Motif ID: TFAP4.p2

Z-value: 1.931


Transcription factors associated with TFAP4.p2:

Gene SymbolEntrez IDGene Name
TFAP4 7023 transcription factor AP-4 (activating enhancer binding protein 4)



Activity profile for motif TFAP4.p2.

activity profile for motif TFAP4.p2


Sorted Z-values histogram for motif TFAP4.p2

Sorted Z-values for motif TFAP4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_-_87122936 4.482 NM_016206
VGLL3
vestigial like 3 (Drosophila)
chr1_+_78126787 3.393 NM_001172309
NM_144573
NEXN

nexilin (F actin binding protein)

chr3_-_87122958 3.304 VGLL3
vestigial like 3 (Drosophila)
chr11_-_47427263 2.946 NM_005055
NM_032645
RAPSN

receptor-associated protein of the synapse

chr12_-_50871953 2.883 NM_001081492
NM_182507
KRT80

keratin 80

chr9_+_133154896 2.807 NM_032728
PPAPDC3
phosphatidic acid phosphatase type 2 domain containing 3
chr1_-_93919789 2.730 NM_003567
BCAR3
breast cancer anti-estrogen resistance 3
chr6_-_154873344 2.231 CNKSR3
CNKSR family member 3
chr4_+_78089931 2.193 SEPT11
septin 11
chr8_-_145090892 2.105 NM_201381
PLEC
plectin
chr6_+_45498354 2.103 RUNX2
runt-related transcription factor 2
chr8_+_104452877 2.101 CTHRC1
collagen triple helix repeat containing 1
chr12_-_46499834 2.082 NM_001098416
NM_015401
HDAC7

histone deacetylase 7

chr6_-_154873480 2.069 CNKSR3
CNKSR family member 3
chr22_+_20068039 2.007 NM_001128635
RIMBP3B
RIMS binding protein 3B
chr10_-_126839056 2.000 NM_001329
CTBP2
C-terminal binding protein 2
chr6_+_129245978 1.947 NM_000426
NM_001079823
LAMA2

laminin, alpha 2

chr16_+_3295433 1.910 NM_153028
ZNF75A
zinc finger protein 75a
chr5_+_129268352 1.870 NM_175856
CHSY3
chondroitin sulfate synthase 3
chr16_-_71650034 1.821 NM_001164766
ZFHX3
zinc finger homeobox 3
chr3_-_126088530 1.787 ITGB5
integrin, beta 5
chr11_+_67534364 1.787 NM_000694
NM_001030010
ALDH3B1

aldehyde dehydrogenase 3 family, member B1

chr1_-_925332 1.769 NM_001142467
NM_021170
HES4

hairy and enhancer of split 4 (Drosophila)

chr11_+_67534371 1.741 ALDH3B1
aldehyde dehydrogenase 3 family, member B1
chr5_-_58370693 1.710 NM_001197221
NM_001197222
PDE4D

phosphodiesterase 4D, cAMP-specific

chr7_-_27180398 1.706 NM_018951
HOXA10
homeobox A10
chr12_+_62523648 1.684


chr13_-_25523164 1.682 NM_001007538
SHISA2
shisa homolog 2 (Xenopus laevis)
chr15_+_72006015 1.623 LOXL1
lysyl oxidase-like 1
chr15_+_90738108 1.605 NM_006011
ST8SIA2
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr4_+_78089968 1.602 SEPT11
septin 11
chr4_+_78089879 1.576 NM_018243
SEPT11
septin 11
chr21_+_36429079 1.544 NM_001236
CBR3
carbonyl reductase 3
chr10_-_30388439 1.534 NM_020848
KIAA1462
KIAA1462
chr1_+_17817397 1.506 ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr2_-_216944911 1.505 NM_020814
MARCH4
membrane-associated ring finger (C3HC4) 4
chr8_+_98857190 1.495 LAPTM4B
lysosomal protein transmembrane 4 beta
chr16_-_3295375 1.486


chrX_-_106846253 1.480 NM_001015881
TSC22D3
TSC22 domain family, member 3
chr22_-_20235372 1.473 NM_001128635
RIMBP3B
RIMS binding protein 3B
chr6_-_154873396 1.440 NM_173515
CNKSR3
CNKSR family member 3
chr11_+_133444175 1.428 JAM3
junctional adhesion molecule 3
chr16_-_65984836 1.427 NM_015964
NM_016140
TPPP3

tubulin polymerization-promoting protein family member 3

chr11_-_66945190 1.411 PPP1CA
protein phosphatase 1, catalytic subunit, alpha isozyme
chr15_-_38420414 1.393 NM_207380
C15orf52
chromosome 15 open reading frame 52
chr18_-_63334902 1.388 NM_032160
DSEL
dermatan sulfate epimerase-like
chr15_-_68933481 1.382 NM_018357
NM_197958
LARP6

La ribonucleoprotein domain family, member 6

chr1_-_39877928 1.368 NM_014571
HEYL
hairy/enhancer-of-split related with YRPW motif-like
chr2_+_56265260 1.346


chr10_+_124210980 1.320 NM_002775
HTRA1
HtrA serine peptidase 1
chr3_+_150191884 1.303 NM_001184720
NM_001184721
NM_004130
GYG1


glycogenin 1


chr1_-_39877883 1.301 HEYL
hairy/enhancer-of-split related with YRPW motif-like
chr2_-_196744546 1.294 NM_004226
STK17B
serine/threonine kinase 17b
chr1_+_143920424 1.291 NM_203458
NOTCH2NL
notch 2 N-terminal like
chr2_+_5750229 1.286 NM_003108
SOX11
SRY (sex determining region Y)-box 11
chr9_-_128924782 1.277 ANGPTL2
angiopoietin-like 2
chr18_-_16945763 1.265 NM_005406
ROCK1
Rho-associated, coiled-coil containing protein kinase 1
chr10_+_11100111 1.259 CELF2
CUGBP, Elav-like family member 2
chr10_+_11099860 1.258 NM_006561
CELF2
CUGBP, Elav-like family member 2
chr20_-_3713509 1.247 CENPB
centromere protein B, 80kDa
chr13_-_109236897 1.244 NM_003749
IRS2
insulin receptor substrate 2
chr1_-_22136263 1.238 NM_005529
HSPG2
heparan sulfate proteoglycan 2
chr17_-_19711580 1.235 NM_001142610
NM_014683
ULK2

unc-51-like kinase 2 (C. elegans)

chr1_-_56817568 1.234 PPAP2B
phosphatidic acid phosphatase type 2B
chr10_+_80498782 1.230 NM_020338
ZMIZ1
zinc finger, MIZ-type containing 1
chr10_-_126839000 1.225 CTBP2
C-terminal binding protein 2
chr1_-_39871226 1.215 HEYL
hairy/enhancer-of-split related with YRPW motif-like
chr9_-_83493415 1.208 NM_005077
TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr1_+_181259317 1.191


chr4_+_81406765 1.191 NM_004464
NM_033143
FGF5

fibroblast growth factor 5

chr9_-_128924819 1.191 NM_012098
ANGPTL2
angiopoietin-like 2
chr7_-_127458231 1.183 NM_022143
LRRC4
leucine rich repeat containing 4
chr10_+_11100075 1.179 CELF2
CUGBP, Elav-like family member 2
chr8_+_98856984 1.177 NM_018407
LAPTM4B
lysosomal protein transmembrane 4 beta
chr6_-_35804337 1.172 NM_001145775
FKBP5
FK506 binding protein 5
chr9_-_128924706 1.172 ANGPTL2
angiopoietin-like 2
chr2_+_238200922 1.171 NM_001137550
LRRFIP1
leucine rich repeat (in FLII) interacting protein 1
chr11_+_133444029 1.162 NM_032801
JAM3
junctional adhesion molecule 3
chr11_-_1975265 1.153 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr17_-_36436979 1.148 NM_031957
KRTAP1-5
keratin associated protein 1-5
chr2_-_196744507 1.143 STK17B
serine/threonine kinase 17b
chr19_+_60691671 1.136 NM_001144950
NM_001195267
SSC5D

scavenger receptor cysteine rich domain containing (5 domains)

chr2_-_219404755 1.133 NM_017431
PRKAG3
protein kinase, AMP-activated, gamma 3 non-catalytic subunit
chr7_-_27136876 1.129 NM_002141
HOXA4
homeobox A4
chr13_+_75108450 1.127 LMO7
LIM domain 7
chr9_+_89302574 1.123 NM_004938
DAPK1
death-associated protein kinase 1
chr2_-_158440587 1.117 NM_001111067
ACVR1
activin A receptor, type I
chr18_+_32131628 1.115 NM_025135
FHOD3
formin homology 2 domain containing 3
chr2_+_132890616 1.114 NM_001508
GPR39
G protein-coupled receptor 39
chr5_-_73972055 1.098 ENC1
ectodermal-neural cortex 1 (with BTB-like domain)
chr5_+_131657964 1.089 NM_003059
SLC22A4
solute carrier family 22 (organic cation/ergothioneine transporter), member 4
chr9_+_89302239 1.087 DAPK1
death-associated protein kinase 1
chr7_-_16427471 1.086 NM_001101417
NM_001101426
ISPD

isoprenoid synthase domain containing

chr1_+_238321794 1.077 NM_020066
FMN2
formin 2
chr8_-_48813236 1.073 CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr15_-_90999606 1.069 NM_207446
FAM174B
family with sequence similarity 174, member B
chr15_+_72005839 1.065 NM_005576
LOXL1
lysyl oxidase-like 1
chr17_+_14145051 1.065 NM_006041
HS3ST3B1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
chr11_-_1975144 1.058 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr4_-_8481085 1.055 ACOX3
acyl-CoA oxidase 3, pristanoyl
chr13_+_23451838 1.054


chr1_-_56817717 1.053 PPAP2B
phosphatidic acid phosphatase type 2B
chr8_+_1759502 1.043 NM_014629
ARHGEF10
Rho guanine nucleotide exchange factor (GEF) 10
chr14_-_22521544 1.042 NM_032876
JUB
jub, ajuba homolog (Xenopus laevis)
chr13_+_23451919 1.034 SPATA13
spermatogenesis associated 13
chr8_+_106400322 1.013 NM_012082
ZFPM2
zinc finger protein, multitype 2
chr12_-_105057940 1.006 NM_014840
NUAK1
NUAK family, SNF1-like kinase, 1
chr14_+_92049396 1.000 NM_024832
RIN3
Ras and Rab interactor 3
chr8_+_144420939 0.996 NM_138465
GLI4
GLI family zinc finger 4
chr15_+_72005875 0.991 LOXL1
lysyl oxidase-like 1
chr15_+_72005864 0.980 LOXL1
lysyl oxidase-like 1
chr21_-_43671355 0.979 NM_173354
SIK1
salt-inducible kinase 1
chr5_+_94981735 0.972 NM_199243
GPR150
G protein-coupled receptor 150
chr1_-_8008979 0.971 NM_018948
ERRFI1
ERBB receptor feedback inhibitor 1
chr7_+_102340579 0.970 NM_001031692
NM_005824
LRRC17

leucine rich repeat containing 17

chr3_-_126088819 0.970 NM_002213
ITGB5
integrin, beta 5
chr8_-_13178399 0.968 DLC1
deleted in liver cancer 1
chr21_+_41461597 0.962 NM_012105
NM_138991
NM_138992
BACE2


beta-site APP-cleaving enzyme 2


chr6_+_45498262 0.960 RUNX2
runt-related transcription factor 2
chr11_-_71202538 0.954 LOC285407
asparagine-linked glycosylation 1 homolog pseudogene
chr11_+_65536037 0.953 NM_001323
CST6
cystatin E/M
chr19_-_2378874 0.946 NM_012458
TIMM13
translocase of inner mitochondrial membrane 13 homolog (yeast)
chr5_-_77980097 0.945 NM_005779
LHFPL2
lipoma HMGIC fusion partner-like 2
chr4_-_10068055 0.942 NM_053042
ZNF518B
zinc finger protein 518B
chr10_+_102749597 0.942 LZTS2
leucine zipper, putative tumor suppressor 2
chr10_+_124211353 0.933 HTRA1
HtrA serine peptidase 1
chr7_+_55400634 0.933 NM_018697
LANCL2
LanC lantibiotic synthetase component C-like 2 (bacterial)
chr1_-_225572419 0.932 NM_003607
NM_014826
CDC42BPA

CDC42 binding protein kinase alpha (DMPK-like)

chr9_-_25668230 0.932 TUSC1
tumor suppressor candidate 1
chr1_-_199704773 0.931 NM_012396
PHLDA3
pleckstrin homology-like domain, family A, member 3
chr10_-_126839546 0.929 NM_001083914
CTBP2
C-terminal binding protein 2
chr11_-_1974992 0.926 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr2_-_161058550 0.924 NM_002897
NM_016836
RBMS1

RNA binding motif, single stranded interacting protein 1

chr13_-_76358370 0.923 KCTD12
potassium channel tetramerisation domain containing 12
chr3_+_144321286 0.922 NM_004267
CHST2
carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
chr16_-_73842884 0.922 NM_001170717
NM_014567
BCAR1

breast cancer anti-estrogen resistance 1

chr2_-_11523666 0.917 E2F6
E2F transcription factor 6
chr15_-_53822468 0.914 NM_173814
PRTG
protogenin
chr12_-_6535481 0.907 NM_001039670
NM_001193457
NM_080730
IFFO1


intermediate filament family orphan 1


chr3_+_124268545 0.906 NM_006810
PDIA5
protein disulfide isomerase family A, member 5
chr14_-_24588916 0.905 NM_014178
STXBP6
syntaxin binding protein 6 (amisyn)
chr1_-_226202210 0.905 NM_003395
WNT9A
wingless-type MMTV integration site family, member 9A
chr9_-_35679902 0.899 NM_003289
NM_213674
TPM2

tropomyosin 2 (beta)

chr16_-_30983909 0.888 NM_001172669
NM_001172670
ZNF668

zinc finger protein 668

chr1_+_26220852 0.887 NM_004455
EXTL1
exostoses (multiple)-like 1
chr13_+_112704028 0.884 MCF2L
MCF.2 cell line derived transforming sequence-like
chr10_-_118021532 0.881 NM_145793
GFRA1
GDNF family receptor alpha 1
chr6_-_132314004 0.879 NM_001901
CTGF
connective tissue growth factor
chr6_-_170735593 0.877 NM_002598
NM_144781
PDCD2

programmed cell death 2

chr10_+_4858321 0.869 NM_001040177
AKR1E2
aldo-keto reductase family 1, member E2
chr4_+_39734902 0.869 NM_018177
N4BP2
NEDD4 binding protein 2
chr2_-_110665188 0.868 NM_033514
LIMS3-LOC440895
LIMS3
LIMS3-LOC440895 read-through
LIM and senescent cell antigen-like domains 3
chr1_-_23376860 0.860 LUZP1
leucine zipper protein 1
chr2_-_11523727 0.854 NM_198256
E2F6
E2F transcription factor 6
chr9_-_35679799 0.851 TPM2
tropomyosin 2 (beta)
chr15_+_72005847 0.851 LOXL1
lysyl oxidase-like 1
chr2_-_219791902 0.851 NM_005689
ABCB6
ATP-binding cassette, sub-family B (MDR/TAP), member 6
chr1_-_151848039 0.845 S100A16
S100 calcium binding protein A16
chr13_-_109757442 0.844 NM_001845
COL4A1
collagen, type IV, alpha 1
chr13_+_112704051 0.842 MCF2L
MCF.2 cell line derived transforming sequence-like
chr8_+_9450800 0.842 TNKS
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chr7_+_154720416 0.840 NM_005542
NM_198336
NM_198337
INSIG1


insulin induced gene 1


chr13_-_20533629 0.839 LATS2
LATS, large tumor suppressor, homolog 2 (Drosophila)
chr1_-_8008934 0.834 ERRFI1
ERBB receptor feedback inhibitor 1
chr19_+_23091616 0.832 ZNF730
zinc finger protein 730
chr8_-_13178327 0.830


chr11_-_1975583 0.828 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr11_-_86061003 0.826 NM_006680
ME3
malic enzyme 3, NADP(+)-dependent, mitochondrial
chr10_+_103338030 0.824 NM_015448
DPCD
deleted in primary ciliary dyskinesia homolog (mouse)
chr8_-_145085616 0.823 NM_201384
PLEC
plectin
chr16_+_15435825 0.823 NM_033201
C16orf45
chromosome 16 open reading frame 45
chr11_-_1974829 0.823 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr18_+_7557313 0.820 NM_001105244
NM_002845
PTPRM

protein tyrosine phosphatase, receptor type, M

chr1_+_10193267 0.816 NM_015074
NM_183416
KIF1B

kinesin family member 1B

chr1_-_925215 0.814 HES4
hairy and enhancer of split 4 (Drosophila)
chr1_+_176329578 0.813 RASAL2
RAS protein activator like 2
chr6_-_166960690 0.811 NM_021135
RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr4_-_1655515 0.810 NM_001013622
NM_001174070
FAM53A

family with sequence similarity 53, member A

chr10_+_23768203 0.810 NM_001145373
OTUD1
OTU domain containing 1
chr11_+_76455574 0.805 NM_004055
CAPN5
calpain 5
chr11_-_86060812 0.804 NM_001014811
ME3
malic enzyme 3, NADP(+)-dependent, mitochondrial
chr13_+_112704077 0.803 MCF2L
MCF.2 cell line derived transforming sequence-like
chr9_+_91409746 0.802 NM_006705
GADD45G
growth arrest and DNA-damage-inducible, gamma
chr1_-_36589744 0.802


chr12_-_54409107 0.796 NM_001040034
NM_001780
CD63

CD63 molecule

chr16_-_63713382 0.792 NM_001797
CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr12_+_88626770 0.791 LOC338758
hypothetical LOC338758
chr8_-_41774296 0.790 NM_000037
NM_020475
NM_020476
NM_020477
ANK1



ankyrin 1, erythrocytic



chr1_-_94475504 0.788 ARHGAP29
Rho GTPase activating protein 29
chr10_-_103337968 0.787 NM_001174084
NM_001174085
NM_013274
POLL


polymerase (DNA directed), lambda


chr4_+_2783743 0.786 NM_001145855
SH3BP2
SH3-domain binding protein 2
chr11_-_118693021 0.784 NM_006500
MCAM
melanoma cell adhesion molecule
chr1_+_51206819 0.782 NM_001262
CDKN2C
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
chr22_+_21094094 0.781


chr3_+_151171755 0.780 LOC646903
hypothetical LOC646903
chr9_+_36126667 0.780 GLIPR2
GLI pathogenesis-related 2
chr11_-_832507 0.775 NM_021128
POLR2L
polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
chr11_+_832821 0.775 NM_001025238
NM_001025239
NM_003271
NM_001025235
NM_001025236
TSPAN4




tetraspanin 4




chr4_-_125853166 0.771 NM_001167882
NM_020337
ANKRD50

ankyrin repeat domain 50

chr17_-_1478859 0.765 NM_152346
SLC43A2
solute carrier family 43, member 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.40 2.76e-03 GO:0022008 neurogenesis
1.11 3.70e-03 GO:0050789 regulation of biological process
1.18 6.09e-03 GO:0007165 signal transduction
1.39 1.13e-02 GO:0048699 generation of neurons
1.10 1.15e-02 GO:0065007 biological regulation
1.16 1.31e-02 GO:0032502 developmental process
1.17 1.50e-02 GO:0023052 signaling
1.11 1.91e-02 GO:0050794 regulation of cellular process
1.28 2.23e-02 GO:0007399 nervous system development
1.46 2.33e-02 GO:0048666 neuron development
1.50 2.58e-02 GO:0031175 neuron projection development
1.17 2.69e-02 GO:0007275 multicellular organismal development
1.53 3.58e-02 GO:0007409 axonogenesis

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.28 4.20e-03 GO:0045095 keratin filament

Nothing significant found in function category.