Motif ID: SP1.p2

Z-value: 1.331


Transcription factors associated with SP1.p2:

Gene SymbolEntrez IDGene Name
SP1 6667 Sp1 transcription factor



Activity profile for motif SP1.p2.

activity profile for motif SP1.p2


Sorted Z-values histogram for motif SP1.p2

Sorted Z-values for motif SP1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SP1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_35572694 3.100 NM_003214
TEAD3
TEA domain family member 3
chr6_+_37245860 2.482 NM_002648
PIM1
pim-1 oncogene
chr17_+_34114924 2.366 MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr16_-_88295595 1.979 NM_152339
SPATA2L
spermatogenesis associated 2-like
chr22_-_18807805 1.962 PI4KAP2
PI4KAP1
phosphatidylinositol 4-kinase, catalytic, alpha pseudogene 2
phosphatidylinositol 4-kinase, catalytic, alpha pseudogene 1
chr5_+_176446425 1.933 NM_002011
NM_213647
FGFR4

fibroblast growth factor receptor 4

chr19_+_7891193 1.932 NM_003083
SNAPC2
small nuclear RNA activating complex, polypeptide 2, 45kDa
chr22_+_20101661 1.868 NM_015094
HIC2
hypermethylated in cancer 2
chr2_+_10101081 1.797 NM_003597
NM_001177716
KLF11

Kruppel-like factor 11

chr1_+_3679168 1.786 NM_001163724
LOC388588
hypothetical protein LOC388588
chr1_-_20685314 1.620 NM_018584
CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr9_+_139566129 1.582 NM_032477
MRPL41
mitochondrial ribosomal protein L41
chr20_-_62151216 1.543 NM_018419
SOX18
SRY (sex determining region Y)-box 18
chr19_-_7840806 1.541 FLJ22184
hypothetical protein FLJ22184
chr19_+_59064795 1.540 MYADM
myeloid-associated differentiation marker
chr3_-_12983959 1.500 NM_014869
IQSEC1
IQ motif and Sec7 domain 1
chr16_+_88422354 1.498 NM_032451
SPIRE2
spire homolog 2 (Drosophila)
chr19_+_38979502 1.491 NM_001129994
NM_001129995
NM_024076
KCTD15


potassium channel tetramerisation domain containing 15


chr17_+_44429748 1.438 NM_001160423
NM_006546
IGF2BP1

insulin-like growth factor 2 mRNA binding protein 1

chr14_-_37134191 1.421 NM_004496
FOXA1
forkhead box A1
chr20_-_60375695 1.420 NM_005560
LAMA5
laminin, alpha 5
chr20_+_60898249 1.419 NM_018270
C20orf20
chromosome 20 open reading frame 20
chr6_+_2945025 1.404 NM_000904
NQO2
NAD(P)H dehydrogenase, quinone 2
chr8_-_146023228 1.365 LOC100130027
hypothetical LOC100130027
chr19_+_59064471 1.326 NM_001020821
NM_001020818
MYADM

myeloid-associated differentiation marker

chr19_-_4017739 1.321 NM_015898
ZBTB7A
zinc finger and BTB domain containing 7A
chr6_+_169866714 1.309 LOC729088
hypothetical LOC729088
chr20_-_3102169 1.307 ProSAPiP1
ProSAPiP1 protein
chr21_-_43368963 1.292 NM_000071
CBS
cystathionine-beta-synthase
chr14_-_37134050 1.290 FOXA1
forkhead box A1
chr22_+_27609889 1.282 NM_032173
ZNRF3
zinc and ring finger 3
chr19_-_16868674 1.262 CPAMD8
C3 and PZP-like, alpha-2-macroglobulin domain containing 8
chr8_-_145661545 1.225 NM_032687
NM_001129888
CYHR1

cysteine/histidine-rich 1

chr22_-_17545872 1.205 SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr19_+_7891884 1.201 SNAPC2
small nuclear RNA activating complex, polypeptide 2, 45kDa
chr11_+_63829616 1.200 NM_004451
ESRRA
estrogen-related receptor alpha
chr17_+_7125702 1.161 NM_001042
SLC2A4
solute carrier family 2 (facilitated glucose transporter), member 4
chr14_-_20562962 1.161 NM_201538
NM_201539
NM_201540
NM_201541
NDRG2



NDRG family member 2



chr17_-_17667580 1.157 SREBF1
sterol regulatory element binding transcription factor 1
chr20_-_60963390 1.144 NM_006602
TCFL5
transcription factor-like 5 (basic helix-loop-helix)
chr9_+_138805581 1.141 NM_032928
TMEM141
transmembrane protein 141
chrX_+_9392980 1.127 NM_005647
TBL1X
transducin (beta)-like 1X-linked
chr17_+_53515725 1.126 NM_080677
DYNLL2
dynein, light chain, LC8-type 2
chr9_-_122679387 1.121 NM_001009936
NM_015651
PHF19

PHD finger protein 19

chr16_-_79687367 1.120 NM_004483
GCSH
glycine cleavage system protein H (aminomethyl carrier)
chr16_+_87047159 1.114 ZFPM1
zinc finger protein, multitype 1
chr16_+_88314884 1.086 NM_152287
ZNF276
zinc finger protein 276
chr4_-_140317686 1.077 ELF2
E74-like factor 2 (ets domain transcription factor)
chr10_+_94439658 1.076 NM_002729
HHEX
hematopoietically expressed homeobox
chr3_-_187025501 1.075 NM_001007225
NM_006548
IGF2BP2

insulin-like growth factor 2 mRNA binding protein 2

chrX_+_30581377 1.068 NM_000167
NM_001128127
NM_203391
GK


glycerol kinase


chr11_-_86343859 1.061 NM_012193
FZD4
frizzled homolog 4 (Drosophila)
chr11_-_65082208 1.060 NM_001130144
NM_001164266
NM_021070
LTBP3


latent transforming growth factor beta binding protein 3


chr16_-_65287967 1.055 NM_178818
NM_181521
CMTM4

CKLF-like MARVEL transmembrane domain containing 4

chr16_+_87047418 1.043 NM_153813
ZFPM1
zinc finger protein, multitype 1
chr1_+_160306093 1.031 NM_001164757
NM_014697
NOS1AP

nitric oxide synthase 1 (neuronal) adaptor protein

chr17_-_34157962 1.031 NM_007144
PCGF2
polycomb group ring finger 2
chr17_-_24077246 1.029 NM_138463
TLCD1
TLC domain containing 1
chr9_+_137511448 1.020 NM_014811
KIAA0649
KIAA0649
chr5_-_134397740 1.004 NM_002653
PITX1
paired-like homeodomain 1
chr20_+_1154763 1.004 NM_001136566
RAD21L1
RAD21-like 1 (S. pombe)
chrX_+_30581458 1.001 GK
glycerol kinase
chr19_-_18409788 0.980 NM_001170939
ISYNA1
inositol-3-phosphate synthase 1
chr19_+_659766 0.975 NM_001040134
NM_002579
PALM

paralemmin

chr1_-_925332 0.973 NM_001142467
NM_021170
HES4

hairy and enhancer of split 4 (Drosophila)

chr14_-_37133927 0.971 FOXA1
forkhead box A1
chr1_+_6596331 0.963 NM_153812
PHF13
PHD finger protein 13
chr8_+_12089673 0.955 FAM85A
family with sequence similarity 85, member A
chr17_+_75366524 0.954 NM_005189
NM_032647
CBX2

chromobox homolog 2

chr20_+_48781457 0.949 NM_032521
PARD6B
par-6 partitioning defective 6 homolog beta (C. elegans)
chr10_-_80875097 0.948 NM_153367
ZCCHC24
zinc finger, CCHC domain containing 24
chr2_-_219960871 0.944 NM_012100
DNPEP
aspartyl aminopeptidase
chr16_+_49139694 0.944 NM_033119
NKD1
naked cuticle homolog 1 (Drosophila)
chr14_+_104337923 0.942 NM_001137601
ZBTB42
zinc finger and BTB domain containing 42
chr17_+_26839143 0.941 RAB11FIP4
RAB11 family interacting protein 4 (class II)
chr6_-_31977747 0.941 NM_181842
ZBTB12
zinc finger and BTB domain containing 12
chr16_-_18845223 0.940 NM_015092
SMG1
SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)
chr8_+_144706699 0.939 NM_001166237
GSDMD
gasdermin D
chr3_-_50311666 0.938 NM_012191
NM_003549
NAT6
HYAL3
N-acetyltransferase 6 (GCN5-related)
hyaluronoglucosaminidase 3
chr8_-_145187553 0.934 NM_017570
OPLAH
5-oxoprolinase (ATP-hydrolysing)
chr1_-_2333863 0.934 NM_002617
NM_153818
PEX10

peroxisomal biogenesis factor 10

chr6_+_167970334 0.930 NM_001040000
MLLT4
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
chr16_-_371823 0.928 NM_021259
TMEM8A
transmembrane protein 8A
chr6_+_43846735 0.921 VEGFA
vascular endothelial growth factor A
chr1_-_44269615 0.920 SLC6A9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr6_-_29703913 0.920 NM_021903
GABBR1
gamma-aminobutyric acid (GABA) B receptor, 1
chr21_-_43369492 0.919 NM_001178008
NM_001178009
CBS

cystathionine-beta-synthase

chr17_-_38978772 0.917 NM_001986
ETV4
ets variant 4
chr3_-_187025438 0.916 IGF2BP2
insulin-like growth factor 2 mRNA binding protein 2
chr7_-_100325209 0.916 NM_001015072
UFSP1
UFM1-specific peptidase 1 (non-functional)
chr20_+_61841662 0.915 SLC2A4RG
SLC2A4 regulator
chr16_+_88315452 0.913 NM_001113525
ZNF276
zinc finger protein 276
chr19_-_4016467 0.912 ZBTB7A
zinc finger and BTB domain containing 7A
chr1_+_945331 0.906 NM_198576
AGRN
agrin
chr9_-_113977285 0.906 NM_022486
SUSD1
sushi domain containing 1
chr9_+_129962292 0.904 NM_024112
C9orf16
chromosome 9 open reading frame 16
chr2_+_218972963 0.900 NM_182642
CTDSP1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
chr20_+_32928065 0.899 ACSS2
acyl-CoA synthetase short-chain family member 2
chrX_+_30581523 0.898 GK
glycerol kinase
chr19_+_10261646 0.896 NM_003259
ICAM5
intercellular adhesion molecule 5, telencephalin
chr17_+_71033339 0.887 NM_001015002
NM_001031803
NM_004524
LLGL2


lethal giant larvae homolog 2 (Drosophila)


chr19_-_55524445 0.885 NM_004977
KCNC3
potassium voltage-gated channel, Shaw-related subfamily, member 3
chr3_-_24511456 0.881 THRB
thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)
chr1_-_2333800 0.873 PEX10
peroxisomal biogenesis factor 10
chr10_-_135021502 0.872 NM_001098483
NM_198472
C10orf125

chromosome 10 open reading frame 125

chr1_+_157246305 0.871 NM_005531
IFI16
interferon, gamma-inducible protein 16
chr19_-_1441403 0.870 NM_017573
PCSK4
proprotein convertase subtilisin/kexin type 4
chr1_-_20684858 0.869 CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr11_+_46359878 0.867 NM_001012333
MDK
midkine (neurite growth-promoting factor 2)
chr12_+_970613 0.865 NM_178039
NM_178040
ERC1

ELKS/RAB6-interacting/CAST family member 1

chr14_-_21064182 0.860 SALL2
sal-like 2 (Drosophila)
chr20_+_34635362 0.857 NM_021809
TGIF2
TGFB-induced factor homeobox 2
chr8_-_37876129 0.852 NM_001002814
NM_025151
RAB11FIP1

RAB11 family interacting protein 1 (class I)

chr8_+_27404508 0.851 NM_001979
EPHX2
epoxide hydrolase 2, cytoplasmic
chr19_+_1442000 0.850 NM_138393
REEP6
receptor accessory protein 6
chr18_+_11971421 0.850 IMPA2
inositol(myo)-1(or 4)-monophosphatase 2
chr1_+_226404037 0.847 NM_020435
GJC2
gap junction protein, gamma 2, 47kDa
chr11_-_67153959 0.842 NM_181843
NUDT8
nudix (nucleoside diphosphate linked moiety X)-type motif 8
chrX_+_138060 0.841 NM_018390
PLCXD1
phosphatidylinositol-specific phospholipase C, X domain containing 1
chr8_-_11762918 0.838 CTSB
cathepsin B
chr1_-_1840564 0.837 NM_178545
TMEM52
transmembrane protein 52
chr17_-_53515563 0.836


chr6_+_44203335 0.830 NM_018426
TMEM63B
transmembrane protein 63B
chr20_+_32927988 0.828 NM_001076552
NM_018677
ACSS2

acyl-CoA synthetase short-chain family member 2

chr22_-_21231421 0.827 NM_206955
NM_206956
NM_006115
NM_206953
NM_206954
PRAME




preferentially expressed antigen in melanoma




chr7_-_100078270 0.825 TFR2
transferrin receptor 2
chr17_-_78199384 0.823 NM_019613
WDR45L
WDR45-like
chr16_-_960982 0.821 NM_022773
LMF1
lipase maturation factor 1
chr10_-_43212166 0.821 NM_001098208
HNRNPF
heterogeneous nuclear ribonucleoprotein F
chr16_-_342399 0.821 NM_003502
NM_181050
AXIN1

axin 1

chr10_-_62431203 0.814 RHOBTB1
Rho-related BTB domain containing 1
chr17_-_75385371 0.814 NM_020649
CBX8
chromobox homolog 8
chr21_-_45173061 0.813 NM_001127491
ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr17_+_75849221 0.812 NM_020914
NM_020954
RNF213

ring finger protein 213

chr11_-_86343737 0.810 FZD4
frizzled homolog 4 (Drosophila)
chr17_+_34115383 0.809 NM_005937
MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr19_-_56585603 0.806 NM_001193623
LOC147646
hypothetical protein LOC147646
chr21_-_36450448 0.805 LOC100506428
hypothetical LOC100506428
chr14_+_101297887 0.805 NM_001161725
NM_001161726
PPP2R5C

protein phosphatase 2, regulatory subunit B', gamma

chr7_+_36159300 0.804 NM_030636
EEPD1
endonuclease/exonuclease/phosphatase family domain containing 1
chr21_+_45649719 0.803


chr13_-_49597776 0.798 DLEU2
deleted in lymphocytic leukemia 2 (non-protein coding)
chr1_+_93686154 0.791 NM_001024948
NM_001164473
NM_017737
FNBP1L


formin binding protein 1-like


chr1_+_945472 0.790 AGRN
agrin
chr9_-_139214962 0.789 NM_001128228
TPRN
taperin
chr20_+_32045087 0.787 RALY
RNA binding protein, autoantigenic (hnRNP-associated with lethal yellow homolog (mouse))
chr11_+_63758550 0.782 NM_003377
VEGFB
vascular endothelial growth factor B
chr7_+_151792052 0.780 LOC100128822
hypothetical LOC100128822
chr1_+_148788410 0.778 NM_019032
NM_025008
ADAMTSL4

ADAMTS-like 4

chr12_+_56621711 0.777 NM_033276
XRCC6BP1
XRCC6 binding protein 1
chr22_-_17546234 0.776 SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr1_+_153366559 0.776 EFNA1
ephrin-A1
chr2_+_10506233 0.775


chr2_+_10101822 0.773 NM_001177718
KLF11
Kruppel-like factor 11
chr22_-_17546296 0.772 NM_005984
SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr15_-_81113676 0.769 NM_030594
CPEB1
cytoplasmic polyadenylation element binding protein 1
chr8_-_145090045 0.769 NM_201382
PLEC
plectin
chr17_-_73636386 0.766 NM_001127198
TMC6
transmembrane channel-like 6
chrX_+_49531209 0.764 NM_001145073
USP27X
ubiquitin specific peptidase 27, X-linked
chr11_+_46359855 0.764 MDK
midkine (neurite growth-promoting factor 2)
chr19_-_45663463 0.763 NM_000713
BLVRB
biliverdin reductase B (flavin reductase (NADPH))
chr5_-_114660139 0.761 NM_001040440
CCDC112
coiled-coil domain containing 112
chr6_-_4080700 0.758 NM_001166010
NM_006117
NM_206836
PECI


peroxisomal D3,D2-enoyl-CoA isomerase


chr2_+_119905812 0.755 NM_183240
TMEM37
transmembrane protein 37
chr20_-_34635091 0.755


chr19_+_59061422 0.750 NM_001020820
MYADM
myeloid-associated differentiation marker
chr4_-_38482805 0.749 NM_003263
TLR1
toll-like receptor 1
chr10_+_92970487 0.746 PCGF5
polycomb group ring finger 5
chr7_-_100262971 0.743 NM_004444
EPHB4
EPH receptor B4
chr7_-_150283794 0.743 NM_172057
KCNH2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr11_+_46359781 0.742 NM_002391
MDK
midkine (neurite growth-promoting factor 2)
chr9_-_139068269 0.738 NM_001246
NM_203468
ENTPD2

ectonucleoside triphosphate diphosphohydrolase 2

chr1_+_945399 0.737


chr16_+_76313909 0.734 NM_001105663
NUDT7
nudix (nucleoside diphosphate linked moiety X)-type motif 7
chr22_-_17546276 0.734 SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr19_-_1441340 0.734 PCSK4
proprotein convertase subtilisin/kexin type 4
chr2_-_219960813 0.734 DNPEP
aspartyl aminopeptidase
chr6_+_34312979 0.728 HMGA1
high mobility group AT-hook 1
chr19_-_1763198 0.727 NM_001178002
NM_138813
ATP8B3

ATPase, aminophospholipid transporter, class I, type 8B, member 3

chr17_-_55824359 0.726 NM_032582
USP32
ubiquitin specific peptidase 32
chr17_-_30783631 0.726 NM_018042
SLFN12
schlafen family member 12
chr1_+_3360880 0.724 NM_014448
ARHGEF16
Rho guanine nucleotide exchange factor (GEF) 16
chr19_-_54314090 0.715 NM_018111
C19orf73
chromosome 19 open reading frame 73
chr6_-_29703725 0.715 GABBR1
gamma-aminobutyric acid (GABA) B receptor, 1
chr17_-_77462325 0.715 PCYT2
phosphate cytidylyltransferase 2, ethanolamine
chr3_+_13496714 0.714 NM_024827
NM_001136041
HDAC11

histone deacetylase 11

chr16_-_11744103 0.713 NM_015914
TXNDC11
thioredoxin domain containing 11
chr19_-_47450991 0.713 ERF
Ets2 repressor factor
chr8_-_11763004 0.712 CTSB
cathepsin B
chr4_+_1764802 0.711 NM_000142
NM_001163213
NM_022965
FGFR3


fibroblast growth factor receptor 3


chr10_-_43212681 0.708 HNRNPF
heterogeneous nuclear ribonucleoprotein F
chr1_-_21868380 0.708 NM_001145657
NM_002885
RAP1GAP

RAP1 GTPase activating protein

chr9_-_122679283 0.707 PHF19
PHD finger protein 19
chr19_+_61344501 0.707 ZNF444
zinc finger protein 444
chr2_-_219960725 0.705 DNPEP
aspartyl aminopeptidase
chr6_+_41622267 0.704 FOXP4
forkhead box P4
chr1_-_84928473 0.704 NM_001166295
NM_001166417
NM_001166293
NM_001166294
NM_014021
SSX2IP




synovial sarcoma, X breakpoint 2 interacting protein




chr7_-_122961808 0.703 NM_178827
IQUB
IQ motif and ubiquitin domain containing
chr8_-_11763023 0.703 CTSB
cathepsin B
chr2_-_74915722 0.700



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.12 1.03e-18 GO:0044237 cellular metabolic process
1.07 3.36e-18 GO:0009987 cellular process
1.10 3.23e-16 GO:0050794 regulation of cellular process
1.14 1.01e-15 GO:0044260 cellular macromolecule metabolic process
1.15 7.55e-15 GO:0019222 regulation of metabolic process
1.15 7.80e-15 GO:0031323 regulation of cellular metabolic process
1.09 1.11e-14 GO:0065007 biological regulation
1.15 3.82e-14 GO:0080090 regulation of primary metabolic process
1.09 4.01e-14 GO:0050789 regulation of biological process
1.18 4.08e-14 GO:0071842 cellular component organization at cellular level
1.17 1.14e-13 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.10 1.44e-13 GO:0044238 primary metabolic process
1.15 4.52e-13 GO:0060255 regulation of macromolecule metabolic process
1.09 7.55e-13 GO:0008152 metabolic process
1.15 9.61e-13 GO:0016043 cellular component organization
1.48 1.77e-12 GO:0016568 chromatin modification
1.17 2.25e-12 GO:0071841 cellular component organization or biogenesis at cellular level
1.15 5.14e-12 GO:0034641 cellular nitrogen compound metabolic process
1.15 7.42e-12 GO:0006807 nitrogen compound metabolic process
1.17 2.58e-11 GO:0010468 regulation of gene expression
1.14 2.79e-11 GO:0071840 cellular component organization or biogenesis
1.17 5.36e-11 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.16 5.63e-11 GO:0051171 regulation of nitrogen compound metabolic process
1.16 6.21e-11 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.11 6.55e-11 GO:0043170 macromolecule metabolic process
1.17 4.65e-10 GO:0051252 regulation of RNA metabolic process
1.16 5.17e-10 GO:0010556 regulation of macromolecule biosynthetic process
1.17 6.46e-10 GO:0090304 nucleic acid metabolic process
1.17 1.04e-09 GO:0048523 negative regulation of cellular process
1.20 1.91e-09 GO:0006996 organelle organization
1.59 3.74e-09 GO:0016569 covalent chromatin modification
1.15 4.53e-09 GO:0031326 regulation of cellular biosynthetic process
1.15 4.76e-09 GO:0009889 regulation of biosynthetic process
1.59 4.80e-09 GO:0016570 histone modification
1.16 3.58e-08 GO:0006355 regulation of transcription, DNA-dependent
1.15 9.02e-08 GO:0048519 negative regulation of biological process
1.25 2.27e-07 GO:0010605 negative regulation of macromolecule metabolic process
1.14 3.23e-07 GO:0048518 positive regulation of biological process
1.17 4.78e-07 GO:0016070 RNA metabolic process
1.23 5.78e-07 GO:0007049 cell cycle
1.29 6.88e-07 GO:0010558 negative regulation of macromolecule biosynthetic process
1.33 8.55e-07 GO:0006325 chromatin organization
1.29 8.70e-07 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.14 1.21e-06 GO:0048522 positive regulation of cellular process
1.23 1.52e-06 GO:0009892 negative regulation of metabolic process
1.18 1.67e-06 GO:0007399 nervous system development
1.27 2.93e-06 GO:0009890 negative regulation of biosynthetic process
1.28 3.46e-06 GO:0051276 chromosome organization
1.23 5.46e-06 GO:0031324 negative regulation of cellular metabolic process
1.22 5.49e-06 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.27 5.62e-06 GO:0031327 negative regulation of cellular biosynthetic process
1.17 7.51e-06 GO:0023051 regulation of signaling
1.15 1.21e-05 GO:0043412 macromolecule modification
1.15 1.38e-05 GO:0006464 protein modification process
1.18 1.53e-05 GO:0009966 regulation of signal transduction
1.27 3.05e-05 GO:0010629 negative regulation of gene expression
1.28 3.56e-05 GO:0045892 negative regulation of transcription, DNA-dependent
1.20 6.78e-05 GO:0032268 regulation of cellular protein metabolic process
1.28 6.80e-05 GO:0051253 negative regulation of RNA metabolic process
1.26 6.93e-05 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.26 9.37e-05 GO:0051172 negative regulation of nitrogen compound metabolic process
1.28 2.28e-04 GO:0048858 cell projection morphogenesis
1.19 3.05e-04 GO:0051246 regulation of protein metabolic process
1.16 3.29e-04 GO:0065009 regulation of molecular function
1.14 3.60e-04 GO:0010467 gene expression
1.27 3.70e-04 GO:0000904 cell morphogenesis involved in differentiation
1.27 4.00e-04 GO:0032990 cell part morphogenesis
1.18 4.09e-04 GO:0010604 positive regulation of macromolecule metabolic process
1.12 4.56e-04 GO:0044267 cellular protein metabolic process
1.20 5.26e-04 GO:0006351 transcription, DNA-dependent
1.25 5.71e-04 GO:0000902 cell morphogenesis
1.24 7.01e-04 GO:0030030 cell projection organization
1.21 8.92e-04 GO:0022402 cell cycle process
1.14 1.12e-03 GO:0034645 cellular macromolecule biosynthetic process
1.11 1.35e-03 GO:0044249 cellular biosynthetic process
1.28 1.43e-03 GO:0048812 neuron projection morphogenesis
1.23 1.66e-03 GO:0032989 cellular component morphogenesis
1.32 1.88e-03 GO:0051098 regulation of binding
1.24 2.17e-03 GO:0000278 mitotic cell cycle
1.14 2.43e-03 GO:0009059 macromolecule biosynthetic process
1.16 2.49e-03 GO:0009893 positive regulation of metabolic process
1.28 2.54e-03 GO:0007409 axonogenesis
1.28 2.62e-03 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.27 2.92e-03 GO:0048667 cell morphogenesis involved in neuron differentiation
1.16 3.38e-03 GO:0031325 positive regulation of cellular metabolic process
1.20 4.08e-03 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.18 4.76e-03 GO:0032774 RNA biosynthetic process
1.19 5.11e-03 GO:0048699 generation of neurons
1.25 5.53e-03 GO:0031175 neuron projection development
1.21 5.59e-03 GO:0022403 cell cycle phase
1.31 6.06e-03 GO:0051329 interphase of mitotic cell cycle
1.21 6.58e-03 GO:0051254 positive regulation of RNA metabolic process
1.08 7.03e-03 GO:0023052 signaling
1.24 7.39e-03 GO:0048585 negative regulation of response to stimulus
1.10 7.69e-03 GO:0009058 biosynthetic process
1.26 8.44e-03 GO:0010648 negative regulation of cell communication
1.30 8.82e-03 GO:0051325 interphase
1.24 9.96e-03 GO:0006974 response to DNA damage stimulus
1.19 1.07e-02 GO:0051173 positive regulation of nitrogen compound metabolic process
1.32 1.15e-02 GO:0051101 regulation of DNA binding
1.18 1.20e-02 GO:0022008 neurogenesis
1.19 1.29e-02 GO:0031399 regulation of protein modification process
1.14 1.36e-02 GO:0009653 anatomical structure morphogenesis
1.23 1.68e-02 GO:0016071 mRNA metabolic process
1.29 1.70e-02 GO:0060284 regulation of cell development
1.25 1.73e-02 GO:0023057 negative regulation of signaling
1.08 1.88e-02 GO:0051716 cellular response to stimulus
1.26 2.00e-02 GO:0006397 mRNA processing
1.14 2.07e-02 GO:0035556 intracellular signal transduction
1.18 2.18e-02 GO:0051128 regulation of cellular component organization
1.19 2.24e-02 GO:2000026 regulation of multicellular organismal development
1.23 2.25e-02 GO:0007010 cytoskeleton organization
1.61 2.53e-02 GO:0006475 internal protein amino acid acetylation
1.26 2.55e-02 GO:0007264 small GTPase mediated signal transduction
1.28 2.63e-02 GO:0007411 axon guidance
1.25 2.92e-02 GO:0009968 negative regulation of signal transduction
1.20 3.08e-02 GO:0051726 regulation of cell cycle
1.99 3.63e-02 GO:0006476 protein deacetylation
1.17 3.82e-02 GO:0048468 cell development
1.48 4.33e-02 GO:0051100 negative regulation of binding
1.15 4.59e-02 GO:0010646 regulation of cell communication
1.20 4.61e-02 GO:0006396 RNA processing
1.53 4.89e-02 GO:0018205 peptidyl-lysine modification
1.53 4.89e-02 GO:0043392 negative regulation of DNA binding
1.31 4.95e-02 GO:0051090 regulation of sequence-specific DNA binding transcription factor activity

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.10 1.76e-56 GO:0044424 intracellular part
1.10 2.81e-56 GO:0005622 intracellular
1.11 1.23e-41 GO:0043226 organelle
1.11 2.63e-41 GO:0043229 intracellular organelle
1.12 2.37e-39 GO:0043227 membrane-bounded organelle
1.12 7.91e-39 GO:0043231 intracellular membrane-bounded organelle
1.16 4.49e-31 GO:0005634 nucleus
1.10 2.21e-26 GO:0005737 cytoplasm
1.24 1.34e-21 GO:0044428 nuclear part
1.25 2.88e-20 GO:0031981 nuclear lumen
1.13 3.50e-20 GO:0044422 organelle part
1.13 7.65e-20 GO:0044446 intracellular organelle part
1.20 7.04e-16 GO:0070013 intracellular organelle lumen
1.19 5.21e-15 GO:0043233 organelle lumen
1.26 6.34e-15 GO:0005654 nucleoplasm
1.03 7.33e-15 GO:0044464 cell part
1.03 8.66e-15 GO:0005623 cell
1.19 1.33e-14 GO:0031974 membrane-enclosed lumen
1.10 3.21e-14 GO:0044444 cytoplasmic part
1.19 7.97e-13 GO:0005829 cytosol
1.31 2.90e-11 GO:0044451 nucleoplasm part
1.14 1.22e-10 GO:0043234 protein complex
1.12 1.50e-09 GO:0032991 macromolecular complex
1.13 3.32e-07 GO:0043228 non-membrane-bounded organelle
1.13 3.32e-07 GO:0043232 intracellular non-membrane-bounded organelle
1.25 1.35e-06 GO:0015630 microtubule cytoskeleton
1.25 1.24e-04 GO:0005694 chromosome
1.14 2.22e-04 GO:0012505 endomembrane system
1.17 4.59e-04 GO:0005794 Golgi apparatus
1.55 9.29e-04 GO:0016585 chromatin remodeling complex
1.35 1.04e-03 GO:0016323 basolateral plasma membrane
1.31 1.20e-03 GO:0005874 microtubule
1.70 1.45e-03 GO:0034708 methyltransferase complex
1.70 1.45e-03 GO:0035097 histone methyltransferase complex
1.13 2.57e-03 GO:0005856 cytoskeleton
1.50 3.21e-03 GO:0005925 focal adhesion
1.41 4.78e-03 GO:0000151 ubiquitin ligase complex
1.46 8.90e-03 GO:0030055 cell-substrate junction
1.30 1.15e-02 GO:0005667 transcription factor complex
1.31 1.46e-02 GO:0016604 nuclear body
1.45 1.72e-02 GO:0005924 cell-substrate adherens junction
1.33 1.74e-02 GO:0030135 coated vesicle
1.57 1.90e-02 GO:0000123 histone acetyltransferase complex
1.21 2.19e-02 GO:0044427 chromosomal part
1.15 2.33e-02 GO:0042995 cell projection
1.33 3.17e-02 GO:0031252 cell leading edge
1.18 3.53e-02 GO:0044431 Golgi apparatus part
1.30 4.03e-02 GO:0000228 nuclear chromosome
1.13 4.26e-02 GO:0000267 cell fraction
1.34 4.46e-02 GO:0070161 anchoring junction

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.14 1.32e-38 GO:0005515 protein binding
1.07 4.80e-32 GO:0005488 binding
1.16 2.25e-09 GO:0003677 DNA binding
1.12 8.36e-09 GO:0003676 nucleic acid binding
1.26 1.08e-07 GO:0019899 enzyme binding
1.21 2.87e-06 GO:0030528 transcription regulator activity
1.30 1.48e-05 GO:0019904 protein domain specific binding
1.44 5.45e-05 GO:0003682 chromatin binding
1.12 6.70e-05 GO:0000166 nucleotide binding
1.17 1.11e-03 GO:0001071 nucleic acid binding transcription factor activity
1.17 1.11e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
1.12 2.32e-03 GO:0032553 ribonucleotide binding
1.12 2.32e-03 GO:0032555 purine ribonucleotide binding
1.24 2.78e-03 GO:0060589 nucleoside-triphosphatase regulator activity
1.12 2.84e-03 GO:0017076 purine nucleotide binding
1.29 3.61e-03 GO:0016563 transcription activator activity
1.11 3.66e-03 GO:0008270 zinc ion binding
1.06 4.29e-03 GO:0003824 catalytic activity
1.12 6.11e-03 GO:0035639 purine ribonucleoside triphosphate binding
1.29 6.49e-03 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.23 6.51e-03 GO:0030695 GTPase regulator activity
1.31 7.82e-03 GO:0003702 RNA polymerase II transcription factor activity
1.16 1.01e-02 GO:0030234 enzyme regulator activity
1.21 1.03e-02 GO:0008092 cytoskeletal protein binding
1.12 2.14e-02 GO:0032559 adenyl ribonucleotide binding
1.16 2.38e-02 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.11 2.59e-02 GO:0016740 transferase activity
1.12 2.64e-02 GO:0030554 adenyl nucleotide binding
1.22 2.97e-02 GO:0016874 ligase activity
1.16 4.18e-02 GO:0016301 kinase activity
1.26 4.52e-02 GO:0016564 transcription repressor activity
1.12 4.80e-02 GO:0005524 ATP binding