Motif ID: FOXN1.p2

Z-value: 1.753


Transcription factors associated with FOXN1.p2:

Gene SymbolEntrez IDGene Name
FOXN1 8456 forkhead box N1



Activity profile for motif FOXN1.p2.

activity profile for motif FOXN1.p2


Sorted Z-values histogram for motif FOXN1.p2

Sorted Z-values for motif FOXN1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXN1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_+_33293915 2.138 NM_012157
NM_001171713
FBXL2

F-box and leucine-rich repeat protein 2

chrX_+_67965517 2.091 NM_004429
EFNB1
ephrin-B1
chr9_-_109290107 1.859 KLF4
Kruppel-like factor 4 (gut)
chrX_-_106846253 1.659 NM_001015881
TSC22D3
TSC22 domain family, member 3
chr17_+_7279485 1.648 NM_178518
TMEM102
transmembrane protein 102
chrX_-_106846684 1.642 TSC22D3
TSC22 domain family, member 3
chr10_+_124211353 1.619 HTRA1
HtrA serine peptidase 1
chr3_-_191321367 1.516 LEPREL1
leprecan-like 1
chr14_+_75521806 1.417 NM_001102564
NM_052873
C14orf179

chromosome 14 open reading frame 179

chr7_-_27120015 1.390 HOXA3
homeobox A3
chr10_+_103103797 1.265 NM_003939
NM_033637
BTRC

beta-transducin repeat containing

chr13_+_20770248 1.206 LOC650794
hypothetical LOC650794
chr11_+_12088639 1.201 NM_014632
MICAL2
microtubule associated monoxygenase, calponin and LIM domain containing 2
chr15_+_68971835 1.178 NM_001199017
NM_017691
NM_001199018
LRRC49


leucine rich repeat containing 49


chr17_-_37196463 1.149 NM_002230
NM_021991
JUP

junction plakoglobin

chr1_-_219982049 1.130 DUSP10
dual specificity phosphatase 10
chr1_-_219982081 1.088 NM_007207
NM_144729
DUSP10

dual specificity phosphatase 10

chr10_-_127574957 1.078 DHX32
DEAH (Asp-Glu-Ala-His) box polypeptide 32
chr1_-_219982016 1.063 DUSP10
dual specificity phosphatase 10
chr12_+_3470685 1.055 NM_019854
PRMT8
protein arginine methyltransferase 8
chr2_-_27966715 1.050 NM_022128
RBKS
ribokinase
chr2_-_202216451 1.049 NM_001044385
ALS2CR4
amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 4
chr12_-_49950236 1.014 NM_001033873
NM_001031628
SMAGP

small cell adhesion glycoprotein

chr3_-_197106828 0.991 NM_001010938
TNK2
tyrosine kinase, non-receptor, 2
chr6_+_116798791 0.991 NM_013352
DSE
dermatan sulfate epimerase
chr2_-_68547893 0.965 NM_001024680
FBXO48
F-box protein 48
chr10_+_127575097 0.930 NM_145235
FANK1
fibronectin type III and ankyrin repeat domains 1
chr12_+_32151351 0.921 NM_001003398
NM_001714
BICD1

bicaudal D homolog 1 (Drosophila)

chr1_+_32992131 0.917


chr3_-_87122958 0.914 VGLL3
vestigial like 3 (Drosophila)
chr3_-_87122936 0.902 NM_016206
VGLL3
vestigial like 3 (Drosophila)
chr8_-_11096257 0.902 NM_173683
XKR6
XK, Kell blood group complex subunit-related family, member 6
chr2_-_73193419 0.894 RAB11FIP5
RAB11 family interacting protein 5 (class I)
chr12_+_87060176 0.891 NM_181783
TMTC3
transmembrane and tetratricopeptide repeat containing 3
chr10_-_120091795 0.879 NM_001134672
NM_022063
C10orf84

chromosome 10 open reading frame 84

chr5_+_156819782 0.876 NIPAL4
NIPA-like domain containing 4
chr3_+_159771646 0.872 NM_001130156
NM_001130157
NM_001195432
NM_001195433
NM_001195434
NM_022443
MLF1





myeloid leukemia factor 1





chr4_-_86106567 0.868 NM_014991
WDFY3
WD repeat and FYVE domain containing 3
chr16_+_49333513 0.845 NM_001042412
CYLD
cylindromatosis (turban tumor syndrome)
chr8_+_32525269 0.842 NM_001160002
NM_001160004
NM_001160005
NM_001160007
NM_001160008
NM_004495
NM_013956
NM_013957
NM_013958
NM_013960
NM_013964
NRG1










neuregulin 1










chr17_-_2250967 0.836 NM_020310
MNT
MAX binding protein
chr3_-_191321601 0.834 NM_018192
LEPREL1
leprecan-like 1
chr2_-_73193581 0.829 NM_015470
RAB11FIP5
RAB11 family interacting protein 5 (class I)
chr18_-_50004770 0.828 MBD2
methyl-CpG binding domain protein 2
chr15_-_68971665 0.819 NM_020147
THAP10
THAP domain containing 10
chr3_+_199171467 0.819 NM_001136049
NM_033029
LMLN

leishmanolysin-like (metallopeptidase M8 family)

chrX_-_15263596 0.810 NM_002641
NM_020473
PIGA

phosphatidylinositol glycan anchor biosynthesis, class A

chrX_-_15263555 0.805 PIGA
phosphatidylinositol glycan anchor biosynthesis, class A
chr9_+_127550298 0.798 NM_001134778
PBX3
pre-B-cell leukemia homeobox 3
chr3_+_157876051 0.796 TIPARP
TCDD-inducible poly(ADP-ribose) polymerase
chrX_-_15263586 0.794 PIGA
phosphatidylinositol glycan anchor biosynthesis, class A
chr2_-_73193566 0.787 RAB11FIP5
RAB11 family interacting protein 5 (class I)
chr3_-_109423858 0.774 NM_018010
IFT57
intraflagellar transport 57 homolog (Chlamydomonas)
chr13_-_23361430 0.764 NM_005932
MIPEP
mitochondrial intermediate peptidase
chr1_-_6473216 0.764 NM_001042664
PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr2_-_85969527 0.760 NM_003896
ST3GAL5
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
chr7_+_138566770 0.756 NM_173569
UBN2
ubinuclein 2
chr16_-_17472238 0.750 NM_022166
XYLT1
xylosyltransferase I
chr2_+_68548173 0.724 NM_173545
APLF
aprataxin and PNKP like factor
chr22_+_27798887 0.719 NM_001039570
NM_032045
KREMEN1

kringle containing transmembrane protein 1

chr14_-_91372365 0.713 NM_001128595
NM_152332
TC2N

tandem C2 domains, nuclear

chr11_-_107969554 0.712 NM_015065
EXPH5
exophilin 5
chr12_-_87059877 0.704 NM_025114
CEP290
centrosomal protein 290kDa
chr9_-_98421894 0.701 NM_003671
NM_033331
CDC14B

CDC14 cell division cycle 14 homolog B (S. cerevisiae)

chr2_-_20114881 0.696 LAPTM4A
lysosomal protein transmembrane 4 alpha
chr9_+_81377419 0.693 TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr2_-_20114761 0.693 LAPTM4A
lysosomal protein transmembrane 4 alpha
chrX_+_15666312 0.692 NM_007220
CA5B
carbonic anhydrase VB, mitochondrial
chr4_+_48038095 0.691 SLAIN2
SLAIN motif family, member 2
chr15_-_37999717 0.685 GPR176
G protein-coupled receptor 176
chr2_+_27966985 0.685 NM_199193
NM_199194
NM_004899
NM_199191
NM_199192
BRE




brain and reproductive organ-expressed (TNFRSF1A modulator)




chr2_+_27967102 0.683 BRE
brain and reproductive organ-expressed (TNFRSF1A modulator)
chr8_+_38363150 0.682 NM_144652
LETM2
leucine zipper-EF-hand containing transmembrane protein 2
chr16_+_49333461 0.680 NM_001042355
NM_015247
CYLD

cylindromatosis (turban tumor syndrome)

chr2_+_27967116 0.673 BRE
brain and reproductive organ-expressed (TNFRSF1A modulator)
chr6_+_148705646 0.673 SASH1
SAM and SH3 domain containing 1
chr9_+_81377289 0.672 TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr12_+_56406296 0.665 LOC100130776
hypothetical LOC100130776
chr3_+_121944247 0.664 NM_005513
GTF2E1
general transcription factor IIE, polypeptide 1, alpha 56kDa
chr5_+_149320480 0.663 NM_000112
SLC26A2
solute carrier family 26 (sulfate transporter), member 2
chr3_+_151013691 0.660 RNF13
ring finger protein 13
chr1_+_101134276 0.660 SLC30A7
solute carrier family 30 (zinc transporter), member 7
chr5_+_99899133 0.649 FAM174A
family with sequence similarity 174, member A
chr19_+_43447262 0.649 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr6_-_75972286 0.647 NM_004370
NM_080645
COL12A1

collagen, type XII, alpha 1

chr7_+_23111928 0.645 KLHL7
kelch-like 7 (Drosophila)
chr3_+_151013672 0.645 RNF13
ring finger protein 13
chr4_+_995395 0.642 FGFRL1
fibroblast growth factor receptor-like 1
chr1_+_101134259 0.641 SLC30A7
solute carrier family 30 (zinc transporter), member 7
chr2_-_20115269 0.640 NM_014713
LAPTM4A
lysosomal protein transmembrane 4 alpha
chr21_+_41461962 0.635 BACE2
beta-site APP-cleaving enzyme 2
chr15_-_38000379 0.631 NM_007223
GPR176
G protein-coupled receptor 176
chr6_+_25387273 0.631 LRRC16A
leucine rich repeat containing 16A
chr15_-_37999519 0.629


chr12_+_42516118 0.627 NM_032256
TMEM117
transmembrane protein 117
chr1_+_101134237 0.620 SLC30A7
solute carrier family 30 (zinc transporter), member 7
chr8_-_38245694 0.619 NM_001102559
NM_001102560
NM_032483
PPAPDC1B


phosphatidic acid phosphatase type 2 domain containing 1B


chr1_+_101134177 0.615 NM_001144884
NM_133496
SLC30A7

solute carrier family 30 (zinc transporter), member 7

chr4_-_88032570 0.614 NM_144645
C4orf36
chromosome 4 open reading frame 36
chr10_+_90740364 0.612 FAS
Fas (TNF receptor superfamily, member 6)
chr13_+_44592585 0.611 NM_004128
GTF2F2
general transcription factor IIF, polypeptide 2, 30kDa
chr15_+_43209422 0.601 NM_017434
NM_175940
DUOX1

dual oxidase 1

chr17_-_46553083 0.600 NM_001130528
NM_003971
SPAG9

sperm associated antigen 9

chr14_+_69148066 0.593 KIAA0247
KIAA0247
chr17_-_40865987 0.590 SH3D20
SH3 domain containing 20
chr19_+_12763285 0.590 JUNB
jun B proto-oncogene
chr17_+_7883076 0.585 NM_001039130
NM_001039131
NM_001141
ALOX15B


arachidonate 15-lipoxygenase, type B


chr1_+_176329895 0.582 RASAL2
RAS protein activator like 2
chr15_-_47235057 0.582 NM_001143887
NM_004236
COPS2

COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)

chr4_-_170770111 0.581 NM_012224
NEK1
NIMA (never in mitosis gene a)-related kinase 1
chr13_+_45524950 0.581


chr17_-_40866062 0.579 NM_174919
SH3D20
SH3 domain containing 20
chr5_+_93980108 0.578 NM_032290
ANKRD32
ankyrin repeat domain 32
chr9_+_96176638 0.578 NM_032558
HIATL1
hippocampus abundant transcript-like 1
chr6_+_25387630 0.577 NM_001173977
NM_017640
LRRC16A

leucine rich repeat containing 16A

chr13_+_35903966 0.576 NM_001111046
NM_001111047
CCNA1

cyclin A1

chr6_+_30002084 0.570


chr2_-_36384 0.568 NM_001077710
FAM110C
family with sequence similarity 110, member C
chr11_+_101423378 0.565 NM_001195005
NM_032930
C11orf70

chromosome 11 open reading frame 70

chr5_+_149320630 0.564 SLC26A2
solute carrier family 26 (sulfate transporter), member 2
chr10_+_93548261 0.563 TNKS2
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
chr12_+_52653176 0.554 NM_014212
HOXC11
homeobox C11
chr1_+_176329925 0.554 RASAL2
RAS protein activator like 2
chr14_+_64086366 0.554 NM_172365
C14orf50
chromosome 14 open reading frame 50
chr2_-_156897286 0.551 NM_006186
NR4A2
nuclear receptor subfamily 4, group A, member 2
chr6_-_18230829 0.542 NM_198586
NHLRC1
NHL repeat containing 1
chr1_+_176329860 0.540 RASAL2
RAS protein activator like 2
chr5_+_60663842 0.534 NM_020928
ZSWIM6
zinc finger, SWIM-type containing 6
chr13_-_45524846 0.533 NM_015070
ZC3H13
zinc finger CCCH-type containing 13
chr5_+_149320539 0.530 SLC26A2
solute carrier family 26 (sulfate transporter), member 2
chr3_-_52065130 0.529 NM_001947
DUSP7
dual specificity phosphatase 7
chr4_+_57066131 0.528 NM_206919
ARL9
ADP-ribosylation factor-like 9
chr2_-_202215593 0.528 NM_152388
ALS2CR4
amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 4
chr9_-_98815676 0.526 HIATL2
hippocampus abundant transcript-like 2
chr2_-_235070431 0.524 NM_005737
ARL4C
ADP-ribosylation factor-like 4C
chr12_-_49949999 0.520 SMAGP
small cell adhesion glycoprotein
chr15_+_47235243 0.519 NM_001001556
GALK2
galactokinase 2
chr12_+_70952729 0.513 NM_013381
TRHDE
thyrotropin-releasing hormone degrading enzyme
chr1_+_54954082 0.510 NM_004623
TTC4
tetratricopeptide repeat domain 4
chr15_-_43209348 0.508 NM_144565
DUOXA1
dual oxidase maturation factor 1
chr6_+_43151922 0.507 NM_002821
NM_152880
NM_152881
NM_152882
PTK7



PTK7 protein tyrosine kinase 7



chr20_+_773283 0.506 NM_031424
FAM110A
family with sequence similarity 110, member A
chr12_+_94135645 0.506 NM_017599
VEZT
vezatin, adherens junctions transmembrane protein
chr6_-_158985727 0.502 NM_006519
DYNLT1
dynein, light chain, Tctex-type 1
chr11_+_66580861 0.498 NM_014578
RHOD
ras homolog gene family, member D
chr5_+_99898922 0.498 NM_198507
FAM174A
family with sequence similarity 174, member A
chr14_-_88087575 0.493 PTPN21
protein tyrosine phosphatase, non-receptor type 21
chr3_-_121944052 0.492 NM_173825
RABL3
RAB, member of RAS oncogene family-like 3
chr8_-_102031943 0.491 NM_001135702
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr12_+_121825021 0.487 NM_032573
NM_201435
CCDC62

coiled-coil domain containing 62

chr19_-_58449752 0.486 ZNF677
zinc finger protein 677
chr8_+_94836247 0.484 NM_001142301
NM_153704
TMEM67

transmembrane protein 67

chr7_+_23111867 0.478 NM_001031710
NM_001172428
KLHL7

kelch-like 7 (Drosophila)

chr17_-_61618276 0.476 NM_145036
CCDC46
coiled-coil domain containing 46
chr15_+_38923914 0.474 NM_001032367
SPINT1
serine peptidase inhibitor, Kunitz type 1
chr1_+_203463654 0.473 NM_014858
TMCC2
transmembrane and coiled-coil domain family 2
chrX_+_17665483 0.471 NM_001037535
NM_001037536
NM_001037540
NM_006746
SCML1



sex comb on midleg-like 1 (Drosophila)



chr14_+_69148062 0.471 NM_014734
KIAA0247
KIAA0247
chr12_-_46585032 0.470 NM_000376
NM_001017535
VDR

vitamin D (1,25- dihydroxyvitamin D3) receptor

chr5_-_93979932 0.469 NM_001145678
NM_173665
KIAA0825

KIAA0825

chr7_+_100302885 0.468 NM_003302
TRIP6
thyroid hormone receptor interactor 6
chr15_+_40353076 0.462 GANC
glucosidase, alpha; neutral C
chr2_+_71534260 0.461 NM_001130976
NM_001130977
NM_001130978
NM_001130979
NM_001130980
NM_001130981
NM_003494
DYSF






dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)






chrX_-_134013644 0.458 NM_001078172
NM_001134321
FAM127B

family with sequence similarity 127, member B

chr2_+_27967159 0.458 BRE
brain and reproductive organ-expressed (TNFRSF1A modulator)
chr12_+_32150922 0.457 BICD1
bicaudal D homolog 1 (Drosophila)
chr1_-_158091760 0.456 NM_001134233
C1orf204
chromosome 1 open reading frame 204
chr13_+_44592647 0.455 GTF2F2
general transcription factor IIF, polypeptide 2, 30kDa
chr9_+_81376666 0.454 NM_007005
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr15_-_57452361 0.452 NM_004998
MYO1E
myosin IE
chr6_+_7486836 0.450 DSP
desmoplakin
chr10_+_91164418 0.450 IFIT5
interferon-induced protein with tetratricopeptide repeats 5
chr5_-_140978664 0.448 DIAPH1
diaphanous homolog 1 (Drosophila)
chr10_+_93548162 0.448 TNKS2
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
chr13_-_44461554 0.447 NM_012345
NUFIP1
nuclear fragile X mental retardation protein interacting protein 1
chr10_+_103901922 0.446 NM_004741
NOLC1
nucleolar and coiled-body phosphoprotein 1
chr7_-_82629735 0.443 PCLO
piccolo (presynaptic cytomatrix protein)
chr15_-_40352765 0.443 NM_001110503
NM_015497
TMEM87A

transmembrane protein 87A

chr14_-_88090641 0.441 NM_007039
PTPN21
protein tyrosine phosphatase, non-receptor type 21
chr11_-_27341251 0.440 NM_030771
NM_080654
CCDC34

coiled-coil domain containing 34

chr15_-_57452345 0.438 MYO1E
myosin IE
chr19_-_54188181 0.437 GYS1
glycogen synthase 1 (muscle)
chr14_-_52487022 0.436 FERMT2
fermitin family member 2
chr15_-_57452357 0.436 MYO1E
myosin IE
chrX_-_106846924 0.436 NM_004089
TSC22D3
TSC22 domain family, member 3
chr9_-_34448477 0.436 NM_001184940
NM_001184941
NM_001184942
NM_001184943
NM_001184944
NM_001184945
NM_147202
C9orf25






chromosome 9 open reading frame 25






chr17_+_45488330 0.434 NM_002204
NM_005501
ITGA3

integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)

chrX_-_13307425 0.433


chr1_+_52380633 0.433 NM_004799
NM_007323
NM_007324
ZFYVE9


zinc finger, FYVE domain containing 9


chr5_-_73973004 0.432 NM_003633
ENC1
ectodermal-neural cortex 1 (with BTB-like domain)
chr13_+_44461657 0.431 NM_018559
KIAA1704
KIAA1704
chr9_-_129370954 0.428 FAM129B
family with sequence similarity 129, member B
chr11_+_116520181 0.426 NM_001184746
NM_001184747
NM_001184748
NM_002572
PAFAH1B2



platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)



chr1_-_203557379 0.425 NM_030952
NUAK2
NUAK family, SNF1-like kinase, 2
chr9_-_15297148 0.424 TTC39B
tetratricopeptide repeat domain 39B
chr9_+_134743532 0.420 C9orf9
chromosome 9 open reading frame 9
chr4_+_95592067 0.418 PDLIM5
PDZ and LIM domain 5
chr5_+_122875691 0.416 NM_001031812
NM_001044722
NM_001044723
NM_004384
CSNK1G3



casein kinase 1, gamma 3



chr1_+_40399642 0.414 RLF
rearranged L-myc fusion
chr1_+_40399618 0.414 NM_012421
RLF
rearranged L-myc fusion

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.30 1.85e-05 GO:0044260 cellular macromolecule metabolic process
1.43 1.94e-03 GO:0006464 protein modification process
1.42 2.39e-03 GO:0043412 macromolecule modification
1.22 8.87e-03 GO:0043170 macromolecule metabolic process
1.18 9.21e-03 GO:0044237 cellular metabolic process
1.33 1.17e-02 GO:0044267 cellular protein metabolic process
1.10 1.48e-02 GO:0009987 cellular process
9.35 2.20e-02 GO:0007141 male meiosis I
1.98 2.61e-02 GO:0070647 protein modification by small protein conjugation or removal
1.29 4.21e-02 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.15 3.74e-10 GO:0044424 intracellular part
1.14 4.86e-10 GO:0005622 intracellular
1.19 6.89e-08 GO:0005737 cytoplasm
1.15 6.30e-05 GO:0043231 intracellular membrane-bounded organelle
1.22 7.65e-05 GO:0005634 nucleus
1.15 7.71e-05 GO:0043227 membrane-bounded organelle
1.12 6.37e-04 GO:0043229 intracellular organelle
1.12 6.61e-04 GO:0043226 organelle
1.72 6.81e-04 GO:0015630 microtubule cytoskeleton
1.92 7.18e-03 GO:0005815 microtubule organizing center
1.33 4.16e-02 GO:0031981 nuclear lumen

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.19 1.29e-05 GO:0005515 protein binding
1.81 5.81e-03 GO:0016874 ligase activity
2.13 1.05e-02 GO:0019787 small conjugating protein ligase activity
2.13 1.83e-02 GO:0004842 ubiquitin-protein ligase activity
1.08 2.50e-02 GO:0005488 binding
1.30 3.18e-02 GO:0000166 nucleotide binding
1.98 3.24e-02 GO:0016881 acid-amino acid ligase activity