Motif ID: ZIC1..3.p2

Z-value: 2.936


Transcription factors associated with ZIC1..3.p2:

Gene SymbolEntrez IDGene Name
ZIC1 7545 Zic family member 1 (odd-paired homolog, Drosophila)
ZIC2 7546 Zic family member 2 (odd-paired homolog, Drosophila)
ZIC3 7547 Zic family member 3 (odd-paired homolog, Drosophila)



Activity profile for motif ZIC1..3.p2.

activity profile for motif ZIC1..3.p2


Sorted Z-values histogram for motif ZIC1..3.p2

Sorted Z-values for motif ZIC1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ZIC1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_+_85169615 6.537 NM_005250
FOXL1
forkhead box L1
chr3_+_160964574 5.312 SCHIP1
schwannomin interacting protein 1
chr15_+_37660568 3.928 NM_003246
THBS1
thrombospondin 1
chr3_-_73756668 3.359 NM_015009
PDZRN3
PDZ domain containing ring finger 3
chr11_+_19691397 3.258 NM_145117
NM_182964
NAV2

neuron navigator 2

chr4_+_72271218 2.941 NM_001098484
NM_001134742
SLC4A4

solute carrier family 4, sodium bicarbonate cotransporter, member 4

chr3_+_64645819 2.874 LOC100507098
hypothetical LOC100507098
chr1_-_21478571 2.834 NM_001113347
ECE1
endothelin converting enzyme 1
chr2_-_144991556 2.583 ZEB2
zinc finger E-box binding homeobox 2
chr16_+_85158357 2.505 NM_005251
FOXC2
forkhead box C2 (MFH-1, mesenchyme forkhead 1)
chr10_-_62373828 2.503 NM_014836
RHOBTB1
Rho-related BTB domain containing 1
chr2_-_144991386 2.470 ZEB2
zinc finger E-box binding homeobox 2
chr7_-_27191287 2.287 NM_005523
HOXA11
homeobox A11
chr9_-_122516399 2.228 NM_001080497
MEGF9
multiple EGF-like-domains 9
chr4_-_140696740 2.216 NM_030648
SETD7
SET domain containing (lysine methyltransferase) 7
chr20_+_19903778 2.173 RIN2
Ras and Rab interactor 2
chr9_+_108665168 2.075 NM_021224
ZNF462
zinc finger protein 462
chr11_+_117983515 2.064 NM_001144758
NM_001144759
PHLDB1

pleckstrin homology-like domain, family B, member 1

chr7_-_112513379 2.055 NM_001146266
NM_001146267
GPR85

G protein-coupled receptor 85

chr21_-_27139143 1.998 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr17_+_58058783 1.982 MRC2
mannose receptor, C type 2
chr10_+_52421120 1.980 PRKG1
protein kinase, cGMP-dependent, type I
chr9_+_111850698 1.976 NM_001004065
NM_001198656
AKAP2

A kinase (PRKA) anchor protein 2

chr21_-_27139563 1.947 NM_006988
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr12_-_50871953 1.944 NM_001081492
NM_182507
KRT80

keratin 80

chr7_-_106088565 1.933 NM_175884
FLJ36031
hypothetical protein FLJ36031
chr5_-_92982927 1.904


chr11_+_111288669 1.893 NM_001541
HSPB2-C11ORF52
HSPB2
HSPB2-C11orf52 read-through transcript
heat shock 27kDa protein 2
chr9_+_101623957 1.890 NM_006981
NM_173199
NR4A3

nuclear receptor subfamily 4, group A, member 3

chr11_+_111288686 1.854 HSPB2-C11ORF52
HSPB2
HSPB2-C11orf52 read-through transcript
heat shock 27kDa protein 2
chr11_-_66898223 1.843 NM_001166212
CLCF1
cardiotrophin-like cytokine factor 1
chr19_-_45888259 1.836 NM_004756
NUMBL
numb homolog (Drosophila)-like
chr16_+_54070302 1.798 NM_004530
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr1_-_39877883 1.784 HEYL
hairy/enhancer-of-split related with YRPW motif-like
chr9_-_112840064 1.780 NM_001401
NM_057159
LPAR1

lysophosphatidic acid receptor 1

chr5_+_175725050 1.779 NM_173664
ARL10
ADP-ribosylation factor-like 10
chr7_-_150576634 1.760 SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr15_-_27901828 1.752 NM_003257
NM_175610
TJP1

tight junction protein 1 (zona occludens 1)

chr1_-_39877928 1.742 NM_014571
HEYL
hairy/enhancer-of-split related with YRPW motif-like
chr13_-_73605914 1.718 NM_007249
KLF12
Kruppel-like factor 12
chr8_-_145097031 1.716 NM_201380
PLEC
plectin
chr19_+_16296632 1.601 NM_016270
KLF2
Kruppel-like factor 2 (lung)
chr11_-_65396775 1.584 NM_016938
EFEMP2
EGF containing fibulin-like extracellular matrix protein 2
chr3_-_71196696 1.578 FOXP1
forkhead box P1
chr2_+_159533329 1.557 NM_001145909
NM_033394
TANC1

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1

chr7_-_27180398 1.546 NM_018951
HOXA10
homeobox A10
chr22_+_19699441 1.540 NM_001159554
NM_005446
P2RX6

purinergic receptor P2X, ligand-gated ion channel, 6

chr4_-_149582948 1.537 NM_000901
NM_001166104
NR3C2

nuclear receptor subfamily 3, group C, member 2

chr8_-_17599438 1.535 NM_020749
MTUS1
microtubule associated tumor suppressor 1
chr13_+_75108450 1.535 LMO7
LIM domain 7
chr16_-_31390926 1.524


chr10_+_72102563 1.521 NM_080722
NM_139155
ADAMTS14

ADAM metallopeptidase with thrombospondin type 1 motif, 14

chr3_+_171619346 1.513 NM_005602
CLDN11
claudin 11
chr7_+_27190688 1.507


chr5_+_71438796 1.505 NM_005909
MAP1B
microtubule-associated protein 1B
chr6_+_45498354 1.500 RUNX2
runt-related transcription factor 2
chr11_-_61415429 1.498 NM_021727
FADS3
fatty acid desaturase 3
chr19_+_16296734 1.468 KLF2
Kruppel-like factor 2 (lung)
chr7_-_150576660 1.463 NM_001003801
SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr5_-_121440704 1.452 NM_001178102
LOX
lysyl oxidase
chr16_+_31390567 1.432 NM_001042454
NM_001164719
TGFB1I1

transforming growth factor beta 1 induced transcript 1

chr5_-_156935283 1.429


chr2_+_202607554 1.422 NM_003507
FZD7
frizzled homolog 7 (Drosophila)
chr7_+_27191534 1.395 HOXA11-AS1
HOXA11 antisense RNA 1 (non-protein coding)
chr2_+_219991342 1.389 NM_001927
DES
desmin
chrX_+_133993984 1.388 NM_001078171
FAM127A
family with sequence similarity 127, member A
chr8_-_134653194 1.373 NM_003033
NM_173344
ST3GAL1

ST3 beta-galactoside alpha-2,3-sialyltransferase 1

chr3_-_55490401 1.353 WNT5A
wingless-type MMTV integration site family, member 5A
chr7_-_27190882 1.342 HOXA11
homeobox A11
chr15_+_61127367 1.338 NM_001018008
TPM1
tropomyosin 1 (alpha)
chr3_+_112273352 1.325 PVRL3
poliovirus receptor-related 3
chr14_+_104218487 1.315


chr6_+_45498262 1.301 RUNX2
runt-related transcription factor 2
chr3_+_155321826 1.301 NM_015595
ARHGEF26
Rho guanine nucleotide exchange factor (GEF) 26
chr1_+_168899936 1.300 NM_006902
NM_022716
PRRX1

paired related homeobox 1

chrX_+_90576252 1.291 NM_080832
PABPC5
poly(A) binding protein, cytoplasmic 5
chr11_-_126375864 1.281 KIRREL3
kin of IRRE like 3 (Drosophila)
chr16_+_30951915 1.275 STX4
syntaxin 4
chr4_-_149582754 1.273 NR3C2
nuclear receptor subfamily 3, group C, member 2
chr3_+_112273464 1.265 NM_015480
PVRL3
poliovirus receptor-related 3
chr16_+_30952382 1.250 NM_004604
STX4
syntaxin 4
chr4_+_15089931 1.243 CC2D2A
coiled-coil and C2 domain containing 2A
chr1_-_86634511 1.238 NM_001007022
NM_001184765
NM_001184766
NM_020729
ODF2L



outer dense fiber of sperm tails 2-like



chr12_+_54400417 1.221 NM_002905
RDH5
retinol dehydrogenase 5 (11-cis/9-cis)
chr5_-_156935317 1.196 NM_033274
ADAM19
ADAM metallopeptidase domain 19
chr10_-_90702490 1.195 NM_001613
ACTA2
actin, alpha 2, smooth muscle, aorta
chr16_+_30952350 1.194 STX4
syntaxin 4
chr20_+_61622985 1.181 PPDPF
pancreatic progenitor cell differentiation and proliferation factor homolog (zebrafish)
chr3_+_189353502 1.179 LPP
LIM domain containing preferred translocation partner in lipoma
chr5_+_131621276 1.171 PDLIM4
PDZ and LIM domain 4
chr13_-_109236897 1.166 NM_003749
IRS2
insulin receptor substrate 2
chr7_+_114350144 1.163 MDFIC
MyoD family inhibitor domain containing
chr1_+_154351082 1.148 NM_005572
NM_170707
NM_170708
LMNA


lamin A/C


chr11_-_110917632 1.145


chr7_-_150576957 1.143 SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr1_-_212791188 1.134 PTPN14
protein tyrosine phosphatase, non-receptor type 14
chr5_+_131621287 1.131 PDLIM4
PDZ and LIM domain 4
chr12_-_47869134 1.129 TUBA1A
tubulin, alpha 1a
chrX_-_134013644 1.123 NM_001078172
NM_001134321
FAM127B

family with sequence similarity 127, member B

chr9_+_111850770 1.121 AKAP2
A kinase (PRKA) anchor protein 2
chr14_+_100362236 1.116 MEG3
maternally expressed 3 (non-protein coding)
chr1_+_155130146 1.115 NM_001080471
PEAR1
platelet endothelial aggregation receptor 1
chr5_+_76047536 1.108 NM_001992
F2R
coagulation factor II (thrombin) receptor
chr14_+_85066265 1.098 FLRT2
fibronectin leucine rich transmembrane protein 2
chr15_-_27901628 1.098 TJP1
tight junction protein 1 (zona occludens 1)
chr19_+_627346 1.092 NM_005860
FSTL3
follistatin-like 3 (secreted glycoprotein)
chr14_+_105012106 1.092 NM_001312
CRIP2
cysteine-rich protein 2
chr11_-_126375895 1.088 NM_001161707
NM_032531
KIRREL3

kin of IRRE like 3 (Drosophila)

chr2_-_175255717 1.087 NM_001077269
WIPF1
WAS/WASL interacting protein family, member 1
chr6_-_85529884 1.087 TBX18
T-box 18
chr12_-_47869067 1.086 NM_006009
TUBA1A
tubulin, alpha 1a
chr12_+_8741746 1.081 NM_020734
RIMKLB
ribosomal modification protein rimK-like family member B
chr7_+_44110527 1.080 AEBP1
AE binding protein 1
chr13_+_30378311 1.075 NM_032849
C13orf33
chromosome 13 open reading frame 33
chr22_-_18841785 1.071 NM_015672
RIMBP3
RIMS binding protein 3
chr14_+_100362204 1.067 MEG3
maternally expressed 3 (non-protein coding)
chr4_+_123967389 1.054 FGF2
fibroblast growth factor 2 (basic)
chr12_-_3732614 1.052 NM_001144958
NM_001144959
NM_032680
EFCAB4B


EF-hand calcium binding domain 4B


chr19_-_54557450 1.049 NM_003598
TEAD2
TEA domain family member 2
chr5_+_131621230 1.045 NM_001131027
NM_003687
PDLIM4

PDZ and LIM domain 4

chr12_+_95112385 1.043 ELK3
ELK3, ETS-domain protein (SRF accessory protein 2)
chr12_+_52653176 1.043 NM_014212
HOXC11
homeobox C11
chr11_-_3035172 1.038 NM_001014437
NM_001194997
NM_001751
NM_139273
CARS



cysteinyl-tRNA synthetase



chr3_-_180652024 1.036 NM_021629
GNB4
guanine nucleotide binding protein (G protein), beta polypeptide 4
chr19_-_51856129 1.035 NM_145056
DACT3
dapper, antagonist of beta-catenin, homolog 3 (Xenopus laevis)
chr12_-_107745455 1.033 NM_001161331
SSH1
slingshot homolog 1 (Drosophila)
chr2_+_200031333 1.032


chr9_+_34980266 1.027 NM_001135005
DNAJB5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr2_+_130846263 1.018 PTPN18
protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
chrX_+_149282097 1.016 NM_001177465
MAMLD1
mastermind-like domain containing 1
chr1_-_151804929 1.016 NM_005978
S100A2
S100 calcium binding protein A2
chr2_-_175578156 1.014 NM_001025201
NM_001822
CHN1

chimerin (chimaerin) 1

chr4_+_123967265 1.011 NM_002006
FGF2
fibroblast growth factor 2 (basic)
chr19_-_60573552 1.007 NM_000641
IL11
interleukin 11
chr3_-_107070400 0.999 NM_170662
CBLB
Cas-Br-M (murine) ecotropic retroviral transforming sequence b
chr11_-_111287657 0.997 NM_001885
CRYAB
crystallin, alpha B
chr15_+_41597097 0.989 NM_002373
MAP1A
microtubule-associated protein 1A
chr10_-_105202012 0.987 CALHM2
calcium homeostasis modulator 2
chr2_+_235525355 0.986 NM_014521
SH3BP4
SH3-domain binding protein 4
chr3_-_180651874 0.986 GNB4
guanine nucleotide binding protein (G protein), beta polypeptide 4
chrX_-_133984157 0.982 NM_001078173
FAM127C
family with sequence similarity 127, member C
chr11_-_122571046 0.974 CLMP
CXADR-like membrane protein
chr17_+_52026058 0.970 NM_005450
NOG
noggin
chr4_+_159311353 0.970 LOC285505
hypothetical protein LOC285505
chr19_-_13808101 0.968 LOC284454
hypothetical LOC284454
chr12_-_3732478 0.966 EFCAB4B
EF-hand calcium binding domain 4B
chr12_+_6179736 0.964 NM_001769
CD9
CD9 molecule
chr17_+_35751796 0.952 NM_001024809
RARA
retinoic acid receptor, alpha
chr11_-_66897584 0.950 NM_013246
CLCF1
cardiotrophin-like cytokine factor 1
chr11_+_122806196 0.947 LOC100128242
hypothetical LOC100128242
chr12_+_2870255 0.942 NM_001160408
NM_003324
TULP3

tubby like protein 3

chr6_+_21701942 0.940 NM_003107
SOX4
SRY (sex determining region Y)-box 4
chr1_+_17817397 0.939 ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr17_-_44010543 0.936 NM_024015
HOXB4
homeobox B4
chr5_-_141684652 0.910 SPRY4
sprouty homolog 4 (Drosophila)
chr15_-_58477407 0.908 NM_001002857
NM_001002858
NM_001136015
NM_004039
ANXA2



annexin A2



chr1_-_204048758 0.902 NM_173854
SLC41A1
solute carrier family 41, member 1
chr17_+_56884560 0.900 TBX4
T-box 4
chr12_+_6517600 0.897


chrX_-_114374860 0.892 NM_020871
LRCH2
leucine-rich repeats and calponin homology (CH) domain containing 2
chr7_-_27120015 0.888 HOXA3
homeobox A3
chr22_+_35777561 0.886 NM_024681
KCTD17
potassium channel tetramerisation domain containing 17
chr12_+_120635021 0.873 NM_001080825
TMEM120B
transmembrane protein 120B
chr1_-_119991912 0.873 NM_001080470
ZNF697
zinc finger protein 697
chr12_-_94466701 0.870 NM_001042403
USP44
ubiquitin specific peptidase 44
chr17_+_45703765 0.867 NM_001168215
TMEM92
transmembrane protein 92
chr1_+_9275518 0.866 NM_025106
SPSB1
splA/ryanodine receptor domain and SOCS box containing 1
chr1_-_93919789 0.865 NM_003567
BCAR3
breast cancer anti-estrogen resistance 3
chr5_+_140835788 0.863 PCDHGC3
protocadherin gamma subfamily C, 3
chr5_-_83715947 0.862 EDIL3
EGF-like repeats and discoidin I-like domains 3
chr11_-_85053709 0.861 CREBZF
CREB/ATF bZIP transcription factor
chr4_+_81406765 0.860 NM_004464
NM_033143
FGF5

fibroblast growth factor 5

chr5_-_141684759 0.860 NM_001127496
NM_030964
SPRY4

sprouty homolog 4 (Drosophila)

chr19_+_4861339 0.859 NM_013282
UHRF1
ubiquitin-like with PHD and ring finger domains 1
chr3_+_185536376 0.857 NM_001171093
FAM131A
family with sequence similarity 131, member A
chr1_+_9275542 0.851 SPSB1
splA/ryanodine receptor domain and SOCS box containing 1
chr13_+_41520888 0.850 NM_152910
NM_178009
DGKH

diacylglycerol kinase, eta

chr6_+_17389752 0.847 NM_001143942
RBM24
RNA binding motif protein 24
chr12_+_12935222 0.846 NM_003979
GPRC5A
G protein-coupled receptor, family C, group 5, member A
chr3_-_130807865 0.846 NM_015103
PLXND1
plexin D1
chr8_+_26296439 0.844 NM_004331
BNIP3L
BCL2/adenovirus E1B 19kDa interacting protein 3-like
chr21_+_41461962 0.842 BACE2
beta-site APP-cleaving enzyme 2
chr20_-_3713509 0.840 CENPB
centromere protein B, 80kDa
chr16_-_73842884 0.839 NM_001170717
NM_014567
BCAR1

breast cancer anti-estrogen resistance 1

chr17_+_17816851 0.837 NM_001130090
NM_001130091
NM_001130092
NM_031294
LRRC48



leucine rich repeat containing 48



chr11_+_45825244 0.836 NM_001127457
CRY2
cryptochrome 2 (photolyase-like)
chr11_+_45825532 0.835 NM_021117
CRY2
cryptochrome 2 (photolyase-like)
chr21_-_35181094 0.834


chr4_-_54625463 0.831 CHIC2
cysteine-rich hydrophobic domain 2
chr21_-_35181308 0.824 RUNX1
runt-related transcription factor 1
chr1_+_148788410 0.815 NM_019032
NM_025008
ADAMTSL4

ADAMTS-like 4

chr1_+_181259317 0.814


chr9_+_34979674 0.810 NM_001135004
NM_012266
DNAJB5

DnaJ (Hsp40) homolog, subfamily B, member 5

chr1_+_31658549 0.809 NM_178865
SERINC2
serine incorporator 2
chr17_-_45629401 0.807


chr12_+_95112131 0.804 NM_005230
ELK3
ELK3, ETS-domain protein (SRF accessory protein 2)
chr12_-_21985433 0.802 ABCC9
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
chr12_+_12935619 0.802 GPRC5A
G protein-coupled receptor, family C, group 5, member A
chr2_-_9061193 0.795 NM_138799
MBOAT2
membrane bound O-acyltransferase domain containing 2
chr7_+_44110470 0.794 NM_001129
AEBP1
AE binding protein 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.21 2.67e-10 GO:0050794 regulation of cellular process
1.17 7.04e-08 GO:0065007 biological regulation
1.18 7.40e-08 GO:0050789 regulation of biological process
1.26 2.86e-06 GO:0032502 developmental process
1.31 3.95e-06 GO:0048731 system development
1.29 4.71e-06 GO:0048856 anatomical structure development
1.26 1.79e-05 GO:0007275 multicellular organismal development
1.36 2.94e-05 GO:0030154 cell differentiation
1.35 3.00e-05 GO:0048869 cellular developmental process
1.56 4.63e-05 GO:0022008 neurogenesis
1.40 4.90e-05 GO:0023051 regulation of signaling
1.42 5.12e-05 GO:0007399 nervous system development
1.98 5.37e-05 GO:0001501 skeletal system development
1.53 7.11e-05 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.56 8.49e-05 GO:0048699 generation of neurons
1.41 1.32e-04 GO:0009653 anatomical structure morphogenesis
1.99 2.75e-04 GO:0061061 muscle structure development
1.40 3.87e-04 GO:0009966 regulation of signal transduction
1.28 5.70e-04 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.53 5.92e-04 GO:0031328 positive regulation of cellular biosynthetic process
1.23 6.52e-04 GO:0031323 regulation of cellular metabolic process
1.56 7.52e-04 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.52 9.54e-04 GO:0009891 positive regulation of biosynthetic process
1.53 1.37e-03 GO:0051173 positive regulation of nitrogen compound metabolic process
1.55 1.49e-03 GO:0010557 positive regulation of macromolecule biosynthetic process
1.22 1.79e-03 GO:0080090 regulation of primary metabolic process
1.56 1.83e-03 GO:0030182 neuron differentiation
1.30 2.09e-03 GO:0048523 negative regulation of cellular process
1.69 2.16e-03 GO:0072358 cardiovascular system development
1.69 2.16e-03 GO:0072359 circulatory system development
1.57 2.36e-03 GO:0051254 positive regulation of RNA metabolic process
1.27 2.66e-03 GO:0048522 positive regulation of cellular process
1.26 3.01e-03 GO:0048518 positive regulation of biological process
1.21 3.38e-03 GO:0023052 signaling
1.55 3.88e-03 GO:0010628 positive regulation of gene expression
1.58 3.97e-03 GO:0045893 positive regulation of transcription, DNA-dependent
1.22 4.69e-03 GO:0060255 regulation of macromolecule metabolic process
1.25 4.76e-03 GO:0051171 regulation of nitrogen compound metabolic process
1.20 6.42e-03 GO:0019222 regulation of metabolic process
1.55 7.91e-03 GO:0030030 cell projection organization
1.81 8.79e-03 GO:0022603 regulation of anatomical structure morphogenesis
1.54 9.46e-03 GO:0007167 enzyme linked receptor protein signaling pathway
1.45 9.56e-03 GO:0048468 cell development
1.26 1.04e-02 GO:0048519 negative regulation of biological process
1.83 1.07e-02 GO:0001944 vasculature development
1.78 1.22e-02 GO:0060284 regulation of cell development
1.39 1.22e-02 GO:0010604 positive regulation of macromolecule metabolic process
2.16 1.29e-02 GO:0043062 extracellular structure organization
1.16 1.46e-02 GO:0032501 multicellular organismal process
1.25 1.64e-02 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.49 1.80e-02 GO:2000026 regulation of multicellular organismal development
1.07 1.99e-02 GO:0009987 cellular process
1.61 2.05e-02 GO:0031175 neuron projection development
1.20 2.24e-02 GO:0007165 signal transduction
2.22 2.32e-02 GO:0042692 muscle cell differentiation
1.98 2.61e-02 GO:0007517 muscle organ development
1.28 2.90e-02 GO:0048583 regulation of response to stimulus
2.44 3.22e-02 GO:0040013 negative regulation of locomotion
1.58 3.35e-02 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.42 3.59e-02 GO:0050793 regulation of developmental process
1.86 3.88e-02 GO:0006897 endocytosis
1.86 3.88e-02 GO:0010324 membrane invagination
1.49 4.41e-02 GO:0045595 regulation of cell differentiation
1.20 4.48e-02 GO:0016043 cellular component organization
1.80 4.55e-02 GO:0001568 blood vessel development
1.23 4.56e-02 GO:0031326 regulation of cellular biosynthetic process
1.24 4.78e-02 GO:0010556 regulation of macromolecule biosynthetic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.65 2.79e-05 GO:0030054 cell junction
2.33 6.85e-05 GO:0005912 adherens junction
2.21 1.81e-04 GO:0070161 anchoring junction
1.07 2.54e-03 GO:0005622 intracellular
3.70 2.92e-03 GO:0005913 cell-cell adherens junction
1.44 8.20e-03 GO:0031410 cytoplasmic vesicle
1.07 1.20e-02 GO:0044424 intracellular part
1.41 2.38e-02 GO:0031982 vesicle
1.23 2.50e-02 GO:0044459 plasma membrane part
1.57 2.99e-02 GO:0045202 synapse
2.22 3.02e-02 GO:0005925 focal adhesion
1.41 4.85e-02 GO:0016023 cytoplasmic membrane-bounded vesicle

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.15 1.69e-06 GO:0005515 protein binding
1.45 5.25e-04 GO:0001071 nucleic acid binding transcription factor activity
1.45 5.25e-04 GO:0003700 sequence-specific DNA binding transcription factor activity
1.42 1.70e-03 GO:0030528 transcription regulator activity
1.07 2.48e-03 GO:0005488 binding
1.49 6.11e-03 GO:0043565 sequence-specific DNA binding