Motif ID: NR3C1.p2

Z-value: 1.232


Transcription factors associated with NR3C1.p2:

Gene SymbolEntrez IDGene Name
NR3C1 2908 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)



Activity profile for motif NR3C1.p2.

activity profile for motif NR3C1.p2


Sorted Z-values histogram for motif NR3C1.p2

Sorted Z-values for motif NR3C1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR3C1.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_-_92670764 2.835 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr10_-_92671005 2.387 NM_014391
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr2_-_56266408 1.479 LOC100129434
hypothetical LOC100129434
chr5_+_149867866 1.336 NM_001543
NDST1
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
chr14_+_99309688 1.324 EML1
echinoderm microtubule associated protein like 1
chr6_+_36752244 1.254 NM_078467
CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr4_+_2783743 1.240 NM_001145855
SH3BP2
SH3-domain binding protein 2
chr18_-_51219880 0.931 TCF4
transcription factor 4
chr15_-_68781662 0.893 NM_001008224
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr13_+_75092570 0.891 NM_005358
LMO7
LIM domain 7
chr6_-_48186868 0.886 C6orf138
chromosome 6 open reading frame 138
chr3_-_150858274 0.879 NM_001168280
NM_015472
WWTR1

WW domain containing transcription regulator 1

chr22_-_37480898 0.707 SUN2
Sad1 and UNC84 domain containing 2
chr11_-_8695974 0.679 ST5
suppression of tumorigenicity 5
chr1_+_160868932 0.663 DDR2
discoidin domain receptor tyrosine kinase 2
chr4_+_2783764 0.662 SH3BP2
SH3-domain binding protein 2
chr6_+_64289585 0.656 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr7_-_150576634 0.616 SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr13_+_112825113 0.611 NM_000504
F10
coagulation factor X
chr11_+_73036241 0.574 NM_001130034
NM_001130035
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr7_-_150576660 0.573 NM_001003801
SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr10_+_114144512 0.549 ACSL5
acyl-CoA synthetase long-chain family member 5
chr12_-_69837831 0.544 TSPAN8
tetraspanin 8
chr15_+_88593765 0.509 NM_001029964
TTLL13
tubulin tyrosine ligase-like family, member 13
chr3_+_173043832 0.491 NM_001164436
TMEM212
transmembrane protein 212
chr2_-_37727472 0.484 CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr9_+_130722994 0.480 NM_001100876
NM_174933
PHYHD1

phytanoyl-CoA dioxygenase domain containing 1

chr2_+_37282516 0.464 LOC100505876
hypothetical LOC100505876
chr7_+_94377145 0.454 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory (inhibitor) subunit 9A


chr7_+_93388951 0.452 NM_004126
GNG11
guanine nucleotide binding protein (G protein), gamma 11
chr5_+_143171918 0.449 NM_021182
HMHB1
histocompatibility (minor) HB-1
chr10_+_24795446 0.444 KIAA1217
KIAA1217
chr19_+_15644885 0.437 NM_023944
CYP4F12
cytochrome P450, family 4, subfamily F, polypeptide 12
chr1_-_181889070 0.427 NM_203454
APOBEC4
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
chr4_-_159312973 0.427 FAM198B
family with sequence similarity 198, member B
chr10_+_24795465 0.424 KIAA1217
KIAA1217
chr11_+_44742551 0.424 NM_130783
TSPAN18
tetraspanin 18
chr17_-_31441390 0.423 NM_002983
CCL3
chemokine (C-C motif) ligand 3
chr15_-_43280664 0.423 NM_138356
SHF
Src homology 2 domain containing F
chr2_-_233586145 0.421 NGEF
neuronal guanine nucleotide exchange factor
chr9_+_119506428 0.405 TLR4
toll-like receptor 4
chr2_-_233586164 0.403 NM_019850
NGEF
neuronal guanine nucleotide exchange factor
chrX_-_83644054 0.402 NM_001177478
NM_001177479
NM_144657
HDX


highly divergent homeobox


chr22_+_39404940 0.402 NM_005297
MCHR1
melanin-concentrating hormone receptor 1
chr7_+_20621769 0.399 NM_001163941
ABCB5
ATP-binding cassette, sub-family B (MDR/TAP), member 5
chr16_+_70654625 0.398 NM_020995
HPR
haptoglobin-related protein
chr7_-_150576957 0.395 SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr11_+_19328846 0.394 NM_001111018
NAV2
neuron navigator 2
chr12_+_79625538 0.392 NM_002469
MYF6
myogenic factor 6 (herculin)
chr9_+_119506446 0.392 TLR4
toll-like receptor 4
chr5_-_172688024 0.388 STC2
stanniocalcin 2
chr1_-_171442937 0.385 NM_003326
TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr11_+_5667494 0.380 NM_006074
TRIM22
tripartite motif containing 22
chr4_+_86918870 0.375 NM_001042669
ARHGAP24
Rho GTPase activating protein 24
chr19_-_15869870 0.369 NM_001082
CYP4F2
cytochrome P450, family 4, subfamily F, polypeptide 2
chr16_-_67039874 0.369 NM_018667
SMPD3
sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
chr9_+_130723507 0.363 PHYHD1
phytanoyl-CoA dioxygenase domain containing 1
chr3_-_11585264 0.363 NM_001128221
VGLL4
vestigial like 4 (Drosophila)
chr5_-_149649380 0.361 CAMK2A
calcium/calmodulin-dependent protein kinase II alpha
chr10_+_170423 0.357 NM_001161482
NM_006624
NM_212479
ZMYND11


zinc finger, MYND-type containing 11


chr16_-_66075216 0.351 NM_001138
AGRP
agouti related protein homolog (mouse)
chr1_+_12325632 0.350 VPS13D
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr17_-_40843530 0.346 ARHGAP27
Rho GTPase activating protein 27
chr15_-_43458247 0.344 NM_001482
GATM
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr7_-_98643024 0.344 NM_001145715
KPNA7
karyopherin alpha 7 (importin alpha 8)
chr7_-_122126422 0.330 NM_139175
RNF133
ring finger protein 133
chr2_-_202271598 0.328 NM_033066
MPP4
membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
chr14_-_44792354 0.328 NM_018353
MIS18BP1
MIS18 binding protein 1
chr5_+_169749068 0.327


chr2_-_175170674 0.325 WIPF1
WAS/WASL interacting protein family, member 1
chr1_-_94359266 0.321 NM_000350
ABCA4
ATP-binding cassette, sub-family A (ABC1), member 4
chr7_+_143263191 0.321 NM_001004685
OR2F2
olfactory receptor, family 2, subfamily F, member 2
chr10_+_685887 0.321 C10orf108
chromosome 10 open reading frame 108
chr9_+_115382760 0.320 NM_021106
RGS3
regulator of G-protein signaling 3
chr5_-_169749215 0.319 NM_004137
KCNMB1
potassium large conductance calcium-activated channel, subfamily M, beta member 1
chr5_-_16791346 0.316 MYO10
myosin X
chr1_+_160868822 0.316 NM_001014796
NM_006182
DDR2

discoidin domain receptor tyrosine kinase 2

chr1_-_177106702 0.314 NM_004673
ANGPTL1
angiopoietin-like 1
chr20_-_44612619 0.308 NM_080721
C20orf123
chromosome 20 open reading frame 123
chr4_+_86918882 0.305 ARHGAP24
Rho GTPase activating protein 24
chr20_-_20641122 0.302 NM_020343
RALGAPA2
Ral GTPase activating protein, alpha subunit 2 (catalytic)
chr3_+_99733432 0.301 NM_005290
GPR15
G protein-coupled receptor 15
chr2_-_31293882 0.298 NM_001145122
CAPN14
calpain 14
chr6_-_32299757 0.297 NM_004557
NOTCH4
notch 4
chr2_+_43919606 0.295 NM_022437
ABCG8
ATP-binding cassette, sub-family G (WHITE), member 8
chr1_-_144426918 0.294 NM_007053
CD160
CD160 molecule
chr19_-_47724365 0.291 NM_001024912
NM_001184813
NM_001184815
NM_001184816
NM_001712
CEACAM1




carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)




chr9_+_132579088 0.290 NM_007313
ABL1
c-abl oncogene 1, non-receptor tyrosine kinase
chr6_+_123151669 0.282 NM_006714
SMPDL3A
sphingomyelin phosphodiesterase, acid-like 3A
chr11_-_58099884 0.281 NM_004811
LPXN
leupaxin
chr21_+_45396903 0.281 ADARB1
adenosine deaminase, RNA-specific, B1
chr10_+_116571485 0.273 NM_001135051
NM_020940
FAM160B1

family with sequence similarity 160, member B1

chr19_-_46504831 0.271


chr14_-_34252695 0.271 NM_021914
CFL2
cofilin 2 (muscle)
chrX_+_46825179 0.269 RGN
regucalcin (senescence marker protein-30)
chr3_+_52254782 0.268 PPM1M
protein phosphatase, Mg2+/Mn2+ dependent, 1M
chr2_-_215998181 0.265 FN1
fibronectin 1
chr5_+_94752803 0.264 NM_152548
FAM81B
family with sequence similarity 81, member B
chr9_+_119506274 0.264 NM_138554
TLR4
toll-like receptor 4
chr6_-_6265874 0.263 F13A1
coagulation factor XIII, A1 polypeptide
chr2_+_143603368 0.262 NM_018460
ARHGAP15
Rho GTPase activating protein 15
chr8_+_1940282 0.262 KBTBD11
kelch repeat and BTB (POZ) domain containing 11
chr1_-_199657468 0.261 NM_003281
TNNI1
troponin I type 1 (skeletal, slow)
chr11_-_33678861 0.255 NM_001166692
C11orf91
chromosome 11 open reading frame 91
chr1_-_205161821 0.253 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr20_-_24987615 0.253 NM_032501
ACSS1
acyl-CoA synthetase short-chain family member 1
chr6_-_133008834 0.253 NM_138327
TAAR1
trace amine associated receptor 1
chr5_-_78318112 0.251 NM_000046
ARSB
arylsulfatase B
chr18_+_70416090 0.250 ZNF407
zinc finger protein 407
chr20_+_30061905 0.247 NM_080625
C20orf160
chromosome 20 open reading frame 160
chr12_-_119172339 0.245 NM_025157
PXN
paxillin
chr22_-_40666168 0.244 NM_001110215
CENPM
centromere protein M
chrX_+_118598325 0.241 NM_181777
UBE2A
ubiquitin-conjugating enzyme E2A (RAD6 homolog)
chr17_-_10265991 0.240 NM_002472
MYH8
myosin, heavy chain 8, skeletal muscle, perinatal
chr20_+_61838389 0.238 NM_017806
LIME1
Lck interacting transmembrane adaptor 1
chr10_+_102662675 0.235 FAM178A
family with sequence similarity 178, member A
chr13_+_45174446 0.235 NM_152719
SPERT
spermatid associated
chr4_+_74498042 0.231 ALB
albumin
chr4_+_91035025 0.230 NM_007351
MMRN1
multimerin 1
chr6_+_116939500 0.230 NM_153711
FAM26E
family with sequence similarity 26, member E
chr5_-_111121691 0.229 NM_001142477
NM_001142476
C5orf13

chromosome 5 open reading frame 13

chr20_+_43283423 0.229 NM_003008
SEMG2
semenogelin II
chr17_-_7996409 0.228 NM_002616
PER1
period homolog 1 (Drosophila)
chr5_+_125786975 0.226 GRAMD3
GRAM domain containing 3
chr4_-_170428768 0.226 NM_020870
SH3RF1
SH3 domain containing ring finger 1
chr17_-_43470134 0.225 NM_016429
COPZ2
coatomer protein complex, subunit zeta 2
chr16_-_66558197 0.223 NM_001145964
SLC12A4
solute carrier family 12 (potassium/chloride transporters), member 4
chrX_+_128741578 0.222 SASH3
SAM and SH3 domain containing 3
chr12_-_69838045 0.222 NM_004616
TSPAN8
tetraspanin 8
chr14_+_87541220 0.221 NM_003608
GPR65
G protein-coupled receptor 65
chr4_+_120276386 0.221 NM_016599
MYOZ2
myozenin 2
chr3_+_152970904 0.219 LOC201651
arylacetamide deacetylase (esterase) pseudogene
chr1_+_111571803 0.214 NM_001025197
NM_004000
CHI3L2

chitinase 3-like 2

chr1_-_111544784 0.214 NM_024901
DENND2D
DENN/MADD domain containing 2D
chr1_+_111544469 0.210


chr13_+_100902942 0.209 NM_004791
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr20_-_4743768 0.206 NM_170774
RASSF2
Ras association (RalGDS/AF-6) domain family member 2
chr14_-_76612286 0.205


chr4_+_74496660 0.204 ALB
albumin
chr3_+_16949585 0.203 NM_015184
PLCL2
phospholipase C-like 2
chr10_-_102663070 0.203


chr16_+_8722068 0.202 NM_001127448
ABAT
4-aminobutyrate aminotransferase
chr6_-_154873480 0.201 CNKSR3
CNKSR family member 3
chr1_+_156490550 0.199 NM_001763
CD1A
CD1a molecule
chr14_+_89792646 0.199 NM_002802
PSMC1
proteasome (prosome, macropain) 26S subunit, ATPase, 1
chr9_+_115382990 0.198 RGS3
regulator of G-protein signaling 3
chr2_-_45648608 0.197 SRBD1
S1 RNA binding domain 1
chr4_-_155731288 0.194 NM_000508
NM_021871
FGA

fibrinogen alpha chain

chr6_-_6265896 0.194 NM_000129
F13A1
coagulation factor XIII, A1 polypeptide
chr1_-_35692668 0.193 KIAA0319L
KIAA0319-like
chr13_+_97403929 0.192 NM_002271
IPO5
importin 5
chrX_+_128741562 0.191 NM_018990
SASH3
SAM and SH3 domain containing 3
chr22_+_42726423 0.190 NM_001003828
PARVB
parvin, beta
chr1_-_60164912 0.189 NM_000775
CYP2J2
cytochrome P450, family 2, subfamily J, polypeptide 2
chr1_-_111544603 0.188


chr2_-_104834344 0.185 LOC100506421
hypothetical LOC100506421
chr11_-_66367279 0.185


chr4_+_74497998 0.185 ALB
albumin
chr10_+_77212524 0.184 NM_032024
C10orf11
chromosome 10 open reading frame 11
chr11_-_117589283 0.182 NM_153206
AMICA1
adhesion molecule, interacts with CXADR antigen 1
chr6_+_42896771 0.182 NM_015349
KIAA0240
KIAA0240
chr17_-_30783631 0.178 NM_018042
SLFN12
schlafen family member 12
chr7_-_92615593 0.178 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr13_-_32757835 0.177 NM_178006
STARD13
StAR-related lipid transfer (START) domain containing 13
chr10_+_91142301 0.177 NM_001548
IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr8_-_29176490 0.177 NM_015254
KIF13B
kinesin family member 13B
chr8_+_67787206 0.176 SGK3
serum/glucocorticoid regulated kinase family, member 3
chr3_+_150065732 0.171 NM_001870
CPA3
carboxypeptidase A3 (mast cell)
chr17_+_7900926 0.170


chr14_+_34831294 0.168 NM_002791
PSMA6
proteasome (prosome, macropain) subunit, alpha type, 6
chr11_+_5667392 0.166 TRIM22
tripartite motif containing 22
chr20_+_61838479 0.164 LIME1
Lck interacting transmembrane adaptor 1
chr9_-_72219359 0.163 NM_001206
KLF9
Kruppel-like factor 9
chr9_+_89722696 0.163 NM_001145124
FAM75C1
family with sequence similarity 75, member C1
chr17_-_34014390 0.162 SRCIN1
SRC kinase signaling inhibitor 1
chr22_+_36008511 0.162 CYTH4
cytohesin 4
chr12_+_58276114 0.162 SLC16A7
solute carrier family 16, member 7 (monocarboxylic acid transporter 2)
chr22_+_36008465 0.162 CYTH4
cytohesin 4
chr14_+_23686547 0.161 RNF31
ring finger protein 31
chr3_-_49289285 0.161 NM_198562
C3orf62
chromosome 3 open reading frame 62
chr10_-_69125932 0.161 NM_013266
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr14_+_23686498 0.160 NM_017999
RNF31
ring finger protein 31
chr11_+_55078358 0.158 NM_001001920
OR4C15
olfactory receptor, family 4, subfamily C, member 15
chrX_+_2619224 0.158 NM_001122898
NM_002414
CD99

CD99 molecule

chr19_-_5821546 0.158 NM_002034
FUT5
fucosyltransferase 5 (alpha (1,3) fucosyltransferase)
chr11_-_64906683 0.157 NM_001077241
NM_182556
SLC25A45

solute carrier family 25, member 45

chr1_+_43539239 0.157 NM_005424
TIE1
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
chrX_+_78087484 0.156 NM_014499
NM_198333
P2RY10

purinergic receptor P2Y, G-protein coupled, 10

chr12_+_15017222 0.155 NM_006205
PDE6H
phosphodiesterase 6H, cGMP-specific, cone, gamma
chr3_+_185300660 0.155 NM_182589
HTR3E
5-hydroxytryptamine (serotonin) receptor 3, family member E
chr6_-_154873396 0.154 NM_173515
CNKSR3
CNKSR family member 3
chr2_-_43919392 0.154 NM_022436
ABCG5
ATP-binding cassette, sub-family G (WHITE), member 5
chr1_+_103961476 0.153 NM_000699
AMY2A
amylase, alpha 2A (pancreatic)
chr3_-_25654659 0.152 TOP2B
topoisomerase (DNA) II beta 180kDa
chr1_-_111544820 0.152 DENND2D
DENN/MADD domain containing 2D
chr7_-_156161130 0.152


chr3_+_49002774 0.151 P4HTM
prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
chr6_+_17390910 0.148 NM_153020
RBM24
RNA binding motif protein 24
chr6_-_130585650 0.147 NM_001017373
SAMD3
sterile alpha motif domain containing 3
chr11_+_66367458 0.147 NM_001032279
NM_005133
RCE1

RCE1 homolog, prenyl protein peptidase (S. cerevisiae)


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.88 5.41e-07 GO:0007608 sensory perception of smell
2.69 1.91e-06 GO:0007606 sensory perception of chemical stimulus
1.33 5.55e-06 GO:0050896 response to stimulus
1.99 6.92e-04 GO:0007600 sensory perception
1.75 1.96e-03 GO:0002376 immune system process
1.97 3.77e-03 GO:0006955 immune response

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.42 1.34e-06 GO:0005886 plasma membrane
1.42 1.71e-06 GO:0071944 cell periphery
1.27 1.10e-04 GO:0044425 membrane part
1.30 2.13e-04 GO:0016021 integral to membrane
1.29 2.24e-04 GO:0031224 intrinsic to membrane
1.21 8.74e-04 GO:0016020 membrane
1.87 1.78e-03 GO:0005615 extracellular space
1.65 1.76e-02 GO:0044421 extracellular region part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.86 1.76e-08 GO:0004872 receptor activity
1.72 1.45e-07 GO:0004871 signal transducer activity
1.72 1.45e-07 GO:0060089 molecular transducer activity
2.88 3.11e-07 GO:0004984 olfactory receptor activity
2.18 6.74e-07 GO:0004930 G-protein coupled receptor activity
1.85 9.16e-06 GO:0004888 transmembrane receptor activity
9.83 3.55e-02 GO:0004522 pancreatic ribonuclease activity