Motif ID: TBX4,5.p2

Z-value: 1.918


Transcription factors associated with TBX4,5.p2:

Gene SymbolEntrez IDGene Name
TBX4 9496 T-box 4
TBX5 6910 T-box 5



Activity profile for motif TBX4,5.p2.

activity profile for motif TBX4,5.p2


Sorted Z-values histogram for motif TBX4,5.p2

Sorted Z-values for motif TBX4,5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TBX4,5.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_4621924 2.123 NM_003963
TM4SF5
transmembrane 4 L six family member 5
chr1_-_205161821 2.112 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr17_-_6958282 1.734 NM_080914
ASGR2
asialoglycoprotein receptor 2
chr19_-_43800374 1.651 NM_001042600
NM_007181
MAP4K1

mitogen-activated protein kinase kinase kinase kinase 1

chr17_+_53769562 1.552 LOC100506779
hypothetical LOC100506779
chr19_-_10074332 1.420 NM_031917
ANGPTL6
angiopoietin-like 6
chr17_+_22823151 1.413 NM_014238
KSR1
kinase suppressor of ras 1
chr10_+_114125003 1.361 NM_203380
ACSL5
acyl-CoA synthetase long-chain family member 5
chr6_+_31731647 1.337 NM_019101
APOM
apolipoprotein M
chr6_+_31651319 1.284 NM_000594
TNF
tumor necrosis factor
chr4_-_105631915 1.274 NM_025212
CXXC4
CXXC finger protein 4
chr3_-_49701085 1.261 NM_020998
MST1
macrophage stimulating 1 (hepatocyte growth factor-like)
chr19_+_18312365 1.255 NM_017712
FKBP8
PGPEP1
FK506 binding protein 8, 38kDa
pyroglutamyl-peptidase I
chr14_+_94148466 1.218 NM_001085
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chrX_+_46825179 1.177 RGN
regucalcin (senescence marker protein-30)
chr6_-_25044156 1.170 FAM65B
family with sequence similarity 65, member B
chr22_-_28992787 1.164 NM_020530
OSM
oncostatin M
chr3_+_187813553 1.155 AHSG
alpha-2-HS-glycoprotein
chr2_+_171280046 1.116 NM_001003845
SP5
Sp5 transcription factor
chr11_-_118405288 1.112 NM_001164280
SLC37A4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr16_+_28785087 1.111 SH2B1
SH2B adaptor protein 1
chr19_+_17377502 1.108 LOC100507535
hypothetical LOC100507535
chr22_+_23153529 1.090 NM_000675
ADORA2A
adenosine A2a receptor
chr4_-_186970366 1.058 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr1_-_114215768 1.048 NM_001193431
NM_012411
NM_015967
PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chr2_+_171280182 1.046


chr2_-_61551350 1.042 NM_014709
USP34
ubiquitin specific peptidase 34
chr2_-_61551403 1.025 USP34
ubiquitin specific peptidase 34
chr3_-_121883647 1.023 HGD
homogentisate 1,2-dioxygenase
chr1_+_154178103 0.989 NM_181885
RXFP4
relaxin/insulin-like family peptide receptor 4
chr3_+_168936125 0.985 NM_001122752
NM_005025
SERPINI1

serpin peptidase inhibitor, clade I (neuroserpin), member 1

chr13_-_33148899 0.971 STARD13
StAR-related lipid transfer (START) domain containing 13
chr6_+_31731667 0.960 APOM
apolipoprotein M
chr22_+_37823174 0.939 NM_001166002
NM_001166003
NM_001166004
NM_181773
APOBEC3H



apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H



chr5_-_43349338 0.936 NM_001098272
NM_002130
HMGCS1

3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)

chr17_-_30440351 0.907 NM_057178
RFFL
ring finger and FYVE-like domain containing 1
chr16_+_48865521 0.903 ADCY7
adenylate cyclase 7
chr7_+_29200850 0.899 CHN2
chimerin (chimaerin) 2
chr16_+_55963899 0.887 NM_002996
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr9_+_114288899 0.882 NM_133465
KIAA1958
KIAA1958
chr5_+_133889584 0.865 NM_015288
PHF15
PHD finger protein 15
chr17_+_31455332 0.862 NM_002984
CCL4
chemokine (C-C motif) ligand 4
chr6_+_167456230 0.861 NM_031409
CCR6
chemokine (C-C motif) receptor 6
chr1_-_200395741 0.855 NM_080588
PTPN7
protein tyrosine phosphatase, non-receptor type 7
chr17_+_4841923 0.855 NM_006612
KIF1C
kinesin family member 1C
chr12_+_56435042 0.851 NM_138396
MARCH9
membrane-associated ring finger (C3HC4) 9
chr17_-_16816113 0.850 NM_012452
TNFRSF13B
tumor necrosis factor receptor superfamily, member 13B
chr17_-_36346240 0.836 KRT23
keratin 23 (histone deacetylase inducible)
chr1_-_159459814 0.831 APOA2
apolipoprotein A-II
chr16_+_55963883 0.828 CX3CL1
chemokine (C-X3-C motif) ligand 1
chr5_-_43349249 0.812 HMGCS1
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
chr17_-_50854054 0.809 NM_012329
MMD
monocyte to macrophage differentiation-associated
chr1_+_204797516 0.796 RASSF5
Ras association (RalGDS/AF-6) domain family member 5
chr1_-_200396328 0.793 PTPN7
protein tyrosine phosphatase, non-receptor type 7
chr3_+_187813538 0.791 NM_001622
AHSG
alpha-2-HS-glycoprotein
chr4_-_105635499 0.780 CXXC4
CXXC finger protein 4
chr16_-_49272741 0.775 NM_001144972
NM_153337
NM_182854
SNX20


sorting nexin 20


chr1_+_149221122 0.766 NM_003568
ANXA9
annexin A9
chr12_-_116021473 0.761 NM_001168325
NM_017899
TESC

tescalcin

chr2_+_171280944 0.756 SP5
Sp5 transcription factor
chr2_+_219453487 0.753 NM_025216
WNT10A
wingless-type MMTV integration site family, member 10A
chr3_+_114733907 0.751 NM_017699
SIDT1
SID1 transmembrane family, member 1
chr17_+_35277942 0.748 NM_198844
NM_199321
ZPBP2

zona pellucida binding protein 2

chr14_+_92188546 0.739 RIN3
Ras and Rab interactor 3
chr17_-_40858775 0.735 NM_199282
ARHGAP27
Rho GTPase activating protein 27
chr5_+_139008667 0.735 CXXC5
CXXC finger protein 5
chr6_-_149847718 0.733 ZC3H12D
zinc finger CCCH-type containing 12D
chr16_-_49272617 0.729 SNX20
sorting nexin 20
chr5_+_133870175 0.724


chr8_+_76482661 0.721 HNF4G
hepatocyte nuclear factor 4, gamma
chr3_+_187813405 0.717 AHSG
alpha-2-HS-glycoprotein
chr6_+_34867794 0.716 UHRF1BP1
UHRF1 binding protein 1
chr19_-_56561444 0.715 NM_001985
ETFB
electron-transfer-flavoprotein, beta polypeptide
chr20_-_22513050 0.715 NM_021784
FOXA2
forkhead box A2
chr1_-_27825633 0.713 NM_001042729
FGR
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
chr3_+_10832867 0.702 NM_014229
SLC6A11
solute carrier family 6 (neurotransmitter transporter, GABA), member 11
chr10_+_114125955 0.696 ACSL5
acyl-CoA synthetase long-chain family member 5
chr2_+_127892489 0.693 PROC
protein C (inactivator of coagulation factors Va and VIIIa)
chr1_+_9522107 0.690 NM_032315
SLC25A33
solute carrier family 25, member 33
chr5_-_142795269 0.687 NM_001018074
NM_001018075
NM_001018077
NR3C1


nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


chr9_-_131845077 0.685 FNBP1
formin binding protein 1
chr11_+_59979857 0.685 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chrX_+_78087484 0.685 NM_014499
NM_198333
P2RY10

purinergic receptor P2Y, G-protein coupled, 10

chr2_+_170298487 0.682


chr22_-_49363711 0.679 NM_004377
NM_152246
NM_001145134
NM_001145135
NM_001145136
NM_152245
CPT1B





carnitine palmitoyltransferase 1B (muscle)





chr7_-_22363036 0.676 NM_012294
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr7_+_29200636 0.673 NM_004067
CHN2
chimerin (chimaerin) 2
chr17_+_72958207 0.671 NM_001113496
SEPT9
septin 9
chr11_+_61279436 0.668 NM_013279
C11orf9
chromosome 11 open reading frame 9
chrX_-_48578878 0.661 NM_013271
PCSK1N
proprotein convertase subtilisin/kexin type 1 inhibitor
chr19_-_56561391 0.654 ETFB
electron-transfer-flavoprotein, beta polypeptide
chr6_+_31691745 0.648 NM_032955
AIF1
allograft inflammatory factor 1
chr2_+_170298700 0.647 KLHL23
kelch-like 23 (Drosophila)
chr11_-_60819110 0.646 VWCE
von Willebrand factor C and EGF domains
chr1_-_27113018 0.645 NM_021969
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr5_-_78318112 0.643 NM_000046
ARSB
arylsulfatase B
chr22_-_49317873 0.637 NM_001014440
ODF3B
outer dense fiber of sperm tails 3B
chr22_-_49317408 0.635 ODF3B
outer dense fiber of sperm tails 3B
chr10_+_114125927 0.635 NM_016234
ACSL5
acyl-CoA synthetase long-chain family member 5
chr17_-_35273947 0.624 NM_012481
NM_183228
NM_183229
NM_183230
NM_183231
NM_183232
IKZF3





IKAROS family zinc finger 3 (Aiolos)





chr19_-_5789740 0.623 FUT6
fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
chr17_-_33178987 0.622 HNF1B
HNF1 homeobox B
chr8_+_56177567 0.619 NM_052898
XKR4
XK, Kell blood group complex subunit-related family, member 4
chr11_-_60819273 0.619 NM_152718
VWCE
von Willebrand factor C and EGF domains
chr10_+_104145421 0.613 NM_002502
NFKB2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr16_+_11966464 0.612 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr1_-_181826086 0.607 NCF2
neutrophil cytosolic factor 2
chr19_+_54530512 0.605 CD37
CD37 molecule
chr6_-_32268615 0.602 GPSM3
G-protein signaling modulator 3
chr7_+_116238309 0.601 CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr5_+_133889243 0.600 PHF15
PHD finger protein 15
chr3_+_52254782 0.599 PPM1M
protein phosphatase, Mg2+/Mn2+ dependent, 1M
chr3_-_10307408 0.594 NM_001134941
NM_016362
GHRL

ghrelin/obestatin prepropeptide

chr18_+_30810889 0.593 NM_001143826
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr1_+_204797079 0.593 NM_182665
RASSF5
Ras association (RalGDS/AF-6) domain family member 5
chr20_-_45410033 0.591 ZMYND8
zinc finger, MYND-type containing 8
chr9_-_103237851 0.588 NM_000035
ALDOB
aldolase B, fructose-bisphosphate
chr19_+_54530458 0.583 CD37
CD37 molecule
chr6_+_97479216 0.580 NM_052904
KLHL32
kelch-like 32 (Drosophila)
chr2_+_218992053 0.578 NM_007127
VIL1
villin 1
chr1_+_204797120 0.574 RASSF5
Ras association (RalGDS/AF-6) domain family member 5
chr20_-_24987615 0.574 NM_032501
ACSS1
acyl-CoA synthetase short-chain family member 1
chr19_+_55398680 0.572 NM_001077186
NM_001145809
NM_024729
MYH14


myosin, heavy chain 14, non-muscle


chr12_-_47545816 0.572 NM_014470
RND1
Rho family GTPase 1
chr5_+_74197473 0.571 LOC441086
hypothetical LOC441086
chr11_+_118483297 0.570 NM_014807
C2CD2L
C2CD2-like
chr1_+_26609893 0.566 LIN28A
lin-28 homolog A (C. elegans)
chr11_+_66952462 0.563 NM_003952
RPS6KB2
ribosomal protein S6 kinase, 70kDa, polypeptide 2
chr6_+_32057779 0.562 NM_007293
NM_001002029
C4A
C4B
complement component 4A (Rodgers blood group)
complement component 4B (Chido blood group)
chr10_+_38685299 0.562 HSD17B7P2
hydroxysteroid (17-beta) dehydrogenase 7 pseudogene 2
chr17_+_72958330 0.562 SEPT9
septin 9
chr2_+_102719773 0.559 TMEM182
transmembrane protein 182
chr14_+_23508922 0.558 NM_001193636
NM_001193637
NM_001193635
DHRS4L2


DHRS4L1
dehydrogenase/reductase (SDR family) member 4 like 2


dehydrogenase/reductase (SDR family) member 4 like 1
chr11_-_114880275 0.557 NM_001098517
NM_014333
CADM1

cell adhesion molecule 1

chr1_+_204797214 0.556 RASSF5
Ras association (RalGDS/AF-6) domain family member 5
chr19_+_53559468 0.556 NM_012451
SYNGR4
synaptogyrin 4
chr1_+_39229474 0.554 NM_001136275
NM_024595
AKIRIN1

akirin 1

chr15_-_41879426 0.553 NM_001033517
SERINC4
serine incorporator 4
chr12_-_52975823 0.551 NFE2
nuclear factor (erythroid-derived 2), 45kDa
chrX_-_70248022 0.549 NM_000206
IL2RG
interleukin 2 receptor, gamma
chr2_-_215382537 0.549 NM_000465
BARD1
BRCA1 associated RING domain 1
chr19_+_54530546 0.547 CD37
CD37 molecule
chr11_-_116605761 0.545 PCSK7
proprotein convertase subtilisin/kexin type 7
chr6_+_167445284 0.545 NM_004367
CCR6
chemokine (C-C motif) receptor 6
chr1_-_181889070 0.544 NM_203454
APOBEC4
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
chr3_+_135996990 0.541 EPHB1
EPH receptor B1
chr17_+_37373195 0.536


chr20_-_44713466 0.535 NM_001193339
NM_001193342
NM_022829
SLC13A3


solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3


chr5_+_140871107 0.532


chr19_+_51059357 0.532 NM_004497
FOXA3
forkhead box A3
chr7_+_150065376 0.532 NM_018384
GIMAP5
GTPase, IMAP family member 5
chr19_+_54530485 0.529 NM_001040031
NM_001774
CD37

CD37 molecule

chr1_-_26505653 0.528 NM_001077262
NM_183008
UBXN11

UBX domain protein 11

chr16_+_10878539 0.526 NM_000246
CIITA
class II, major histocompatibility complex, transactivator
chr10_-_101831579 0.526 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr9_-_131845277 0.525 NM_015033
FNBP1
formin binding protein 1
chr11_-_65070625 0.524 LTBP3
latent transforming growth factor beta binding protein 3
chr2_+_69822754 0.521 ANXA4
annexin A4
chr11_-_4371463 0.521 NM_003141
TRIM21
tripartite motif containing 21
chr6_+_132170847 0.520 NM_006208
ENPP1
ectonucleotide pyrophosphatase/phosphodiesterase 1
chr14_+_23633101 0.518 NM_001018073
NM_004563
PCK2

phosphoenolpyruvate carboxykinase 2 (mitochondrial)

chr6_-_149847809 0.518 NM_207360
ZC3H12D
zinc finger CCCH-type containing 12D
chr22_+_33792125 0.517 NM_001008494
ISX
intestine-specific homeobox
chr11_-_74914066 0.516 NM_030792
GDPD5
glycerophosphodiester phosphodiesterase domain containing 5
chr15_+_41879912 0.516 NM_016400
C15orf63
chromosome 15 open reading frame 63
chr8_+_145700272 0.514 NM_005309
GPT
glutamic-pyruvate transaminase (alanine aminotransferase)
chr12_+_70120028 0.514 NM_003667
LGR5
leucine-rich repeat containing G protein-coupled receptor 5
chr6_+_132170888 0.513 ENPP1
ectonucleotide pyrophosphatase/phosphodiesterase 1
chr7_-_76883642 0.513 NM_017439
PION
pigeon homolog (Drosophila)
chr10_+_97505398 0.512 NM_001164178
NM_001164181
NM_001164179
NM_001164182
NM_001164183
NM_001776
ENTPD1





ectonucleoside triphosphate diphosphohydrolase 1





chr2_+_96355661 0.511 NM_178495
NM_001163524
ITPRIPL1

inositol 1,4,5-triphosphate receptor interacting protein-like 1

chr6_-_41781655 0.509 TFEB
transcription factor EB
chr15_+_86983038 0.508 NM_002201
ISG20
interferon stimulated exonuclease gene 20kDa
chr7_-_960897 0.506 ADAP1
ArfGAP with dual PH domains 1
chrX_-_130250715 0.505 NM_001170963
IGSF1
immunoglobulin superfamily, member 1
chr8_-_145132551 0.504 PARP10
poly (ADP-ribose) polymerase family, member 10
chr15_-_63457378 0.502 NM_004884
IGDCC3
immunoglobulin superfamily, DCC subclass, member 3
chr2_-_231498184 0.502 NM_005683
GPR55
G protein-coupled receptor 55
chr3_+_135996734 0.502 NM_004441
EPHB1
EPH receptor B1
chr17_+_52689372 0.500 NM_170721
MSI2
musashi homolog 2 (Drosophila)
chr15_-_36644122 0.499 NM_001128602
NM_005739
RASGRP1

RAS guanyl releasing protein 1 (calcium and DAG-regulated)

chr1_-_205012348 0.497 NM_000572
IL10
interleukin 10
chr15_-_77085056 0.497 NM_153815
RASGRF1
Ras protein-specific guanine nucleotide-releasing factor 1
chr11_+_70915960 0.496 NM_001012503
KRTAP5-7
keratin associated protein 5-7
chr1_+_9522133 0.496 SLC25A33
solute carrier family 25, member 33
chr17_+_43373887 0.494 NM_018129
PNPO
pyridoxamine 5'-phosphate oxidase
chr19_+_10242763 0.489 ICAM1
intercellular adhesion molecule 1
chr5_+_140870881 0.486


chr19_+_54530497 0.483 CD37
CD37 molecule
chr1_-_20122638 0.483 NM_014589
PLA2G2E
phospholipase A2, group IIE
chr14_+_74964261 0.483 NM_001135047
JDP2
Jun dimerization protein 2
chr4_+_1273662 0.481 NM_001017405
NM_005882
MAEA

macrophage erythroblast attacher

chr17_+_43374021 0.480 PNPO
pyridoxamine 5'-phosphate oxidase
chr12_+_68028397 0.479 NM_000239
LYZ
lysozyme
chr17_-_3407780 0.474 TRPV3
transient receptor potential cation channel, subfamily V, member 3
chr2_-_102719732 0.472 NM_032718
MFSD9
major facilitator superfamily domain containing 9
chr10_-_95350949 0.472 NM_006744
RBP4
retinol binding protein 4, plasma
chr20_+_35406497 0.470 NM_005417
SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chr13_+_112808102 0.469 NM_000131
NM_019616
F7

coagulation factor VII (serum prothrombin conversion accelerator)

chr14_-_53491019 0.469 NM_130851
BMP4
bone morphogenetic protein 4

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.62 1.12e-03 GO:0016126 sterol biosynthetic process
1.12 1.27e-03 GO:0065007 biological regulation
3.81 2.20e-03 GO:0006695 cholesterol biosynthetic process
1.08 2.74e-03 GO:0009987 cellular process
1.12 8.50e-03 GO:0050789 regulation of biological process
1.59 2.65e-02 GO:0006066 alcohol metabolic process
1.45 3.09e-02 GO:0006955 immune response
1.11 4.30e-02 GO:0050794 regulation of cellular process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.12 1.16e-05 GO:0005737 cytoplasm
1.50 2.33e-04 GO:0044432 endoplasmic reticulum part
1.53 3.26e-04 GO:0005789 endoplasmic reticulum membrane
1.52 3.95e-04 GO:0042175 nuclear membrane-endoplasmic reticulum network
1.40 5.11e-04 GO:0005783 endoplasmic reticulum
1.06 5.38e-03 GO:0005622 intracellular
1.29 5.84e-03 GO:0012505 endomembrane system
1.12 8.82e-03 GO:0044444 cytoplasmic part
1.23 1.17e-02 GO:0031090 organelle membrane
1.12 1.62e-02 GO:0044446 intracellular organelle part
1.06 1.68e-02 GO:0044424 intracellular part
1.12 1.93e-02 GO:0044422 organelle part
1.07 4.54e-02 GO:0043226 organelle

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.14 2.42e-06 GO:0005515 protein binding
1.41 3.07e-02 GO:0019899 enzyme binding