Motif ID: ZBTB6.p2

Z-value: 1.423


Transcription factors associated with ZBTB6.p2:

Gene SymbolEntrez IDGene Name
ZBTB6 10773 zinc finger and BTB domain containing 6



Activity profile for motif ZBTB6.p2.

activity profile for motif ZBTB6.p2


Sorted Z-values histogram for motif ZBTB6.p2

Sorted Z-values for motif ZBTB6.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ZBTB6.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_78829342 2.034 NM_001098816
ODZ4
odz, odd Oz/ten-m homolog 4 (Drosophila)
chr17_+_52026058 1.750 NM_005450
NOG
noggin
chr12_-_51200347 1.441 NM_000424
KRT5
keratin 5
chr14_+_58174489 1.348 NM_001079520
NM_016651
DACT1

dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)

chr6_+_21701942 1.310 NM_003107
SOX4
SRY (sex determining region Y)-box 4
chr16_-_71650034 1.063 NM_001164766
ZFHX3
zinc finger homeobox 3
chr16_-_66007650 1.032 NM_013304
ZDHHC1
zinc finger, DHHC-type containing 1
chr1_-_115014151 0.926 NM_198459
DENND2C
DENN/MADD domain containing 2C
chr7_+_143683365 0.907 NM_005435
ARHGEF5
Rho guanine nucleotide exchange factor (GEF) 5
chr10_-_105604942 0.853 NM_014631
SH3PXD2A
SH3 and PX domains 2A
chrX_-_54538591 0.809 FGD1
FYVE, RhoGEF and PH domain containing 1
chr12_+_26003218 0.797 NM_001164748
NM_007211
RASSF8

Ras association (RalGDS/AF-6) domain family (N-terminal) member 8

chr12_-_51132129 0.784 NM_005555
KRT6B
keratin 6B
chr5_-_72780107 0.770 NM_004472
FOXD1
forkhead box D1
chr20_+_19903778 0.757 RIN2
Ras and Rab interactor 2
chr9_-_21549696 0.753 LOC554202
hypothetical LOC554202
chr17_-_7323528 0.753 ZBTB4
zinc finger and BTB domain containing 4
chr1_+_182622987 0.740 C1orf21
chromosome 1 open reading frame 21
chr1_-_212791188 0.738 PTPN14
protein tyrosine phosphatase, non-receptor type 14
chr19_+_62703113 0.729 NM_198542
ZNF773
zinc finger protein 773
chr16_-_62573 0.717 NM_022450
RHBDF1
rhomboid 5 homolog 1 (Drosophila)
chr19_+_62703136 0.714 ZNF773
zinc finger protein 773
chr4_-_140696740 0.709 NM_030648
SETD7
SET domain containing (lysine methyltransferase) 7
chr13_-_20533703 0.705 NM_014572
LATS2
LATS, large tumor suppressor, homolog 2 (Drosophila)
chr19_+_58750305 0.704 NM_001079907
ZNF331
zinc finger protein 331
chr2_-_235070431 0.693 NM_005737
ARL4C
ADP-ribosylation factor-like 4C
chrX_+_73557809 0.688 NM_006517
SLC16A2
solute carrier family 16, member 2 (monocarboxylic acid transporter 8)
chr10_-_73203202 0.686 NM_022153
C10orf54
chromosome 10 open reading frame 54
chr6_+_108988761 0.684 NM_001455
FOXO3
forkhead box O3
chr10_-_95231933 0.680 NM_013451
NM_133337
MYOF

myoferlin

chr12_+_54612055 0.678 NM_201444
NM_201445
NM_201554
DGKA


diacylglycerol kinase, alpha 80kDa


chr1_-_212791467 0.671 PTPN14
protein tyrosine phosphatase, non-receptor type 14
chr17_-_7323667 0.669 NM_001128833
ZBTB4
zinc finger and BTB domain containing 4
chr1_+_182622850 0.668 C1orf21
chromosome 1 open reading frame 21
chr1_-_143750988 0.660 NM_001198832
PDE4DIP
phosphodiesterase 4D interacting protein
chr19_+_45915122 0.616 ITPKC
inositol 1,4,5-trisphosphate 3-kinase C
chr5_-_149662640 0.610 NM_001012301
ARSI
arylsulfatase family, member I
chr5_-_57791544 0.608 NM_006622
PLK2
polo-like kinase 2
chr8_-_49996353 0.602 NM_003068
SNAI2
snail homolog 2 (Drosophila)
chr12_-_51173238 0.601 NM_005554
KRT6A
keratin 6A
chr18_+_40513889 0.592 NM_001130110
SETBP1
SET binding protein 1
chr5_-_54866126 0.589 NM_003711
NM_176895
RNF138P1
PPAP2A

ring finger protein 138 pseudogene 1
phosphatidic acid phosphatase type 2A

chr4_-_177950658 0.588 NM_005429
VEGFC
vascular endothelial growth factor C
chr2_+_220017617 0.578 SPEG
SPEG complex locus
chr6_-_72187168 0.575 C6orf155
chromosome 6 open reading frame 155
chr4_+_30331543 0.574 PCDH7
protocadherin 7
chr5_-_72779585 0.571 FOXD1
forkhead box D1
chr15_-_38420414 0.570 NM_207380
C15orf52
chromosome 15 open reading frame 52
chr8_-_48813256 0.565 NM_005195
CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr8_-_48813236 0.556 CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr16_-_85099941 0.555 LOC400550
hypothetical LOC400550
chr2_+_159533329 0.537 NM_001145909
NM_033394
TANC1

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1

chr4_-_4008063 0.537 LOC348926
family with sequence similarity 86, member A pseudogene
chr1_-_59020875 0.534 JUN
jun proto-oncogene
chr1_-_203557379 0.527 NM_030952
NUAK2
NUAK family, SNF1-like kinase, 2
chr10_-_33663777 0.503 NM_001024628
NM_001024629
NM_003873
NRP1


neuropilin 1


chr10_-_33663984 0.496 NRP1
neuropilin 1
chr6_+_45497796 0.490 NM_004348
RUNX2
runt-related transcription factor 2
chr3_-_75566781 0.490 FAM86DP
family with sequence similarity 86, member D, pseudogene
chr4_+_30330963 0.490 NM_001173523
NM_002589
NM_032456
NM_032457
PCDH7



protocadherin 7



chr2_-_217267742 0.489 IGFBP5
insulin-like growth factor binding protein 5
chr21_-_38210531 0.489 NM_002240
KCNJ6
potassium inwardly-rectifying channel, subfamily J, member 6
chr11_+_45825532 0.487 NM_021117
CRY2
cryptochrome 2 (photolyase-like)
chr2_-_19421852 0.486 NM_145260
OSR1
odd-skipped related 1 (Drosophila)
chr4_+_123967389 0.478 FGF2
fibroblast growth factor 2 (basic)
chr12_-_51912101 0.478 NM_000966
RARG
retinoic acid receptor, gamma
chr12_-_95317928 0.476 CDK17
cyclin-dependent kinase 17
chr5_+_131621276 0.475 PDLIM4
PDZ and LIM domain 4
chr12_-_105165805 0.475 NM_006825
CKAP4
cytoskeleton-associated protein 4
chr4_+_123967265 0.473 NM_002006
FGF2
fibroblast growth factor 2 (basic)
chr1_-_223907283 0.470 NM_001008493
NM_018212
ENAH

enabled homolog (Drosophila)

chr5_-_9599157 0.469 NM_003966
SEMA5A
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
chr10_+_22580992 0.465


chr17_-_45633873 0.465 COL1A1
collagen, type I, alpha 1
chr4_+_30331289 0.465 PCDH7
protocadherin 7
chr17_+_62804036 0.463 PITPNC1
phosphatidylinositol transfer protein, cytoplasmic 1
chr9_-_34448477 0.463 NM_001184940
NM_001184941
NM_001184942
NM_001184943
NM_001184944
NM_001184945
NM_147202
C9orf25






chromosome 9 open reading frame 25






chr17_-_45633986 0.462 NM_000088
COL1A1
collagen, type I, alpha 1
chr7_-_143523582 0.461 NM_001003702
ARHGEF35
Rho guanine nucleotide exchange factor (GEF) 35
chr11_-_35503720 0.458 NM_001001991
NM_015430
PAMR1

peptidase domain containing associated with muscle regeneration 1

chr5_+_79021401 0.458 NM_153610
CMYA5
cardiomyopathy associated 5
chr17_-_40263124 0.453 NM_005497
GJC1
gap junction protein, gamma 1, 45kDa
chr12_-_51153788 0.452 NM_173086
KRT6C
keratin 6C
chr7_-_112513379 0.450 NM_001146266
NM_001146267
GPR85

G protein-coupled receptor 85

chr8_-_134653194 0.448 NM_003033
NM_173344
ST3GAL1

ST3 beta-galactoside alpha-2,3-sialyltransferase 1

chr12_-_107775462 0.448 NM_001161330
NM_018984
SSH1

slingshot homolog 1 (Drosophila)

chr1_-_231498081 0.447 NM_014801
PCNXL2
pecanex-like 2 (Drosophila)
chrX_-_51256035 0.442 NUDT11
nudix (nucleoside diphosphate linked moiety X)-type motif 11
chr1_-_240754620 0.442 NM_152666
PLD5
phospholipase D family, member 5
chr10_-_63698463 0.442 NM_145307
RTKN2
rhotekin 2
chr10_-_76829857 0.442 ZNF503
zinc finger protein 503
chr20_+_6696744 0.440 NM_001200
BMP2
bone morphogenetic protein 2
chr10_+_123862430 0.436 TACC2
transforming, acidic coiled-coil containing protein 2
chr19_+_62690890 0.435 NM_001098491
NM_001098492
NM_001098493
NM_001098494
NM_001098495
NM_001098496
NM_024691
ZNF419






zinc finger protein 419






chr13_-_76358370 0.433 KCTD12
potassium channel tetramerisation domain containing 12
chr1_-_212791597 0.431 NM_005401
PTPN14
protein tyrosine phosphatase, non-receptor type 14
chr10_+_72642274 0.429 NM_170744
UNC5B
unc-5 homolog B (C. elegans)
chr11_+_32069183 0.427 RCN1
reticulocalbin 1, EF-hand calcium binding domain
chr5_-_151046638 0.420 SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
chr5_-_151046680 0.419 NM_003118
SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
chr19_+_43447262 0.414 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr11_+_109469296 0.414 NM_033390
ZC3H12C
zinc finger CCCH-type containing 12C
chr1_+_182622751 0.413 NM_030806
C1orf21
chromosome 1 open reading frame 21
chr17_+_1580504 0.413 WDR81
WD repeat domain 81
chr5_+_131621287 0.411 PDLIM4
PDZ and LIM domain 4
chr9_-_21999270 0.409 NM_004936
NM_078487
CDKN2B

cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)

chr11_+_45825244 0.409 NM_001127457
CRY2
cryptochrome 2 (photolyase-like)
chr1_-_32940850 0.407 SYNC
syncoilin, intermediate filament protein
chr8_+_30361485 0.405 NM_001008710
NM_001008711
NM_001008712
NM_006867
RBPMS



RNA binding protein with multiple splicing



chr17_+_9489578 0.405 NM_153210
USP43
ubiquitin specific peptidase 43
chr8_+_25098296 0.404 DOCK5
dedicator of cytokinesis 5
chr1_+_182622809 0.399 C1orf21
chromosome 1 open reading frame 21
chr6_-_82518576 0.396 FAM46A
family with sequence similarity 46, member A
chr16_+_55217085 0.394 NM_175617
MT1E
metallothionein 1E
chr9_-_101621964 0.393


chr3_-_48675321 0.391 NM_001407
CELSR3
cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)
chr3_-_191321367 0.384 LEPREL1
leprecan-like 1
chrX_-_41667174 0.382 NM_001126054
NM_001126055
NM_003688
CASK


calcium/calmodulin-dependent serine protein kinase (MAGUK family)


chr1_-_151804929 0.381 NM_005978
S100A2
S100 calcium binding protein A2
chr12_-_47868563 0.380 TUBA1A
tubulin, alpha 1a
chr11_+_110916629 0.380 LAYN
layilin
chr6_+_149109841 0.379 NM_005715
UST
uronyl-2-sulfotransferase
chr2_+_85213884 0.377 NM_031283
TCF7L1
transcription factor 7-like 1 (T-cell specific, HMG-box)
chr17_+_35853177 0.377 NM_001552
IGFBP4
insulin-like growth factor binding protein 4
chr1_-_142535878 0.375 LOC100286793
FLJ39739
hypothetical LOC100286793
hypothetical FLJ39739
chr7_+_115926855 0.375 CAV2
caveolin 2
chr8_+_143778529 0.374 NM_001160354
NM_001160355
NM_017527
LY6K


lymphocyte antigen 6 complex, locus K


chr5_+_49998677 0.372 PARP8
poly (ADP-ribose) polymerase family, member 8
chr4_-_119493322 0.371 NM_003619
PRSS12
protease, serine, 12 (neurotrypsin, motopsin)
chr2_-_72906538 0.371 NM_015189
EXOC6B
exocyst complex component 6B
chr18_+_7557313 0.371 NM_001105244
NM_002845
PTPRM

protein tyrosine phosphatase, receptor type, M

chr9_-_88159076 0.371 ZCCHC6
zinc finger, CCHC domain containing 6
chr10_-_59697636 0.370 NM_152230
IPMK
inositol polyphosphate multikinase
chr15_-_99635144 0.369 NM_018445
NM_203472
SELS

selenoprotein S

chr22_+_31527678 0.367 TIMP3
TIMP metallopeptidase inhibitor 3
chr11_-_11986704 0.367 NM_001018057
DKK3
dickkopf homolog 3 (Xenopus laevis)
chr10_+_75343352 0.363 PLAU
plasminogen activator, urokinase
chr18_+_20260603 0.362 NM_018439
IMPACT
Impact homolog (mouse)
chr11_+_65414450 0.362 NM_006848
CCDC85B
coiled-coil domain containing 85B
chr11_+_116575249 0.360 NM_001001522
NM_003186
TAGLN

transgelin

chr7_-_5429702 0.357 NM_001080495
TNRC18
trinucleotide repeat containing 18
chr18_+_20260609 0.355 IMPACT
Impact homolog (mouse)
chr12_-_91063441 0.354 NM_001731
BTG1
B-cell translocation gene 1, anti-proliferative
chr16_+_85158357 0.350 NM_005251
FOXC2
forkhead box C2 (MFH-1, mesenchyme forkhead 1)
chr19_+_627346 0.349 NM_005860
FSTL3
follistatin-like 3 (secreted glycoprotein)
chr5_+_134102067 0.348 NM_001745
CAMLG
calcium modulating ligand
chr10_+_88718167 0.346 NM_006829
C10orf116
chromosome 10 open reading frame 116
chr10_+_81882477 0.346 PLAC9
placenta-specific 9
chr21_-_42789369 0.346 NM_080860
RSPH1
radial spoke head 1 homolog (Chlamydomonas)
chr17_+_62803824 0.345 PITPNC1
phosphatidylinositol transfer protein, cytoplasmic 1
chr10_-_33663305 0.342 NRP1
neuropilin 1
chr17_+_73886290 0.342 NM_024419
PGS1
phosphatidylglycerophosphate synthase 1
chr7_-_143622188 0.340 ARHGEF5
Rho guanine nucleotide exchange factor (GEF) 5
chr22_+_31527744 0.339 TIMP3
TIMP metallopeptidase inhibitor 3
chr15_+_72006015 0.337 LOXL1
lysyl oxidase-like 1
chr16_+_639278 0.336 NM_145294
WDR90
WD repeat domain 90
chr4_-_99798563 0.336 NM_005723
TSPAN5
tetraspanin 5
chr8_-_38444398 0.334 NM_001174065
NM_001174066
NM_001174067
FGFR1


fibroblast growth factor receptor 1


chr3_+_61522310 0.333 PTPRG
protein tyrosine phosphatase, receptor type, G
chr22_+_29819343 0.332 SMTN
smoothelin
chr11_-_67029349 0.332 NM_001130848
NM_004910
PITPNM1

phosphatidylinositol transfer protein, membrane-associated 1

chr3_+_127118130 0.330 LOC100125556
family with sequence similarity 86, member A pseudogene
chr11_-_110917632 0.328


chr22_-_19122047 0.325 SCARF2
scavenger receptor class F, member 2
chr6_-_10520264 0.324 TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr17_+_62804385 0.323 NM_012417
NM_181671
PITPNC1

phosphatidylinositol transfer protein, cytoplasmic 1

chr11_+_110916442 0.322 NM_178834
LAYN
layilin
chr5_+_52812236 0.321 NM_006350
NM_013409
FST

follistatin

chr2_-_197499584 0.321 NM_024989
PGAP1
post-GPI attachment to proteins 1
chr3_+_48482625 0.321 TREX1
three prime repair exonuclease 1
chr1_-_154808944 0.321 NM_178229
IQGAP3
IQ motif containing GTPase activating protein 3
chr10_+_47875229 0.319 NM_001040084
NM_001098845
ANXA8L2
ANXA8
ANXA8L1
annexin A8-like 2
annexin A8
annexin A8-like 1
chr9_+_127549437 0.319 NM_006195
PBX3
pre-B-cell leukemia homeobox 3
chr16_+_30952382 0.319 NM_004604
STX4
syntaxin 4
chr22_+_38720881 0.319 NM_138435
FAM83F
family with sequence similarity 83, member F
chr9_-_88159143 0.319 NM_001185059
NM_001185074
NM_024617
ZCCHC6


zinc finger, CCHC domain containing 6


chr16_+_49333461 0.318 NM_001042355
NM_015247
CYLD

cylindromatosis (turban tumor syndrome)

chr2_-_158440587 0.317 NM_001111067
ACVR1
activin A receptor, type I
chr14_-_24588916 0.315 NM_014178
STXBP6
syntaxin binding protein 6 (amisyn)
chr2_+_36436873 0.314 NM_016441
CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr7_-_43875597 0.313 NM_032014
MRPS24
mitochondrial ribosomal protein S24
chr7_+_158341961 0.313 NM_018051
WDR60
WD repeat domain 60
chr1_-_93919789 0.309 NM_003567
BCAR3
breast cancer anti-estrogen resistance 3
chr11_+_71176145 0.309 NM_001099653
NM_018172
NM_152563
FAM86C


family with sequence similarity 86, member C


chr10_+_81882409 0.308 PLAC9
placenta-specific 9
chr2_+_238265617 0.308 LRRFIP1
leucine rich repeat (in FLII) interacting protein 1
chr4_+_87734489 0.308 NM_006264
NM_080683
NM_080684
NM_080685
PTPN13



protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)



chr1_+_160797853 0.307 NM_003115
UAP1
UDP-N-acteylglucosamine pyrophosphorylase 1
chr5_-_171547700 0.307 STK10
serine/threonine kinase 10
chr1_+_15145001 0.306 NM_001017999
KAZN
kazrin, periplakin interacting protein
chr11_+_76455574 0.306 NM_004055
CAPN5
calpain 5
chr11_-_11987115 0.304 DKK3
dickkopf homolog 3 (Xenopus laevis)
chr9_-_21325239 0.304 NM_018847
KLHL9
kelch-like 9 (Drosophila)
chrX_+_17303798 0.302 NHS
Nance-Horan syndrome (congenital cataracts and dental anomalies)
chr13_-_20533629 0.302 LATS2
LATS, large tumor suppressor, homolog 2 (Drosophila)
chr17_-_31146660 0.302 NM_001032278
NM_024302
MMP28

matrix metallopeptidase 28

chr15_+_68971835 0.301 NM_001199017
NM_017691
NM_001199018
LRRC49


leucine rich repeat containing 49


chr3_-_52065130 0.301 NM_001947
DUSP7
dual specificity phosphatase 7
chr12_+_32151351 0.299 NM_001003398
NM_001714
BICD1

bicaudal D homolog 1 (Drosophila)

chr18_-_22382497 0.299 NM_001142730
KCTD1
potassium channel tetramerisation domain containing 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.10 1.87e-06 GO:0009987 cellular process
1.14 5.27e-04 GO:0050794 regulation of cellular process
1.58 7.85e-04 GO:0032989 cellular component morphogenesis
1.60 7.98e-04 GO:0000902 cell morphogenesis
1.36 1.10e-03 GO:0007399 nervous system development
1.22 1.29e-03 GO:0016043 cellular component organization
1.29 1.64e-03 GO:0048523 negative regulation of cellular process
1.12 1.65e-03 GO:0065007 biological regulation
1.31 2.34e-03 GO:0006464 protein modification process
1.62 2.39e-03 GO:0032990 cell part morphogenesis
1.26 5.06e-03 GO:0048519 negative regulation of biological process
1.61 5.37e-03 GO:0048858 cell projection morphogenesis
1.12 5.66e-03 GO:0050789 regulation of biological process
1.60 6.55e-03 GO:0000904 cell morphogenesis involved in differentiation
1.19 7.40e-03 GO:0032502 developmental process
1.43 8.66e-03 GO:0048468 cell development
1.19 9.20e-03 GO:0023052 signaling
1.51 1.48e-02 GO:0030030 cell projection organization
1.44 1.53e-02 GO:0051128 regulation of cellular component organization
1.26 1.81e-02 GO:0048869 cellular developmental process
1.35 1.84e-02 GO:0009893 positive regulation of metabolic process
1.19 2.08e-02 GO:0071840 cellular component organization or biogenesis
1.20 2.34e-02 GO:0048856 anatomical structure development
1.19 2.36e-02 GO:0007165 signal transduction
1.36 2.48e-02 GO:0010604 positive regulation of macromolecule metabolic process
1.27 2.62e-02 GO:0043412 macromolecule modification
1.61 3.23e-02 GO:0007409 axonogenesis
2.48 3.24e-02 GO:0030336 negative regulation of cell migration
2.48 3.24e-02 GO:2000146 negative regulation of cell motility
1.59 3.94e-02 GO:0048667 cell morphogenesis involved in neuron differentiation
1.23 3.97e-02 GO:0048522 positive regulation of cellular process
1.22 4.31e-02 GO:0048518 positive regulation of biological process
1.58 4.33e-02 GO:0048812 neuron projection morphogenesis
1.19 4.41e-02 GO:0007275 multicellular organismal development
2.39 4.47e-02 GO:0051271 negative regulation of cellular component movement
1.21 4.74e-02 GO:0048731 system development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.38 1.28e-05 GO:0005856 cytoskeleton
1.79 6.46e-04 GO:0015629 actin cytoskeleton
1.44 6.74e-04 GO:0042995 cell projection
1.53 1.02e-03 GO:0030054 cell junction
2.63 5.88e-03 GO:0030426 growth cone
1.06 8.72e-03 GO:0005622 intracellular
2.55 1.03e-02 GO:0030427 site of polarized growth
1.57 1.43e-02 GO:0043005 neuron projection
1.09 1.62e-02 GO:0005737 cytoplasm
1.33 2.27e-02 GO:0044430 cytoskeletal part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.14 5.81e-06 GO:0005515 protein binding
1.07 1.49e-04 GO:0005488 binding
1.78 2.49e-04 GO:0042578 phosphoric ester hydrolase activity
1.78 1.03e-02 GO:0016791 phosphatase activity
1.34 4.36e-02 GO:0001071 nucleic acid binding transcription factor activity
1.34 4.36e-02 GO:0003700 sequence-specific DNA binding transcription factor activity