Motif ID: TP53.p2

Z-value: 1.217


Transcription factors associated with TP53.p2:

Gene SymbolEntrez IDGene Name
TP53 7157 tumor protein p53



Activity profile for motif TP53.p2.

activity profile for motif TP53.p2


Sorted Z-values histogram for motif TP53.p2

Sorted Z-values for motif TP53.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TP53.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_10455100 1.150 DFFA
DNA fragmentation factor, 45kDa, alpha polypeptide
chr20_-_62151216 1.080 NM_018419
SOX18
SRY (sex determining region Y)-box 18
chr1_-_10455190 1.016 NM_004401
NM_213566
DFFA

DNA fragmentation factor, 45kDa, alpha polypeptide

chr8_-_23138517 1.014 TNFRSF10A
tumor necrosis factor receptor superfamily, member 10a
chr19_-_6542012 0.987 CD70
CD70 molecule
chr19_-_47438583 0.965 GSK3A
glycogen synthase kinase 3 alpha
chr17_+_73721924 0.960 BIRC5
baculoviral IAP repeat containing 5
chr9_+_80101810 0.958 NM_021154
NM_058179
PSAT1

phosphoserine aminotransferase 1

chr11_-_47356642 0.917 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr19_-_47438518 0.889 GSK3A
glycogen synthase kinase 3 alpha
chr11_-_47356650 0.887 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr19_-_47438563 0.866 NM_019884
GSK3A
glycogen synthase kinase 3 alpha
chr6_+_24511123 0.862 NM_020662
MRS2
MRS2 magnesium homeostasis factor homolog (S. cerevisiae)
chr11_-_47356672 0.859 NM_001080547
NM_003120
SPI1

spleen focus forming virus (SFFV) proviral integration oncogene spi1

chr2_+_74610666 0.850 HTRA2
HtrA serine peptidase 2
chr20_-_47238082 0.821 STAU1
staufen, RNA binding protein, homolog 1 (Drosophila)
chr19_-_47438548 0.802 GSK3A
glycogen synthase kinase 3 alpha
chr11_-_47356562 0.786 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr2_+_74610624 0.785 HTRA2
HtrA serine peptidase 2
chr17_+_73721871 0.784 NM_001012270
NM_001012271
NM_001168
BIRC5


baculoviral IAP repeat containing 5


chr19_-_47438384 0.778 GSK3A
glycogen synthase kinase 3 alpha
chr19_-_2407954 0.776 NM_032737
LMNB2
lamin B2
chr2_-_74610481 0.753 NM_181575
AUP1
ancient ubiquitous protein 1
chr9_+_129962292 0.752 NM_024112
C9orf16
chromosome 9 open reading frame 16
chr2_+_74610395 0.740 HTRA2
HtrA serine peptidase 2
chr19_-_6542082 0.737 CD70
CD70 molecule
chr2_+_169021039 0.735 NM_203463
LASS6
LAG1 homolog, ceramide synthase 6
chr2_-_74610346 0.727 AUP1
ancient ubiquitous protein 1
chr11_-_47356479 0.722 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr2_+_74610635 0.702 HTRA2
HtrA serine peptidase 2
chr2_-_74610323 0.687 AUP1
ancient ubiquitous protein 1
chr2_+_169021001 0.686 LASS6
LAG1 homolog, ceramide synthase 6
chr2_+_74610494 0.684 HTRA2
HtrA serine peptidase 2
chr2_-_74610332 0.677 AUP1
ancient ubiquitous protein 1
chr2_-_74610325 0.672 AUP1
ancient ubiquitous protein 1
chr6_+_36206239 0.668 NM_002754
MAPK13
mitogen-activated protein kinase 13
chr19_+_61344501 0.658 ZNF444
zinc finger protein 444
chr2_-_74610331 0.658 AUP1
ancient ubiquitous protein 1
chr2_+_74610751 0.631 HTRA2
HtrA serine peptidase 2
chr19_+_15644885 0.626 NM_023944
CYP4F12
cytochrome P450, family 4, subfamily F, polypeptide 12
chr20_+_34667624 0.625 C20orf24
chromosome 20 open reading frame 24
chr15_-_62242352 0.625 NM_000942
PPIB
peptidylprolyl isomerase B (cyclophilin B)
chr2_+_176761552 0.621 NM_024501
HOXD1
homeobox D1
chr16_-_87244896 0.609 NM_000101
CYBA
cytochrome b-245, alpha polypeptide
chr22_-_16637221 0.601 BID
BH3 interacting domain death agonist
chr2_-_171998681 0.599 METTL8
methyltransferase like 8
chr2_+_171998988 0.585 NM_001164821
NM_025000
DCAF17

DDB1 and CUL4 associated factor 17

chr3_-_13032130 0.584


chr4_+_6726699 0.576 LOC93622
hypothetical LOC93622
chr1_+_43084846 0.563 NM_015911
ZNF691
zinc finger protein 691
chr20_+_34667566 0.558 NM_018840
NM_199483
C20orf24

chromosome 20 open reading frame 24

chr22_-_16637194 0.557 BID
BH3 interacting domain death agonist
chr3_-_24511456 0.553 THRB
thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)
chr9_-_125732005 0.553 NM_020946
NM_024820
DENND1A

DENN/MADD domain containing 1A

chr5_-_176763991 0.544 F12
coagulation factor XII (Hageman factor)
chr20_+_34667590 0.542 C20orf24
chromosome 20 open reading frame 24
chr15_-_62242145 0.542 PPIB
peptidylprolyl isomerase B (cyclophilin B)
chr3_-_44494108 0.534 ZNF445
zinc finger protein 445
chr1_-_52936573 0.534 C1orf163
chromosome 1 open reading frame 163
chr20_-_43022286 0.532 NM_006809
TOMM34
translocase of outer mitochondrial membrane 34
chr5_-_167938875 0.528 PANK3
pantothenate kinase 3
chr1_-_45578193 0.528 NM_001048174
NM_001048172
NM_001048173
NM_001048171
NM_001128425
NM_012222
MUTYH





mutY homolog (E. coli)





chr3_-_44494160 0.526 NM_181489
ZNF445
zinc finger protein 445
chr11_+_817584 0.517 NM_173584
EFCAB4A
EF-hand calcium binding domain 4A
chr5_+_176446425 0.511 NM_002011
NM_213647
FGFR4

fibroblast growth factor receptor 4

chr15_-_62242237 0.511 PPIB
peptidylprolyl isomerase B (cyclophilin B)
chr17_-_58877276 0.506 NM_001017916
NM_001915
CYB561

cytochrome b-561

chr15_-_62242243 0.505 PPIB
peptidylprolyl isomerase B (cyclophilin B)
chr11_+_3833495 0.504 NM_003156
STIM1
stromal interaction molecule 1
chr11_+_279113 0.504 NM_025092
ATHL1
ATH1, acid trehalase-like 1 (yeast)
chr2_+_112372651 0.501 NM_006343
MERTK
c-mer proto-oncogene tyrosine kinase
chr11_+_63758550 0.499 NM_003377
VEGFB
vascular endothelial growth factor B
chr15_-_62242259 0.496 PPIB
peptidylprolyl isomerase B (cyclophilin B)
chr19_+_13090101 0.493 NM_052876
NACC1
nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
chr8_-_145671947 0.492 FOXH1
forkhead box H1
chr20_+_61054443 0.490 NM_022082
SLC17A9
solute carrier family 17, member 9
chr1_-_52936611 0.487 NM_023077
C1orf163
chromosome 1 open reading frame 163
chr1_-_52936602 0.483 C1orf163
chromosome 1 open reading frame 163
chr4_-_9727542 0.482 WDR1
WD repeat domain 1
chr2_+_74610333 0.481 HTRA2
HtrA serine peptidase 2
chr4_+_6726555 0.478 LOC93622
hypothetical LOC93622
chr7_+_72206961 0.475 GTF2IP1
general transcription factor IIi, pseudogene 1
chr19_+_61344341 0.469 NM_018337
ZNF444
zinc finger protein 444
chr5_-_167938991 0.468 NM_024594
PANK3
pantothenate kinase 3
chr2_-_74610263 0.465 AUP1
ancient ubiquitous protein 1
chr9_-_103200697 0.463 NM_019051
MRPL50
mitochondrial ribosomal protein L50
chr7_-_74291367 0.462 GTF2IP1
general transcription factor IIi, pseudogene 1
chr4_-_9727598 0.461 NM_005112
NM_017491
WDR1

WD repeat domain 1

chr22_-_16637160 0.457 BID
BH3 interacting domain death agonist
chr3_-_52779911 0.457 NM_001193533
NM_003157
NEK4

NIMA (never in mitosis gene a)-related kinase 4

chr20_-_47238310 0.451 NM_001037328
NM_004602
NM_017452
NM_017453
NM_017454
STAU1




staufen, RNA binding protein, homolog 1 (Drosophila)




chr17_+_69939130 0.442 NM_022036
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr2_+_171999042 0.435 DCAF17
DDB1 and CUL4 associated factor 17
chr9_-_168913 0.431 NM_001145355
NM_001145356
NM_018491
CBWD2
CBWD1


COBW domain containing 2
COBW domain containing 1


chr9_+_103200939 0.430 NM_003452
NM_197977
ZNF189

zinc finger protein 189

chr19_-_2407921 0.426 LMNB2
lamin B2
chr4_-_9727476 0.420 WDR1
WD repeat domain 1
chr12_-_46385991 0.419 RPAP3
RNA polymerase II associated protein 3
chr7_+_92699588 0.419 NM_017667
NM_024553
CCDC132

coiled-coil domain containing 132

chr3_-_186454509 0.415 NM_001166415
NM_001966
EHHADH

enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase

chr4_-_108860740 0.412 NM_005443
PAPSS1
3'-phosphoadenosine 5'-phosphosulfate synthase 1
chr1_+_45578370 0.412 TOE1
target of EGR1, member 1 (nuclear)
chr1_+_45578464 0.403 TOE1
target of EGR1, member 1 (nuclear)
chr3_-_49435114 0.399 NM_000481
NM_001164710
NM_001164711
NM_001164712
AMT



aminomethyltransferase



chr9_-_137992967 0.397 NM_016172
UBAC1
UBA domain containing 1
chr19_-_6432765 0.389 NM_024898
DENND1C
DENN/MADD domain containing 1C
chr17_-_78000890 0.388 NM_001193655
C17orf62
chromosome 17 open reading frame 62
chr14_-_30959487 0.385 HEATR5A
HEAT repeat containing 5A
chr12_+_54832470 0.383 NM_002475
MYL6B
myosin, light chain 6B, alkali, smooth muscle and non-muscle
chr22_-_29231597 0.378 NM_001161368
NM_174977
SEC14L4

SEC14-like 4 (S. cerevisiae)

chr12_-_52980914 0.375 NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr10_-_118755077 0.374 NM_001127211
NM_018330
KIAA1598

KIAA1598

chr12_+_131577229 0.372 NM_001142641
FBRSL1
fibrosin-like 1
chrX_+_38548373 0.368 MID1IP1
MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))
chr12_-_14612057 0.366 NM_024829
PLBD1
phospholipase B domain containing 1
chr1_+_3679168 0.363 NM_001163724
LOC388588
hypothetical protein LOC388588
chr12_+_122652572 0.360 NM_020936
DDX55
DEAD (Asp-Glu-Ala-Asp) box polypeptide 55
chr20_+_61054539 0.356 SLC17A9
solute carrier family 17, member 9
chr14_+_67156323 0.354 NM_001172
ARG2
arginase, type II
chr22_+_18085990 0.353 SEPT5-GP1BB
SEPT5
SEPT5-GP1BB read-through transcript
septin 5
chr2_+_74610039 0.349 NM_013247
NM_145074
HTRA2

HtrA serine peptidase 2

chr16_+_55963899 0.343 NM_002996
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr10_-_91394881 0.338 PANK1
pantothenate kinase 1
chrX_+_38548316 0.336 MID1IP1
MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))
chr14_+_67156386 0.335 ARG2
arginase, type II
chr16_-_10943716 0.334 NM_014015
DEXI
Dexi homolog (mouse)
chr15_+_38319326 0.333 NM_020168
PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr1_+_25471470 0.332 NM_001127691
NM_016124
RHD

Rh blood group, D antigen

chr1_-_25619863 0.332 NM_020485
NM_138616
NM_138617
NM_138618
RHCE



RHD
Rh blood group, CcEe antigens



Rh blood group, D antigen
chr5_-_176763789 0.331 F12
coagulation factor XII (Hageman factor)
chr1_+_154318954 0.330 LMNA
lamin A/C
chr1_-_247119516 0.328 NM_001136036
ZNF692
zinc finger protein 692
chr22_-_16637238 0.328 NM_001196
NM_197967
BID

BH3 interacting domain death agonist

chr22_-_37569962 0.326 NM_014293
NPTXR
neuronal pentraxin receptor
chr16_-_10943656 0.326 DEXI
Dexi homolog (mouse)
chr17_-_28228184 0.324 MYO1D
myosin ID
chr9_+_129226535 0.318 ZNF79
zinc finger protein 79
chr19_-_57981827 0.318 NM_198457
ZNF600
zinc finger protein 600
chr20_-_52223918 0.318 NM_000782
NM_001128915
CYP24A1

cytochrome P450, family 24, subfamily A, polypeptide 1

chr21_-_42172476 0.315 NM_001040424
NM_022115
PRDM15

PR domain containing 15

chr4_-_40211324 0.314 RBM47
RNA binding motif protein 47
chrX_-_70390704 0.313 NM_201599
ZMYM3
zinc finger, MYM-type 3
chr1_+_153799637 0.307 LOC645676
hypothetical LOC645676
chr1_-_54644663 0.307 NM_001009955
SSBP3
single stranded DNA binding protein 3
chr19_-_2407870 0.305 LMNB2
lamin B2
chr15_+_38843535 0.303 NM_005258
GCHFR
GTP cyclohydrolase I feedback regulator
chr1_+_45578256 0.303 TOE1
target of EGR1, member 1 (nuclear)
chr8_+_95801375 0.302 DPY19L4
dpy-19-like 4 (C. elegans)
chr12_+_108038774 0.300 ACACB
acetyl-CoA carboxylase beta
chr2_+_233443237 0.298 NM_206895
C2orf82
chromosome 2 open reading frame 82
chrX_-_153767625 0.296 NM_019863
F8
coagulation factor VIII, procoagulant component
chr8_+_95801277 0.296 NM_181787
DPY19L4
dpy-19-like 4 (C. elegans)
chr11_+_66927955 0.294 TBC1D10C
TBC1 domain family, member 10C
chr1_+_45738442 0.294 NM_015506
MMACHC
methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
chr4_-_9727456 0.294 WDR1
WD repeat domain 1
chr20_+_56899904 0.293 GNAS
GNAS complex locus
chr20_+_56900116 0.291 NM_001077488
GNAS
GNAS complex locus
chr7_+_137795387 0.291 NM_003852
NM_015905
TRIM24

tripartite motif containing 24

chr19_+_34994701 0.289 NM_001238
CCNE1
cyclin E1
chr1_+_42920946 0.288 YBX1
Y box binding protein 1
chr11_-_107969554 0.283 NM_015065
EXPH5
exophilin 5
chr9_+_129226473 0.280 NM_007135
ZNF79
zinc finger protein 79
chr1_-_158334983 0.279 NM_052868
IGSF8
immunoglobulin superfamily, member 8
chr19_+_17831670 0.278 NM_000980
RPL18A
ribosomal protein L18a
chr3_+_44355007 0.277 C3orf23
chromosome 3 open reading frame 23
chr16_+_387176 0.277 NM_005009
NME4
non-metastatic cells 4, protein expressed in
chr7_-_100077072 0.277 NM_003227
TFR2
transferrin receptor 2
chr4_-_47611255 0.273 NM_152995
NFXL1
nuclear transcription factor, X-box binding-like 1
chr12_+_54784632 0.271 PA2G4
proliferation-associated 2G4, 38kDa
chrX_+_153767803 0.270 NM_001007523
NM_001007524
NM_012151
F8A2
F8A3
F8A1
coagulation factor VIII-associated (intronic transcript) 2
coagulation factor VIII-associated (intronic transcript) 3
coagulation factor VIII-associated (intronic transcript) 1
chr17_-_4841628 0.270 NM_001167985
NM_001167986
NM_001167987
NM_213726
INCA1



inhibitor of CDK, cyclin A1 interacting protein 1



chr7_+_150065594 0.269 GIMAP5
GTPase, IMAP family member 5
chr19_+_7859380 0.265 NM_025061
LRRC8E
leucine rich repeat containing 8 family, member E
chr3_+_44355217 0.264 C3orf23
chromosome 3 open reading frame 23
chr8_+_42315132 0.263 NM_002690
POLB
polymerase (DNA directed), beta
chrX_+_129133234 0.263 NM_004794
RAB33A
RAB33A, member RAS oncogene family
chr3_-_49434874 0.263 AMT
aminomethyltransferase
chr3_-_42892195 0.263 CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr20_-_5048443 0.262 NM_182649
PCNA
proliferating cell nuclear antigen
chr2_+_241193492 0.262 NM_001195381
NM_001195382
GPR35

G protein-coupled receptor 35

chr2_-_26058941 0.262 NM_002254
KIF3C
kinesin family member 3C
chr18_-_42751305 0.259 NM_004671
NM_173206
PIAS2

protein inhibitor of activated STAT, 2

chr4_-_9727394 0.259 WDR1
WD repeat domain 1
chr19_-_2002222 0.259 NM_017572
NM_199054
MKNK2

MAP kinase interacting serine/threonine kinase 2

chr6_-_166502119 0.257 NM_003181
T
T, brachyury homolog (mouse)
chr9_-_129226312 0.255


chr12_-_14611820 0.255 PLBD1
phospholipase B domain containing 1
chr16_-_31013626 0.252 NM_024006
NM_206824
VKORC1

vitamin K epoxide reductase complex, subunit 1

chr15_+_38240501 0.251 NM_001211
BUB1B
budding uninhibited by benzimidazoles 1 homolog beta (yeast)
chr14_+_67156405 0.251 ARG2
arginase, type II
chr4_+_6835354 0.248 NM_001100590
NM_014743
KIAA0232

KIAA0232

chr4_+_6835363 0.248 KIAA0232
KIAA0232
chr16_-_31013594 0.246 VKORC1
vitamin K epoxide reductase complex, subunit 1
chr12_+_22090485 0.246 CMAS
cytidine monophosphate N-acetylneuraminic acid synthetase
chr5_+_141328805 0.246 NM_004290
NM_183398
NM_183400
RNF14


ring finger protein 14


chr5_+_27508139 0.246 LOC643401
hypothetical protein LOC643401
chr3_+_9919511 0.245 NM_001193380
NM_153480
IL17RE

interleukin 17 receptor E

chr4_-_9727384 0.245


chr17_-_70380663 0.245 NM_004110
NM_024417
FDXR

ferredoxin reductase

chr12_+_22090399 0.244 NM_018686
CMAS
cytidine monophosphate N-acetylneuraminic acid synthetase

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.31 1.97e-06 GO:0044444 cytoplasmic part
1.21 2.73e-05 GO:0005737 cytoplasm
1.64 1.45e-04 GO:0012505 endomembrane system
1.49 1.00e-03 GO:0031090 organelle membrane
1.17 1.42e-03 GO:0043227 membrane-bounded organelle
1.17 1.78e-03 GO:0043231 intracellular membrane-bounded organelle
1.25 2.47e-03 GO:0044446 intracellular organelle part
1.25 2.75e-03 GO:0044422 organelle part
1.11 3.40e-03 GO:0005622 intracellular
1.14 3.70e-03 GO:0043226 organelle
1.14 4.18e-03 GO:0043229 intracellular organelle
1.12 5.05e-03 GO:0044424 intracellular part

Nothing significant found in function category.