Motif ID: NFE2L2.p2

Z-value: 3.104


Transcription factors associated with NFE2L2.p2:

Gene SymbolEntrez IDGene Name
NFE2L2 4780 nuclear factor (erythroid-derived 2)-like 2



Activity profile for motif NFE2L2.p2.

activity profile for motif NFE2L2.p2


Sorted Z-values histogram for motif NFE2L2.p2

Sorted Z-values for motif NFE2L2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFE2L2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_977163 7.056 NM_022042
NM_134425
NM_213613
SLC26A1


solute carrier family 26 (sulfate transporter), member 1


chr16_+_2023279 5.359 SLC9A3R2
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
chr10_-_76538859 4.895 NM_001007271
NM_001007272
NM_001007273
DUSP13


dual specificity phosphatase 13


chr19_-_54350457 4.417 NM_002152
HRC
histidine rich calcium binding protein
chr20_-_581844 4.211 NM_080725
SRXN1
sulfiredoxin 1
chr22_+_43451600 4.144 PRR5
proline rich 5 (renal)
chr22_+_19699441 4.037 NM_001159554
NM_005446
P2RX6

purinergic receptor P2X, ligand-gated ion channel, 6

chr11_+_118463906 3.836 NM_001024382
HMBS
hydroxymethylbilane synthase
chr1_+_153232685 3.727 NM_018655
LENEP
lens epithelial protein
chr8_-_11242408 3.685 LOC100129129
hypothetical LOC100129129
chr22_+_43451351 3.618 NM_001017530
NM_001198721
NM_015366
PRR5


proline rich 5 (renal)


chrX_-_100527799 3.597 NM_000061
BTK
Bruton agammaglobulinemia tyrosine kinase
chr1_-_156923111 3.577 NM_003126
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr7_+_37926943 3.551 EPDR1
ependymin related protein 1 (zebrafish)
chrX_-_154216929 3.547 NM_001289
CLIC2
chloride intracellular channel 2
chr6_+_150112537 3.474 PCMT1
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr8_-_30704762 3.451 GSR
glutathione reductase
chr16_-_1369613 3.408 NM_001193389
NM_023076
UNKL

unkempt homolog (Drosophila)-like

chrX_+_9391314 3.352 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr16_+_88515917 3.334 NM_001197181
TUBB3
tubulin, beta 3
chr16_+_29984611 3.317 ALDOA
aldolase A, fructose-bisphosphate
chr6_+_32229599 3.309 NM_005155
PPT2-EGFL8
PPT2
PPT2-EGFL8 read-through transcript
palmitoyl-protein thioesterase 2
chr6_-_32121784 3.195 NM_032470
TNXB
tenascin XB
chr16_+_29984544 3.181 NM_184041
ALDOA
aldolase A, fructose-bisphosphate
chr6_+_32229278 3.142 NM_138717
PPT2
palmitoyl-protein thioesterase 2
chr16_+_29984591 3.102 ALDOA
aldolase A, fructose-bisphosphate
chr2_+_87536174 3.050 NCRNA00152
non-protein coding RNA 152
chr2_+_87536106 3.009 NCRNA00152
non-protein coding RNA 152
chr16_+_29984647 3.004 ALDOA
aldolase A, fructose-bisphosphate
chr6_+_150112511 2.998 NM_005389
PCMT1
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr16_+_29984621 2.936 ALDOA
aldolase A, fructose-bisphosphate
chr6_-_31812049 2.902 CLIC1
chloride intracellular channel 1
chr14_+_102672745 2.883 TNFAIP2
tumor necrosis factor, alpha-induced protein 2
chrX_+_153423652 2.846 NM_001099856
IKBKG
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
chr19_-_10474266 2.822 NM_012289
KEAP1
kelch-like ECH-associated protein 1
chr4_+_22608252 2.784


chr1_-_45045543 2.781 NM_001013632
TCTEX1D4
Tctex1 domain containing 4
chr17_-_25642962 2.770 NM_000386
BLMH
bleomycin hydrolase
chr6_-_31812266 2.767 CLIC1
chloride intracellular channel 1
chr19_-_53914768 2.766 NM_001130915
MAMSTR
MEF2 activating motif and SAP domain containing transcriptional regulator
chr6_-_31812251 2.719 CLIC1
chloride intracellular channel 1
chr6_-_31812260 2.717 CLIC1
chloride intracellular channel 1
chr6_+_150112549 2.715 PCMT1
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr6_-_30792830 2.682 MDC1
mediator of DNA-damage checkpoint 1
chr6_-_31812283 2.639 CLIC1
chloride intracellular channel 1
chr6_-_31853027 2.631 NM_025258
C6orf27
chromosome 6 open reading frame 27
chr12_-_51629874 2.623 KRT8
keratin 8
chr6_-_31812214 2.618 CLIC1
chloride intracellular channel 1
chr17_+_72883759 2.535 NM_001113494
SEPT9
septin 9
chr6_-_30793436 2.520 NM_014641
MDC1
mediator of DNA-damage checkpoint 1
chr3_+_142569988 2.518 ZBTB38
zinc finger and BTB domain containing 38
chr17_+_77910411 2.482 NM_207459
TEX19
testis expressed 19
chr20_+_34206070 2.463 NM_012156
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr12_+_54361596 2.434 NM_152637
METTL7B
methyltransferase like 7B
chr16_-_28528149 2.429 NM_177530
NM_177534
SULT1A1

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

chr6_-_31812297 2.396 NM_001288
CLIC1
chloride intracellular channel 1
chr16_-_28515195 2.383 NM_177528
SULT1A2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr6_-_31812072 2.382 CLIC1
chloride intracellular channel 1
chr1_-_199390183 2.368 TMEM9
transmembrane protein 9
chr7_-_1465487 2.360 MICALL2
MICAL-like 2
chr5_+_179180447 2.356 NM_003900
SQSTM1
sequestosome 1
chr12_+_54361685 2.330 METTL7B
methyltransferase like 7B
chr16_+_82544327 2.264 NM_182981
OSGIN1
oxidative stress induced growth inhibitor 1
chr22_-_25344037 2.264 CRYBB1
crystallin, beta B1
chr22_-_25343959 2.244 NM_001887
CRYBB1
crystallin, beta B1
chr5_+_179180509 2.223 SQSTM1
sequestosome 1
chr11_+_123600553 2.213 NM_001007249
OR8G2
olfactory receptor, family 8, subfamily G, member 2
chr20_+_41621119 2.192 SGK2
serum/glucocorticoid regulated kinase 2
chr16_-_68317945 2.152 NM_000903
NM_001025433
NM_001025434
NQO1


NAD(P)H dehydrogenase, quinone 1


chr16_+_30903963 2.128 NM_001142777
NM_001142778
NM_025193
HSD3B7


hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7


chr20_+_41621079 2.103 NM_170693
SGK2
serum/glucocorticoid regulated kinase 2
chr5_+_179180517 2.083 SQSTM1
sequestosome 1
chr7_-_100667750 2.080 NM_014343
CLDN15
claudin 15
chr6_+_154449334 2.079 NM_001145287
OPRM1
opioid receptor, mu 1
chr1_-_93030538 2.066 NM_005665
EVI5
ecotropic viral integration site 5
chr16_-_28528780 2.047 NM_001055
NM_177529
SULT1A1

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

chr22_+_18388656 2.031 C22orf25
chromosome 22 open reading frame 25
chr14_-_20642214 2.023


chr22_+_21042091 2.021 IGLV1-44
IGL@
immunoglobulin lambda variable 1-44
immunoglobulin lambda locus
chr10_+_85889164 2.017 NM_014394
GHITM
growth hormone inducible transmembrane protein
chr13_+_112746908 2.014 MCF2L
MCF.2 cell line derived transforming sequence-like
chr15_+_38520594 2.014 NM_014952
BAHD1
bromo adjacent homology domain containing 1
chr22_+_21079355 1.984


chr3_-_121883647 1.945 HGD
homogentisate 1,2-dioxygenase
chr3_-_121884091 1.938 NM_000187
HGD
homogentisate 1,2-dioxygenase
chr19_+_18560494 1.816 NM_001100418
NM_001100419
C19orf60

chromosome 19 open reading frame 60

chr2_-_11523666 1.798 E2F6
E2F transcription factor 6
chr22_+_21053972 1.795


chr2_-_219881937 1.791 PTPRN
protein tyrosine phosphatase, receptor type, N
chr16_-_30032330 1.791 NM_024307
GDPD3
glycerophosphodiester phosphodiesterase domain containing 3
chr11_-_66898223 1.788 NM_001166212
CLCF1
cardiotrophin-like cytokine factor 1
chr2_-_11523727 1.771 NM_198256
E2F6
E2F transcription factor 6
chr19_-_50977592 1.763 NM_001081560
NM_001081562
NM_004409
DMPK


dystrophia myotonica-protein kinase


chr9_+_129962292 1.756 NM_024112
C9orf16
chromosome 9 open reading frame 16
chr22_+_21495273 1.755


chr22_+_20316968 1.755 NM_152612
CCDC116
coiled-coil domain containing 116
chr1_-_7923464 1.748 NM_001561
TNFRSF9
tumor necrosis factor receptor superfamily, member 9
chr6_-_28429950 1.745 NM_145909
ZNF323
zinc finger protein 323
chr16_+_30876115 1.717 NM_014712
SETD1A
SET domain containing 1A
chr17_+_44429748 1.709 NM_001160423
NM_006546
IGF2BP1

insulin-like growth factor 2 mRNA binding protein 1

chr17_+_14145051 1.707 NM_006041
HS3ST3B1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
chr3_-_115826481 1.701 NM_001164346
ZBTB20
zinc finger and BTB domain containing 20
chr9_-_115880372 1.676 AMBP
alpha-1-microglobulin/bikunin precursor
chr22_+_21116283 1.632


chr17_-_77474597 1.547 NM_032711
MAFG
v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)
chr1_+_19511326 1.529 NM_001040125
NM_001040126
NM_017765
PQLC2


PQ loop repeat containing 2


chr22_+_21370394 1.529 IGL@
immunoglobulin lambda locus
chr16_+_155972 1.525 NM_001003938
HBM
hemoglobin, mu
chr20_-_581808 1.522 SRXN1
sulfiredoxin 1
chr15_-_32875040 1.512 NM_005159
ACTC1
actin, alpha, cardiac muscle 1
chr12_+_63084317 1.512 NM_007235
XPOT
exportin, tRNA (nuclear export receptor for tRNAs)
chr22_+_21094094 1.505


chr21_+_31953803 1.494 NM_000454
SOD1
superoxide dismutase 1, soluble
chr9_+_131291224 1.448 LOC100506190
hypothetical LOC100506190
chr7_+_72883128 1.445 NM_001305
CLDN4
claudin 4
chr20_+_48240867 1.412 CEBPB
CCAAT/enhancer binding protein (C/EBP), beta
chr22_-_17846621 1.410 UFD1L
ubiquitin fusion degradation 1 like (yeast)
chr22_-_17846711 1.403 UFD1L
ubiquitin fusion degradation 1 like (yeast)
chr22_-_17846725 1.401 NM_001035247
NM_005659
UFD1L

ubiquitin fusion degradation 1 like (yeast)

chr19_-_50977485 1.397 DMPK
dystrophia myotonica-protein kinase
chr17_+_27795635 1.389 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr11_+_46358909 1.383 NM_001012334
MDK
midkine (neurite growth-promoting factor 2)
chr9_-_115880494 1.363 NM_001633
AMBP
alpha-1-microglobulin/bikunin precursor
chr9_-_115880425 1.349 AMBP
alpha-1-microglobulin/bikunin precursor
chr17_-_35140307 1.332 NM_032339
C17orf37
chromosome 17 open reading frame 37
chr9_-_126309510 1.329 NM_004959
NR5A1
nuclear receptor subfamily 5, group A, member 1
chrX_-_70243362 1.327 NM_001025265
CXorf65
chromosome X open reading frame 65
chr17_-_53764867 1.325


chr22_+_21407066 1.308


chr1_-_159543847 1.303 MPZ
myelin protein zero
chr19_+_1199548 1.290 NM_177401
MIDN
midnolin
chr3_+_156280129 1.289 NM_000902
MME
membrane metallo-endopeptidase
chr1_-_114103616 1.288 PHTF1
putative homeodomain transcription factor 1
chr2_-_224175293 1.284 SCG2
secretogranin II
chr1_-_45249603 1.280 NM_024602
HECTD3
HECT domain containing 3
chr1_-_52117021 1.279 NM_001101662
NM_002525
NRD1

nardilysin (N-arginine dibasic convertase)

chr6_+_64289585 1.256 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr5_-_149515613 1.246 NM_002609
PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr12_-_49897743 1.235 POU6F1
POU class 6 homeobox 1
chr15_-_81037554 1.234 NM_001079533
NM_001079534
NM_001079535
CPEB1


cytoplasmic polyadenylation element binding protein 1


chr22_+_21393107 1.231 IGLJ3
immunoglobulin lambda joining 3
chr19_-_50977586 1.228 DMPK
dystrophia myotonica-protein kinase
chr6_+_32003380 1.227 C2
complement component 2
chr17_+_77529070 1.225 ASPSCR1
alveolar soft part sarcoma chromosome region, candidate 1
chr22_+_20899155 1.225


chr19_+_45564549 1.212 PLD3
phospholipase D family, member 3
chr16_+_30326864 1.212 ZNF771
zinc finger protein 771
chr6_+_31782618 1.210 NM_001003693
LY6G6F
lymphocyte antigen 6 complex, locus G6F
chr1_-_94147574 1.209 NM_002061
GCLM
glutamate-cysteine ligase, modifier subunit
chr15_+_57691272 1.207 NM_004751
GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr5_-_149515502 1.206 PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr9_+_131291144 1.206


chr10_-_71562520 1.204 AIFM2
apoptosis-inducing factor, mitochondrion-associated, 2
chr17_-_35140255 1.202 C17orf37
chromosome 17 open reading frame 37
chr6_+_36518521 1.198 NM_173562
KCTD20
potassium channel tetramerisation domain containing 20
chr1_-_176205672 1.197 NM_033127
SEC16B
SEC16 homolog B (S. cerevisiae)
chr9_-_115880366 1.185 AMBP
alpha-1-microglobulin/bikunin precursor
chrX_-_152863251 1.183 NM_002910
RENBP
renin binding protein
chr16_-_73830480 1.174 NM_001170721
BCAR1
breast cancer anti-estrogen resistance 1
chr16_+_72888231 1.171 PSMD7
proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
chr1_-_52116965 1.169 NRD1
nardilysin (N-arginine dibasic convertase)
chr12_+_54910767 1.169 NM_001135195
SLC39A5
solute carrier family 39 (metal ion transporter), member 5
chr1_-_52116994 1.167 NRD1
nardilysin (N-arginine dibasic convertase)
chr7_+_150319076 1.158 NM_000603
NOS3
nitric oxide synthase 3 (endothelial cell)
chr22_-_39189369 1.157 MKL1
megakaryoblastic leukemia (translocation) 1
chr16_+_72888161 1.155 NM_002811
PSMD7
proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
chr10_+_121400926 1.154 BAG3
BCL2-associated athanogene 3
chr16_+_28413421 1.146 NM_018690
APOBR
apolipoprotein B receptor
chr5_-_95184221 1.143 NM_001118890
NM_002064
GLRX

glutaredoxin (thioltransferase)

chr6_-_36518643 1.140 NM_152990
PXT1
peroxisomal, testis specific 1
chr6_-_101018271 1.138 NM_005068
SIM1
single-minded homolog 1 (Drosophila)
chr1_-_94147616 1.131 GCLM
glutamate-cysteine ligase, modifier subunit
chr3_-_39209075 1.113 NM_194293
NM_001198621
XIRP1

xin actin-binding repeat containing 1

chr1_-_172258129 1.112


chr15_+_57691382 1.105 GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr6_+_36518778 1.099 KCTD20
potassium channel tetramerisation domain containing 20
chr2_+_119905812 1.094 NM_183240
TMEM37
transmembrane protein 37
chr10_+_121400881 1.090 BAG3
BCL2-associated athanogene 3
chr8_-_59734975 1.090 NSMAF
neutral sphingomyelinase (N-SMase) activation associated factor
chr16_+_30326386 1.089 ZNF771
zinc finger protein 771
chr19_-_56260135 1.087 NM_015596
KLK13
kallikrein-related peptidase 13
chr3_-_180460372 1.085 NM_171829
KCNMB3
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr10_+_121400741 1.069 NM_004281
BAG3
BCL2-associated athanogene 3
chr8_-_59734939 1.065 NSMAF
neutral sphingomyelinase (N-SMase) activation associated factor
chr16_+_30326077 1.063 NM_001142305
NM_016643
ZNF771

zinc finger protein 771

chr3_-_195571748 1.060 NM_001135057
NM_130830
LRRC15

leucine rich repeat containing 15

chrX_-_110400406 1.060 NM_014289
CAPN6
calpain 6
chr11_+_2881080 1.058 SLC22A18
solute carrier family 22, member 18
chr10_+_134751398 1.054 NM_001083909
GPR123
G protein-coupled receptor 123
chr8_-_59734957 1.048 NM_003580
NSMAF
neutral sphingomyelinase (N-SMase) activation associated factor
chr1_-_223683141 1.046 NM_194442
LBR
lamin B receptor
chr1_-_109770474 1.035 NM_002790
PSMA5
proteasome (prosome, macropain) subunit, alpha type, 5
chr14_+_38772870 1.034 NM_054024
MIA2
melanoma inhibitory activity 2
chr22_+_25347927 1.031 NM_001886
CRYBA4
crystallin, beta A4
chr20_+_48240705 1.028 CEBPB
CCAAT/enhancer binding protein (C/EBP), beta
chr1_-_6585485 1.025 NM_014851
KLHL21
kelch-like 21 (Drosophila)
chr10_-_71562602 1.021 NM_001198696
NM_032797
AIFM2

apoptosis-inducing factor, mitochondrion-associated, 2

chr5_-_95184121 1.008 GLRX
glutaredoxin (thioltransferase)
chr12_-_54387732 1.008 ITGA7
integrin, alpha 7
chr1_-_45249554 1.004 HECTD3
HECT domain containing 3

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
5.69 1.72e-04 GO:0006521 regulation of cellular amino acid metabolic process
4.46 3.49e-04 GO:0051351 positive regulation of ligase activity
4.94 1.14e-03 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
4.94 1.14e-03 GO:0072395 signal transduction involved in cell cycle checkpoint
4.94 1.14e-03 GO:0072401 signal transduction involved in DNA integrity checkpoint
4.94 1.14e-03 GO:0072404 signal transduction involved in G1/S transition checkpoint
4.94 1.14e-03 GO:0072413 signal transduction involved in mitotic cell cycle checkpoint
4.94 1.14e-03 GO:0072422 signal transduction involved in DNA damage checkpoint
4.94 1.14e-03 GO:0072431 signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint
4.94 1.14e-03 GO:0072474 signal transduction involved in mitotic cell cycle G1/S checkpoint
4.55 1.42e-03 GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
4.71 2.12e-03 GO:0033238 regulation of cellular amine metabolic process
4.71 2.12e-03 GO:0071158 positive regulation of cell cycle arrest
1.28 2.18e-03 GO:0032501 multicellular organismal process
3.89 2.69e-03 GO:0051340 regulation of ligase activity
4.19 4.22e-03 GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
4.43 4.60e-03 GO:0031571 mitotic cell cycle G1/S transition DNA damage checkpoint
4.14 5.00e-03 GO:0051443 positive regulation of ubiquitin-protein ligase activity
4.04 6.97e-03 GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
3.49 1.29e-02 GO:0090068 positive regulation of cell cycle process
4.18 2.09e-02 GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
3.86 2.48e-02 GO:0031575 mitotic cell cycle G1/S transition checkpoint
3.86 2.48e-02 GO:0071779 G1/S transition checkpoint
3.08 2.48e-02 GO:0010565 regulation of cellular ketone metabolic process
4.74 2.84e-02 GO:0032313 regulation of Rab GTPase activity
4.74 2.84e-02 GO:0032483 regulation of Rab protein signal transduction
3.59 3.12e-02 GO:0051438 regulation of ubiquitin-protein ligase activity
2.00 3.40e-02 GO:0007599 hemostasis
4.00 3.43e-02 GO:0051352 negative regulation of ligase activity
4.00 3.43e-02 GO:0051444 negative regulation of ubiquitin-protein ligase activity
1.49 3.73e-02 GO:0003008 system process
1.92 3.91e-02 GO:0050878 regulation of body fluid levels
1.74 4.41e-02 GO:0006508 proteolysis
3.68 4.48e-02 GO:2000045 regulation of G1/S transition of mitotic cell cycle

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
5.13 4.46e-05 GO:0000502 proteasome complex
1.28 4.31e-03 GO:0005886 plasma membrane
1.28 5.83e-03 GO:0071944 cell periphery
1.39 1.59e-02 GO:0044459 plasma membrane part

Gene overrepresentation in function category:

enrichment   p-value GO term description
4.64 7.93e-03 GO:0005097 Rab GTPase activator activity
2.06 2.54e-02 GO:0004175 endopeptidase activity