Motif ID: IKZF2.p2

Z-value: 1.335


Transcription factors associated with IKZF2.p2:

Gene SymbolEntrez IDGene Name
IKZF2 22807 IKAROS family zinc finger 2 (Helios)



Activity profile for motif IKZF2.p2.

activity profile for motif IKZF2.p2


Sorted Z-values histogram for motif IKZF2.p2

Sorted Z-values for motif IKZF2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of IKZF2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_128644510 2.800 UGGT1
UDP-glucose glycoprotein glucosyltransferase 1
chr1_+_99884018 2.399 NM_017734
PALMD
palmdelphin
chrX_+_73080887 1.979 NCRNA00183
non-protein coding RNA 183
chr18_+_3443771 1.894 NM_173211
TGIF1
TGFB-induced factor homeobox 1
chr18_+_27281729 1.824 NM_001944
DSG3
desmoglein 3
chr4_-_89963177 1.815 NM_001015045
FAM13A
family with sequence similarity 13, member A
chr9_+_12764988 1.752 NM_203403
C9orf150
chromosome 9 open reading frame 150
chr9_+_74956494 1.729 NM_000700
ANXA1
annexin A1
chrX_-_19598912 1.710 NM_001184960
SH3KBP1
SH3-domain kinase binding protein 1
chr18_+_30812205 1.629 NM_001143827
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr4_+_124537334 1.526 NM_199327
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr6_-_47117951 1.481 NM_025048
NM_153840
GPR110

G protein-coupled receptor 110

chr5_-_59100194 1.440 NM_001197218
PDE4D
phosphodiesterase 4D, cAMP-specific
chr21_-_38792173 1.385 NM_001136155
NM_182918
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr11_+_101488380 1.367 NM_001195045
YAP1
Yes-associated protein 1
chr14_+_62740878 1.342 NM_020663
RHOJ
ras homolog gene family, member J
chr6_-_128883125 1.308 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chrX_-_102828238 1.304 NM_001142418
NM_001142423
NM_001142424
NM_001142425
NM_001142426
NM_001142429
NM_001142430
NM_012286
MORF4L2







mortality factor 4 like 2







chr2_-_162808123 1.298 NM_004460
FAP
fibroblast activation protein, alpha
chr18_+_54013575 1.255 NM_001144970
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr9_+_676640 1.254


chr13_+_48582389 1.237 NM_014923
FNDC3A
fibronectin type III domain containing 3A
chr17_-_64649608 1.223 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr9_+_696744 1.221 NM_153186
KANK1
KN motif and ankyrin repeat domains 1
chr4_+_95595419 1.216 PDLIM5
PDZ and LIM domain 5
chr20_-_17487480 1.151 NM_001161705
BFSP1
beaded filament structural protein 1, filensin
chr4_+_170817787 1.132 CLCN3
chloride channel 3
chr18_+_30544193 1.125 NM_001198941
NM_032978
DTNA

dystrobrevin, alpha

chr17_-_32730804 1.124 NM_198837
NM_198838
ACACA

acetyl-CoA carboxylase alpha

chr4_+_124540114 1.109 NM_005841
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr11_+_65027721 1.098


chr12_-_84754112 1.098 RASSF9
Ras association (RalGDS/AF-6) domain family (N-terminal) member 9
chr14_+_85066265 1.095 FLRT2
fibronectin leucine rich transmembrane protein 2
chr7_-_83662152 1.089 NM_006080
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr5_+_92944680 1.083 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr11_-_95715976 1.074 NM_032427
MAML2
mastermind-like 2 (Drosophila)
chr10_+_102123589 1.067 NCRNA00263
non-protein coding RNA 263
chrX_-_10504852 1.064 NM_001193277
MID1
midline 1 (Opitz/BBB syndrome)
chr4_-_152366970 1.062 NM_001009555
NM_001128923
SH3D19

SH3 domain containing 19

chr1_-_68470585 1.049 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr1_+_24518501 1.043 NM_001195010
GRHL3
grainyhead-like 3 (Drosophila)
chr1_-_159604287 1.030 NM_001013625
C1orf192
chromosome 1 open reading frame 192
chr8_-_6407882 1.028 NM_001118887
NM_001118888
NM_001147
ANGPT2


angiopoietin 2


chr13_-_47885018 1.026 LPAR6
lysophosphatidic acid receptor 6
chr8_-_17599438 1.022 NM_020749
MTUS1
microtubule associated tumor suppressor 1
chr2_+_102320148 1.021 NM_003856
IL1RL1
interleukin 1 receptor-like 1
chr8_-_13416554 1.005 NM_024767
NM_182643
DLC1

deleted in liver cancer 1

chr10_+_5478521 1.004 NM_005863
NET1
neuroepithelial cell transforming 1
chr18_+_54039818 0.997 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chrX_-_15593074 0.994 NM_020665
TMEM27
transmembrane protein 27
chr5_+_145296313 0.984 NM_152550
SH3RF2
SH3 domain containing ring finger 2
chr1_+_86785346 0.980 NM_012128
CLCA4
chloride channel accessory 4
chr13_-_47885248 0.974 LPAR6
lysophosphatidic acid receptor 6
chr13_+_96672541 0.967 NM_144778
NM_207304
MBNL2

muscleblind-like 2 (Drosophila)

chr4_-_115120251 0.962 NM_024590
ARSJ
arylsulfatase family, member J
chr4_-_24590867 0.954 NM_173463
CCDC149
coiled-coil domain containing 149
chr1_+_68070573 0.949


chr6_-_111995213 0.941 NM_001164283
TRAF3IP2
TRAF3 interacting protein 2
chr2_-_151052391 0.927 NM_005168
RND3
Rho family GTPase 3
chr8_-_102029997 0.916 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr7_-_41709191 0.916 NM_002192
INHBA
inhibin, beta A
chr2_+_201755865 0.903 NM_001230
NM_032974
NM_032977
CASP10


caspase 10, apoptosis-related cysteine peptidase


chr7_-_75794919 0.900 YWHAG
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
chr9_-_15240113 0.892 NM_001168342
TTC39B
tetratricopeptide repeat domain 39B
chr11_-_62229477 0.889 BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr3_-_150533948 0.886 NM_001184723
NM_138786
TM4SF18

transmembrane 4 L six family member 18

chr20_+_19815075 0.870 RIN2
Ras and Rab interactor 2
chr20_-_14266200 0.869 NM_013281
NM_198391
FLRT3

fibronectin leucine rich transmembrane protein 3

chr3_+_195336625 0.862 NM_005524
HES1
hairy and enhancer of split 1, (Drosophila)
chr2_+_228386800 0.842 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr3_+_195336631 0.839 HES1
hairy and enhancer of split 1, (Drosophila)
chr10_-_29963906 0.835 NM_021738
SVIL
supervillin
chr1_-_109957195 0.819 NM_005272
GNAT2
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
chr3_+_29297806 0.814 NM_001003792
NM_001003793
NM_001177711
NM_001177712
NM_014483
RBMS3




RNA binding motif, single stranded interacting protein 3




chr3_-_71715431 0.813 NM_001012505
NM_032682
FOXP1

forkhead box P1

chr5_-_58607673 0.812 NM_001197220
PDE4D
phosphodiesterase 4D, cAMP-specific
chr11_-_85115105 0.810 NM_206927
NM_206928
SYTL2

synaptotagmin-like 2

chr1_+_159435728 0.786 NM_004550
NDUFS2
NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
chr10_-_29963847 0.785


chr5_-_16791346 0.782 MYO10
myosin X
chr11_+_65026382 0.781


chr1_-_79244948 0.769 NM_022159
ELTD1
EGF, latrophilin and seven transmembrane domain containing 1
chr4_-_159312973 0.767 FAM198B
family with sequence similarity 198, member B
chr3_-_170346760 0.767 NM_001105077
NM_001163999
NM_005241
MECOM


MDS1 and EVI1 complex locus


chr17_+_29606408 0.760 NM_002982
CCL2
chemokine (C-C motif) ligand 2
chr1_+_61642287 0.756 NFIA
nuclear factor I/A
chr14_-_49543987 0.755 NM_001012706
C14orf182
chromosome 14 open reading frame 182
chr10_-_116434364 0.749 NM_001003407
NM_001003408
ABLIM1

actin binding LIM protein 1

chr5_+_40877053 0.749 NM_032587
CARD6
caspase recruitment domain family, member 6
chr16_+_54158084 0.739 NM_032330
CAPNS2
calpain, small subunit 2
chr3_-_173911467 0.739 NM_001146276
NM_001146277
NM_001146278
NM_020792
NCEH1



neutral cholesterol ester hydrolase 1



chr4_+_130236731 0.729 NM_001099783
C4orf33
chromosome 4 open reading frame 33
chr22_-_41685827 0.728 NM_001184971
PACSIN2
protein kinase C and casein kinase substrate in neurons 2
chr11_-_10272256 0.727 NM_030962
SBF2
SET binding factor 2
chr1_+_84539876 0.718 NM_001134663
SAMD13
sterile alpha motif domain containing 13
chr1_-_12599934 0.713 NM_004753
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr11_+_20000938 0.708 NAV2
neuron navigator 2
chr3_+_11242666 0.706 NM_001098211
HRH1
histamine receptor H1
chr11_-_104344473 0.702 NM_001225
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr10_+_102111361 0.700 SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr1_+_53253204 0.695 SCP2
sterol carrier protein 2
chr1_+_19807168 0.693


chr1_+_24518398 0.693 NM_198173
NM_198174
GRHL3

grainyhead-like 3 (Drosophila)

chr12_-_15706340 0.691 EPS8
epidermal growth factor receptor pathway substrate 8
chr6_+_136214495 0.691 NM_018945
PDE7B
phosphodiesterase 7B
chr2_-_105381855 0.687 NM_001039492
NM_001450
NM_201555
FHL2


four and a half LIM domains 2


chr18_-_35634247 0.685 LOC647946
hypothetical LOC647946
chr15_+_60838053 0.684 TLN2
talin 2
chr18_+_54039779 0.676 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr2_-_101134146 0.666 NM_001102426
TBC1D8
TBC1 domain family, member 8 (with GRAM domain)
chr2_-_197499584 0.666 NM_024989
PGAP1
post-GPI attachment to proteins 1
chr1_+_201862845 0.665 ATP2B4
ATPase, Ca++ transporting, plasma membrane 4
chr8_-_133841988 0.665 NM_001145153
NM_144649
TMEM71

transmembrane protein 71

chr1_-_171286634 0.662 NM_005092
TNFSF18
tumor necrosis factor (ligand) superfamily, member 18
chr12_-_51153788 0.660 NM_173086
KRT6C
keratin 6C
chr11_+_5597749 0.659 NM_001003827
TRIM34
tripartite motif containing 34
chrX_+_56772391 0.656 LOC550643
hypothetical LOC550643
chr1_-_151804929 0.653 NM_005978
S100A2
S100 calcium binding protein A2
chr11_+_65023556 0.653


chr2_-_134042500 0.652 NM_207363
NM_207481
NCKAP5

NCK-associated protein 5

chr4_-_153523113 0.652 NM_001013415
FBXW7
F-box and WD repeat domain containing 7
chrX_-_15198509 0.641 NM_001168531
ASB9
ankyrin repeat and SOCS box containing 9
chrX_+_135079120 0.639 NM_001159704
FHL1
four and a half LIM domains 1
chr1_+_34993234 0.636 NM_005268
GJB5
gap junction protein, beta 5, 31.1kDa
chr14_+_38804226 0.636 NM_203354
CTAGE5
CTAGE family, member 5
chr5_-_139706044 0.636 HBEGF
heparin-binding EGF-like growth factor
chr7_-_13996166 0.636 NM_001163147
NM_004956
ETV1

ets variant 1

chr2_+_108571336 0.635 NM_001193488
LIMS1
LIM and senescent cell antigen-like domains 1
chr20_+_12937616 0.634 NM_018327
SPTLC3
serine palmitoyltransferase, long chain base subunit 3
chr1_+_53253161 0.634 NM_001007099
NM_001007100
NM_001007250
SCP2


sterol carrier protein 2


chr11_+_18374388 0.633 NM_001165414
LDHA
lactate dehydrogenase A
chr2_+_36777406 0.633 VIT
vitrin
chr11_+_113671744 0.632 NM_006169
NNMT
nicotinamide N-methyltransferase
chr18_+_54039730 0.632 NM_001144966
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr14_-_49932366 0.631 NM_004196
CDKL1
cyclin-dependent kinase-like 1 (CDC2-related kinase)
chr1_-_23393808 0.628 NM_000864
HTR1D
5-hydroxytryptamine (serotonin) receptor 1D
chr5_+_96237399 0.626 NM_001130140
NM_022350
ERAP2

endoplasmic reticulum aminopeptidase 2

chr2_+_108571209 0.624 LIMS1
LIM and senescent cell antigen-like domains 1
chr5_-_16795336 0.624 MYO10
myosin X
chr17_+_36515166 0.622 NM_001146041
KRTAP4-9
keratin associated protein 4-9
chr12_-_51629874 0.616 KRT8
keratin 8
chr1_+_161305558 0.615 NM_001113381
RGS4
regulator of G-protein signaling 4
chr8_+_32698892 0.613 NM_001159996
NRG1
neuregulin 1
chr3_+_69895310 0.612 NM_001184967
MITF
microphthalmia-associated transcription factor
chr7_+_134226727 0.610 CALD1
caldesmon 1
chr19_+_11061146 0.608 LDLR
low density lipoprotein receptor
chr1_-_109420091 0.608 NM_005645
TAF13
TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
chr5_-_16561936 0.607 NM_019000
FAM134B
family with sequence similarity 134, member B
chrX_-_15198093 0.606 NM_001031739
NM_001168530
NM_024087
ASB9


ankyrin repeat and SOCS box containing 9


chr4_+_88187215 0.605 AFF1
AF4/FMR2 family, member 1
chr17_-_37196463 0.605 NM_002230
NM_021991
JUP

junction plakoglobin

chr2_+_101680594 0.604 NM_004834
NM_145686
NM_145687
MAP4K4


mitogen-activated protein kinase kinase kinase kinase 4


chr11_-_56846246 0.600 TNKS1BP1
tankyrase 1 binding protein 1, 182kDa
chr16_+_83349816 0.600 USP10
ubiquitin specific peptidase 10
chr4_-_122304925 0.598 NM_024873
TNIP3
TNFAIP3 interacting protein 3
chrX_-_73430064 0.596 MIR374AHG
mir-374a-545 cluster host gene (non-protein coding)
chr4_-_153493133 0.594 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chr1_+_148532885 0.585 NM_018997
NM_031901
MRPS21

mitochondrial ribosomal protein S21

chr14_+_38720085 0.583 PNN
pinin, desmosome associated protein
chr8_+_39890484 0.581 NM_002164
IDO1
indoleamine 2,3-dioxygenase 1
chr14_+_23907065 0.580 NM_001198965
NM_004554
NFATC4

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4

chr6_-_29752909 0.578 NM_001109809
ZFP57
zinc finger protein 57 homolog (mouse)
chr5_+_61910318 0.577 NM_181506
LRRC70
leucine rich repeat containing 70
chr12_-_52939584 0.575 NM_001127322
CBX5
chromobox homolog 5
chr10_-_18980512 0.575 NM_182543
NSUN6
NOP2/Sun domain family, member 6
chr19_+_11061124 0.570 LDLR
low density lipoprotein receptor
chr2_-_231697999 0.563 NM_000867
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B
chr6_+_52393763 0.562 NM_001172420
EFHC1
EF-hand domain (C-terminal) containing 1
chr6_+_121798443 0.561 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr1_-_21478571 0.561 NM_001113347
ECE1
endothelin converting enzyme 1
chr4_+_15080586 0.560 NM_001080522
NM_001164720
NM_020785
CC2D2A


coiled-coil and C2 domain containing 2A


chr4_+_159351092 0.559 TMEM144
transmembrane protein 144
chr14_+_85066207 0.559 NM_013231
FLRT2
fibronectin leucine rich transmembrane protein 2
chr5_-_32424352 0.556 ZFR
zinc finger RNA binding protein
chr1_+_181422016 0.555 LAMC2
laminin, gamma 2
chr6_-_132314004 0.555 NM_001901
CTGF
connective tissue growth factor
chr5_+_54491702 0.551 NM_001008397
GPX8
glutathione peroxidase 8 (putative)
chr12_-_27126721 0.550 NM_001080406
C12orf71
chromosome 12 open reading frame 71
chr3_-_147361912 0.550 NM_000935
NM_182943
PLOD2

procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2

chr6_-_32447626 0.548 NM_006781
C6orf10
chromosome 6 open reading frame 10
chr5_-_92942680 0.542 FLJ42709
hypothetical LOC441094
chr2_+_108571177 0.540 NM_004987
LIMS1
LIM and senescent cell antigen-like domains 1
chr3_+_25445071 0.535 RARB
retinoic acid receptor, beta
chr16_+_20819488 0.533 NM_001128301
NM_001128302
LYRM1

LYR motif containing 1

chr2_-_189752575 0.533 NM_000393
COL5A2
collagen, type V, alpha 2
chr6_-_10520592 0.532 NM_001032280
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr1_+_144439069 0.531 NM_002614
PDZK1
PDZ domain containing 1
chr9_+_108665168 0.528 NM_021224
ZNF462
zinc finger protein 462
chr4_-_70760381 0.524 NM_005420
SULT1E1
sulfotransferase family 1E, estrogen-preferring, member 1
chr4_-_159313167 0.521 NM_016613
FAM198B
family with sequence similarity 198, member B
chr6_-_56615544 0.521 NM_001723
NM_015548
DST

dystonin

chr14_+_31615959 0.520 ARHGAP5
Rho GTPase activating protein 5
chr7_+_134226690 0.520 NM_033139
NM_033140
CALD1

caldesmon 1

chr4_-_122357104 0.517 NM_001128843
TNIP3
TNFAIP3 interacting protein 3
chr12_+_12829807 0.517 NM_030817
APOLD1
apolipoprotein L domain containing 1
chr2_+_33514896 0.517 NM_170672
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr16_+_22432344 0.517 NM_001135865
LOC100132247
NPIPL3
nuclear pore complex interacting protein related gene
nuclear pore complex interacting protein-like 3
chr10_+_91077581 0.516 NM_001549
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr4_-_90197140 0.515 NM_014883
FAM13A
family with sequence similarity 13, member A
chr3_-_64647325 0.511 ADAMTS9
ADAM metallopeptidase with thrombospondin type 1 motif, 9

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.11 8.37e-03 GO:0005681 spliceosomal complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.11 4.72e-03 GO:0005515 protein binding