+_29606408 2.003 NM_002982
CCL2
chemokine (C-C motif) ligand 2
chr21_-_27261276 2.002 NM_007038
ADAMTS5
ADAM metallopeptidase with thrombospondin type 1 motif, 5
chr3_-_113842652 1.991 NM_199511
NM_199512
CCDC80

coiled-coil domain containing 80

chrX_+_56772391 1.974 LOC550643
hypothetical LOC550643
chr13_+_96672541 1.938 NM_144778
NM_207304
MBNL2

muscleblind-like 2 (Drosophila)

chr13_-_32822759 1.931 STARD13
StAR-related lipid transfer (START) domain containing 13
chr3_+_158637273 1.920 NM_002852
PTX3
pentraxin 3, long
chr5_+_55182963 1.909 NM_139017
IL31RA
interleukin 31 receptor A
chr7_-_41709191 1.903 NM_002192
INHBA
inhibin, beta A
chr3_+_11242666 1.871 NM_001098211
HRH1
histamine receptor H1
chr1_-_94475504 1.867 ARHGAP29
Rho GTPase activating protein 29
chr1_+_98899734 1.860 NM_015976
NM_152238
SNX7

sorting nexin 7

chr11_+_5597749 1.845 NM_001003827
TRIM34
tripartite motif containing 34
chr2_-_237987545 1.844 COL6A3
collagen, type VI, alpha 3
chr17_-_15104768 1.842 NM_153322
PMP22
peripheral myelin protein 22
chr2_-_237987553 1.833 COL6A3
collagen, type VI, alpha 3
chr9_-_128924819 1.824 NM_012098
ANGPTL2
angiopoietin-like 2
chr18_+_7936885 1.823 PTPRM
protein tyrosine phosphatase, receptor type, M
chr1_+_161305558 1.821 NM_001113381
RGS4
regulator of G-protein signaling 4
chr22_+_29808845 1.800 SMTN
smoothelin
chr2_+_110013297 1.772 NM_033514
LIMS3-LOC440895
LIMS3
LIMS3-LOC440895 read-through
LIM and senescent cell antigen-like domains 3
chr8_+_107351519 1.770 NM_001198533
NM_018002
LOC346887
OXR1

similar to solute carrier family 16 (monocarboxylic acid transporters), member 14
oxidation resistance 1

chr10_+_91077581 1.768 NM_001549
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr19_+_46417117 1.768 AXL
AXL receptor tyrosine kinase
chr6_-_134537699 1.750 NM_005627
SGK1
serum/glucocorticoid regulated kinase 1
chr6_-_134537637 1.743 SGK1
serum/glucocorticoid regulated kinase 1
chr4_-_89963177 1.723 NM_001015045
FAM13A
family with sequence similarity 13, member A
chr5_-_59100091 1.723 PDE4D
phosphodiesterase 4D, cAMP-specific
chr2_-_204108151 1.722 NM_203365
NM_213589
RAPH1

Ras association (RalGDS/AF-6) and pleckstrin homology domains 1

chr2_-_110665188 1.708 NM_033514
LIMS3-LOC440895
LIMS3
LIMS3-LOC440895 read-through
LIM and senescent cell antigen-like domains 3
chr16_+_65868913 1.699 NM_015432
PLEKHG4
pleckstrin homology domain containing, family G (with RhoGef domain) member 4
chr11_+_113672407 1.683 NNMT
nicotinamide N-methyltransferase
chr18_+_64616296 1.678 NM_024781
CCDC102B
coiled-coil domain containing 102B
chr12_+_10074542 1.657 NM_207345
CLEC9A
C-type lectin domain family 9, member A
chr7_+_28692122 1.652 NM_001011666
CREB5
cAMP responsive element binding protein 5
chr11_-_66898223 1.651 NM_001166212
CLCF1
cardiotrophin-like cytokine factor 1
chr5_-_59100194 1.638 NM_001197218
PDE4D
phosphodiesterase 4D, cAMP-specific
chr5_+_34720368 1.615 NM_001145521
NM_001145525
RAI14

retinoic acid induced 14

chr2_-_237987509 1.602 COL6A3
collagen, type VI, alpha 3
chr6_-_2580296 1.600 NM_152554
C6orf195
chromosome 6 open reading frame 195
chr9_+_5500544 1.585 NM_025239
PDCD1LG2
programmed cell death 1 ligand 2
chr20_+_19863716 1.583 RIN2
Ras and Rab interactor 2
chr6_-_158985727 1.571 NM_006519
DYNLT1
dynein, light chain, Tctex-type 1
chr3_+_103029523 1.571 NM_001005474
NFKBIZ
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr13_-_22905822 1.558 NM_014363
SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr2_-_237987579 1.556 NM_004369
NM_057164
NM_057165
NM_057166
NM_057167
COL6A3




collagen, type VI, alpha 3




chr8_+_42671718 1.556 NM_000749
CHRNB3
cholinergic receptor, nicotinic, beta 3
chr2_-_237987554 1.552 COL6A3
collagen, type VI, alpha 3
chr1_-_94475840 1.551 NM_004815
ARHGAP29
Rho GTPase activating protein 29
chr1_-_151804929 1.549 NM_005978
S100A2
S100 calcium binding protein A2
chr11_-_68537243 1.544 NM_001098515
NM_145015
MRGPRF

MAS-related GPR, member F

chr20_-_14266200 1.542 NM_013281
NM_198391
FLRT3

fibronectin leucine rich transmembrane protein 3

chr3_-_113841448 1.539 CCDC80
coiled-coil domain containing 80
chr17_-_44022595 1.539 HOXB3
homeobox B3
chr16_+_4842077 1.517 NM_016936
UBN1
ubinuclein 1
chr5_-_73973004 1.507 NM_003633
ENC1
ectodermal-neural cortex 1 (with BTB-like domain)
chr5_-_146813343 1.495 NM_001387
DPYSL3
dihydropyrimidinase-like 3
chr6_-_112682401 1.491 LAMA4
laminin, alpha 4
chr8_-_93144039 1.490


chr17_-_30783631 1.489 NM_018042
SLFN12
schlafen family member 12
chr2_+_108637698 1.488 NM_001193485
LIMS1
LIM and senescent cell antigen-like domains 1
chr2_-_189752575 1.487 NM_000393
COL5A2
collagen, type V, alpha 2
chr4_-_70661018 1.484 NM_014465
SULT1B1
sulfotransferase family, cytosolic, 1B, member 1
chr3_+_69216747 1.470 NM_006407
ARL6IP5
ADP-ribosylation-like factor 6 interacting protein 5
chr1_-_79244948 1.464 NM_022159
ELTD1
EGF, latrophilin and seven transmembrane domain containing 1
chr18_+_27281729 1.464 NM_001944
DSG3
desmoglein 3
chr18_+_3441589 1.462 NM_170695
NM_173210
TGIF1

TGFB-induced factor homeobox 1

chr6_-_112186977 1.459 NM_153048
FYN
FYN oncogene related to SRC, FGR, YES
chr1_-_89261021 1.458 NM_018284
GBP3
guanylate binding protein 3
chr17_-_40339919 1.455 GFAP
glial fibrillary acidic protein
chr8_-_49996353 1.443 NM_003068
SNAI2
snail homolog 2 (Drosophila)
chr11_-_71458739 1.436 NUMA1
nuclear mitotic apparatus protein 1
chr12_-_90097384 1.431 NM_133503
DCN
decorin
chr2_-_227952249 1.416 NM_024795
TM4SF20
transmembrane 4 L six family member 20
chr6_+_116798791 1.416 NM_013352
DSE
dermatan sulfate epimerase
chr19_+_42689881 1.412 ZNF793
zinc finger protein 793
chr6_-_33862690 1.411 NM_001143944
LEMD2
LEM domain containing 2
chr2_-_55090759 1.407 NM_007008
RTN4
reticulon 4
chr11_-_104344473 1.406 NM_001225
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr3_-_124893875 1.406 MYLK
myosin light chain kinase
chr4_+_109033868 1.406 NM_001136257
NM_152621
SGMS2

sphingomyelin synthase 2

chr3_-_109423858 1.406 NM_018010
IFT57
intraflagellar transport 57 homolog (Chlamydomonas)
chr17_-_5428491 1.400 NM_001033053
NM_014922
NM_033004
NM_033006
NM_033007
NLRP1




NLR family, pyrin domain containing 1




chr16_-_63713485 1.386 CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr1_+_46151845 1.383 MAST2
microtubule associated serine/threonine kinase 2
chr21_-_38792173 1.381 NM_001136155
NM_182918
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr2_-_201930311 1.380 NM_001127391
NM_139163
ALS2CR12

amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 12

chr16_-_63713382 1.374 NM_001797
CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr16_-_63713466 1.373 CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr1_+_215871288 1.369 NM_138796
SPATA17
spermatogenesis associated 17
chr6_-_112682459 1.368 NM_001105206
NM_001105207
NM_001105208
NM_001105209
NM_002290
LAMA4




laminin, alpha 4




chr21_-_35174742 1.368 RUNX1
runt-related transcription factor 1
chr5_-_58607673 1.360 NM_001197220
PDE4D
phosphodiesterase 4D, cAMP-specific
chr20_-_17487480 1.354 NM_001161705
BFSP1
beaded filament structural protein 1, filensin
chr9_+_88953378 1.349 NM_001001709
C9orf170
chromosome 9 open reading frame 170
chr5_+_38481392 1.344 NM_182801
EGFLAM
EGF-like, fibronectin type III and laminin G domains
chr12_-_48902692 1.339 NM_001113547
LIMA1
LIM domain and actin binding 1
chr1_-_215870935 1.336 NM_018040
GPATCH2
G patch domain containing 2
chr11_-_35503720 1.328 NM_001001991
NM_015430
PAMR1

peptidase domain containing associated with muscle regeneration 1

chr1_-_224993498 1.328 NM_002221
ITPKB
inositol 1,4,5-trisphosphate 3-kinase B
chr8_-_6407882 1.326 NM_001118887
NM_001118888
NM_001147
ANGPT2


angiopoietin 2


chr12_+_55201854 1.314 NM_002898
RBMS2
RNA binding motif, single stranded interacting protein 2
chr11_-_8849485 1.312 ST5
suppression of tumorigenicity 5
chr5_+_61910318 1.306 NM_181506
LRRC70
leucine rich repeat containing 70
chr12_-_15706340 1.302 EPS8
epidermal growth factor receptor pathway substrate 8
chr3_+_25444753 1.300 NM_016152
RARB
retinoic acid receptor, beta
chr7_+_838663 1.298 NM_001130965
SUN1
Sad1 and UNC84 domain containing 1
chr18_+_3437607 1.298 NM_173207
TGIF1
TGFB-induced factor homeobox 1
chr11_+_101488380 1.298 NM_001195045
YAP1
Yes-associated protein 1
chr3_+_25445071 1.297 RARB
retinoic acid receptor, beta
chr4_-_149582948 1.282 NM_000901
NM_001166104
NR3C2

nuclear receptor subfamily 3, group C, member 2

chr6_-_112682573 1.269 LAMA4
laminin, alpha 4
chr2_-_37727472 1.266 CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr9_-_83493415 1.259 NM_005077
TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr2_-_192420168 1.254 NM_004657
SDPR
serum deprivation response
chr9_-_116920232 1.237 NM_002160
TNC
tenascin C
chr15_-_68842799 1.236 NM_018003
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr9_-_116608113 1.233 NM_005118
TNFSF15
tumor necrosis factor (ligand) superfamily, member 15
chr2_+_108637916 1.231 LIMS1
LIMS3
LIM and senescent cell antigen-like domains 1
LIM and senescent cell antigen-like domains 3
chr5_+_38882017 1.228 OSMR
oncostatin M receptor
chr1_+_24518501 1.224 NM_001195010
GRHL3
grainyhead-like 3 (Drosophila)
chr10_-_29963906 1.219 NM_021738
SVIL
supervillin
chr2_-_192419896 1.215 SDPR
serum deprivation response
chr3_+_69895651 1.214 NM_006722
MITF
microphthalmia-associated transcription factor
chr9_-_13269562 1.201 MPDZ
multiple PDZ domain protein
chr4_+_169654742 1.198 NM_001166108
NM_016081
PALLD

palladin, cytoskeletal associated protein

chr21_-_26867138 1.191 NM_052954
CYYR1
cysteine/tyrosine-rich 1
chr1_+_183970093 1.188 NM_031935
HMCN1
hemicentin 1
chr4_-_104240413 1.186 NM_020139
BDH2
3-hydroxybutyrate dehydrogenase, type 2
chr10_-_62373828 1.177 NM_014836
RHOBTB1
Rho-related BTB domain containing 1
chr4_+_95595419 1.174 PDLIM5
PDZ and LIM domain 5
chr7_+_22733290 1.170 NM_000600
IL6
interleukin 6 (interferon, beta 2)
chr12_+_50592379 1.165 NM_001077401
ACVRL1
activin A receptor type II-like 1
chr1_-_149047329 1.159 NM_000396
CTSK
cathepsin K
chr9_-_15240113 1.157 NM_001168342
TTC39B
tetratricopeptide repeat domain 39B
chr3_-_150578207 1.153 NM_014220
TM4SF1
transmembrane 4 L six family member 1
chr12_-_9913724 1.149 NM_005127
CLEC2B
C-type lectin domain family 2, member B
chr4_+_146820805 1.146 NM_001080531
C4orf51
chromosome 4 open reading frame 51

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.14 2.67e-02 GO:0051781 positive regulation of cell division

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.38 2.52e-03 GO:0044421 extracellular region part
2.60 2.59e-02 GO:0031091 platelet alpha granule
3.09 2.97e-02 GO:0005581 collagen
1.23 3.21e-02 GO:0005576 extracellular region
1.92 3.71e-02 GO:0005912 adherens junction

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.66 1.73e-02 GO:0003779 actin binding