Motif ID: ZEB1.p2

Z-value: 4.591


Transcription factors associated with ZEB1.p2:

Gene SymbolEntrez IDGene Name
ZEB1 6935 zinc finger E-box binding homeobox 1



Activity profile for motif ZEB1.p2.

activity profile for motif ZEB1.p2


Sorted Z-values histogram for motif ZEB1.p2

Sorted Z-values for motif ZEB1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ZEB1.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_22363036 7.892 NM_012294
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr19_+_40431359 7.552 NM_015925
NM_205834
NM_205835
LSR


lipolysis stimulated lipoprotein receptor


chr19_+_40431618 7.311 LSR
lipolysis stimulated lipoprotein receptor
chr8_+_120289735 7.222 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr22_+_38720881 7.151 NM_138435
FAM83F
family with sequence similarity 83, member F
chr11_+_32808045 6.124 NM_024081
PRRG4
proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
chr17_-_37196463 5.947 NM_002230
NM_021991
JUP

junction plakoglobin

chr19_+_40431122 5.603 LSR
lipolysis stimulated lipoprotein receptor
chr4_-_35922288 5.389 NM_015230
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr19_+_40431678 5.114 LSR
lipolysis stimulated lipoprotein receptor
chr8_-_144887876 5.039 NM_198488
FAM83H
family with sequence similarity 83, member H
chr1_-_27159462 5.032 NM_152365
C1orf172
chromosome 1 open reading frame 172
chr1_-_208046011 4.871 NM_006147
IRF6
interferon regulatory factor 6
chr2_-_166358792 4.468 GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chr6_-_10527772 4.451 NM_001042425
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr19_+_43447262 4.447 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr2_-_166358951 4.413 GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chr11_-_64368616 4.302 NM_017525
CDC42BPG
CDC42 binding protein kinase gamma (DMPK-like)
chr2_-_166359016 4.290 NM_004482
GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chr19_-_60587414 4.277 NM_001190764
LOC388564
hypothetical protein LOC388564
chr8_-_127639647 4.169 FAM84B
family with sequence similarity 84, member B
chr18_+_27332024 4.042 NM_001943
DSG2
desmoglein 2
chr5_+_68746694 4.023 NM_001038603
MARVELD2
MARVEL domain containing 2
chr20_+_48781457 3.896 NM_032521
PARD6B
par-6 partitioning defective 6 homolog beta (C. elegans)
chr3_-_48446405 3.884 NM_001130082
PLXNB1
plexin B1
chr4_+_75529716 3.804 NM_001657
AREG
amphiregulin
chr6_+_143423723 3.598 AIG1
androgen-induced 1
chr16_-_66827449 3.577 NM_024939
ESRP2
epithelial splicing regulatory protein 2
chr21_-_42060266 3.448 NM_020639
RIPK4
receptor-interacting serine-threonine kinase 4
chr1_-_159257595 3.439 NM_016946
F11R
F11 receptor
chr1_+_24518398 3.280 NM_198173
NM_198174
GRHL3

grainyhead-like 3 (Drosophila)

chr1_-_159257567 3.264 F11R
F11 receptor
chr1_+_36544549 3.242 NM_001162530
SH3D21
SH3 domain containing 21
chr21_-_42060334 3.241 RIPK4
receptor-interacting serine-threonine kinase 4
chr1_-_159257486 3.236 F11R
F11 receptor
chr6_+_143423738 3.133 AIG1
androgen-induced 1
chr1_+_24518501 3.110 NM_001195010
GRHL3
grainyhead-like 3 (Drosophila)
chr4_+_75699652 3.093 NM_001657
AREG
amphiregulin
chr2_-_216586488 3.090 NM_018000
MREG
melanoregulin
chr8_-_17702991 3.068


chr6_+_7486836 3.046 DSP
desmoplakin
chr20_-_6051562 3.017 FERMT1
fermitin family member 1
chr19_+_43447078 3.016 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr6_+_7486891 3.007 DSP
desmoplakin
chr5_+_76150637 3.006 F2RL1
coagulation factor II (thrombin) receptor-like 1
chr2_+_17585287 3.000 NM_003385
VSNL1
visinin-like 1
chr2_+_17585462 2.987 VSNL1
visinin-like 1
chr21_-_41140908 2.971 NM_001389
DSCAM
Down syndrome cell adhesion molecule
chr6_+_7486862 2.935 NM_001008844
NM_004415
DSP

desmoplakin

chr12_-_32940931 2.895 NM_001005242
NM_004572
PKP2

plakophilin 2

chr5_+_76150588 2.877 NM_005242
F2RL1
coagulation factor II (thrombin) receptor-like 1
chr8_+_95722448 2.857 ESRP1
epithelial splicing regulatory protein 1
chr19_+_6415259 2.837 NM_139161
NM_174881
CRB3

crumbs homolog 3 (Drosophila)

chr14_-_66948523 2.808 NM_016445
PLEK2
pleckstrin 2
chr14_-_66948612 2.788 PLEK2
pleckstrin 2
chr6_+_143423656 2.774 NM_016108
AIG1
androgen-induced 1
chr1_-_44269719 2.703 NM_001024845
SLC6A9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr17_+_26839143 2.699 RAB11FIP4
RAB11 family interacting protein 4 (class II)
chr16_-_65287967 2.634 NM_178818
NM_181521
CMTM4

CKLF-like MARVEL transmembrane domain containing 4

chr16_+_67236730 2.546 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr11_-_550706 2.543 NM_173573
C11orf35
chromosome 11 open reading frame 35
chr18_+_59295123 2.540 NM_002639
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr21_-_41140457 2.503 DSCAM
Down syndrome cell adhesion molecule
chr17_+_35147738 2.466 GRB7
growth factor receptor-bound protein 7
chr7_-_97868101 2.441 BAIAP2L1
BAI1-associated protein 2-like 1
chr1_+_1971762 2.404 NM_002744
PRKCZ
protein kinase C, zeta
chr1_-_44269615 2.393 SLC6A9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr21_-_43670348 2.386 SIK1
salt-inducible kinase 1
chr20_-_60375695 2.366 NM_005560
LAMA5
laminin, alpha 5
chr4_+_152549776 2.365 NM_001109977
FAM160A1
family with sequence similarity 160, member A1
chr12_-_51200347 2.352 NM_000424
KRT5
keratin 5
chr14_-_70345485 2.313 NM_033141
MAP3K9
mitogen-activated protein kinase kinase kinase 9
chr17_+_71229110 2.307 NM_000213
NM_001005731
ITGB4

integrin, beta 4

chr12_+_56271259 2.305 PIP4K2C
phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
chr18_-_45975163 2.300 NM_001080467
MYO5B
myosin VB
chr12_+_56271181 2.294 NM_001146258
NM_001146259
NM_001146260
NM_024779
PIP4K2C



phosphatidylinositol-5-phosphate 4-kinase, type II, gamma



chr17_+_71229191 2.284 ITGB4
integrin, beta 4
chr17_+_71229151 2.282 ITGB4
integrin, beta 4
chr2_+_118562499 2.274 NM_016133
INSIG2
insulin induced gene 2
chr2_+_111594921 2.250 NM_006538
NM_138621
NM_207002
BCL2L11


BCL2-like 11 (apoptosis facilitator)


chr8_+_144888275 2.199 LOC100128338
hypothetical LOC100128338
chr1_-_149586341 2.193 NM_000449
NM_001025603
RFX5

regulatory factor X, 5 (influences HLA class II expression)

chr7_+_149651202 2.190 NM_001142928
NM_023942
LRRC61

leucine rich repeat containing 61

chr1_-_58815753 2.181 NM_002353
TACSTD2
tumor-associated calcium signal transducer 2
chr19_-_6718417 2.157 NM_005490
SH2D3A
SH2 domain containing 3A
chr7_+_26298018 2.143 NM_013322
SNX10
sorting nexin 10
chr1_-_149586298 2.137 RFX5
regulatory factor X, 5 (influences HLA class II expression)
chr3_+_46996150 2.136 NM_015175
NBEAL2
neurobeachin-like 2
chrX_+_130985316 2.135 NM_001042452
MST4
serine/threonine protein kinase MST4
chr3_-_48445719 2.126 NM_002673
PLXNB1
plexin B1
chr7_+_29570024 2.109 PRR15
proline rich 15
chr22_-_20314274 2.108 NM_001017964
YDJC
YdjC homolog (bacterial)
chr2_+_120233676 2.104 NM_002830
PTPN4
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
chr17_-_28228002 2.103 NM_015194
MYO1D
myosin ID
chr2_-_224410444 2.093 AP1S3
adaptor-related protein complex 1, sigma 3 subunit
chr14_-_20636337 2.068 ZNF219
zinc finger protein 219
chr1_-_158182006 2.064 NM_001135050
NM_020789
IGSF9

immunoglobulin superfamily, member 9

chr11_-_65895640 2.060 NM_001532
SLC29A2
solute carrier family 29 (nucleoside transporters), member 2
chr1_-_58815415 2.039 TACSTD2
tumor-associated calcium signal transducer 2
chr19_+_43446937 2.031 NM_001166103
NM_021102
SPINT2

serine peptidase inhibitor, Kunitz type, 2

chr1_+_60053050 2.027 NM_015888
HOOK1
hook homolog 1 (Drosophila)
chr17_-_30440351 2.026 NM_057178
RFFL
ring finger and FYVE-like domain containing 1
chr3_+_10832867 2.011 NM_014229
SLC6A11
solute carrier family 6 (neurotransmitter transporter, GABA), member 11
chr2_-_74522513 2.004 RTKN
rhotekin
chr17_-_28228300 2.000 MYO1D
myosin ID
chr1_+_32979930 1.990 NM_020888
KIAA1522
KIAA1522
chr2_+_47449790 1.979 NM_002354
EPCAM
epithelial cell adhesion molecule
chr19_-_51909416 1.977 NM_001079882
PRKD2
protein kinase D2
chr17_+_35147697 1.969 NM_005310
GRB7
growth factor receptor-bound protein 7
chr2_-_74522534 1.962 RTKN
rhotekin
chr2_-_224410544 1.949 NM_001039569
AP1S3
adaptor-related protein complex 1, sigma 3 subunit
chr1_-_27113018 1.948 NM_021969
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr9_+_138805637 1.939 TMEM141
transmembrane protein 141
chr2_-_74522563 1.930 NM_001015055
RTKN
rhotekin
chr21_+_42807052 1.925 SLC37A1
solute carrier family 37 (glycerol-3-phosphate transporter), member 1
chr17_-_28228184 1.924 MYO1D
myosin ID
chr16_+_67328693 1.922 NM_004360
CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr1_+_61980679 1.918 NM_176877
INADL
InaD-like (Drosophila)
chr10_-_62163083 1.889 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr14_+_64240902 1.878 NM_015549
PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr3_-_45162783 1.871


chr1_-_21821597 1.870 RAP1GAP
RAP1 GTPase activating protein
chr16_+_67328715 1.860 CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr4_-_152155827 1.858 LRBA
LPS-responsive vesicle trafficking, beach and anchor containing
chr5_+_665404 1.845 NM_018140
CEP72
centrosomal protein 72kDa
chr12_+_68418829 1.843 NM_022456
NM_175624
RAB3IP

RAB3A interacting protein (rabin3)

chr10_-_71663076 1.842 NM_021129
PPA1
pyrophosphatase (inorganic) 1
chr5_+_665454 1.840 CEP72
centrosomal protein 72kDa
chr1_+_111690717 1.840 NM_181643
C1orf88
chromosome 1 open reading frame 88
chr16_+_67328805 1.816 CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr19_-_40693176 1.815 NM_001126059
DMKN
dermokine
chr6_+_54819527 1.812 NM_001010872
FAM83B
family with sequence similarity 83, member B
chr11_+_550868 1.801 NM_001143993
RASSF7
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
chr1_+_29086156 1.790 NM_001166005
NM_001166007
NM_004437
NM_203342
NM_203343
EPB41




erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)




chr1_+_29086206 1.763 EPB41
erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)
chr19_-_14177980 1.761 NM_001008701
NM_014921
LPHN1

latrophilin 1

chr12_+_48303607 1.760 NM_012272
PRPF40B
PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae)
chr2_-_99124466 1.756 NM_182911
TSGA10
testis specific, 10
chr8_+_86563382 1.752 NM_000067
CA2
carbonic anhydrase II
chr16_+_45475717 1.742 NM_133443
GPT2
glutamic pyruvate transaminase (alanine aminotransferase) 2
chr5_-_168660293 1.741 NM_003062
SLIT3
slit homolog 3 (Drosophila)
chr22_-_20314366 1.723 YDJC
YdjC homolog (bacterial)
chr17_-_6400470 1.720 NM_001165966
NM_031220
PITPNM3

PITPNM family member 3

chr3_-_45162847 1.719 CDCP1
CUB domain containing protein 1
chr17_+_9489578 1.716 NM_153210
USP43
ubiquitin specific peptidase 43
chr1_+_205293217 1.702 NM_001018053
NM_006212
PFKFB2

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2

chr5_+_167651063 1.700 NM_001161661
NM_001161662
NM_015238
WWC1


WW and C2 domain containing 1


chr2_+_47449951 1.696 EPCAM
epithelial cell adhesion molecule
chr19_+_60283571 1.694 NM_017729
EPS8L1
EPS8-like 1
chr2_-_121759237 1.689 NM_014553
TFCP2L1
transcription factor CP2-like 1
chr4_+_128922852 1.683 NM_014278
HSPA4L
heat shock 70kDa protein 4-like
chr17_+_71033339 1.681 NM_001015002
NM_001031803
NM_004524
LLGL2


lethal giant larvae homolog 2 (Drosophila)


chr3_-_24511456 1.666 THRB
thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)
chr7_-_76883642 1.662 NM_017439
PION
pigeon homolog (Drosophila)
chr9_-_40782062 1.661 NM_033160
ZNF658
zinc finger protein 658
chr8_-_81246215 1.656 NM_001025253
NM_005079
TPD52

tumor protein D52

chr2_+_190981257 1.655 NM_017694
MFSD6
major facilitator superfamily domain containing 6
chr7_+_26298136 1.653 SNX10
sorting nexin 10
chr6_+_44203335 1.653 NM_018426
TMEM63B
transmembrane protein 63B
chr3_-_191321367 1.645 LEPREL1
leprecan-like 1
chr7_+_16759845 1.645 NM_014399
TSPAN13
tetraspanin 13
chr12_+_7174230 1.642 NM_014718
CLSTN3
calsyntenin 3
chr5_+_74197473 1.641 LOC441086
hypothetical LOC441086
chr20_-_6051860 1.641 FERMT1
fermitin family member 1
chr3_-_45162865 1.639 CDCP1
CUB domain containing protein 1
chr4_+_128922924 1.633 HSPA4L
heat shock 70kDa protein 4-like
chr2_-_36384 1.619 NM_001077710
FAM110C
family with sequence similarity 110, member C
chr12_-_78608873 1.610 NM_002583
PAWR
PRKC, apoptosis, WT1, regulator
chr3_-_45162901 1.602 NM_022842
NM_178181
CDCP1

CUB domain containing protein 1

chr8_-_75396016 1.598 NM_020647
JPH1
junctophilin 1
chr8_+_102574012 1.596 GRHL2
grainyhead-like 2 (Drosophila)
chr16_+_70217564 1.595 NM_001017967
NM_052858
MARVELD3

MARVEL domain containing 3

chr2_+_99124379 1.592 NM_144706
C2orf15
chromosome 2 open reading frame 15
chr14_-_60817709 1.591 TMEM30B
transmembrane protein 30B
chr14_-_60817946 1.588


chr6_+_30960305 1.576 NM_013993
DDR1
discoidin domain receptor tyrosine kinase 1
chr3_+_188131209 1.558 ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr17_-_35911340 1.549 NM_032865
TNS4
tensin 4
chr19_+_7608010 1.545 STXBP2
syntaxin binding protein 2
chr1_+_181422016 1.539 LAMC2
laminin, gamma 2
chr22_-_37062114 1.533 CSNK1E
casein kinase 1, epsilon
chr7_+_29569978 1.528 PRR15
proline rich 15
chr14_-_60817663 1.524 TMEM30B
transmembrane protein 30B
chr8_-_143482433 1.522 NM_145003
TSNARE1
t-SNARE domain containing 1
chr6_+_150505849 1.517 NM_030949
PPP1R14C
protein phosphatase 1, regulatory (inhibitor) subunit 14C
chr17_-_21097170 1.516 NM_152914
C17orf103
chromosome 17 open reading frame 103
chr17_+_72789086 1.515 NM_001113491
SEPT9
septin 9
chr4_+_128922930 1.513 HSPA4L
heat shock 70kDa protein 4-like
chr19_+_43486640 1.508 NM_033520
C19orf33
chromosome 19 open reading frame 33
chr20_-_62081752 1.504 SAMD10
sterile alpha motif domain containing 10
chr1_+_203740391 1.500 CDK18
cyclin-dependent kinase 18
chr12_-_44949474 1.488 NM_001077484
NM_030674
SLC38A1

solute carrier family 38, member 1

chr11_+_75157414 1.487 NM_032564
DGAT2
diacylglycerol O-acyltransferase 2
chr4_+_85723080 1.487 NM_001263
CDS1
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
chr1_+_3360880 1.471 NM_014448
ARHGEF16
Rho guanine nucleotide exchange factor (GEF) 16
chr14_-_60817621 1.456


chr11_+_75157450 1.455 DGAT2
diacylglycerol O-acyltransferase 2
chr19_+_7608015 1.440 STXBP2
syntaxin binding protein 2
chr2_+_215885063 1.437 ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr17_+_35148084 1.436 NM_001030002
GRB7
growth factor receptor-bound protein 7

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.11 5.49e-04 GO:0008152 metabolic process
1.12 1.21e-03 GO:0044237 cellular metabolic process
1.36 1.40e-02 GO:0044093 positive regulation of molecular function
1.11 1.41e-02 GO:0044238 primary metabolic process
1.27 1.70e-02 GO:0033036 macromolecule localization
1.15 2.23e-02 GO:0051179 localization
1.29 4.78e-02 GO:0008104 protein localization

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.16 3.26e-17 GO:0005737 cytoplasm
1.08 7.53e-09 GO:0005622 intracellular
1.16 1.38e-08 GO:0044444 cytoplasmic part
1.08 2.75e-08 GO:0044424 intracellular part
1.14 3.23e-06 GO:0044446 intracellular organelle part
1.14 1.56e-05 GO:0044422 organelle part
1.22 4.09e-04 GO:0031090 organelle membrane
1.26 6.20e-04 GO:0012505 endomembrane system
1.31 3.92e-03 GO:0005794 Golgi apparatus
1.20 6.73e-03 GO:0005829 cytosol
1.06 2.91e-02 GO:0043226 organelle
1.06 2.93e-02 GO:0043229 intracellular organelle

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.11 1.99e-05 GO:0005515 protein binding
1.37 3.07e-04 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.24 7.58e-04 GO:0017076 purine nucleotide binding
1.23 1.01e-03 GO:0032553 ribonucleotide binding
1.23 1.01e-03 GO:0032555 purine ribonucleotide binding
1.24 1.03e-03 GO:0035639 purine ribonucleoside triphosphate binding
1.25 1.13e-03 GO:0016740 transferase activity
1.20 1.83e-03 GO:0000166 nucleotide binding
1.23 1.76e-02 GO:0005524 ATP binding
1.23 1.84e-02 GO:0030554 adenyl nucleotide binding
1.23 2.05e-02 GO:0032559 adenyl ribonucleotide binding
1.10 4.35e-02 GO:0003824 catalytic activity